Article
Immunology
Xiaogao Jin, Yanlin Wang
Summary: The study revealed that globular adiponectin induced the production of inflammatory cytokines in Raw 264.7 cells, while full-length adiponectin promoted macrophage migration.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Environmental Sciences
Yoo-Jin Park, Won-Ki Pang, Do-Yeal Ryu, Elikanah Olusayo Adegoke, Md Saidur Rahman, Myung-Geol Pang
Summary: The study suggests that exposure to BPA may induce male infertility by disrupting the ability of basal cells to perceive environmental changes and reducing macrophage phagocytosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Lan Gao, Tong Lyu, Yingmin Lyu
Summary: SQUAMOSA Promoter-Binding Protein-Like (SPL) genes are plant-specific transcription factors that regulate floral induction and development, fertility, light signals, hormonal transduction, and stress response in plants. This study identified and analyzed 32 PySPL genes with complete SBP conserved domain in the genome of Prunus x yedoensis 'Somei-yoshino'. The results provide insights into the function and importance of SPL genes in flowering.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Tong Lei, Jiayu Zhang, Qian Zhang, Xinran Ma, Yanan Xu, Yang Zhao, Lianfeng Zhang, Zhongbing Lu, Yong Zhao
Summary: Tissue-resident macrophages are derived from different precursor cells and their differentiation is regulated by various signaling pathways. The transcription factor Irf4 may play a crucial role in their differentiation. Lysm-GFP reporter mice can be used to distinguish newly formed and long-term surviving tissue-resident macrophages.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Environmental Sciences
Yorum Hwang, Jongmin Kim, Youngryel Ryu
Summary: Drought stress leads to an increase in leaf-level steady-state fluorescence yield but decreases the maximum photosynthetic rate, stomatal conductance, and quantum yield of Photosystem II. Canopy structural changes, such as changes in leaf inclination angle and crown cover, contribute to the reduction of canopy-level solar-induced chlorophyll fluorescence (SIF) under drought stress conditions. Understanding the impact of canopy structural changes is important for interpreting SIF reduction in drought conditions.
REMOTE SENSING OF ENVIRONMENT
(2023)
Article
Environmental Sciences
Matias S. Netto, Jordana Georgin, Dison S. P. Franco, Evandro S. Mallmann, Edson Luiz Foletto, Marcelo Godinho, Diana Pinto, Guilherme L. Dotto
Summary: Hydrochar prepared from Prunus serrulata bark through hydrothermal treatment showed high adsorption efficiency for removing atrazine from river waters, with low cost and high efficacy.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Entomology
Tadahisa Urano, Hisatomo Taki, Etsuko Shoda-Kagaya
Summary: The red-necked longhorn beetle Aromia bungii primarily infests peach trees rather than flowering cherry trees. While the impact of A.bungii is currently more severe on flowering cherry trees in Japan, there is a greater long-term risk to Prunus persica.
Article
Integrative & Complementary Medicine
Jia-yi Zhao, Jin Pu, Jian Fan, Xin-yu Feng, Jian-wen Xu, Rong Zhang, Yan Shang
Summary: The study investigates the effects of Tanshinone IIA (Tan-IIA) on acute lung injury (ALI) and finds that Tan-IIA can prevent ALI-induced inflammation and improve alveolar epithelial repair by regulating macrophage polarization.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2022)
Article
Toxicology
Sean M. Harris, Kelly M. Bakulski, John Dou, Ethan Houskamp, Eleanor C. Scheeres, Emily Schellenboom, Olivia Harlow, Rita Loch-Caruso, Erica Boldenow
Summary: The study shows that DCVC inhibits inflammatory responses in macrophages. Transcriptomic analysis reveals 1399 differentially expressed genes in cells co-treated with DCVC and LPS. DCVC+LPS treatment downregulates pathways related to acute inflammatory response, production of molecular mediator of immune response, and phagocytosis. Additionally, DCVC inhibits the increase of IL-113, IL-6, and TNF-alpha levels induced by LPS.
