Article
Agriculture, Multidisciplinary
Yulin Zhao, Haoyan Huang, Ning Lv, Chunyan Huang, Huili Chen, Han Xing, Chaorui Guo, Ning Li, Di Zhao, Xijing Chen, Yongjie Zhang
Summary: In this study, the thiol-GSH conjugates of GP, termed M532-1 and M532-2, were identified for the first time. The catalytic activities of GSTs were investigated both in vitro and in vivo. It was found that GSTA1-1 and GSTA4-4 exhibited high activity in the formation of both thiol-GSH conjugates, with GSTA4-4 specifically catalyzing M532-2 formation in vitro. The study demonstrated the inactivation of GP by GSTs and suggested that interindividual variability of GSTs may be a risk factor for susceptibility to GE-induced hepatotoxicity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Urology & Nephrology
Seunghyeok Choi, Seon Pyo Hong, Jung Hyun Bae, Sang Heon Suh, Hosung Bae, Kyung Pyo Kang, Hyuek Jong Lee, Gou Young Koh
Summary: This study reveals that high blood glucose in diabetes mellitus activates YAP/TAZ through the canonical Hippo pathway, leading to excessive proliferation of MCs, extracellular matrix deposition, endothelial cell impairment, glomerular sclerosis, albuminuria, and reduced glomerular filtration rate, which are the hallmarks of DN. Mechanistically, YAP/TAZ bind and stabilize N-Myc protein, enhancing its transcriptional activity and eventually causing MC impairments and DN pathogenesis.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Medicine, Research & Experimental
Yaoyu Liu, Xiaojie Li, Minglan Zhao, Yifan Wu, Yuan Xu, Xiuming Li, Lizhe Fu, Liqiao Han, Wei Zhou, Qinghong Hu, Junqi Chen, Jiuyao Zhou, Xusheng Liu, Hua Lin, Junbiao Wu
Summary: Dysfunction of mesangial cells and infiltration of macrophages are significant pathological features in glomerular lesions. Recent studies highlight the importance of the crosstalk between kidney resident cells and inflammatory cells in the development of DN.
Article
Medicine, Research & Experimental
Cheng-Huang Shen, Jin-Yi Wu, Shou-Chieh Wang, Chi-Hung Wang, Chen-Tai Hong, Pei-Yu Liu, Sin-Rong Wu, Yi-Wen Liu
Summary: Glutathione S-transferases (GSTs) play an important role in metabolism and detoxification of various substances. A study found that GSTM2 gene expression is lower in advanced stages of bladder urothelial carcinoma, and overexpression of GSTM2 inhibits invasion, migration, and tumor formation of bladder cancer cells. The study also identified an SP1 site and several phytochemicals that can affect GSTM2 expression, with berberrubine and resveratrol being the most effective. Furthermore, it was found that a DNA methylation inhibitor and berberrubine can influence the methylation level of the GSTM2 gene.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Plant Sciences
Yuwei Cao, Leifeng Xu, Hua Xu, Panpan Yang, Guoren He, Yuchao Tang, Xianyu Qi, Meng Song, Jun Ming
Summary: The study identified the LhGST gene in Asiatic hybrid lilies, which may be involved in anthocyanin sequestration and transport in lily tepals. Functional analysis confirmed the role of LhGST in anthocyanin accumulation. Additionally, the promoter of LhGST contains various hormone- and stress-responsive elements, and is regulated by a MYB transcription factor.
PLANT CELL REPORTS
(2021)
Article
Chemistry, Medicinal
Xia Zhu, Zongli Deng, Yanjuan Cao, Zihui Zhou, Wen Sun, Chang Liu, Siwen Fan, Xiao-Xing Yin
Summary: The role of PDE4D in diabetic nephropathy (DN) was explored and it was investigated whether resveratrol protects against DN through inhibiting PDE4D. The results showed that resveratrol attenuates the development of DN by preventing mitochondrial fission through inhibiting PDE4D.
