Article
Food Science & Technology
Xiao-min Zhang, Chao-yang Xu, Teng Hui, Ke-zhou Cai, Hui Zhou, Cong-gui Chen, Bao-cai Xu
Summary: This study found that vinegars can inhibit the generation of carcinogenic substance BaP and improve sensory evaluation in barbecued pork sausages. Vinegars achieve the inhibition of BaP by decreasing pH and scavenging free radicals.
Article
Agriculture, Multidisciplinary
Yanfang Li, Zhihao Liu, Gillian Manka Tamia, Xiaohua He, Jianghao Sun, Pei Chen, Seong-Ho Lee, Thomas T. Y. Wang, Boyan Gao, Zhuohong Xie, Liangli Lucy Yu
Summary: Different types of phenolic compounds in tomato seeds were analyzed, with the insoluble bound fraction showing stronger antioxidant activity and anti-cancer cell proliferation effects. The soluble free and insoluble bound fractions significantly inhibited colorectal cancer cell proliferation, providing a basis for the future use of tomato seeds as nutraceuticals in dietary supplements and functional foods.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Seymanur Ertosun, Volkan Aylanc, Soraia I. Falcao, Miguel Vilas-Boas
Summary: Adding bee pollen and bee bread to bread can enhance the antioxidant activity of bread. While some compounds may be affected during processing, phenolamides are more stable than flavonoids under heat treatment.
Article
Biochemistry & Molecular Biology
Gabriela Stanciu, Florin Aonofriesei, Simona Lupsor, Elena Oancea, Magdalena Mititelu
Summary: The aim of this study was to identify and exploit the local plant resources with biologically active properties from the Dobrogea area, Romania. Black poplar buds were collected and macerated to evaluate their qualities as antioxidant and antimicrobial agents. The results showed that the hydroalcoholic macerates of black poplar buds contained high concentrations of phenolic compounds and exhibited potent antioxidant and antimicrobial activities.
Article
Chemistry, Applied
Iftikhar Ali Khan, Ji Luo, Haibo Shi, Ye Zou, Asad Khan, Zongshuai Zhu, Weimin Xu, Daoying Wang, Ming Huang
Summary: The study found that a combination of allspice and perilla frutescens seed extract had the best effect in reducing the formation of HCAs in pan-fried chicken meat patties, with phenolic compounds showing the greatest inhibitory effect on the formation of IQ.
Article
Materials Science, Multidisciplinary
Citlali Alejandra Marin-Flores, Odin Rodriguez-Nava, Margarita Garcia-Hernandez, Rosario Ruiz-Guerrero, Fernando Juarez-Lopez, Angel de Jesus Morales-Ramirez
Summary: ZnO particles were synthesized and their free radical scavenging activity properties were evaluated in this study. The results showed that the scavenging activity increased with smaller particle size and lower ZnO dosage. A pseudo-first-order kinetics model may be present in the reaction.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Article
Materials Science, Ceramics
Zhaojun Qi, Sen Wang, Yan Li, Lifeng Wang, Lin Zhao, Qiang Ge, Jin Zhong Zhang
Summary: The novel free radical scavenger ML-Ti3C2Tx MXene exhibits high scavenging efficiency due to its intrinsic reducing property, rather than hydrogen donation ability from surface functional groups. The observed scavenging activity is attributed to the reducing property of ML-Ti3C2Tx, as compared to other materials.
CERAMICS INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Victoria Golovchenko, Sergey Popov, Vasily Smirnov, Victor Khlopin, Fedor Vityazev, Shinen Naranmandakh, Andrey S. Dmitrenok, Alexander S. Shashkov
Summary: The above-ground part of Salsola passerine contains polysaccharides that can be extracted with water and alkaline solutions, and these polysaccharides have similar monosaccharide composition and antioxidant activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kristina Bimbiraite-Surviliene, Mantas Stankevicius, Simona Sustauskaite, Agnieszka Gegotek, Audrius Maruska, Elzbieta Skrzydlewska, Zita Barsteigiene, Ieva Akuneca, Ona Ragazinskiene, Audronis Lukosius
Summary: The study compared the composition and resulting antioxidant and biological properties of summer savory at different growth stages collected in the botanical garden of Vytautas Magnus University in central Lithuania climatic conditions.
