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Chemistry, Medicinal
Toni Kuehl, Maya G. Georgieva, Harald Huebner, Maria Lazarova, Matthias Vogel, Bodo Haas, Martina I. Peeva, Aneliya A. Balacheva, Ivan P. Bogdanov, Luigi Milella, Maria Ponticelli, Tsvetomir Garev, Immacolata Faraone, Roumyana Detcheva, Borislav Minchev, Polina Petkova-Kirova, Lyubka Tancheva, Reni Kalfin, Atanas G. Atanasov, Liudmil Antonov, Tamara I. Pajpanova, Kiril Kirilov, Marcus Gastreich, Peter Gmeiner, Diana Imhof, Nikolay T. Tzvetkov
Summary: The modulatory interactions between neurotensin (NT) and the dopaminergic neurotransmitter system in the brain suggest that NT may be associated with the progression of Parkinson's disease (PD). NT exerts its neurophysiological effects by interactions with the human NT receptors type 1 (hNTS1) and 2 (hNTS2). The development of NT-based analogs targeting hNTS1 and hNTS2 receptors shows potential for the treatment of PD and other CNS disorders.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Silvia Mihaylova, Tamara Paipanova, Kaloyan Georgiev
Summary: This study aimed to improve the analgesic effects of neurotensin through modifications to enhance selectivity for NTS2 and prevent proteolytic degradation. Six peptides were synthesised and tested for their analgesic activity in mice. Peptide T3 showed a significant reduction in pain sensitivity in a peripheral pain model, while other peptides had minimal impact. These findings provide insights into developing neurotensin mimetics for targeted pain modulation.
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Cardiac & Cardiovascular Systems
Solene E. Boitard, Mathilde Keck, Robin Deloux, Pierre-Emmanuel Girault-Sotias, Yannick Marc, Nadia De Mota, Delphine Compere, Onnik Agbulut, Fabrice Balavoine, Catherine Llorens-Cortes
Summary: QGC606 treatment improves cardiac function and reduces cardiac remodeling and fibrosis in mice post-MI, without lowering blood pressure.
CANADIAN JOURNAL OF CARDIOLOGY
(2022)
Review
Food Science & Technology
Linjiang Zhu, Yuting Xue, Jiacheng Feng, Yuxin Wang, Yuele Lu, Xiaolong Chen
Summary: Tetrahydrocurcumin (THCu) is a reduction metabolite of curcumin with strong antioxidant, anti-inflammatory, and antibacterial properties. It has better solubility, stability, and bioavailability than curcumin, making it a desirable ingredient in functional foods and cosmetics. While current industrial production relies on chemical synthesis, microbial/enzymatic transformation methods are being explored as more environmentally-friendly alternatives. This review focuses on the production technology, synthesis strategies, bioconversion methods, detection methods, and potential applications of THCu.
Article
Biochemistry & Molecular Biology
Gregory S. Keyes, Kristen Maiden, Christopher E. Ramsden
Summary: The derivatives of linoleic acid are believed to play a crucial role in the formation of the skin permeability barrier. The researchers have developed methods for synthesizing these derivatives and stable analogs, providing a new approach for studying these compounds.
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
(2021)
Article
Chemistry, Multidisciplinary
Andrew Leber, Raquel Hontecillas, Victoria Zoccoli-Rodriguez, Marion Ehrich, Jyoti Chauhan, Josep Bassaganya-Riera
Summary: The study found that NX-13 is safe and well-tolerated in rats at oral doses as high as 1000 mg/kg. No significant changes were observed in weight, clinical signs, blood parameters, or tissue pathology between treated and control rats. Pharmacokinetic analysis showed that NX-13 has a favorable gastrointestinal localized profile.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Urology & Nephrology
Cody L. Dunton, J. Todd Purves, Francis M. Hughes, Huixia Jin, Jiro Nagatomi
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2018)
Article
Multidisciplinary Sciences
Nathalie Nasr, Adele Faucherre, Marc Borsotto, Catherine Heurteaux, Jean Mazella, Chris Jopling, Hamid Moha Ou Maati
SCIENTIFIC REPORTS
(2018)
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Engineering, Biomedical
Srikanth Sivaraman, Nicholas Amoroso, Xinzhu Gu, J. Todd Purves, Francis M. Hughes, William R. Wagner, Jiro Nagatomi
ANNALS OF BIOMEDICAL ENGINEERING
(2019)
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Endocrinology & Metabolism
Francis M. Hughes, Nathan A. Hirshman, Brian M. Inouye, Huixia Jin, Eloise W. Stanton, Chloe E. Yun, Leah G. Davis, Jonathan C. Routh, J. Todd Purves
Review
Pharmacology & Pharmacy
Jean Mazella, Marc Borsotto, Catherine Heurteaux
FRONTIERS IN PHARMACOLOGY
(2019)
Review
Pharmacology & Pharmacy
Alaeddine Djillani, Mariel Pietri, Jean Mazella, Catherine Heurteaux, Marc Borsotto
PHARMACOLOGY & THERAPEUTICS
(2019)
Review
Pharmacology & Pharmacy
Alaeddine Djillani, Jean Mazella, Catherine Heurteaux, Marc Borsotto
FRONTIERS IN PHARMACOLOGY
(2019)
Editorial Material
Pharmacology & Pharmacy
Jean Mazella, Marc Borsotto, Catherine Heurteaux
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Neurosciences
Mariel Pietri, Alaeddine Djillani, Jean Mazella, Marc Borsotto, Catherine Heurteaux
Article
Marine & Freshwater Biology
Lisa A. May, Athena R. Burnett, Carl Miller, Emily Pisarski, Laura F. Webster, Zachary J. Moffitt, Paul Pennington, Edward Wirth, Greg Baker, Robert Ricker, Cheryl M. Woodley
AQUATIC TOXICOLOGY
(2020)
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Biotechnology & Applied Microbiology
Mary C. Bridges, Cheryl M. Woodley, Esther C. Peters, Lisa A. May, Sylvia B. Galloway
MARINE BIOTECHNOLOGY
(2020)
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Immunology
Jianxuan Wu, Byron W. Hayes, Cassandra Phoenix, Gustavo Sosa Macias, Yuxuan Miao, Hae Woong Choi, Francis M. Hughes, J. Todd Purves, R. Lee Reinhardt, Soman N. Abraham
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Physiology
Nathan A. Hirshman, Francis M. Hughes, Huixia Jin, William T. Harrison, Simon W. White, Isabelle Doan, Shelby N. Harper, Patrick D. Leidig, J. Todd Purves
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2020)
Article
Urology & Nephrology
Shelby N. Harper, Patrick D. Leidig, Francis M. Hughes, Huixia Jin, J. Todd Purves
RESEARCH AND REPORTS IN UROLOGY
(2019)
Article
Physiology
Francis M. Hughes, Stephanie J. Sexton, Patrick D. Ledig, Chloe E. Yun, Huixia Jin, J. Todd Purves
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2019)