Article
Multidisciplinary Sciences
Zhongshun Liu, Congwei Jiang, Zhangmengxue Lei, Sihan Dong, Linlin Kuang, Chenxu Huang, Ying Gao, Mu Liu, Hui Xiao, Patrick Legembre, Jae U. Jung, Huaping Liang, Xiaozhen Liang
Summary: Type I interferons (IFNs) are the first line of defense against invading pathogens. This study identified a previously unknown protein, PINLYP, that interacts with TBK1 to induce the production of type I IFN. Loss of PINLYP impaired the activation of IRF3 and the production of IFN induced by various viruses and Toll-like receptor ligands. Mice lacking PINLYP were more susceptible to lethal virus infection, highlighting the importance of PINLYP in the host defense against viral infections.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Microbiology
Robert J. Stott-Marshall, Toshana L. Foster
Summary: In this study, researchers identified ZMPSTE24 as a restriction factor against arenaviruses and found that it cooperates with IFITMs to inhibit viral infection. They also discovered that ZMPSTE24 and IFITMs restrict viral entry and replication by perturbing cellular endocytosis and highlight the importance of cellular membrane integrity for productive fusion of arenaviruses.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Robert A. Saxton, Lukas T. Henneberg, Marco Calafiore, Leon Su, Kevin M. Jude, Alan M. Hanash, K. Christopher Garcia
Summary: This study engineered a high-affinity IL-22 superagonist to investigate the molecular mechanisms of the IL-22 signaling pathway. They found that precise control of IL-22 signaling can be achieved by modulating receptor expression levels and signaling bias, leading to tissue protection effects.
Article
Immunology
Morgan Brisse, Qinfeng Huang, Mizanur Rahman, Da Di, Yuying Liang, Hinh Ly
Summary: The study demonstrates the crucial roles of MDA5 and RIG-I in controlling Pichinde virus infection in mice. Knockout of MDA5 or both MDA5 and RIG-I results in significantly higher virus titers and lower early IFN-I expression following PICV infection, but a later and heightened adaptive immune response for clearance of the infection is observed.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Xintong He, Ye Sun, Jianzhang Lu, Faiza Naz, Shenglin Ma, Jian Liu
Summary: Cytoplasmic DNA plays a crucial role in the pathogenesis of inflammatory diseases and cancer, including COVID-19 and lung carcinoma. However, understanding the specific roles of various cytoplasmic DNA-related pathways and their interactions in different inflammatory diseases is challenging. This review summarizes the latest findings on cytoplasmic DNA and its signaling pathways in inflammatory lung conditions and lung cancer progression. It provides insights into the development of common lung diseases and discusses the potential immunotherapy strategies by targeting cytoplasmic DNA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Wiebke Nicolay, Rebecca Moeller, Sina Kahl, Florian W. R. Vondran, Thomas Pietschmann, Stefan Kunz, Gisa Gerold
Summary: Our study reveals that Hep3B cells closely mimic RNA sensing through RLR and TLR3 pathways in primary hepatocytes, indicating their potential as an in vitro model for studying immune response to RNA viruses in hepatocytes.
Article
Biochemistry & Molecular Biology
Line Lykke Andersen, Yiqi Huang, Christian Urban, Lila Oubraham, Elena Winheim, Che Stafford, Dennis Nagl, Fionan O'Duill, Thomas Ebert, Thomas Engleitner, Soren Riis Paludan, Anne Krug, Roland Rad, Veit Hornung, Andreas Pichlmair
Summary: The immune system plays a crucial role in maintaining tissue homeostasis and defending against invading pathogens, and extracellular nucleotides are known to contribute to immune signaling specificity. This study focused on the responses of human macrophages to extracellular nucleotides, specifically looking at the P2Y family of nucleotide-sensing GPRC receptors. The findings reveal the important functions of P2Y receptors in regulating both inflammatory and antiviral responses in macrophages.