PHYTOTHERAPY RESEARCH
(2023)
Article
Genetics & Heredity
Xiaoyu Duan, Xuejing Yu, Yidan Wang, Wei Fu, Ruifang Cao, Lu Yang, Xueling Ye
Summary: This study identified and analyzed 46 GST genes in cucumber, and found that most of these genes respond to cold stress. GO and KEGG analysis suggested that these genes may respond to cold stress through glutathione metabolism.
FRONTIERS IN GENETICS
(2022)
Article
Entomology
Marija Vukcevic, Aleksandra Nikolic-Kokic, Ivan Aleksic, Sanja Todorovic, Zorana Orescanin-Dusic, Dusko Blagojevic, Dragana Despot
Summary: Controlling the number of ticks as carriers of infectious diseases is important, but their protective mechanisms can complicate the process. We investigated the relationship between tick abundance and glutathione-S-transferases activity (GSTs) after pyrethroid treatment. We collected ticks from six locations in Belgrade, tested their GSTs activity, and correlated it with tick numbers. The results showed a correlation between tick abundance and GSTs activity. Treatment efficiency varied by location but was similar in both spring and autumn. GSTs activity reflects the influence of local chemicals and pyrethroid, indicating its potential for improving tick removal practices.
JOURNAL OF ECONOMIC ENTOMOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Jia-Nan Liu, Jing-Hui Xi, Zhun Wang, Shi-Wen Zhao, Xiao Wang, Yun-Wei Bu, Ke-Xin Zhou, Yu Pan, Shang Wang
Summary: In this study, 31 glutathione S-transferases (GSTs) were identified from the antennal transcriptome of Holotrichia parallela, with HpGSTd1 showing the highest expression level. Recombinant HpGSTd1 was found to have degradation activity towards various unsaturated aldehyde volatiles, and the metabolite of cinnamaldehyde was identified using high-resolution mass spectrometry (HRMS). Molecular docking analysis and site-directed mutagenesis revealed the key residues of HpGSTd1 involved in odorant degradation. The unsaturated aldehyde volatiles also elicited behavioral and electrophysiological responses in H. parallela. These findings suggest that HpGSTd1 plays an essential role in inactivating odorants in this underground pest, providing new insights for identifying molecular targets and exploring effective olfactory regulators.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Genetics & Heredity
Ke-Xue Li, Miao-Jin Ji, Hai-Jian Sun
Summary: Phytochemicals, including resveratrol, have emerged as alternative therapies with therapeutic effects on various pathologies, including diabetic kidney disease. Resveratrol has been found to have a broad spectrum of health benefits, particularly in ameliorating chronic or acute kidney injury in the renal system. Further research is needed to overcome limitations, such as poor bioavailability, and improve the efficacy of resveratrol in diabetic nephropathy therapy.
Review
Immunology
Qi Jin, Tongtong Liu, Yuan Qiao, Donghai Liu, Liping Yang, Huimin Mao, Fang Ma, Yuyang Wang, Liang Peng, Yongli Zhan
Summary: Diabetic nephropathy (DN) can cause end-stage renal disease. Oxidative stress plays a crucial role in the development of DN, leading to various pathological processes and promoting inflammation. Polyphenols, such as quercetin, resveratrol, curcumin, and phenolic acid, have shown antioxidant and anti-inflammatory effects by targeting Nrf2, SIRT1, HMGB1, NF-κB, and NLRP3. However, further research is needed to fully understand the molecular mechanisms and clinical applications of polyphenols in DN.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Manuela Harloff, Sally Prueschenk, Roland Seifert, Jens Schlossmann
Summary: The study demonstrated the beneficial effects of sGC activator cinaciguat in treating diabetic nephropathy in a mouse model. Activation of sGC may be a potential therapy option for patients with Type 1 diabetes.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Agronomy
Guojun Zhang, Linqin Meng, Rui Chen, Wen Wang, Xiangfeng Jing, Keyan Zhu-Salzman, Weining Cheng
Summary: This study characterized delta and epsilon GST genes in S. mosellana for the first time, showing increased expression in larvae feeding on resistant wheat varieties. The tissue-specific expression and metabolic capabilities of these SmGSTs suggest their importance in detoxifying wheat defensive compounds during feeding, potentially contributing to host plant adaptation in this pest species.
