Article
Nutrition & Dietetics
Maria Sorokina, Kira S. McCaffrey, Erin E. Deaton, Guoying Ma, Jose M. Ordovas, Penelope M. Perkins-Veazie, Christoph Steinbeck, Amnon Levi, Laurence D. Parnell
Summary: This manuscript introduces a catalog of 1,679 small molecules occurring in watermelon and their cheminformatics analysis for diverse features, highlighting the importance of this catalog for precision nutrition and plant breeding efforts. Improved and comprehensive collections of natural products accessible to the public will be especially useful for researchers in nutrition, cheminformatics, bioinformatics, and drug development.
FRONTIERS IN NUTRITION
(2021)
Article
Chemistry, Multidisciplinary
Georg Niggemeyer, Anastasia Knyazeva, Raphael Gasper, Dale Corkery, Pia Bodenbinder, Julian J. Holstein, Sonja Sievers, Yao-Wen Wu, Herbert Waldmann
Summary: Design and synthesis of pseudo-natural products through recombination of natural product fragments enables the discovery of novel biologically relevant chemical matter. In this study, the combination of this principle with macrocycle formation was described, leading to the efficient synthesis of 163 macrocyclic pseudo-natural products. Biological investigation revealed their potent inducers of autophagy-related processes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Pharmacology & Pharmacy
Cameron Ryall, Sanjukta Duarah, Shuo Chen, Haijun Yu, Jingyuan Wen
Summary: The application of modern delivery techniques to natural bioactive products has shown promise in improving their effectiveness in wound healing. By utilizing systems such as microneedles and lipid-based vesicles, natural products like curcumin and aloe vera can overcome the barrier of the stratum corneum and enhance their permeability. This improvement can provide novel wound-healing therapies for individuals who prefer traditional compounds, thereby reducing medical inequalities.
Review
Integrative & Complementary Medicine
Leng Ying-Rong, Zhang Mei-Hui, Luo Jian-Guang, Zhang Hao
Summary: NASH, a common clinical condition that can lead to advanced liver diseases, lacks effective therapy, making it crucial to understand its pathogenic mechanisms for developing innovative treatments. Natural constituents from medicinal plants are emerging as a new hope for NASH therapy, with increasing studies focusing on their potential as therapeutic agents.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Review
Biochemistry & Molecular Biology
Raul R. Rodriguez-Berrios, Stephen R. Isbel, Alejandro Bugarin
Summary: Polypropionate units, found in many natural products, have antimicrobial and therapeutic potential. This review includes all epoxide-based methodologies developed by research groups such as Kishi, Katsuki, Marashall, Miyashita, Prieto, Sarabia, Jung, McDonald, etc. for the synthesis of polypropionates. The review also includes the isolation and biological activities of synthetized polypropionates and related natural products.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Julian M. Feilner, Immanuel Plangger, Klaus Wurst, Thomas Magauer
Summary: This study utilized highly functionalized bifunctional alkenes to achieve a polyene tetracyclization, leading to the total synthesis of the tricyclic diterpenoid pimara-15-en-3 alpha-8 alpha-diol. The versatile route also allowed for the preparation of a diverse library of cyclization precursors for the total synthesis of the tetracyclic nor-diterpenoid norflickinflimiod C, providing insights into complex pentacyclic products.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Pharmacology & Pharmacy
Jia-Chen Xue, Shuo Yuan, Xiao-Ting Hou, Huan Meng, Bao-Hong Liu, Wen-Wen Cheng, Ming Zhao, Hong-Ben Li, Xue-Fen Guo, Chang Di, Min-Jie Li, Qing-Gao Zhang
Summary: This article summarizes the pathogenesis of ulcerative colitis (UC), including the regulatory role of the NLRP3 inflammasome and the recent natural products targeting NLRP3. Studies have shown that NLRP3 is associated with UC susceptibility and maintains intestinal stability by responding to pathogenic microorganisms. Natural products have shown promise in treating UC with their multi-target effects and fewer side effects.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yeqin Yuan, Huizhi Long, Ziwei Zhou, Yuting Fu, Binyuan Jiang
Summary: Breast cancer is the most common cancer in women, with a rising incidence that poses significant challenges for treatment. The PI3K-AKT pathway and its targets play crucial roles in breast cancer development, and natural products and drugs targeting this pathway show potential for treatment. This review discusses the role of the PI3K-AKT signaling pathway in breast cancer and highlights the use of natural products and drugs targeting this pathway in clinical trials.