Article
Chemistry, Applied
Francisco Javier Leyva-Jimenez, Rodrigo Oliver-Simancas, Ines Castangia, Antonio M. Rodriguez-Garcia, M. Elena Alanon
Summary: The excessive use of plastic in food packaging is a global concern, and hydrogels are emerging as a sustainable alternative. Natural hydrogels can be functionalized with bioactive compounds to improve film properties and extend the shelf-life of food products.
FOOD HYDROCOLLOIDS
(2023)
Article
Chemistry, Analytical
Dian Yang, Li Li, Lei Cao, Yan Zhang, Mingfeng Ge, Ruhong Yan, Wen-Fei Dong
Summary: This research utilized procyanidins to prepare fluorescent carbon dots (PCDs) with strong reducibility and high water solubility, which can scavenge radicals and image cells. Experimental results indicate that PCDs have the potential to be a biomedicine.
Article
Agriculture, Multidisciplinary
Yanfang Li, Ming Li, Jiaping Liu, Wenhao Zheng, Yaqiong Zhang, Tongcheng Xu, Boyan Gao, Liangli Yu
Summary: The study analyzed the profiles of soluble and insoluble phenolic compounds in 11 commercial red sorghums using UPLC/QTOF-MS, identifying a total of 48 phenolic compounds with 8 compounds discovered for the first time in sorghums. The research found that 3-deoxyanthocyanidins significantly contributed to the antioxidant capacities of red sorghums, with 5-methoxy-luteolinidin showing the strongest correlation. Additionally, the soluble phenolic fraction of B13 dose-dependently inhibited cell proliferation and inflammation in specific cell lines.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Ana Margarida Silva, Ana Sofia Luis, Manuela M. Moreira, Ricardo Ferraz, Tanja Brezo-Borjan, Jaroslava Svarc-Gajic, Paulo C. Costa, Cristina Delerue-Matos, Francisca Rodrigues
Summary: This study evaluated the optimal subcritical water extraction temperature for polyphenolic compounds from Actinidia arguta leaves and found that 123℃ was the optimal temperature, resulting in high content of phenolic and flavonoid compounds with good antioxidant properties.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2022)
Article
Spectroscopy
Seda Uzunboy, Ozge Karakas, Sema Demirci-cekic, Resat Apak
Summary: A selective and simple colorimetric method for determining sulfate anion radical has been developed, using Cr(III) as an activator for persulfate. This method allows measurement of the formation and scavenging of sulfate anion radical, as well as other UV-absorbing sulfate radical scavengers.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Food Science & Technology
Vanesa Sanchez-Martin, Paloma Morales, Amelia Gonzalez-Porto, Amaia Iriondo-DeHond, Marta B. Lopez-Parra, Maria Dolores Del Castillo, Xavier F. Hospital, Manuela Fernandez, Eva Hierro, Ana Haza
Summary: This study investigated the physicochemical properties, total phenolic content, and antioxidant capacity of Spanish thyme honey and chestnut honey. The results showed that the addition of propolis improved the antioxidant capacity of honey, making it an excellent natural source of antioxidants. These mixtures can be used as potential food ingredients, preservatives, and natural sweeteners enriched in antioxidants and bioactive compounds.
Review
Biochemistry & Molecular Biology
Veer Singh, Nidhi Singh, Manisha Verma, Rashmi Kamal, Ritesh Tiwari, Mahesh Sanjay Chivate, Sachchida Nand Rai, Ashish Kumar, Anupama Singh, Mohan P. Singh, Emanuel Vamanu, Vishal Mishra
Summary: Hexavalent chromium is a highly soluble environmental contaminant that is 100 times more toxic than trivalent chromium. It is mainly derived from leather, chrome plating, coal mining, and paint industries. Hexavalent chromium is recognized as a carcinogen and mutagen, and it can cause damage to multiple organs. Its toxicity depends on its oxidation state, with the reduction to Cr (III) generating reactive oxygen species (ROS) and chromium intermediate species. ROS are responsible for oxidative tissue damage and disruption of cell organelles, and can be neutralized by the antioxidant system.