PEST MANAGEMENT SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Zhi-Xiang Liu, Xiao-Rong Xing, Xin-Hao Liang, Jian-hao Ding, Yi-Jiangcheng Li, Ying Shao, Fu-An Wu, Jun Wang, Sheng Sheng
Summary: Glyphodes pyloalis, a destructive pest on mulberry trees, poses a significant threat to the sericultural industry in China. This study reveals the important roles of glutathione-S-transferases (GSTs) in the tolerance of the insecticides phoxim and chlorfenapyr in G. pyloalis.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Chao Hu, Ji-Yuan Liu, Wei Wang, David Mota-Sanchez, Shun He, Yu Shi, Xue-Qing Yang
Summary: This study reports the involvement of GSTs in lambda-cyhalothrin resistance in the globally quarantined fruit pest Cydia pomonella. Most GST genes were upregulated in response to exposure to lambda-cyhalothrin, and their mRNA levels were considerably higher in a resistant population compared to susceptible strains. Recombinant CpGSTd3 was found to have the highest metabolic rate for lambda-cyhalothrin, supporting the role of GSTs in sequestration of the insecticide.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Medicine, General & Internal
Tao Peng, Hongyu Li, Zhao Hu, Lejin Yang, Xiangdong Yang
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2015)
Article
Medicine, General & Internal
Haiyan Wan, Zhao Hu, Jinhong Wang, Shimei Zhang, Xiangdong Yang, Tao Peng
Article
Medicine, General & Internal
Lianhuan Ma, Chunlei Han, Tao Peng, Naie Li, Bei Zhang, Xiaowen Zhen, Xiangdong Yang
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2016)
Review
Multidisciplinary Sciences
Tao Peng, Zhao Hu, Tingting Xie, Baodong Jiang, Junhui Zhen, Xiangdong Yang
Article
Virology
Tao Peng, Tingting Xie, Lei Liu, Junhui Zhen, Xiangdong Yang
JOURNAL OF MEDICAL VIROLOGY
(2018)
Article
Oncology
Xianhua Li, Zhaoli Gao, Haiqing Gao, Baoying Li, Tao Peng, Bei Jiang, Xiangdong Yang, Zhao Hu
MOLECULAR MEDICINE REPORTS
(2017)
Article
Oncology
Tao Peng, Xiangdi Chang, Jie Wang, Junhui Zhen, Xiangdong Yang, Zhao Hu
MOLECULAR MEDICINE REPORTS
(2017)
Article
Medicine, General & Internal
Weiwei Shi, Ling Guo, Guangyi Liu, Tao Peng, Hongyu Li, Tingting Xie, Dengren Li, Junhui Zhen, Yan Wang, Huimin Yang, Xiangdong Yang
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2018)
Review
Medicine, General & Internal
Tao Peng, Zhao Hu, Xiangdong Yang, Yanxia Gao, Chengjun Ma
Article
Urology & Nephrology
Tao Peng, Xia Li, Zhao Hu, Xiangdong Yang, Chengjun Ma
Article
Medicine, Research & Experimental
Tao Peng, Zhao Hu, Hongnan Zheng, Junhui Zhen, Chengjun Ma, Xiangdong Yang
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2018)
Article
Pharmacology & Pharmacy
Nan Chen, Jian-bo Zhang, Qiujie Zhang, Yun-peng Zhao, Li-yan Li, Li-wei Liu, Fei Yu, Xin Yu, Tao Peng, Kuan-xiao Tang
BMC PHARMACOLOGY & TOXICOLOGY
(2018)
Article
Medicine, General & Internal
Hua Li, Yan-ke Guo, Ying-lin Cui, Tao Peng
Review
Medicine, Research & Experimental
Yuping Liu, Li Zhang, Yingshan Yang, Tao Peng
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2020)
Article
Public, Environmental & Occupational Health
S. Zhang, Y. Wang, W. Guo, X. Yang, Z. Hu, T. Peng
RURAL AND REMOTE HEALTH
(2016)