Article
Physiology
Adan Dagnino-Acosta, Agustin Guerrero-Hernandez
Summary: PKC inhibitors stimulate Ca2+ release from internal stores by increasing SR Ca2+ leak mediated by translocon activation. This increased leak does not deplete the Ca2+ store, but rather compensates by increasing SERCA pump activity, leading to a new steady-state level. This change also results in increased activity of high conductance, Ca2+-sensitive potassium channels.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Oncology
Fang-Yun Zhao, Shuang-Lan Xu, Chun-Fang Zhang, Jie Liu, Yue Zhang, Jiao Yang, Xi-Qian Xing
Summary: The study found that PDGF enhances the proliferation and migration of PASMCs by regulating NFATc2, suggesting a potential therapeutic target for PAH treatment.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Pharmacology & Pharmacy
Marc Q. Mazzuca, Kadir Buyukcelebi, Chen Lin, Raouf A. Khalil
Summary: The study suggests that the increased microvascular intrinsic tone and arterial stiffness may contribute to hypertensive disorders in pregnancy. It further reveals the involvement of increased active myogenic tone, changes in arterial wall structure and mechanics, and elevated levels of collagen-I in the regulation of blood flow and vascular resistance during hypertensive pregnancy.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Cell Biology
Liyu Deng, Jidong Chen, Ting Wang, Bin Chen, Lei Yang, Jing Liao, Yuqin Chen, Jian Wang, Haiyang Tang, Junbo Yi, Kang Kang, Li Li, Deming Gou
Summary: The study reveals the significance of the PDGF/MEK/ERK/PMCA4 axis in intracellular Ca2+ homeostasis in PASMCs, indicating a functional role of PMCA4 in pulmonary arterial remodeling and PAH development.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Madison Boskind, Nikitha Nelapudi, Grace Williamson, Bobby Mendez, Rucha Juarez, Lubo Zhang, Arlin B. Blood, Christopher G. Wilson, Jose Luis Puglisi, Sean M. Wilson
Summary: Intracellular Ca2+ signals play a crucial role in regulating various cellular processes. However, analyzing stochastic and rapid subcellular Ca2+ responses is time-consuming and often requires visual analysis. This study aimed to automate the analysis of Ca2+ fluorescence data from vascular myocytes without introducing errors. The results showed that the automated analysis techniques were reliable, with no significant differences compared to manual analysis. This automated approach will improve the workflow of spatial and temporal analysis of Ca2+ imaging data.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Chengjian He, Naijian Ge, Xiangdong Wang, Hai Li, Shiguang Chen, Yefa Yang
Summary: This study evaluated the safety and efficacy of conversion therapy with portal vein embolization (PVE) and transcatheter arterial chemoembolization (TACE) in patients with large unresectable hepatocellular carcinoma (HCC) and ipsilateral portal vein tumor thrombus (PVTT). The results showed that PVE + TACE treatment prolonged overall survival and conferred more favorable outcomes compared to treatment with tyrosine kinase inhibitors (TKIs) + TACE.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Florent Artru, Naik Vietti-Violi, Christine Sempoux, Joana Vieira Barbosa, Fabio Becce, Nelly Sah, Astrid Marot, Pierre Deltenre, Eleni Moschouri, Montserrat Fraga, Arnaud Hocquelet, Rafael Duran, Darius Moradpour, Pierre-Emmanuel Rautou, Alban Denys
Summary: This retrospective study aimed to evaluate the long-term outcomes of patients with chronic non-cirrhotic extrahepatic portal vein obstruction (CNC-EHPVO) who underwent portal vein recanalisation (PVR) without transjugular intrahepatic portosystemic shunt (TIPS) insertion. The study found that PVR without TIPS was feasible and safe, and associated with improved muscle mass and decreased spleen volume in patients with technical success.
Review
Cell Biology
Yingqiu Cui, Maik Gollasch, Mario Kassmann
Summary: The arterial myogenic response is a critical mechanism in maintaining constant blood flow and protecting delicate organs. The activation of mechanosensors, such as angiotensin II type 1 receptors (AT1R), plays a crucial role in this process. Aging affects the development of myogenic response. This review summarizes recent progress in understanding the role of AT1R and other mechanosensors in arterial myogenic response, along with the implications for healthy aging.