Article
Fisheries
Sylvie M. A. Quiniou, Jonathan Crider, Kristianna L. Felch, Eva Bengten, Pierre Boudinot
Summary: In this study, we identified the complete repertoire of IFNs and IFN receptor genes in channel catfish. We found 16 type I IFN genes representing six previously defined subgroups, as well as two type II IFN genes and their respective receptors. Our findings provide a comprehensive resource for future research on the innate antiviral immunity of channel catfish.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Immunology
Yu-Qing Lu, Jing Wu, Xiang-Ji Wu, Hui Ma, Yan-Xiu Ma, Rong Zhang, Meng-Nan Su, Nan Wu, Gong-Yin Chen, Hong-Song Chen, Xiao-Ben Pan
Summary: Research shows that IFI16 plays a role in sensing HBV infection and early changes in IFI16 mRNA in PBMCs can predict HBeAg seroconversion. Additionally, interferons can influence IFI16 degradation and subcellular location.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Virology
Sam Drury, Grace Claussen, Allison Zetterman, Hideaki Moriyama, Etsuko N. N. Moriyama, Luwen Zhang
Summary: The study identified the existence of the IRF9 gene in cartilaginous fish and discovered unique isoforms of IRF9 in old world monkeys and great apes. These isoforms, named primate-specific IRF9 (PS-IRF9), have a different C-terminal region compared to canonical IRF9. Two PS-IRF9s were found in humans, and their RNA transcripts and proteins were detected. PS-IRF9 may have unique biological functions and be involved in the regulation of the IFN pathway in a primate-specific manner.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Immunology
Mohamed L. Sobah, Aimee C. Scott, Miranda Laird, Cassandra Koole, Clifford Liongue, Alister C. Ward
Summary: By investigating the zebrafish socs3b gene, it was found that socs3b gene plays a critical role in regulating neutrophil production and macrophage activation.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Hiroyuki Oshiumi
Summary: Vaccination is the best way to prevent infectious diseases, but vaccine efficacy and adverse reactions vary among individuals. miRNAs in serum EVs can regulate immune responses and vaccine efficacy, such as miR-192 and miR-21. EV miRNAs can be used as tools to improve vaccine efficacy and predict immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jing-Ping Huang, Jing Li, Yan-Ping Xiao, Liang-Guo Xu
Summary: Our research reveals that BAG6 is a critical regulator in the RIG-I/VISA-mediated innate immune response. It inhibits the aggregation of VISA and attenuates the recruitment of TRAF2, thereby inhibiting the activation of the RLR signaling pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Elisabet Diaz-Beneitez, Liliana Lilibeth Cubas-Gaona, Oscar Candelas-Rivera, Ana Benito-Zafra, Maria Teresa Sanchez-Aparicio, Lisa Miorin, Jose F. Rodriguez, Adolfo Garcia-Sastre, Dolores Rodriguez
Summary: Infectious Bursal Disease Virus (IBDV) is an immunosuppressive disease that affects domestic chickens. This study found that TRIM25 plays an important role in the pathogenesis of IBDV by enhancing the activation of IFN-inducing pathway mediated by MDA5.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Medicine, General & Internal
Riccardo Sarzani, Francesco Spannella, Federico Giulietti, Chiara Di Pentima, Piero Giordano, Andrea Giacometti
Summary: The use of glucocorticoid drugs like dexamethasone for severe COVID-19 patients, especially those requiring mechanical ventilation or supplemental oxygen therapy, has shown the largest benefit. However, there may be no benefit for patients without hypoxemia. Administering dexamethasone after several days of symptoms can lead to positive outcomes, but early administration may have potential harm, with the optimum time for glucocorticoid administration still being debated.
INTERNAL AND EMERGENCY MEDICINE
(2022)
Article
Virology
Morgan Mann, David S. Roberts, Yanlong Zhu, Yi Li, Jia Zhou, Ying Ge, Allan R. Brasier
Summary: The study reveals that RSV infection alters the interaction proteins of BRD4, with 101 proteins significantly enriched in the BRD4 complex responsive to both RSV infection and BRD4 inhibition. These proteins are mainly transcription factors and transcriptional coactivators, including members of the AP1 transcription factor complex.
Article
Virology
Xiaofang Xu, Morgan Mann, Dianhua Qiao, Allan R. Brasier
Summary: The research utilized SMRT sequencing and short-read mRNA sequencing to characterize changes in mRNA processing in epithelial cells in response to RSV infection, revealing differential splicing and polyadenylation, particularly involving cell cycle control and the innate immune response pathway.
Article
Virology
Takaaki Koma, Masaru Yokoyama, Osamu Kotani, Naoya Doi, Nina Nakanishi, Hayato Okubo, Shun Adachi, Akio Adachi, Hironori Sato, Masako Nomaguchi
Summary: A single amino acid adaptive mutation in the V3 loop tip of Env-gp120 was found to selectively control the interactions between gp120 and CD4/CCR5 receptors in a host cell species-specific manner, influencing viral replication ability and cell tropism. This discovery may significantly advance our understanding of the HIV-1 entry mechanism and contribute to the development of effective antiviral strategies.
JOURNAL OF VIROLOGY
(2021)
Article
Virology
Shumpei P. Yasuda, Kenta Shimizu, Takaaki Koma, Nguyen Thuy Hoa, Mai Quynh Le, Zhuoxing Wei, Devinda S. Muthusinghe, Sithumini M. W. Lokupathirage, Futoshi Hasebe, Tetsu Yamashiro, Jiro Arikawa, Kumiko Yoshimatsu
Summary: Experimentally infected rats showed transient IgM production followed by increased IgG response and avidity maturation, while naturally infected rats had simultaneous high rates of IgM and IgG antibodies, with most of them developing chronic infection. IgG avidity in female rats was associated with decreased viral load in the lungs, in contrast to male rats where no relationship was observed.
Review
Physics, Applied
Takeo Minamikawa, Takaaki Koma, Akihiro Suzuki, Kentaro Nagamatsu, Takeshi Yasui, Koji Yasutomo, Masako Nomaguchi
Summary: This paper provides an overview of virus inactivation technology using deep ultraviolet light-emitting diode (DUV-LED) and discusses the impact of DUV-LED irradiation on SARS-CoV-2.
