Article
Pharmacology & Pharmacy
Priya Sharma, Manish Kumar, Nitin Bansal
Summary: The study demonstrates that ellagic acid pre-treatment protects rats from cognitive impairment and motor disturbances induced by 3-NP, largely by inhibiting oxido-nitrosative stress and promoting mitochondrial function. These findings suggest that EA supplementation may have protective potential against symptoms of Huntington's disease.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Samar M. Shawki, Mohammed A. Saad, Rania M. Rahmo, Walaa Wadie, Hanan S. El-Abhar
Summary: Liraglutide shows neuroprotective potential in a rat model of Huntington's disease by modulating multiple molecular signaling pathways and reducing apoptosis and oxidative stress, demonstrating a neurotherapeutic effect.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Food Science & Technology
Pradeep Singh, Garima Mishra, Mulugeta Molla, Yohannes Shumet Yimer, Woretaw Sisay, Yared Andargie, Amien Ewunetie
Summary: Huntington's disease is a neurodegenerative disease that poses a major threat to the elderly population. It is caused by the expansion of repeats, triggering the formation of a mutant huntingtin protein that leads to neuronal death. Herbal nutraceuticals, enriched with antioxidants, are believed to have significant effects on Huntington's disease.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Pharmacology & Pharmacy
Pei Teng Lum, Mahendran Sekar, Lay Jing Seow, Mohd Farooq Shaikh, Alina Arulsamy, Thaarvena Retinasamy, Siew Hua Gan, Charles Gnanaraj, Norhaizan Mohd Esa, Gobinath Ramachawolran, Vetriselvan Subramaniyan, Suresh V. Chinni, Yuan Seng Wu
Summary: Huntington's disease (HD) is a neurodegenerative disease that affects the daily performances and life quality of patients. Mangiferin, a compound found in the Mangifera indica plant, has been proven to have medicinal benefits against memory and cognitive impairment in neurodegenerative diseases. This study aims to evaluate the neuroprotective effect of mangiferin against 3-nitropropionic acid (3NP) induced HD in rat models.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wael A. Mahdi, Shareefa A. AlGhamdi, Amira M. Alghamdi, Syed Sarim Imam, Sultan Alshehri, Mohammad A. Almaniea, Baraa Mohammed Hajjar, Fahad A. Al-Abbasi, Nadeem Sayyed, Imran Kazmi
Summary: This study aimed to analyze the neuroprotective effect of hibiscetin on rats with 3-nitropropionic acid-induced Huntington's disease. The results suggest that hibiscetin successfully restored the body weight and improved several biochemical and neuroinflammatory parameters in the rats.
Article
Food Science & Technology
Wei-Jian Li, Xuan Zhang, Ming Shen, Hong-Lin Liu, Li-Ren Ding
Summary: This study investigated the cytotoxicity of 3-Nitropropionic acid (3-NP) during mouse oocyte maturation and the protective effects of Sulforaphane (SFN). The results showed that 3-NP inhibited oocyte maturation in a dose-dependent manner, while SFN significantly alleviated the defects caused by 3-NP. In addition, 3-NP disrupted mitochondrial functions in oocytes, leading to oxidative stress and increased apoptosis. SFN supplementation had significant cytoprotective effects, mitigating these damages.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Marwa El-Sayed El-Shamarka, Ayman E. El-Sahar, Muhammed A. Saad, Naglaa Assaf, Rabab H. Sayed
Summary: Inosine attenuated 3-NP-induced HD-like symptoms in rats by activating the A2AR/BDNF/TrKB/ERK/CREB signaling pathway.
Article
Biochemistry & Molecular Biology
Vittoria Borgonetti, Nicoletta Galeotti
Summary: This study investigated the potential enhancement of choline activity through association with adaptogen plant extracts. The results showed that the combination of choline with adaptogens can attenuate the effects of oxidative stress and improve memory in chronic stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Kadine Cabey, Dani M. Long, Alexander Law, Nora E. Gray, Christine McClure, Maya Caruso, Parnian Lak, Kirsten M. Wright, Jan F. Stevens, Claudia S. Maier, Amala Soumyanath, Doris Kretzschmar
Summary: Due to the increasing aging population, age-related diseases and changes such as cognitive decline and sleep disturbances have become a growing health threat. This study suggests that oxidative stress may be behind many of these changes. The herbs Withania somnifera and Centella asiatica have shown potential in reducing oxidative stress and improving age-related impairments in behavior, indicating that they might promote healthy aging in humans.