AGEING RESEARCH REVIEWS
(2023)
Article
Pharmacology & Pharmacy
Mark W. Majesky, Mary C. M. Weiser -Evans
Summary: The adventitia is a complex and dynamic tissue that receives input signals from various sources to regulate the structural and mechanical properties of blood vessels. It plays a crucial role in vascular development, homeostasis, and repair.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Hongliang Li, Jin Ryeol An, Mi Seon Seo, Minji Kang, Ryeon Heo, Seojin Park, Seo-Yeong Mun, Young Min Bae, Eun-Taek Han, Jin-Hee Han, Wanjoo Chun, Sung Hun Na, Won Sun Park
Summary: The study found that BKCa channel function in umbilical arterial smooth muscle cells of GDM patients was impaired, leading to reduced vasorelaxation activity, primarily due to decreased expression levels of BKCa channels rather than the influence of protein kinases.
Article
Chemistry, Medicinal
Duncan E. E. Shaw, Nichola Smith, Rene Beerli, Simona Cotesta, Pier-Luca D'Alessandro, Anne-Marie Edwards, Rene Lattmann, Dimitrios Lizos, Robert Pulz, Lisa Rooney, Bindi Sohal, Caroline Rynn, Jessica Taylor, Thomas Troxler, Gareth Williams, Sabine Guth, David Rowlands
Summary: Pulmonary arterial hypertension (PAH) is a devastating rare disease with a high unmet medical need. In this study, a novel small-molecule inhibitor targeting SMURF1 ligase was designed and synthesized. The lead molecule 38 showed good oral pharmacokinetics and significant efficacy in a rodent model of pulmonary hypertension.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Yen-Lin Chen, Zdravka Daneva, Maniselvan Kuppusamy, Matteo Ottolini, Thomas M. Baker, Eliska Klimentova, Soham A. Shah, Jennifer D. Sokolowski, Min S. Park, Swapnil K. Sonkusare
Summary: This study demonstrates the role of TRPV4(SMC) channels in blood pressure regulation, showing that their activity increases resting blood pressure in normal mice. The study also reveals the opposite effects of α1AR-TRPV4(SMC) signaling and intraluminal pressure-TRPV4(SMC)-BK channel signaling on blood pressure. In hypertension, constrictor α1AR-PKCα-TRPV4 signaling is upregulated, while dilator pressure-TRPV4-BK channel signaling is disrupted, leading to increased vasoconstriction and elevated blood pressure.
Review
Cell Biology
Chien-Jung Lin, Austin J. Cocciolone, Jessica E. Wagenseil
Summary: Elastin is an important protein that provides elasticity to the arterial wall, allowing it to stretch and recoil. Changes in the amount and assembly of elastin can lead to alterations in arterial structure and mechanical behavior, affecting cardiovascular function.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Xiaoze Wang, Yuxin Guo, Li Yang, Xuefeng Luo
Summary: This study reports the use of an intrahepatic arterial targeting wire to assist in portal vein puncture in cirrhotic patients with complete obliterative portal vein thrombosis (PVT). The technical success rate of TIPS placement was 90% (18/20), with a median number of three punctures. No severe complications occurred.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Clotilde Raynard, Nolwenn Tessier, Anda Huna, Marine Warnier, Jean-Michel Flaman, Fabien Van Coppenolle, Sylvie Ducreux, Nadine Martin, David Bernard