TOXICOLOGY IN VITRO
(2022)
Article
Immunology
Mai M. Abdelmoaty, Pravin Yeapuri, Jatin Machhi, Katherine E. Olson, Farah Shahjin, Vikas Kumar, You Zhou, Jingjing Liang, Kabita Pandey, Arpan Acharya, Siddappa N. Byrareddy, R. Lee Mosley, Howard E. Gendelman
Summary: Following SARS-CoV-2 infection, the host mounts a robust innate immune response characterized by a pro-inflammatory storm, leading to end-organ tissue damage.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Julie A. Tomolonis, Xin Xu, Kshiti H. Dholakia, Chunchao Zhang, Linjie Guo, Amy N. Courtney, Siyue Wang, Julien Balzeau, Gabriel A. Barragan, Gengwen Tian, Erica J. Di Pierro, Leonid S. Metelitsa
Summary: We have identified a novel protumorigenic circuit between neuroblastoma (NB) cells and monocytes that is triggered and sustained by tumor necrosis factor alpha (TNF-alpha). The interaction between NB cells and monocytes leads to activation of monocytes and production of pro-inflammatory cytokines, resulting in tumor progression and therapy resistance. Targeting this mechanism could be a potential therapeutic strategy for NB.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Biochemistry & Molecular Biology
Nataliya Mushenkova, Nikita G. Nikiforov, Nikolay K. Shakhpazyan, Varvara A. Orekhova, Nikolay K. Sadykhov, Alexander N. Orekhov
Summary: Chronic inflammation, particularly low-grade inflammation, is an important mechanism of osteoarthritis (OA). Macrophages play a central role in chronic inflammation, pain, cartilage destruction, and bone remodeling. However, reducing macrophage content in the joints can have deleterious effects in OA models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Majid Zeinali, Azam Shafaei, Houshang Rafatpanah, Arman Mosavat, Naser Tayebi-Meybodi, Hossein Hosseinzadeh, Seyed Abdolrahim Rezaee
Summary: This study investigated the sub-acute toxicity of diazinon (DZN) and the protective activities of chrysin (CH) on the immune system of mice. The results showed that DZN can damage the liver and suppress immune cell populations and functions, while CH can overcome the toxic effects of DZN and enhance immune cell and antibody production.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Alberto Canfran-Duque, Noemi Rotllan, Xinbo Zhang, Irene Andres-Blasco, Bonne M. Thompson, Jonathan Sun, Nathan L. Price, Marta Fernandez-Fuertes, Joseph W. Fowler, Diego Gomez-Coronado, William C. Sessa, Chiara Giannarelli, Robert J. Schneider, George Tellides, Jeffrey G. McDonald, Carlos Fernandez-Hernando, Yajaira Suarez
Summary: The accumulation of 25-hydroxycholesterol (25-HC) in human coronary atherosclerotic lesions accelerates atherosclerosis progression and promotes plaque instability through autocrine and paracrine actions. Macrophage-derived 25-HC intensifies the inflammatory response of lipid-loaded macrophages and inhibits smooth muscle cell migration within the plaque. These effects are independent of 25-HC-mediated modulation of transcriptional activity.
