Article
Food Science & Technology
Ausra Adomeniene, Petras Rimantas Venskutonis
Summary: This study evaluated the inhibitory activity of Dioscorea nipponica leaf and tuber extracts on important physiological enzymes. The leaf extract showed stronger enzyme inhibition than the tuber extract, which may be attributed to differences in secondary metabolite composition. The results provide valuable information for the development of functional foods and nutraceuticals with health benefits.
Article
Plant Sciences
Ausra Adomeniene, Audrius Pukalskas, Ona Ragazinskiene, Petras Rimantas Venskutonis
Summary: This study identified 41 compounds in the leaf and tuber hydroethanolic extracts of Dioscorea caucasica using UPLC-QTOF/MS. The main phytochemicals in the leaves were hydroxycinnamates and flavonoids, while steroidal glycosides, fatty acids, and carbohydrates were found in the tubers. The leaf extracts showed strong inhibitory activity against key enzymes, including alpha-amylase, alpha-glucosidase, acetylcholinesterase, and angiotensin-converting enzyme. These findings contribute to the development of new functional foods and nutraceuticals.
Article
Biochemistry & Molecular Biology
Dominika Kajszczak, Agnieszka Kowalska-Baron, Dorota Sosnowska, Anna Podsedek
Summary: This study investigated the composition of phenolic compounds in V opulus bark and flower, as well as their inhibitory effects on digestion and enzymes. The results showed that phenolic extracts from the bark and flower could reduce the absorption of potato starch and inhibit alpha-amylase and alpha-glucosidase. The findings provide a basis for further development of V opulus bark compounds as components of nutraceuticals and functional foods with antidiabetic activity.
Article
Biochemistry & Molecular Biology
Jia Zhang, Ya-Nan Li, Lin-Bo Guo, Jun He, Peng-Hui Liu, Hai-Yan Tian, Wei-Ku Zhang, Jie-Kun Xu
Summary: A phytochemical investigation of the roots of Euphorbia fischeriana Steud. led to the isolation of eleven undescribed gallotannins, fishertannins A-K, together with four known analogues. Fishertannin A, possessing an unusual skeleton, showed the strongest inhibitory activity against alpha-glucosidase. These findings indicate the potential antidiabetic activity of the compounds from E. fischeriana.
Article
Biochemistry & Molecular Biology
Wengang Zhang, Yongli Lan, Bin Dang, Jie Zhang, Wancai Zheng, Yan Du, Xijuan Yang, Zhonghong Li
Summary: Five different solvent extracts of highland barley bran were analyzed and compared for their polyphenol profile, antioxidant activity, and enzyme inhibitory activities. The acetone extract had the highest content of phenolic compounds, flavonoids, and antioxidant capacity. The ethyl acetate extract exhibited the highest inhibitory activity against alpha-glucosidase and alpha-amylase enzymes. Black barley bran is a valuable raw material for the development of polyphenol-rich functional foods with antioxidant and hypoglycemic potential.
Article
Biochemistry & Molecular Biology
Dominika Kajszczak, Agnieszka Kowalska-Baron, Anna Podsedek
Summary: Phytochemicals from Viburnum opulus L. fruits show potential antidiabetic effects by inhibiting carbohydrate digestive enzymes, glycation, and displaying antioxidant properties. Among tested samples, the ethyl acetate fraction of purified extract exhibited the highest phenolic content and strongest inhibitory effects, suggesting promising applications in nutraceuticals and functional foods.
Article
Food Science & Technology
Fengyu Guo, Jie An, Minlong Wang, Weibo Zhang, Chong Chen, Xueying Mao, Siyuan Liu, Pengjie Wang, Fazheng Ren
Summary: In this study, Quercimeritrin was identified as a selective inhibitor of alpha-glucosidase and shown to effectively control postprandial blood glucose in vivo. The results provide insights into using flavone aglycones to improve postprandial blood glucose levels.
Article
Food Science & Technology
Maryam Mousavi, Vajiheh Fadaei, Behrouz Akbari-adergani
Summary: Date kernel as a functional food component was studied for its effects on physicochemical, nutritional, and organoleptic properties, as well as the beneficial effects of semi-prepared dry soup samples. The results showed that the addition of date kernel powder improved the nutritional properties and increased antioxidant and enzyme inhibitory activities. The sensory evaluation indicated that samples with 4%w/w date kernel powder had the highest acceptability.
FOOD SCIENCE & NUTRITION
(2023)
Article
Plant Sciences
Alev Onder, Ahsen Sevde Cinar, Merve Yuzbasioglu Baran, Ayse Kuruuzum-Uz, Antoaneta Trendafilova
Summary: The phytochemical investigation of the n-hexane extract of Seseli petraeum M. Bieb., a plant growing in northern Turkey, led to the isolation of a new pyranocoumarin and 12 known coumarins. These coumarins exhibited notable inhibitory activity against the alpha-glucosidase enzyme and low inhibitory potential against alpha-amylase.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Plant Sciences
Mohamad Gazali, Odi Jolanda, Amir Husni, Fadzilah Adibah Abd Nurjanah, Fadzilah Adibah Abd Majid, Zuriat, Rina Syafitri
Summary: This study aimed to determine the antidiabetic activity of extracts and fractions from the green seaweed Halimeda tuna. The results showed that the ethyl acetate fraction and methanol extract exhibited strong inhibitory activity against alpha-amylase and alpha-glucosidase. Additionally, these extracts and fractions contained various secondary metabolites that may contribute to their inhibitory activity.