Article
Immunology
Weam W. IbrahimnAff, Nora O. Abdel RasheednAff
Summary: The study explored the neuroprotective effects of diapocynin, a specific NADPH oxidase inhibitor, against the 3-nitropropionic acid (3-NP) model of Huntington's disease (HD) in rats. The results showed that diapocynin attenuated oxidative stress, neuroinflammation, glial activation, and apoptosis induced by 3-NP. Diapocynin also improved motor functions and histopathological derangements associated with HD. The findings suggest that diapocynin could be a promising candidate for the management of HD.
INFLAMMOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Muhammad Afzal, Nadeem Sayyed, Khalid Saad Alharbi, Sami Alzarea, Mohammed Salem Alshammari, Fadhel A. Alomar, Sattam Khulaif Alenezi, Anwarulabedin Mohsin Quazi, Abdulaziz Alzarea, Imran Kazmi
Summary: This study evaluates the anti-Huntington's effect of rosiridin against 3-NPA-induced HD-like effects in rats. Results show that rosiridin improves behavioral parameters, modulates biochemical parameters, and reduces neuroinflammation.
Article
Pharmacology & Pharmacy
Rasool Haddadi, Shahla Eyvari-Brooshghalan, Sajjad Makhdoomi, Ahmad Fadaiie, Alireza Komaki, Afsoon Daneshvar
Summary: This study found that silymarin has neuroprotective effects against 3-NP-induced neurotoxicity. Silymarin attenuates behavioral deficits, oxidative stress status, and neuroinflammation, possibly through mitigating oxidative stress status.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Thamer H. Albekairi, Arzoo Kamra, Sudeep Bhardwaj, Sidharth Mehan, Aditi Giri, Manisha Suri, Abdulrahman Alshammari, Metab Alharbi, Abdullah F. Alasmari, Acharan S. Narula, Reni Kalfin
Summary: Huntington's disease (HD) is a genetic disorder characterized by gene mutation and neuronal loss. A study has shown that beta Boswellic acid (beta-BA), in combination with vitamin E, has neuroprotective effects and can improve behavioral impairments in HD. The treatment with beta-BA restored neurotransmitter levels and enzyme activity, suggesting its potential in preventing neurological diseases like HD.
Article
Geriatrics & Gerontology
Vishal Kumar, Charan Singh, Arti Singh
Summary: In this study, the protective effect of hydroalcoholic extract of Centella asiatica (HA-CA) on 3-NP-induced Huntington's disease (HD) in adult zebrafish was investigated. The results showed that HA-CA reduced neuroinflammation and neurobehavioral deficits caused by 3-NP, and ameliorated memory dysfunction, body weight loss, and neuronal damage. HA-CA exhibited strong antioxidant activity and decreased levels of inflammatory factors in the brain.
REJUVENATION RESEARCH
(2022)
Article
Medicine, Research & Experimental
Nora O. Abdel Rasheed, Weam W. Ibrahim
Summary: This study demonstrates that telmisartan has neuroprotective effects in a rat model of Huntington's disease, improving motor and cognitive dysfunction and reducing oxidative stress, neuro-inflammation, and apoptosis. These effects may be achieved through the activation of peroxisome proliferator activated receptor-gamma and blockade of angiotensin-II receptor type 1.
Article
Engineering, Chemical
Chandrakant R. Sonawane, Kuldeep Tolia, Anand Pandey, Atul Kulkarni, Hitesh Punchal, Kishor Kumar Sadasivuni, Anil Kumar, Mohammad Khalid
Summary: In this paper, a numerical investigation and evaluation of the thermal characteristics of a closed-loop pulsating heat pipe are performed. The volume of fluid method is used to simulate the two-phase flow inside the heat pipe, and the numerical results are compared and validated with experimental data. The study concludes that a filling ratio of 65% is the optimized charge quality for the current configuration of the pulsating heat pipe.