Article
Infectious Diseases
Mahendra P. Singh, Shabnam Shabir, Aman Singh Deopa, Sanchina Raj Raina, Farkad Bantun, Naif A. Jalal, Noha E. Abdel-razik, Yahya F. Jamous, Maryam S. Alhumaidi, Khadijah A. Altammar, Ahmed Hjazi, Sandeep Kumar Singh, Emanuel Vamanu
Summary: The study demonstrates that Urtica dioica and biologically synthesized silver nanoparticles have antibacterial and antioxidant properties, and they show positive effects on cellular toxicity, biochemical markers, and behavioral patterns in Drosophila melanogaster.
Review
Environmental Sciences
Veer Singh, Nidhi Singh, Sachchida Nand Rai, Ashish Kumar, Anurag Kumar Singh, Mohan P. Singh, Ansuman Sahoo, Shashank Shekhar, Emanuel Vamanu, Vishal Mishra
Summary: Urbanization and industrialization cause environmental contamination and the presence of toxic heavy metal ions, leading to health issues. Traditional methods for heavy metal decontamination have drawbacks, necessitating the development of cost-effective and eco-friendly solutions. This review focuses on heavy metal contamination, toxicity, and the use of biological approaches for removal.
Article
Biology
Emanuel Vamanu, Florentina Gatea, Ionela Avram, Gabriel Lucian Radu, Sandeep Kumar Singh
Summary: The administration of chokeberry extract in the GIS1 system was found to have a strong antimicrobial effect and the presence of new organic acids as biomarkers. It gradually increased antioxidant status for up to three months and then decreased along with the reduction of Enterobacteriaceae. Butyric acid was generally unaffected by the antimicrobial effect after three months. The controlled use of this extract corrected the dysbiotic pattern resulting from the long-term use of sweeteners.
Review
Medicine, Research & Experimental
Rachit Jain, Nusrat Begum, Kamatham Pushpa Tryphena, Shashi Bala Singh, Saurabh Srivastava, Sachchida Nand Rai, Emanuel Vamanu, Dharmendra Kumar Khatri
Summary: Parkinson's disease (PD) is characterized by the degeneration of dopaminergic neurons and the accumulation of alpha-synuclein protein in Lewy bodies, leading to mitochondrial dysfunction. Mitochondrial dynamics, including movement within and between cells, are impaired in PD. Various proteins, enzymes, and molecules are involved in regulating mitochondrial movement. Understanding these pathways is crucial for developing mitochondrial transplant therapy for PD. Techniques such as mitochondrial coculture and mitoception are being explored for their potential translational value. This review focuses on the importance of understanding intercellular and intracellular mitochondrial dynamics in PD and highlights the potential of mitochondrial transplant therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Nazish Tabassum, Virendra Singh, Vivek K. Chaturvedi, Emanuel Vamanu, Mohan P. Singh
Summary: The objective of this study was to investigate the synthesis, structural and morphological characteristics, cytotoxic effects, and antibacterial activity of rhombohedral-structured, flower-like Fe2O3 nanoparticles. XRD, UV-Vis, FTIR, SEM, EDX, TEM, and HR-TEM techniques were used to analyze the nanoparticles. The study found potential cytotoxic activity against MCF-7 and HEK-293 cells and suggested the use of Fe2O3 nanoparticles in antibacterial applications.
Article
Medicine, General & Internal
Divya Mishra, Ashish Mishra, Sachchida Nand Rai, Emanuel Vamanu, Mohan P. Singh
Summary: This study identified 13 hub genes that are overexpressed in both glioblastoma multiforme (GBM) and hepatocellular carcinoma (HCC). It was found that these genes are hypomethylated and contribute to genetic alterations, resulting in chromosomal instability and aneuploidy. A 13-gene predictive model was obtained and validated, suggesting that these hub genes could serve as prognostic biomarkers and potential therapeutic targets for inhibiting tumorigenesis and metastasis.
Article
Medicine, General & Internal
Divya Mishra, Ashish Mishra, Sachchida Nand Rai, Emanuel Vamanu, Mohan P. Singh
Summary: Breast cancer is a common and deadly disease in women. This study aimed to identify new biomarkers for diagnosis and treatment. Using TCGA datasets, differentially expressed genes (DEGs) were identified and analyzed for functional enrichment and protein-protein interaction networks. Hub genes were selected and their association with overall survival (OS) was analyzed. A total of 824 DEGs were identified, mainly enriched in cell proliferation and signal transduction. Five hub genes, AURKA, BUB1B, CCNA2, CCNB2, and PBK, were found to be associated with poor OS in breast cancer patients. These genes were hypomethylated and involved in chromosomal instability and aneuploidy. The study highlighted the potential of these hub genes as diagnostic and therapeutic targets for breast cancer.