Article
Chemistry, Applied
Qing-Qing Lv, Juan-Juan Cao, Rui Liu, Han-Qing Chen
Summary: Two polysaccharide fractions, WXA-1 and AXA-1, were isolated from wheat bran in this study. Structural analysis revealed that they are heteropolysaccharides, with AXA-1 showing stronger inhibitory effects on enzyme activities compared to WXA-1.
Article
Food Science & Technology
Yanglin Ji, Dong Liu, Yan Jin, Juan Zhao, Jiang Zhao, Heyu Li, Liwei Li, Hua Zhang, Hao Wang
Summary: The study found that bilberry extract had inhibitory activity against alpha-glucosidase and alpha-amylase, acting as a mixed-type inhibitor and changing the enzyme structure and stability. In vivo study also showed a hypoglycaemic effect of bilberry extract. Molecular docking assay indicated that bilberry extract could be a potential glycosidase inhibitor.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Plant Sciences
Ha-Rim Kim, Paulrayer Antonisamy, Ye-Seul Kim, Guemsan Lee, Hyang-Do Ham, Kang-Beom Kwon
Summary: The study indicates that the plant extract of Amomum villosum Lomb or Indian cardamom dried fruits has significant inhibitory effects on the activity of alpha-glucosidase, making it a potential natural treatment option for type-2 diabetes with fewer side effects than acarbose.
PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Imane Abdelli, Nabila Benariba, Sara Adjdir, Zohra Fekhikher, Ismail Daoud, Mohammed Terki, Hanane Benramdane, Said Ghalem
Summary: The study revealed that tannic acid is a functional inhibitor of alpha-glucosidase and alpha-amylase activities and can be used as an alternative for regulating post-prandial hyperglycaemia. Among the phenolic compounds tested, L1 showed the best docking scores and the lowest energy score in interaction with both enzymes.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Pharmacology & Pharmacy
Asmae Hbika, Nour Elhouda Daoudi, Abdelhamid Bouyanzer, Mohamed Bouhrim, Hicham Mohti, El Hassania Loukili, Hamza Mechchate, Rashad Al-Salahi, Fahd A. Nasr, Mohamed Bnouham, Abdelhamid Zaid
Summary: This study analyzed the chemical composition of Artemisia absinthium extracts and evaluated their effects on pancreatic alpha-amylase and intestinal alpha-glucosidase enzymes. The extracts showed high polyphenol and flavonoid content and exhibited antioxidant and enzyme inhibitory activities. The aqueous extract also demonstrated blood glucose-lowering effects.
Article
Integrative & Complementary Medicine
Lokesh K. Mishra, Dipayan Sarkar, Rao Mentreddy, Kalidas Shetty
JOURNAL OF HERBAL MEDICINE
(2020)
Article
Food Science & Technology
Kridsada Unban, Pratthana Kochasee, Kalidas Shetty, Chartchai Khanongnuch
Review
Biochemistry & Molecular Biology
Lena Galvez Ranilla
Article
Nutrition & Dietetics
Alessandra Nishioka, Eric de Castro Tobaruela, Layanne Nascimento Fraga, Francisco A. Tomas-Barberan, Franco Maria Lajolo, Neuza Mariko Aymoto Hassimotto
Summary: This study identified large interindividual variations in the biological response to citrus flavanones and aimed to understand the main determinants underlying these differences in metabolism and excretion. A new stratification based on metabolic profiles was proposed for volunteers, suggesting a possible relationship between gut microbiota composition, polymorphisms of phase II enzymes, and the interindividual variability of metabolism.
Article
Biochemistry & Molecular Biology
Aliyu Dantani Abdullahi, Pratthana Kodchasee, Kridsada Unban, Thanawat Pattananandecha, Chalermpong Saenjum, Apinun Kanpiengjai, Kalidas Shetty, Chartchai Khanongnuch
Summary: The study found that Miang extracts fermented by non-filamentous fungi-based and filamentous fungi-based processes had higher phenolic contents and better antioxidant and anti-inflammatory activities compared to young and mature tea leaves. These fermented Miang extracts showed enhanced protection against hydrogen peroxide-induced ROS production in colorectal cells and inhibition of nitric oxide production induced by lipopolysaccharide, indicating their potential as natural bioactive functional ingredients for preventing free radical and inflammatory-mediated diseases.
Article
Chemistry, Medicinal
Vanessa Moreira, Regina Stanquevis, Eduardo Pinheiro Amaral, Franco Maria Lajolo, Neuza Mariko Aymoto Hassimotto
Summary: The anthocyanin extracts from purple maize demonstrated anti-inflammatory effects by reducing leukocyte migration, inhibiting pro-inflammatory cytokines, and downregulating protein expression levels under experimental conditions. This suggests a potential preventive and anti-inflammatory activity of purple maize anthocyanins.