CHEMICAL ENGINEERING COMMUNICATIONS
(2023)
Article
Computer Science, Artificial Intelligence
Selvin Shabu Lilly Pushpam Jany Shabu, Kusum Yadav, Elham Kariri, Kamal Kumar Gola, Mohd AnulHaq, Anil Kumar
Summary: This paper investigates trajectory data query processing and similarity measurement methods in a cloud environment. By extending traditional data processing techniques and leveraging the highly parallel processing capabilities of large clusters in the cloud, a two-phase trajectory similarity measure is proposed. Additionally, new methods for trajectory clustering and query processing are developed, which involve trajectory analysis and evaluation to reduce computational difficulty and workload compared to existing methods.
Article
Automation & Control Systems
J. Refonaa, Dinh Tran Ngoc Huy, Nguyen Dinh Trung, Hoang Van Thuc, Roop Raj, Mohd Anul Haq, Anil Kumar
Summary: Structural engineering is a specialized field that deals with the stability of structures and buildings. Optimization of cost and time is crucial in construction processes. Artificial neural network (ANN) has been developed to handle issues related to cost estimation and optimization, enhancing construction procedures and methodologies using deep learning techniques.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2023)
Article
Engineering, Electrical & Electronic
P. Saini, L. K. Balyan, A. Kumar, G. K. Singh
Summary: This paper presents a comparison scenario of adaptive spectral filtering for resolution of the Gibbs phenomenon. Several spectral filter functions are compared using Chebyshev collocation and Legendre collocation spectral methods, in terms of pointwise and L-2 normed-wise convergence analysis of computed filtered approximations.
SIGNAL IMAGE AND VIDEO PROCESSING
(2023)
Article
Pharmacology & Pharmacy
Radhika T. Krishnakumar, Amrita Asok, Zubair U. Mohamed, Uma D. Padma, Dipu T. Sathyapalan, Merlin Moni, Sabarish Balachandran, Anil Kumar, Rajesh Nair, Surendran Sudhindran, Sanjeev K. Singh
JOURNAL OF PHARMACY PRACTICE
(2023)
Correction
Computer Science, Hardware & Architecture
Priyanka Paliwal, Julian L. Webber, Abolfazl Mehbodniya, Mohd Anul Haq, Anil Kumar, Prem Kumar Chaurasiya
JOURNAL OF SUPERCOMPUTING
(2023)
Article
Computer Science, Information Systems
Himanshu Singh, Anil Kumar, Lokendra K. Balyan
Summary: This paper introduces an image enhancement method based on fractional differintegral based adaptive filtering, which utilizes the advantages of fractional-order differentiation and fractional-order integration for adaptive textural boosting and contrast enhancement. It also proposes a differintegration based fractional-order multi-scale Retinex framework for effective reflectance channel computation. The paper discusses the compatibility of the proposed method with other image pre-processing methods and presents different variants for overall quality improvement.
MULTIMEDIA TOOLS AND APPLICATIONS
(2023)
Article
Green & Sustainable Science & Technology
B. Sarkar, B. Das, P. K. Sundaram, S. S. Mali, A. P. Anurag, A. Upadhyaya, N. Chandra, B. P. Bhatt, A. Kumar
Summary: This study analyzed the energy input-output and GHG emission in vegetable production in the Chotanagpur plateau region and found that both tomato and okra cultivation were profitable. The study also emphasized the importance of efficient input use in reducing GHG emissions.
ENVIRONMENT DEVELOPMENT AND SUSTAINABILITY
(2023)
Article
Management
Luai Jraisat, Mohannad Jreissat, Arvind Upadhyay, Anil Kumar
Summary: This research explores the integration of Blockchain Technology (BCT) with Reverse Supply Chain Networks (RSCN) and its impact on sustainability performance. A conceptual framework for BCT in RSCN was developed through qualitative research, using primary and secondary data from four case studies in Jordan. The findings highlight the potential of BCT in improving sustainability performance in supply chains.
