Article
Cell & Tissue Engineering
Junqing Li, Zhihua Wang, Juan Wang, Qian Guo, Yi Fu, Zihan Dai, Minghao Wang, Yu Bai, Xin Liu, Paul R. Cooper, Jiayuan Wu, Wenxi He
Summary: The study found that AREG promoted odontoblastic differentiation in dental pulp stem cells, facilitating regeneration and mineralization processes.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Hematology
Alan E. Mast, Wolfram Ruf
Summary: Tissue factor pathway inhibitor (TFPI) is an anticoagulant protein that inhibits the initiation phase of coagulation. TFPI acts at cells expressing tissue factor (TF) and at sites of injury, regulating bleeding in hemophilia. It has different isoforms that inhibit factor Xa and TF-FVIIa, and by forming complexes with cellular receptors, TFPI alters cellular trafficking and signaling pathways. Antibodies to TFPI's Kunitz 2 domain can effectively block thrombin generation in vessel injury and be used in hemophilia treatment.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Emergency Medicine
Keyang Chen, Zhiheng Rao, Siyang Dong, Yajing Chen, Xulan Wang, Yongde Luo, Fanghua Gong, Xiaokun Li
Summary: Following injury, the repair or regeneration process of tissues can lose control under chronic traumatic or pathological conditions, resulting in partial restoration of structure and function along with the development of fibrosis, scarring or even pathogenesis.
Review
Biochemistry & Molecular Biology
Tatsuo Kawai, Katherine J. Elliott, Rosario Scalia, Satoru Eguchi
Summary: ADAMs play a key role in cell signaling by shedding cytokines and growth factors, leading to cell proliferation and inflammation. Among them, ADAM17 is the most extensively studied member and may have significant implications in cardiovascular diseases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jun Li, Limin Luo, Yonggang Zhang, Xiao Dong, Shuyi Dang, Xiaogang Guo, Wenhui Ding
Summary: This study investigates the role of adiponectin in urotensin II-induced TNF-alpha and alpha-SMA expression and the associated signaling pathways. The results suggest that adiponectin plays an important role in vascular remodeling and may serve as a novel therapeutic target for cardiovascular disease.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2022)
Article
Cardiac & Cardiovascular Systems
Daniel S. Gaul, Natacha Calatayud, Jurgen Pahla, Nicole R. Bonetti, Yu-Jen Wang, Julien Weber, Samuele Ambrosini, Luca Liberale, Sarah Costantino, Shafeeq A. Mohammed, Simon Kraler, Lambertus J. Van Tits, Lisa Pasterk, Daria Vdovenko, Alexander Akhmedov, Frank Ruschitzka, Francesco Paneni, Thomas F. Luscher, Giovanni G. Camici, Christian M. Matter
Summary: Deletion of endothelial SIRT6 gene accelerates arterial thrombosis in mice, and silencing of SIRT6 enhances TF expression and activates inflammatory pathways in cultured human aortic endothelial cells.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Cell Biology
Gloria Riitano, Antonella Capozzi, Serena Recalchi, Daniela Caissutti, Agostina Longo, Vincenzo Mattei, Fabrizio Conti, Roberta Misasi, Tina Garofalo, Maurizio Sorice, Valeria Manganelli
Summary: This study analyzed the induction of Tissue Factor (TF) expression in endothelial cells by anti-beta 2-GPI antibodies from patients with APS through a LRP6 signal transduction pathway involving lipid rafts. The results showed that the anti-beta 2-GPI antibodies triggered LRP6 phosphorylation and subsequent activation of beta-catenin, leading to TF expression on the cell surface.
Review
Engineering, Biomedical
Aysegul Dede Eren, Steven Vermeulen, Tara C. Schmitz, Jasper Foolen, Jan de Boer
Summary: Cells and their surrounding extracellular matrix (ECM) participate in dynamic reciprocity to maintain tissue homeostasis. This involves the deposition of ECM by cells, which then presents the signals that define cell identity. The relationship between cell shape, ECM, and tissue homeostasis is important for understanding pathological conditions and for manipulating cell function in micro-fabricated platforms. This manuscript discusses the loop of phenotype in tendon tissue homeostasis, focusing on cell shape, ECM organization, and signal transduction pathways.