Article
Immunology
Ewelina Hoffman, Paulina Napieralska, Rhamiya Mahendran, Darragh Murnane, Victoria Hutter
Summary: This study aimed to distinguish between activated and non-activated alveolar macrophage using high content image analysis techniques, and to explore the generation process of 'foamy' macrophage phenotypes. The results showed distinct morphological and functional features of macrophages activated by LPS/IFN-gamma, as well as the proinflammatory characteristics of 'foamy' macrophages induced by certain compounds.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yong Sub Shin, Kwan Joong Kim, Hyein Park, Mi-Gi Lee, Sueungmok Cho, Soo-Im Choi, Ho Jin Heo, Dae-Ok Kim, Gun-Hee Kim
Summary: The study showed that the Ecklonia cava phlorotannin-rich extract (ECPE) has antioxidative, neuroprotective, and anti-apoptotic effects on neuronal PC-12 cells, suggesting its potential for the development of functional materials to improve cognition and memory.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Food Science & Technology
Chi Heung Cho, Young Sung Jung, Jong Min Kim, Tae Gyu Nam, Sang-Hoon Lee, Hye Sung Cho, Myoung Chong Song, Ho Jin Heo, Dae-Ok Kim
Summary: The Actinidia eriantha cv. Bidan extract (AEE) showed neuroprotective effects by reducing reactive oxygen species levels and suppressing apoptotic cell death, resulting in improvements in learning and spatial memory in Aβ1-42-treated mice. AEE also increased endogenous antioxidant systems in mouse brain tissue and contained caffeic acid derivatives, suggesting its potential to improve cognitive function as a source of antioxidant phenolics.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Min-Jeong Kim, Eun-Sang Hwang, Kwan Joong Kim, Sungho Maeng, Ho Jin Heo, Ji-Ho Park, Dae-Ok Kim
Summary: This study found that EGCG can alleviate scopolamine-induced learning and memory impairments and improve brain function. This may be achieved through mechanisms such as improving cholinergic function and reducing oxidative stress.
Article
Chemistry, Applied
Mi-Seon Kim, Young Sung Jung, Davin Jang, Chi Heung Cho, Sang-Hoon Lee, Nam Soo Han, Dae-Ok Kim
Summary: This study evaluated the antioxidant capacity, bioaccessibility, and bioavailability of 12 soy isoflavones (SIs). The results showed that SIs were stable under gastric digestion conditions but unstable under small intestinal digestion conditions for acetyl and malonyl conjugates. SI aglycones had higher permeability and cellular accumulation than their glucosides. A small amount of intact SI conjugates were found in the cell and in the basolateral side of each Transwell.
Article
Food Science & Technology
Briana M. Nosal, Junichi R. Sakaki, Dae-Ok Kim, Ock K. Chun
Summary: The brewing methods and types of coffee can affect the antioxidant capacity of coffee consumers, with capsule coffee showing higher total phenolic content and antioxidant capacity.
FOOD SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Integrative & Complementary Medicine
Eun-Sang Hwang, Ga-Young Choi, Kwan Joong Kim, Min-Jeong Kim, Seok Lee, Jin-Won Lee, Dae-Ok Kim, Ji-Ho Park
Summary: Vitamin C (VC) can lower blood pressure in spontaneously hypertensive rats (SHRs) by directly targeting ACE I production and may improve endothelial function, with the frequency of administration affecting its effectiveness.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Tsendsuren Tungalag, Kye Won Park, Dong Kwon Yang
Summary: Oxidative stress plays a significant role in the pathogenesis of heart diseases, and butein exhibits potential antioxidant effects in cardiomyocytes, providing protection against oxidative damage and suggesting its therapeutic potential for cardiac diseases.
Article
Agriculture, Multidisciplinary
Young Sung Jung, Hyoung-Geun Kim, Seon Min Oh, Dae Young Lee, Cheon-Seok Park, Dae-Ok Kim, Nam-In Baek
Summary: Using amylosucrase from Deinococcus geothermalis, alpha-linked glucosylation of Soybean isoflavone aglycones (SIAs) was achieved, resulting in 13 alpha-linked glucosyl SIAs with confirmed colors in solution. The structures of the compounds were identified using mass spectrometry and multidimensional nuclear magnetic resonance spectroscopy. The study suggests a strategy for the synthesis of bioactive compounds with enhanced water solubility through alpha-linked glucosylation, with the products attached to the C-4 ' of SIAs found to be more water-soluble than those attached to the C-7 and/or beta-linkages.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Kwan Joong Kim, Eun-Sang Hwang, Min-Jeong Kim, Chan-Su Rha, Myoung Chong Song, Sungho Maeng, Ji-Ho Park, Dae-Ok Kim
Summary: The study demonstrated the cognitive-enhancing effect of Pinus densiflora Sieb. et Zucc. bark extract (PBE). PBE improved cognitive impairment in rats through its antioxidant properties and enhancement of long-term potentiation (LTP) induction in organotypic hippocampal slices.