Article
Nutrition & Dietetics
Napapan Kangwan, Sarawut Kongkarnka, Nitsara Boonkerd, Kridsada Unban, Kalidas Shetty, Chartchai Khanongnuch
Summary: This study found that probiotics and synbiotics extracted from traditional Thai fermented tea leaves have a protective effect against DSS-induced colitis in mice. They can alleviate symptoms, restore intestinal integrity, and inhibit inflammation. Compared to conventional drugs, they demonstrate higher efficacy.
Article
Nutrition & Dietetics
Bruna J. Quintanilha, Daniela F. S. Chaves, Elisa Brasili, Telma A. F. Correa, Vinicius Cooper Capetini, Frederico Moraes Ferreira, Inar A. Castro, Neuza M. A. Hassimotto, Marcelo M. Rogero, Franco M. Lajolo
Summary: This study found that the intake of high-fat, high-carbohydrate (HFHC) meals with orange juice can modulate the expression of miRNAs linked to pancreatic beta-cell function. In a crossover design study involving twelve healthy subjects, it was observed that the intake of HFHC meal + orange juice increased the expression of plasma miR-375, which is a biomarker of pancreatic beta-cell function, and contributed to preventing hyperglycemia.
CLINICAL NUTRITION ESPEN
(2022)
Article
Biochemistry & Molecular Biology
Thiecla Katiane Osvaldt Rosales, Neuza Mariko Aymoto Hassimotto, Franco Maria Lajolo, Joao Paulo Fabi
Summary: Anthocyanins are important phenolic compounds responsible for pigment in plants. Regular intake of anthocyanins can reduce the risk of diseases in humans. However, molecular instability and digestion process can lead to low absorption and bioavailability of anthocyanins. Studies have been conducted to find alternatives to improve stability and protect against degradation by intestinal microbiota, including the use of nanotechnology systems.
Review
Microbiology
Adnorita Fandah Oktariani, Yan Ramona, Putu Eka Sudaryatma, Ida Ayu Mirah Meliana Dewi, Kalidas Shetty
Summary: This review discusses the role of histamine-producing bacteria in fish and seafood products, and the consequences of human food poisoning caused by histamine consumption. Methods to control histamine production are also proposed.
Article
Nutrition & Dietetics
Layanne Nascimento Fraga, Dragan Milenkovic, Franco Maria Lajolo, Neuza Mariko Aymoto Hassimotto
Summary: This study identified novel polymorphisms associated with higher absorption of flavanones, providing a basis for personalized nutritional guidelines for consuming flavanone-rich foods for better health benefits.
Article
Nutrition & Dietetics
Karina Gama dos Santos, Marcos Yukio Yoshinaga, Isaias Glezer, Adriano de Britto Chaves-Filho, Aline Alves de Santana, Cristiane Kovacs, Carlos Daniel Magnoni, Franco Maria Lajolo, Sayuri Miyamoto, Neuza Mariko Aymoto Hassimotto
Summary: This study examined the impact of orange juice on the lipidome profile of obese and insulin-resistant subjects using a combined untargeted/targeted lipidomic analysis. The results showed that orange juice intake led to a significant decrease in diastolic blood pressure and blood lipid profile.
CLINICAL NUTRITION ESPEN
(2022)
Article
Plant Sciences
Renata A. Carnauba, Flavia M. Sarti, Neuza M. A. Hassimotto, Franco M. Lajolo
Summary: Studies have found significant disparities in bioactive compound consumption across populations depending on their geographic origin. The aim of this research was to estimate the intake of bioactive compounds in different regions of Brazil and identify the major contributors. The study analyzed data from the National Dietary Survey 2017-2018, including food intake information from 46,164 individuals aged ≥10 years. The results showed variations in the intake of polyphenols and carotenoids across different regions, with the South having higher polyphenol intake and the Midwest having higher carotenoid intake. Tea and coffee were the main contributors to polyphenol intake in different regions, while acai, caja juice, mango, and corn were important sources of carotenoid intake in specific regions. The findings highlight the potential of food plants in developing marketable products and increasing bioactive compound intake.
Article
Horticulture
Pradeepika Chintha, Dipayan Sarkar, Kenneth Pecota, Munevver Dogramaci, Kalidas Shetty
Summary: Beneficial lactic acid bacteria (LAB) fermentation can enhance the retention of phenolic bioactives in sweet potatoes, improving their human health protective functional qualities.
Article
Biotechnology & Applied Microbiology
Kridsada Unban, Wirunya Chaichana, Sasitorn Baipong, Aliyu Dantani Abdullahi, Apinun Kanpiengjai, Kalidas Shetty, Chartchai Khanongnuch
Summary: Miang, a traditional fermented tea from Northern Thailand, contains potential probiotic bacteria. Among the 133 lactic acid bacteria (LAB) isolates from Miang, 5 strains were selected for their high tolerance to bile and acidic conditions, inhibitory activity against human pathogens, and survival in simulated gastrointestinal conditions. These strains also showed different responses to antibiotics, cell surface properties, and exhibited antioxidant activity.
FERMENTATION-BASEL
(2021)