Summary: The regulation of calcium ion (Ca2+) levels during cellular senescence is not well understood. This study found that several senescence inducers increased intracellular Ca2+ content in human mammary epithelial cells (HMECs), and the expression of the Ca2+-binding protein CALB1 was upregulated through the Ca2+-dependent calcineurin/NFAT pathway. Overexpression of CALB1 buffered the rise in intracellular Ca2+ levels observed in senescent cells. Additionally, increased expression of Ca2+-binding proteins calbindins was found to be a common marker of senescent cells. These findings suggest that Ca2+ and Ca2+-binding proteins play a crucial role in regulating cellular senescence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Benoit J. Gentil, Erin O'Ferrall, Colin Chalk, Luis F. Santana, Heather D. Durham, Rami Massie
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2017)
Article
Biology
Oscar Vivas, Claudia M. Moreno, Luis F. Santana, Bertil Hille
Article
Biochemistry & Molecular Biology
Debapriya Ghosh, Madeline Nieves-Cintron, Sendoa Tajada, Ingrid Brust-Mascher, Mary C. Horne, Johannes W. Hell, Rose E. Dixon, Luis F. Santana, Manuel F. Navedo
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2018)
Article
Biochemical Research Methods
Daisuke Sato, Rose E. Dixon, Luis F. Santana, Manuel F. Navedo
PLOS COMPUTATIONAL BIOLOGY
(2018)
Article
Multidisciplinary Sciences
Madeline Nieves-Cintron, Arsalan U. Syed, Olivia R. Buonarati, Robert R. Rigor, Matthew A. Nystoriak, Debapriya Ghosh, Kent C. Sasse, Sean M. Ward, Luis F. Santana, Johannes W. Hell, Manuel F. Navedo
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
F. Donelson Smith, Mitchell H. Omar, Patrick J. Nygren, Joseph Soughayer, Naoto Hoshi, Ho-Tak Lau, Calvin G. Snyder, Tess C. Branon, Debapriya Ghosh, Lorene K. Langeberg, Alice Y. Ting, Luis F. Santana, Shao-En Ong, Manuel F. Navedo, John D. Scott
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Cell & Tissue Engineering
Ana De La Mata, Sendoa Tajada, Samantha O'Dwyer, Collin Matsumoto, Rose E. Dixon, Nirmala Hariharan, Claudia M. Moreno, Luis Fernando Santana
Article
Biology
Maria Paz Prada, Arsalan U. Syed, Olivia R. Buonarati, Gopireddy R. Reddy, Matthew A. Nystoriak, Debapriya Ghosh, Sergi Simo, Daisuke Sato, Kent C. Sasse, Sean M. Ward, Luis F. Santana, Yang K. Xiang, Johannes W. Hell, Madeline Nieves-Cintron, Manuel F. Navedo
Article
Medicine, Research & Experimental
Arsalan U. Syed, Gopireddy R. Reddy, Debapriya Ghosh, Maria Paz Prada, Matthew A. Nystoriak, Stefano Morotti, Eleonora Grandi, Padmini Sirish, Nipavan Chiamvimonvat, Johannes W. Hell, Luis F. Santana, Yang K. Xiang, Madeline Nieves-Cintron, Manuel F. Navedo
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Article
Physiology
Daisuke Sato, Gonzalo Hernandez-Hernandez, Collin Matsumoto, Sendoa Tajada, Claudia M. Moreno, Rose E. Dixon, Samantha O'Dwyer, Manuel F. Navedo, James S. Trimmer, Colleen E. Clancy, Marc D. Binder, L. Fernando Santana
JOURNAL OF GENERAL PHYSIOLOGY
(2019)
Article
Biology
Jie-Xian Dong, Yongam Lee, Michael Kirmiz, Stephanie Palacio, Camelia Dumitras, Claudia M. Moreno, Richard Sando, L. Fernando Santana, Thomas C. Sudhof, Belvin Gong, Karl D. Murray, James S. Trimmer
Article
Cell Biology
Scott A. Tiscione, Oscar Vivas, Kenneth S. Ginsburg, Donald M. Bers, Daniel S. Ory, Luis F. Santana, Rose E. Dixon, Eamonn J. Dickson
JOURNAL OF CELL BIOLOGY
(2019)
Article
Biology
Nicholas C. Vierra, Michael Kirmiz, Deborah van der List, L. Fernando Santana, James S. Trimmer
Article
Cell Biology
Benjamin M. Drum, Can Yuan, Ana de la Mata, Nathan Grainger, L. Fernando Santana
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2020)
Article
Multidisciplinary Sciences
Samantha C. O'Dwyer, Stephanie Palacio, Collin Matsumoto, Laura Guarina, Nicholas R. Klug, Sendoa Tajada, Barbara Rosati, David McKinnon, James S. Trimmer, L. Fernando Santana
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)