Article
Food Science & Technology
Amirhossein Abedini, Parisa Sadighara, Mahmood Alizadeh Sani, David Julian McClements
Summary: Biogenic amines (BAs) are compounds produced in foods containing proteins and amino acids by microorganisms, and the use of food additives can have a significant impact on the quality and safety of food products, affecting the production of BAs in different ways.
Review
Biochemistry & Molecular Biology
Xinyu Liu, Peijun Zhang, Qiao Zhao, Ancheng C. Huang
Summary: Plant natural products have diverse applications in various industries and synthetic biology provides a promising approach for their sustainable and cost-effective production. However, the potential of using plants as hosts for producing these compounds is often overlooked due to the challenges in plant engineering. This manuscript summarizes the biosynthesis of plant natural products, with a focus on industrially important terpenoids, alkaloids, and phenylpropanoids, as well as the strategies and hosts used to engineer their production. It also discusses the opportunities and challenges of using plant synthetic biology for rapid and scalable production of high-value plant natural products.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2023)
Review
Nutrition & Dietetics
Raissa Mara Kao Yien, Ana Paula dos Santos Matos, Anne Caroline Candido Gomes, Denise de Abreu Garofalo, Ralph Santos-Oliveira, Naomi Kato Simas, Eduardo Ricci
Summary: Biodiversity is important in the Asteraceae family, and some species have pharmacological potential. The search for new substances from natural products has been ongoing for years, but developing a final product remains challenging. Nanotechnology has emerged as a tool to improve the pharmacokinetic parameters of active substances and formulations. This study reviewed the use of nanotechnology in developing formulations from Asteraceae species from 2010 to 2021, and found that nanoemulsions were the most commonly used formulation. Nanotechnology has shown to improve the pharmacokinetic parameters of active substances.
Review
Chemistry, Applied
Antonio Del Rio Flores, Colin C. Barber, Maanasa Narayanamoorthy, Di Gu, Yuanbo Shen, Wenjun Zhang
Summary: Natural products are biologically produced compounds that play important roles in various biological processes. The biosynthetic pathways and potential applications of isonitrile and alkyne functionalities are still not fully understood. Understanding these pathways is crucial for rational design of biogenic molecules with these functionalities.
ANNUAL REVIEW OF CHEMICAL AND BIOMOLECULAR ENGINEERING
(2022)
News Item
Chemistry, Multidisciplinary
Jun-Jie Chen, Huan-Ming Huang
Summary: In this study, a new strategy using N2O as the oxygen source under mild conditions was developed for the conversion of aryl halides to phenols.
Article
Chemistry, Organic
Marc Paul Beller, Ulrich Koert
Summary: This review discusses the total syntheses of preussochromones A, D, E, and F, as well as the structural revisions of preussochromones E and F. It demonstrates the successful use of alpha-keto esters and alpha,beta-diketo esters as valuable reactants in stereoselective cyclization reactions in total synthesis.
SYNTHESIS-STUTTGART
(2022)
Review
Biotechnology & Applied Microbiology
Rong Gong, Le Yu, Yini Qin, Neil P. J. Price, Xinyi He, Zixin Deng, Wenqing Chen
Summary: Antibiotic resistance is a growing threat to global health, prompting the need to accelerate the development of new drugs derived from natural products. Nucleoside antibiotics play significant roles in healthcare and plant protection, and understanding their biosynthesis can enhance production and structural diversification. Recent advancements in synthetic biology strategies are improving the production of nucleoside antibiotics and accessing their chemical diversities.
BIOTECHNOLOGY ADVANCES
(2021)
