Review
Immunology
Lauren W. Kaminsky, Rana Al-Sadi, Thomas Y. Ma
Summary: The intestinal epithelial tight junction (TJ) barrier plays a crucial role in intestinal diseases, especially inflammatory bowel diseases. The IL-1 beta-induced increase in intestinal TJ permeability is a key factor in the inflammatory process.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Weiwei Wen, Yihan Xu, Wenwei Qian, Liangyu Huang, Jianfeng Gong, Yi Li, Weiming Zhu, Zhen Guo
Summary: A combination of adherent-invasive Escherichia coli (AIEC) and polyunsaturated fatty acid (PUFA) supplementation can increase lipid peroxidation and ferroptosis in intestinal epithelial cells (IECs), leading to the induction and exacerbation of intestinal inflammation.
Article
Nutrition & Dietetics
Emily Wang, Yeyi Zhu, Rana F. Chehab, Jing Wu, Stefanie N. Hinkle, Natalie L. Weir, Andrew A. Bremer, Jiaxi Yang, Zhen Chen, Michael Y. Tsai, Cuilin Zhang
Summary: The study found that mid-to-late pregnancy is a critical period for fetal growth, with plasma DHA and Delta 5-desaturase activity positively associated with neonatal anthropometric measures.
Article
Immunology
Shaosong Xi, Yunguang Wang, Chenghao Wu, Weihua Peng, Ying Zhu, Wei Hu
Summary: The study shows that disturbance of intestinal flora leads to the release of exosomes from intestinal epithelial cells. These exosomes cause M1 polarization in the mesenteric lymph nodes and the accumulation of circulating IL-1β. Circulating IL-1β promotes neuronal damage and apoptosis in an autophagy-dependent manner. Targeting intestinal flora or IEC-derived exosomes may contribute to the treatment of SAE.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Nutrition & Dietetics
Zhen-Sen Chen, Mu-Ming Yu, Kuo Wang, Xiang-Long Meng, Yan-Cun Liu, Song-Tao Shou, Yan-Fen Chai
Summary: This study aimed to investigate whether omega-3 polyunsaturated fatty acids (PUFAs) have a protective effect on sepsis-induced cardiomyopathy (SIC). The findings showed that pretreatment with omega-3 PUFAs can attenuate cardiomyocyte apoptosis, reduce the production of proinflammatory cytokines, improve SIC, and increase the survival rate of septic mice.
Article
Pediatrics
Kathleen M. Gustafson, Danielle N. Christifano, Dirk Hoyer, Alexander Schmidt, Susan E. Carlson, John Colombo, Nicole B. Mathis, Scott A. Sands, Lynn Chollet-Hinton, Alexandra R. Brown, Dinesh Pal Mudaranthakam, Byron J. Gajewski
Summary: This study aimed to investigate the effect of maternal DHA supplementation on maternal-infant DHA equilibrium and fetal neurodevelopment. The results showed that pregnant women who received a higher dose of DHA were more likely to achieve maternal-infant DHA equilibrium at delivery, but this equilibrium status did not significantly impact fetal neurodevelopment.
PEDIATRIC RESEARCH
(2022)
Article
Nutrition & Dietetics
Huimin Zhang, Zhenxia Xu, Wenchao Chen, Fenghong Huang, Shouwen Chen, Xu Wang, Chen Yang
Summary: In this study, it was found that supplementation with algal oil could alleviate intestinal damage and inflammation induced by ceftriaxone sodium in mice. The algal oils inhibited the activity of pro-inflammatory cytokines TNF-alpha, IL-6, and MPO, increased the expression of tight junction protein ZO-1, and regulated the composition of gut microbiota.
FRONTIERS IN NUTRITION
(2023)
Article
Multidisciplinary Sciences
Shaojie Cui, Glenn Simmons, Goncalo Vale, Yaqin Deng, Jungyeon Kim, Hyeonwoo Kim, Ruihui Zhang, Jeffrey G. McDonald, Jin Ye
Summary: This study reveals that Fas-associated factor 1 (FAF1) interacts directly with free polyunsaturated fatty acids (PUFAs) and this interaction is crucial for protecting cells from ferroptosis. FAF1 assembles a globular structure that sequesters free PUFAs into a hydrophobic core, preventing PUFA peroxidation and ultimately inhibiting ferroptosis initiation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Environmental Sciences
Marua Abu Risha, Asghar Ali, Puntita Siengdee, Nares Trakooljul, Dirk Dannenberger, Klaus Wimmers, Siriluck Ponsuksili
Summary: Climate change-induced temperature fluctuations have detrimental effects on the health and productivity of farm animals. This study investigates the impact of temperature stress on muscle cell differentiation, growth, and membrane fatty acid composition, revealing changes in molecular pathways related to lipid metabolism and fatty acid elongation.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Toxicology
Hao Chen, Siqi Zhang, Wan Shen, Claudia Salazar, Alexandra Schneider, Lauren H. Wyatt, Ana G. Rappold, David Diaz-Sanchez, Robert B. Devlin, James M. Samet, Haiyan Tong
Summary: This study demonstrates that short-term exposure to low-level ambient air pollution is associated with cardiovascular responses, and that dietary intake of omega-3 polyunsaturated fatty acids may provide protection against these cardiovascular effects in healthy adults.