ACTA BIOMATERIALIA
(2023)
Review
Biochemistry & Molecular Biology
Shanshan Song, Zhangping Xiao, Frank J. Dekker, Gerrit J. Poelarends, Barbro N. Melgert
Summary: The family of macrophage migration inhibitory factor (MIF) proteins in humans consists of MIF, D-dopachrome tautomerase (D-DT), and DDT-like (DDTL). MIF has various effects on cellular processes, while the functions of D-DT and DDTL are still unclear. Targeting MIF therapeutically should be carefully considered due to its multiple functions.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Mariam Ahmed Galal, Samhar Samer Alouch, Buthainah Saad Alsultan, Huda Dahman, Nouf Abdullah Alyabis, Sarah Ammar Alammar, Ahmad Aljada
Summary: This comprehensive review thoroughly explores the intricate involvement of insulin receptor isoforms and insulin-like growth factor receptors in the insulin and insulin-like growth factor signaling pathway, emphasizing their crucial roles in cancer development and resistance to anti-cancer drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Katie E. Cohen, Boran Katunaric, Mary E. Schulz, Gopika SenthilKumar, Micaela S. Young, James E. Mace, Julie K. Freed
Summary: This study found that chronic administration of exogenous adiponectin can restore nitric oxide as the mediator of flow-induced dilation in arterioles from patients with coronary artery disease. The Adiponectin Receptor 1 (AdipoR1) plays a critical role in adiponectin-induced NO signaling during shear. Additionally, osmotin, a plant-derived protein, showed similar effects to adiponectin.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Suhasini Rajan, Christian Schremmer, Jonas Weber, Philipp Alt, Fabienne Geiger, Alexander Dietrich
Summary: Members of the TRP superfamily, particularly TRPV4, play crucial roles in respiratory system physiology and pathology, serving as potential therapeutic targets for diseases like asthma, lung fibrosis, edema, and infections.
Article
Urology & Nephrology
Yanyang Li, Pan Liu, Yalu Zhou, Hiroshi Maekawa, John B. B. Silva, Mohammed Javeed Ansari, Khaled Boubes, Yazan Alia, Dilip K. K. Deb, Benjamin R. R. Thomson, Jing Jin, Susan E. E. Quaggin
Summary: Background ischemia-reperfusion acute kidney injury (IR-AKI) affects a significant percentage of hospitalized patients. This study investigated the molecular mechanisms underlying kidney injury and protection related to the activation of the angiopoietin-Tie2 signaling pathway. It also explored the potential therapeutic benefits of deleting VE-PTP or injecting a new angiopoietin mimetic.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Hematology
Joan D. Beckman, Angelica DaSilva, Elena Aronovich, Aithanh Nguyen, Julia Nguyen, Geneva Hargis, David Reynolds, Gregory M. Vercellotti, Brian Betts, David K. Wood
Summary: This study demonstrates the anti-inflammatory and antithrombotic effects of JAK-STAT inhibitors in vascular endothelial cells, reducing the risk of thrombosis and inhibiting inflammatory responses.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Nutrition & Dietetics
Flavia G. De Carvalho, Vitor R. Munoz, Camila F. C. Brandao, Fernando M. Simabuco, Isadora C. B. Pavan, Susana C. B. R. Nakandakari, Jose Rodrigo Pauli, Leandro P. De Moura, Eduardo R. Ropelle, Julio Sergio Marchini, Adelino S. R. da Silva, Ellen C. de Freitas
Summary: Taurine supplementation showed positive effects on insulin signaling and mitochondrial metabolism in mice and adipocytes. However, the 8-week taurine administration did not change the expression of related proteins in the adipose tissue of obese women.