Article
Biochemistry & Molecular Biology
Shabnam Shabir, Amit Sehgal, Joydeep Dutta, Inderpal Devgon, Sandeep K. Singh, Walaa F. Alsanie, Abdulhakeem S. Alamri, Majid Alhomrani, Abdulaziz Alsharif, Mohammed Abubaker Mohammed Basalamah, Hani Faidah, Farkad Bantun, Abdullah Ali Saati, Emanuel Vamanu, Mahendra P. Singh
Summary: Nanotechnology has the potential to treat neurodegenerative diseases. In this study, bio-mediated zinc oxide nanoparticles were synthesized using plant extracts and their antimicrobial and antioxidant properties were evaluated. The results showed that nanoparticles prepared with Murraya koenigii extracts exhibited the strongest activity. These findings suggest that green-engineered nanoparticles could be an effective treatment for neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Somnath Sahoo, Sarika Sharma, Mahendra P. Singh, Sandeep K. Singh, Emanuel Vamanu, Kongara Hanumantha Rao
Summary: The human commensal yeast Candida albicans is pathogenic and exhibits metabolic flexibility and morphogenetic transition to survive under host niche environmental conditions. N-acetylglucosamine (GlcNAc) available at the host infection sites induces cellular signalling and plays multifaceted roles in this pathogen. Understanding the molecular mechanisms involved in GlcNAc-induced cellular processes is crucial for developing antifungal therapeutics.
Article
Biochemistry & Molecular Biology
Laura-Dorina Dinu, Florentina Gatea, Florentina Roaming Israel, Milena Lakicevic, Nebojsa Dedovic, Emanuel Vamanu
Summary: This preliminary study investigated the impact of a lactic-fermented bee pollen postbiotic on the cardiovascular microbiota through in vitro tests. The results showed that the postbiotic increased the number of beneficial bacteria and decreased the number of pathogenic bacteria associated with cardiovascular risks. Furthermore, the postbiotic increased the concentration of lactic and acetic acids, both of which have antihypertensive effects.
Article
Environmental Sciences
Simran Kauts, Yachana Mishra, Sumaira Yousuf, Rima Bhardwaj, Sandeep K. Singh, Fahad M. Alshabrmi, Mahmoud Abdurahman, Emanuel Vamanu, Mahendra P. Singh
Summary: Microplastic pollution is widespread in the natural environment and has detrimental effects on living organisms. The size, time of exposure, and amount of microplastic particles are key factors in determining their toxicological effects. Research on fruit flies exposed to PET microplastics found decreased locomotory activities, delayed development, and reduced survival rate in female flies.
Article
Biology
Ionela Avram, Diana Pelinescu, Florentina Gatea, Robertina Ionescu, Alexandru Barcan, Razvan Rosca, Anca Zanfirescu, Emanuel Vamanu
Summary: The study evaluated the in vitro effect of a new extract from Boletus edulis on the human microbiota. The results showed that the extract can modulate the microbial pattern and reduce inflammatory progression.
Review
Medicine, General & Internal
Neha Rana, Sandeep Kumar Singh, Najitha A. Banu, Ahmed Hjazi, Emanuel Vamanu, Mahendra P. Singh
Summary: Metabolic syndrome is a complex condition caused by imbalances in caloric intake and energy expenditure. Plant extracts, with their antioxidant, anti-inflammatory, and insulin-sensitizing properties, offer a promising option for treating metabolic disorders with minimal side effects. However, their limited solubility and stability hinder their effectiveness. The development of green-engineered nanoparticles that enhance the bioavailability and stability of plant-based products has opened up new possibilities for treating metabolic diseases such as obesity, diabetes, and cancer.
MEDICINA-LITHUANIA
(2023)
Article
Biotechnology & Applied Microbiology
Laura-Dorina Dinu, Ovidiu Iordache, Emanuel Vamanu
Summary: This study compared the degradation of different types of disposable personal care products in soil and found that textiles degrade more quickly than animal-based products, and this process is influenced by soil type. Sanitary pads had the least degradation, followed by wet wipes and cosmetic pads. Changes in soil microbial counts and cellulolytic activity were correlated with the degradation process.
FERMENTATION-BASEL
(2022)