PARTICLE AND FIBRE TOXICOLOGY
(2022)
Article
Agricultural Engineering
Anil Kumar Patel, Ajeet Singh Chauhan, Prashant Kumar, Philippe Michaud, Vijai Kumar Gupta, Jo-Shu Chang, Chiu-Wen Chen, Cheng-Di Dong, Reeta Rani Singhania
Summary: This article provides an update on the production of essential fatty acids from potential microbes and explores novel strategies to promote the accumulation of omega-3 and omega-6 through engineering and omics approaches.
BIORESOURCE TECHNOLOGY
(2022)
Article
Anatomy & Morphology
Hassan Reda Hassan Elsayed, Hanan S. Anbar, Mohammed R. Rabei, Mohamed Adel, Randa El-Gamal
Summary: The study found that Omega-3 fatty acids could decrease MTX-induced splenic injury, reduce oxidative stress markers, improve anti-apoptotic and anti-inflammatory conditions, and increase immune cell levels. Therefore, Omega-3 may be a promising adjuvant therapy for MTX, helping prevent its deleterious effects on the spleen.
Article
Biochemistry & Molecular Biology
Haruhiko Jimbo, Koki Yuasa, Kensuke Takagi, Takashi Hirashima, Sumie Keta, Makiko Aichi, Hajime Wada
Summary: Our study showed that PUFAs accelerate the photodamage to PSII in Synechocystis cells, while monounsaturated fatty acids do not have this effect. PUFAs are specifically incorporated into the sn-2 position of PG molecules, a process that requires the involvement of acyl-ACP synthetase.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biodiversity Conservation
Ana M. M. Goncalves, Carolina P. Rocha, Joao C. Marques, Fernando J. M. Goncalves
Summary: The toxic effects of pesticides, especially in aquatic ecosystems, have been a major concern for environmental and human safety. Biomarkers, such as antioxidant enzymes and fatty acids, are crucial in assessing the impacts of pesticides on organisms. Fatty acids have been identified as potential biomarkers due to their sensitivity to alterations in organism homeostasis, particularly in freshwater communities.
ECOLOGICAL INDICATORS
(2021)
Editorial Material
Medicine, Research & Experimental
Philip C. Calder, Nicolaas E. P. Deutz
Summary: This article summarizes two highly cited papers published in Clinical Science in 1982 and 2011, which investigated the effects of stable isotope-labeled amino acids infusion and high-dose omega-3 fatty acid intake on skeletal muscle protein synthesis. These papers provide experimental approaches to study human physiology, novel insights into the impact of nutritional state and specific nutrients on muscle protein synthesis, and potential interventions for preventing and reversing muscle mass decline.
Article
Chemistry, Applied
Dong Hao Wang, Zhen Wang, Xu Li, Secilia Martinez, Genevieve James, Md Saydur Rahman, J. Thomas Brenna
Summary: Sea urchin gonads are considered a delicacy in Japan and other cultures, with a complex fatty acid profile that poses analytical challenges. A comprehensive study using tandem mass spectrometry revealed over 100 fatty acids, including unique double bond structures. The presence of unusual unsaturates in sea urchin gonad lipids may have potential effects on mammalian signaling pathways and offer novel bioactivities.
Article
Biochemistry & Molecular Biology
Michael A. Crawford, Yiqun Wang, David E. Marsh, Mark R. Johnson, Enitan Ogundipe, Ahamed Ibrahim, Hemalatha Rajkumar, S. Kowsalya, Kumar S. D. Kothapalli, J. T. Brenna
Summary: This article highlights the progress made in nutrition knowledge over the past century and the major gaps in implementing that knowledge, with a focus on the celebration of the centenary of the National Institute of Nutrition in India. It points out the global issue of brain famine and the neglect of neurocognitive health in food policies. The importance of proper nutrition for mothers before conception and during pregnancy in ensuring intellectual development is emphasized. The article calls for placing the nutritional requirements for the brain at the top of the list in nutrition education and food policy.