JAPANESE JOURNAL OF APPLIED PHYSICS
(2021)
Correction
Multidisciplinary Sciences
Takeo Minamikawa, Takaaki Koma, Akihiro Suzuki, Takahiko Mizuno, Kentaro Nagamatsu, Hideki Arimochi, Koichiro Tsuchiya, Kaoru Matsuoka, Takeshi Yasui, Koji Yasutomo, Masako Nomaguchi
SCIENTIFIC REPORTS
(2021)
Article
Virology
Emily K. Mantlo, Junki Maruyama, John T. Manning, Timothy G. Wanninger, Cheng Huang, Jeanon N. Smith, Michael Patterson, Slobodan Paessler, Takaaki Koma
Summary: This study reveals the importance of glycans and specific residues in the GPC of arenaviruses for virulence. By rational design of mutations, the researchers successfully attenuated the highly pathogenic MACV and provided insights for the development of potential vaccines for highly pathogenic arenaviruses. Furthermore, they found that a specific residue substitution greatly impaired MACV replication in neuronal cells.
JOURNAL OF VIROLOGY
(2022)
Article
Biochemical Research Methods
Yanlong Zhu, Stephane Esnault, Ying Ge, Nizar N. Jarjour, Allan R. Brasier
Summary: Airway remodeling in patients with asthma is associated with leukocyte numbers and remodeling markers. Patients with lower FEV1 have distinct dynamic responses to allergens.
CLINICAL PROTEOMICS
(2022)
Article
Biochemistry & Molecular Biology
Yanlong Zhu, Stephane Esnault, Ying Ge, Nizar N. Jarjour, Allan R. Brasier
Summary: This study analyzed metabolites in bronchoalveolar fluid (BALF) during a bronchial antigen challenge and identified distinct metabolic responses, providing insight into pathogenic and protective subtypes in allergic asthma.
Editorial Material
Virology
Allan R. Brasier
Article
Biochemistry & Molecular Biology
Dianhua Qiao, Melissa Skibba, Xiaofang Xu, Allan R. Brasier
Summary: Epithelial mesenchymal plasticity (EMP) is a complex cellular reprogramming event that plays a major role in tissue homeostasis. Recently, the unfolded protein response (UPR) was found to trigger EMP through the IRE1 alpha-XBP1s axis, enhancing glucose shunting to protein N glycosylation. By identifying the genomic targets of XBP1s using CUT&RUN, it was discovered that XBP1s peaks were located near various promoters of genes controlling Rho-GTPase signaling, N-linked glycosylation, and ER-Golgi transport. Moreover, the IRE1 alpha-XBP1s pathway was shown to regulate mesenchymal transcription factors and hexosamine biosynthesis in EMP by recruiting activated RNA Pol II to GC-rich promoters.
NUCLEIC ACIDS RESEARCH
(2023)
Editorial Material
Medicine, Research & Experimental
Allan R. Brasier
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Review
Medicine, Research & Experimental
Allan. R. R. Brasier, Shannon. L. L. Casey, Peggy Hatfield, Patrick. W. W. Kelly, Whitney. A. A. Sweeney, Marin Schweizer, Bo Liu, Elizabeth. S. S. Burnside
Summary: This study proposes a model for developing leadership in translational teams (TTs) from team formation to dissemination and implementation. It identifies the stable impact of leadership behaviors on team development and emphasizes the importance of ongoing reflection, evaluation, and practice to enhance leadership skills. The study also provides a comprehensive multi-level evaluation framework to track the growth of TT leadership skills.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Review
Medicine, Research & Experimental
Allan R. Brasier, Shannon L. Casey, Felice Resnik, Betsy Rolland, Elizabeth S. Burnside
Summary: Successful translation involves the application of research and product development to advance healthcare interventions. Training in team skills and attitudes can enhance translational team performance. Interdisciplinary teams undergo developmental phases, with each phase promoting knowledge generation and translation. Antecedents of stage-dependent competencies and assessment rubrics can guide training interventions for improving performance in the clinical context.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Review
Medicine, Research & Experimental
Allan R. Brasier, Elizabeth S. Burnside, Betsy Rolland
Summary: A translational team is a type of interdisciplinary team that aims to improve human health. Understanding how to promote team performance in the areas of affect, communication, management, collaborative problem-solving, and leadership is essential. This study conducted a literature review to identify key competencies that enhance team performance and develop strategies for training interventions.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Ankita Chadda, Alexander G. Kozlov, Binh Nguyen, Timothy M. Lohman, Eric A. Galburt
Summary: In this study, it was found that the DNA damage response in Mycobacterium tuberculosis differs from well-studied model bacteria. The DNA repair helicase UvrD1 in Mtb is activated through a redox-dependent process and is closely associated with the homo-dimeric Ku protein. Additionally, Ku protein is shown to stimulate the helicase activity of UvrD1.
JOURNAL OF MOLECULAR BIOLOGY
(2024)
