期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 24, 期 9, 页码 451-459出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2013.05.001
关键词
RIP140; coregulator; nuclear receptors; metabolism; inflammation; development
资金
- Wellcome Trust [079200/Z/06/Z]
- Genesis Trust
- European Commission [HEALTH-F2-2011-278373]
- Wellcome Trust [079200/Z/06/Z] Funding Source: Wellcome Trust
Nuclear receptors (NRs) regulate tissue development and function by controlling transcription from distinct sets of genes in response to fluctuating levels of hormones or cues that modulate receptor activity. Such target gene activation or repression depends on the recruitment of coactivators or corepressors that lead to chromatin remodelling in the vicinity of target genes. Similarly to receptors, coactivators and corepressors often serve pleiotropic functions, and Nrip1 (RIP140) is no exception, playing roles in animal development and physiology. At first sight, however, RIP140 is unusual in its ability to function either as a coactivator or as a corepressor, and also serve a cytoplasmic role. The functions of RIP140 in different tissues will be summarised together with its potential contribution to disease.
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