Article
Chemistry, Applied
Chan-Su Rha, Eun Kyu Jang, Jong Suk Lee, Ji-Sung Kim, Min-Ji Ko, Sol Lim, Gun Hwan Park, Dae-Ok Kim
Summary: A study was conducted on the chemical constituents of soybean leaves and their correlations across phenotypes, growing periods, and cultivation areas using targeted metabolomics and machine learning models. The distribution of isoflavones and flavonols was found to be influenced by the growing period and cultivation area, and the neural network model showed the best predictive capacity for the differences in soybean leaves.
Article
Food Science & Technology
Ga-Young Choi, Kwan Joong Kim, Ho-Sub Park, Eun-Sang Hwang, Jae-Min Cho, Hyun-Bum Kim, Dae-Ok Kim, Ji-Ho Park
Summary: The study investigated the potential anti-atopic dermatitis (AD) effects of a herbal combination of Lithospermum erythrorhizon (LE), Houttuynia cordata (HC), and Spirodela polyrhiza (SP). Through ultra-high-pressure liquid chromatography (UHPLC)-Orbitrap mass spectrometer (MS), a total of 42 compounds were identified in LE, HC, SP, and the combined herb extract of LE, HC, and SP (LHS). The LHS showed increased concentration of flavonoid glycosides compared to individual extracts, and effectively inhibited the key characteristics of AD such as epidermal thickness increase, mast cell proliferation, and immunoglobulin E release.
FOOD SCIENCE AND BIOTECHNOLOGY
(2023)
Review
Food Science & Technology
Young Sung Jung, Hyunbin Seong, Nam Soo Han, Dae-Ok Kim
Summary: Soybean is an important crop and a significant dietary source of isoflavones. Understanding the bioaccessibility and bioavailability of soy isoflavones is crucial for comprehending their bioactivities. This review evaluates reports using in vitro methods to study the bioavailability of soy isoflavones and discusses how their molecular structures influence their bioactivities.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Food Science & Technology
Eun-Ha Park, Inil Lee, Gi-Cheol Park, Seung-Ju Lee, Kwan Joong Kim, Jisuk Yun, Dae-Ok Kim
Summary: Canola meal, a by-product of canola oil processing, has antioxidant and skin anti-aging effects. This is due to the bioactive compounds found in canola meal, particularly the antioxidative phenolics present in canola meal extract (CME).
FOOD SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Young Sung Jung, Hyoung-Geun Kim, Seon Min Oh, Dae Young Lee, Cheon-Seok Park, Dae-Ok Kim, Nam-In Baek
Summary: Soybean isoflavone aglycones (SIAs) have low water solubility in the human body. By glycosylation, SIAs can obtain structural diversity and change their physicochemical properties, including water solubility. The alpha-linked glucosylation of SIAs was achieved using amylosucrase from Deinococcus geothermalis. 13 alpha-linked glucosyl SIAs were obtained and their structures were identified by mass spectrometry and multidimensional nuclear magnetic resonance spectroscopy. The glucosylated SIAs attached to C-4' were found to be more water-soluble than those attached to C-7 and/or beta-linkages.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Min Young Um, Minseok Yoon, Minji Kim, Jonghoon Jung, Seonghui Kim, Dae-Ok Kim, Suengmok Cho
Summary: This study aimed to investigate the effects and underlying mechanisms of curcuminoids and their constituents on the sleep-wake cycle of mice. The results showed that curcuminoids reduced sleep latency and increased sleep duration by interacting with H1R. These findings suggest the potential importance of curcuminoids in treating insomnia.