SUPPLY CHAIN FORUM
(2023)
Review
Engineering, Electrical & Electronic
Geetam Richhariya, Anil Kumar, Akash Kumar Shukla, K. N. Shukla, Bhim Charan Meikap
Summary: Dye-sensitized solar cells (DSSCs) are a cost-effective, easy-to-fabricate, and eco-friendly option among photovoltaic devices. The choice of counter electrode (CE) materials significantly impacts the performance of DSSCs. By exploring economical and stable alternatives to expensive platinum, the efficiency of DSSCs can be improved. This article focuses on various replacements for platinum-based CEs, offering innovative research opportunities in the field of renewable energy.
JOURNAL OF ELECTRONIC MATERIALS
(2023)
Article
Food Science & Technology
Shimpy, Mahesh Kumar, Anil Kumar
Summary: This article provides an overview of solar drying technologies for small rural agricultural farms, focusing on domestic applications. A significant amount of perishable items are wasted annually at the household level due to various reasons. The article reviews and presents natural and forced convection solar dryers, highlighting their temperature and thermal efficiency. Natural convection solar dryers are suitable for rural areas due to their simple design and lower requirements, while forced convection solar dryers offer better performance and faster drying time for high moisture content products. The designs of indirect and mixed-mode solar dryers in domestic applications are rare. Solar dryers have the potential to reduce drying costs by 50% and improve returns by 30%.
FOOD ENGINEERING REVIEWS
(2023)
Review
Pharmacology & Pharmacy
Richmond Arthur, Umashanker Navik, Puneet Kumar
Summary: Artemisinins and their derivatives can be repurposed as neuroprotective agents by modulating the PI3K/Akt pathway to inhibit oxidative stress, neuroinflammation, and apoptosis in neurodegenerative disorders.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Mandeep Kumar, T. P. Nhung Nguyen, Jasleen Kaur, Thakur Gurjeet Singh, Divya Soni, Randhir Singh, Puneet Kumar
Summary: Artificial intelligence (AI) is a machine science that imitates human behavior and intelligent data analysis using specialized algorithms, deep learning, and machine learning. It provides an automated and reliable tool for accurately and rapidly making decisions in the digital world where a vast amount of medical data is generated daily. AI has been widely applied in various fields in pharmaceutical science, particularly in pharmacological research, aiding in the analysis of preclinical and clinical trial data, drug discovery/manufacturing, disease diagnosis, personalized treatment, clinical trial research, radiotherapy, surgical robotics, electronic health records, and epidemic outbreak prediction. Additionally, AI is instrumental in evaluating biomarkers and diseases. This review explains the models and processes of machine learning and discusses their role in pharmacological science, illustrating the relevance and potential of AI with deep learning and machine learning in pharmacological research.
PHARMACOLOGICAL REPORTS
(2023)
Article
Pharmacology & Pharmacy
Rishav Gupta, Divya Soni, Shubham Upadhayay, Maanvi Dhureja, Puneet Kumar
Summary: Epilepsy is a disease characterized by excessive excitatory neuronal firing and motor, psychomotor, and sensory impairments. Current therapies fall short in producing satisfactory outcomes due to the complexity of the disease, inadequate diagnosis, and the rise of drug-resistant epilepsy. This study investigated the potential of repurposing the drug "noscapine" for the management of epilepsy and its associated complications. The results showed that noscapine pretreatment attenuated the behavioral and biochemical changes induced by prolonged PTZ treatment in mice, suggesting its potential as a new antiepileptic agent.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Amandeep Kaur, Navneet Singh, Harmanpreet Kaur, Violina Kakoty, Deep Shikha Sharma, Rubiya Khursheed, Molakpogu Ravindra Babu, Vancha Harish, Gaurav Gupta, Monica Gulati, Puneet Kumar, Harish Dureja, Nahed S. Alharthi, Farhan R. Khan, Zia Ur Rehman, Mohammed Ageeli Hakami, Mrunali Patel, Rashmin Patel, Milad Zandi, Sukriti Vishwas, Kamal Dua, Sachin Kumar Singh
Summary: Neurodegenerative diseases (NDs) pose a burden on human lives and economies, and traditional treatment approaches are ineffective in the long term. Dendrimers offer promise as nanocarriers for drug delivery, providing a non-invasive approach for treating NDs. However, limitations in elimination and cytotoxicity need to be addressed.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)