Article
Cardiac & Cardiovascular Systems
Silvio Antoniak, Jessica C. Cardenas, Laura J. Buczek, Frank C. Church, Nigel Mackman, Rafal Pawlinski
Editorial Material
Hematology
Nigel Mackman, Silvio Antoniak
Article
Hematology
Michael F. Bode, Alyson C. Auriemma, Steven P. Grover, Yohei Hisada, Alex Rennie, Weeranun D. Bode, Rashi Vora, Saravanan Subramaniam, Brian Cooley, Patricia Andrade-Gordon, Silvio Antoniak, Nigel Mackman
THROMBOSIS RESEARCH
(2018)
Article
Cardiac & Cardiovascular Systems
Silvio Antoniak, Kohei Tatsumi, Clare M. Schmedes, Steven P. Grover, Rafal Pawlinski, Nigel Mackman
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2018)
Article
Cell Biology
Kohei Tatsumi, Clare M. Schmedes, E. Reaves Houston, Emily Butler, Nigel Mackman, Silvio Antoniak
CELLULAR IMMUNOLOGY
(2019)
Article
Hematology
Alexander A. Boucher, Leah Rosenfeldt, Duaa Mureb, Jessica Shafer, Bal Krishan Sharma, Adam Lane, Rebecca R. Crowther, Melanie C. McKell, Jordan Whitt, Theresa Alenghat, Joseph Qualls, Silvio Antoniak, Nigel Mackman, Matthew J. Flick, Kris A. Steinbrecher, Joseph S. Palumbo
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2020)
Article
Hematology
Silvio Antoniak, Kohei Tatsumi, Clare M. Schmedes, Grant J. Egnatz, Alyson C. Auriemma, Vanthana Bharathi, Tracy Stokol, Melinda A. Beck, John H. Griffin, Joseph S. Palumbo, Nigel Mackman
Summary: The study found that PAR1 modulates the immune response during IAV infection by different cell types and protease activations. Lack of PAR1 leads to exacerbated lung inflammation, further promoting the severity and mortality of IAV infection.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Review
Cell Biology
Silvio Antoniak, Nigel Mackman
Summary: Platelets play a crucial role in maintaining vascular integrity after injury and contribute to the immune response to pathogens. During viral infections, they can both reduce blood-borne viruses by engulfing them and enhance inflammation and tissue injury.
Review
Hematology
Nigel Mackman, Steven P. Grover, Silvio Antoniak
Summary: TF expression is increased during viral infections, particularly in lung epithelial cells of COVID-19 patients. Increased TF expression associated with viral infections may contribute to thrombosis.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Hematology
Saravanan Subramaniam, Yamini Ogoti, Irene Hernandez, Mark Zogg, Fady Botros, Robert Burns, Jacob T. DeRousse, Chris Dockendorff, Nigel Mackman, Silvio Antoniak, Craig Fletcher, Hartmut Weiler
Summary: The study found that the combined action of coagulation proteases and the TLR3 ligand poly(I:C) affects the gene expression levels of human endothelial cells, promoting the prothrombotic and proinflammatory functions of endothelial cells. The synergistic costimulation with thrombin and poly(I:C) requires proteolytic activation of protease-activated receptor 1 (PAR1) by thrombin and transactivation of PAR2 by the PAR1-tethered ligand, resulting in a positive feedback mechanism that reinforces and amplifies the prothrombotic and proinflammatory function of endothelial cells in response to the viral RNA analogue poly(I:C).
Article
Hematology
Robert H. Lee, Tomohiro Kawano, Steven P. Grover, Vanthana Bharathi, David Martinez, Dale O. Cowley, Nigel Mackman, Wolfgang Bergmeier, Silvio Antoniak
Summary: The study created a mouse line with megakaryocyte/platelet-specific deletion of PAR4 and demonstrated the critical role of platelet PAR4 in venous thrombosis and hemostatic plug stability.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Microbiology
Oscar Negron, Woosuk S. Hur, Joni Prasad, David S. Paul, Sarah E. Rowe, Jay L. Degen, Sara R. Abrahams, Silvio Antoniak, Brian P. Conlon, Wolfgang Bergmeier, Magnus Hook, Matthew J. Flick
Summary: The binding between fibrinogen and Staphylococcus aureus plays a crucial role in the host antimicrobial response against infection. However, fibrin polymer formation alone is not enough to prevent microbial dissemination.
Article
Hematology
Steven P. Grover, Vanthana Bharathi, Jens J. Posma, John H. Griffin, Joseph S. Palumbo, Nigel Mackman, Silvio Antoniak
Summary: The chemotherapeutic drug doxorubicin is cardiotoxic and can cause irreversible heart failure. In addition, it induces the activation of coagulation. Thrombin-mediated activation of protease-activated receptor 1 (PAR1) has been found to contribute to doxorubicin-induced cardiac injury.
Article
Hematology
Steven P. Grover, Clare M. Schmedes, Alyson C. Auriemma, Emily Butler, Molly L. Parrish, Adam Miszta, Audrey C. Cleuren, Mayken Visser, Stefan Heitmeier, Jens J. Posma, Henri M. Spronk, Silvio Antoniak, Alisa S. Wolberg, Rafal Pawlinski, David Gailani, Nigel Mackman
Review
Hematology
Silvio Antoniak
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2018)
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)