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
(2022)
Article
Environmental Sciences
Inmaculada Salcedo-Bellido, Esperanza Amaya, Celia Perez-Diaz, Anabel Soler, Fernando Vela-Soria, Pilar Requena, Rocio Barrios-Rodriguez, Ruth Echeverria, Francisco M. Perez-Carrascosa, Raquel Quesada-Jimenez, Piedad Martin-Olmedo, Juan Pedro Arrebola
Summary: This study analyzed adipose tissue samples from the GraMo cohort in Southern Spain to identify the bioaccumulation patterns of alpha-, beta- hexachlorocyclohexane (HCH) and dicofol in relation to sociodemographic, dietary, and lifestyle factors. The study found different predictors associated with the levels of these organochlorine pesticides (OCP), suggesting distinct bioaccumulation patterns.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Alla Y. Molchanova, Svetlana N. Rjabceva, Tigran B. Melik-Kasumov, Nikolay B. Pestov, Plamena R. Angelova, Vadim V. Shmanai, Olga L. Sharko, Andrei Bekish, Genevieve James, Hui Gyu Park, Irina A. Udalova, J. Thomas Brenna, Mikhail S. Shchepinov
Summary: Arachidonic acid (ARA) is easily oxidized and its oxidation products induce inflammatory responses. This study found that deuterated ARA (D-ARA) can protect lungs from adverse effects of inflammation and reduce lung damage caused by acute lung injury, suggesting a potential therapeutic avenue for severe infections and inflammatory diseases.
Article
Education & Educational Research
Rocio Barrios-Rodriguez, Inmaculada Salcedo-Bellido, Jose Juan Jimenez-Moleon, Macarena Lozano-Lorca, Noelia Galiano-Castillo, Enrique Jose Cobos, Jose Damaso Vilchez Rienda, Rocio Olmedo-Requena, Carmen Amezcua-Prieto, Sandra Martin-Pelaez, Carmen Maria Gonzalez Domenech, Juan Pedro Arrebola Moreno, Raul A. Rica, Maria Eugenia Garcia-Rubino, Pilar Requena
Summary: In a peer-review of teaching (PRT) program, the use of pre and post-observation questionnaires enhanced self-reflection, while the nominal group technique (NGT) helped in reaching a consensus on improvements. The questionnaires revealed that PRT was effective in identifying weaknesses but not strengths, and teachers experienced a reduction in negative feelings during the observation process. The NGT emphasized the importance of pairing teachers from different knowledge areas and providing information to future participants to enhance the PRT program and increase faculty participation.
INTERNATIONAL JOURNAL FOR ACADEMIC DEVELOPMENT
(2022)
Article
Environmental Sciences
Francisco Miguel Perez-Carrascosa, Rocio Barrios-Rodriguez, Celia Gomez-Pena, Inmaculada Salcedo-Bellido, Maria Eugenia Velasco-Garcia, Jose Juan Jimenez-Moleon, Antonio Garcia-Ruiz, Jose Luis Navarro-Espigares, Pilar Requena, Carmen Munoz-Sanchez, Juan Pedro Arrebola
Summary: This study longitudinally explores the public healthcare costs associated with long-term exposure to a mixture of 8 persistent organic pollutants (POPs) in residents of two areas in Granada Province, Southern Spain. The results suggest that long-term exposure to these pollutants may increase healthcare costs and impact the efficiency of healthcare systems. However, further research is needed to determine whether interventions to reduce human exposure should be considered in healthcare policies, due to the limitations of the study.
ENVIRONMENTAL RESEARCH
(2022)
Article
Ophthalmology
Genevieve James, Whitney Bohannan, Eniola Adewunmi, Karsten Schmidt, Hui Gyu Park, Mikhail S. Shchepinov, Martin -Paul Agbaga, J. Thomas Brenna
Summary: D-DHA, a compound with higher resistance to oxidative damage, has the potential to treat eye diseases. By consuming D-DHA, it can replace natural DHA in the body and rapidly accumulate in ocular tissues, achieving therapeutic effects.
EXPERIMENTAL EYE RESEARCH
(2022)
Review
Gastroenterology & Hepatology
Marta Exposito Miranda, Luz Garcia-Valdes, Elena Espigares-Rodriguez, Ester Leno-Duran, Pilar Requena
Summary: Non-celiac gluten sensitivity (NCGS) is a newly recognized pathology related to gluten. This review discusses its etiology, differential diagnosis, and symptoms. In addition to gluten, other components of wheat or FODMAPs may also contribute to NCGS. The diagnostic protocol and biomarkers for NCGS are still controversial. Common symptoms include abdominal pain, fatigue, and nutritional deficiencies. Further research is needed to better understand the etiopathogenesis and clinical features of NCGS.
GASTROENTEROLOGIA Y HEPATOLOGIA
(2023)
Article
Environmental Sciences
Pilar Requena, Celia Perez-Diaz, Vicente Mustieles, Francisco M. Peinado, Josefa Leon, Francisco M. Perez-Carrascosa, Hanne Frederiksen, Inmaculada Salcedo-Bellido, Rocio Barrios-Rodriguez, Juan Pedro Arrebola
Summary: This study investigates the associations between human phthalate exposure and the onset of chronic diseases with an immunological component. The results suggest that certain phthalates are correlated with cytokines and acute phase proteins, indicating potential subclinical immuno-inflammatory actions of these pollutants.
ENVIRONMENTAL RESEARCH
(2023)
Article
Food Science & Technology
Genevieve James, Kevin Stephenson, Meghan Callaghan-Gillespie, Mohamed Tabita Kamara, Hui Gyu Park, J. Thomas Brenna, Mark J. J. Manary
Summary: This study aimed to prepare RUTF formulations with DHA and measure its retention. The results showed that most of the DHA was retained in the final product, and adding DHA at the latest manufacturing stage achieved the best retention rate.
Article
Physics, Multidisciplinary
Michael A. Crawford, Andrew J. Sinclair, Yiqun Wang, Walter F. Schmidt, C. Leigh Broadhurst, Simon C. Dyall, Larry Horn, J. Thomas Brenna, Mark R. Johnson
Summary: In George Wald's Nobel Prize acceptance speech, he proposed a hypothesis that docosahexaenoic acid (DHA) traps the energy released during the visual process and carries it to the brain, explaining the previously unresolved issues of information transfer speed and photon wavelength conservation.
Review
Biochemistry & Molecular Biology
J. Thomas Brenna, Marina G. Sergeeva, Nikolay B. Pestov, Tatyana V. Korneenko, Mikhail S. Shchepinov
Summary: This article discusses a new approach, using oxidation-resistant hexadeuterated arachidonic acid (D-ARA), to attenuate pathological inflammatory reactions by buffering the eicosanoid pathways. Enzymatic processing of released arachidonic acid by phospholipase A2 yields bioactive eicosanoids, some of which have pro-inflammatory, pro-angiogenesis, and pro-thrombosis effects. D-ARA, resistant to both enzymatic and non-enzymatic oxidation pathways, may play a role in mitigating inflammation-related disorders.
FREE RADICAL RESEARCH
(2023)
Article
Environmental Sciences
R. Barrios-Rodriguez, C. Garde, F. M. Perez-Carrascosa, J. Exposito, F. M. Peinado, M. Fernandez Rodriguez, P. Requena, I. Salcedo-Bellido, J. P. Arrebola
Summary: Chronic exposure to persistent organic pollutants (POPs) is suspected to contribute to breast cancer onset. This study analyzed the contribution of long-term exposure to five POPs to mortality, recurrence, metastasis, and second primary tumors in breast cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Nutrition & Dietetics
Ester Leno-Duran, Marcos Micha Mabale, Marina Garcia-Perez, Aurora Bueno-Cavanillas, Rocio Barrios-Rodriguez, Pilar Requena
Summary: According to this systematic review, a healthy diet, such as the Mediterranean diet and plant-based diet, can help reduce the risk of SARS-CoV-2 infection and severity of COVID-19. Specifically, high consumption of vegetables, legumes, and cereals, as well as low intake of dairy products and red meat, showed a protective effect. Vitamin and probiotic supplements also lowered the risk.
NUTRICION HOSPITALARIA
(2023)
Article
Social Sciences, Interdisciplinary
Salvador Aljazairi, Inmaculada Salcedo-Bellido, Rocio Barrios-Rodriguez, Pilar Requena
Summary: This study compared student performance in oral and multiple-choice question online exams and evaluated their satisfaction through a questionnaire. While oral exams resulted in higher scores, students preferred multiple-choice question exams as they felt more comfortable and believed it allowed them to showcase their knowledge better.
REIDOCREA-REVISTA EECTRONICA DE INVESTIGACION Y DOCENCIA CREATIVA
(2022)
