Article
Plant Sciences
Tung-Yi Lin, Wei-Jyun Hua, Hsin Yeh, Ai-Jung Tseng
Summary: The study demonstrates that FIPs LZ-8 and GMI induce changes in the proteomic profile of tumor lesions in LLC1 cell-bearing mouse, potentially regulating heat shock proteins (HSPs)-related cell viability and inhibiting cell migration and inducing apoptosis. Inhibition of HSPs may contribute to the anti-lung cancer activity of FIPs.
Review
Biochemistry & Molecular Biology
Elena Obrador, Rosario Salvador-Palmer, Ali Jihad-Jebbar, Rafael Lopez-Blanch, Thanh H. Dellinger, Ryan W. Dellinger, Jose M. Estrela
Summary: Pterostilbene has shown effectiveness against melanoma by inhibiting adrenocorticotropic hormone production in the brain and promoting cancer cell death via lysosomal membrane permeabilization. It has been found to be safe when administered intravenously in mice, suggesting its potential as an adjuvant therapy in cancer treatment. Further research is needed to optimize its bioavailability and efficacy.
Review
Immunology
Zarema Albakova, Yana Mangasarova
Summary: Heat shock proteins act as molecular chaperones, supporting tumor development by regulating various cellular processes in cancer. Investigating their intracellular and extracellular immunologic functions provides crucial insights for the development of effective immunotherapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell & Tissue Engineering
Ju-Fang Liu, Po-Chun Chen, Thai-Yen Ling, Chun-Han Hou
Summary: This study demonstrates that heat shock induces the expression of HSPs in hPDMCs through the activation of ROS, p38 MAPK, Akt signaling, and HSF1, which plays a protective role.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Cell Biology
Ariadni Androvitsanea, Kostas Stylianou, Eleni Drosataki, Ioannis Petrakis
Summary: Research has shown that heat-shock proteins can have varying effects on the immune system, either triggering immune responses or alleviating them, which is important for studying and treating autoimmune diseases.
Article
Medicine, Research & Experimental
Yujing Du, Zhao Chen, Ping Yan, Chunli Zhang, Xiaojiang Duan, Xueqi Chen, Meng Liu, Lei Kang, Xing Yang, Yan Fan, Jianhua Zhang, Rongfu Wang
Summary: The study identified heat shock protein 70 (HSP70) as the binding target for RRL, revealing a potential interaction between RRL and the nucleotide-binding domain (NBD) of HSP70. Clathrin-dependent endocytosis and macropinocytosis were suggested as vital internalization mechanisms of RRL. In vivo, Tc-99m-MAG3-RRL demonstrated satisfactory tumor accumulation and targeting, providing a promising probe for visualizing overexpressed HSP70 tumor sections.
MOLECULAR PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Jianbo Su, Tao Liao, Zhe Ren, Ying Kuang, Wenqian Yu, Qianqian Qiao, Bingbing Jiang, Xueqin Chen, Ziqiang Xu, Cao Li
Summary: A combined anticancer nanosystem named EGCG@PDA was prepared for enhanced chemodynamic therapy (CDT)/photothermal therapy (PTT) by coating polydopamine nanoparticles (PDA NPs) with an (-)-epigallocatechin gallate (EGCG)/iron (Fe) metal-polyphenol network (MPN). The MPN shell of EGCG@PDA could be degraded by the weakly acidic intracellular environment, releasing EGCG and Fe3+. EGCG inhibited the expression of heat shock proteins (HSPs) in cancer cells for enhanced PTT, and also catalyzed the Fenton reaction for CDT by reducing Fe3+ to Fe2+ and decomposing hydrogen peroxide (H2O2) to generate hydroxyl radicals (center dot OH).
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Mathematics, Applied
Feng Dai, Linjie Ma
Summary: In a bounded and smooth domain with homogeneous Neumann conditions, we establish the existence of globally bounded classical solutions for different competition conditions in the remodeling of extracellular matrix.
ZEITSCHRIFT FUR ANGEWANDTE MATHEMATIK UND PHYSIK
(2023)
Article
Mathematics, Applied
Feng Dai, Bin Liu
Summary: This paper deals with the global existence, uniqueness, and boundedness of two species cancer invasion haptotaxis model. The novelty lies in considering unbounded function mu(EMT) (c(1), c(2), m, v) and the possibility of not taking into account the logistic source in cell equations. Through discussions on different parameters and initial conditions, new conclusions are proposed and the previous research results are improved.
SIAM JOURNAL ON MATHEMATICAL ANALYSIS
(2022)
Article
Medicine, General & Internal
Zarema Albakova, Diogo Dubart Norinho, Yana Mangasarova, Alexander Sapozhnikov
Summary: Heat shock proteins (HSPs) have been implicated in various cancers and may serve as potential biomarkers. While no specific HSP chaperone-based urine biomarker has been discovered, by utilizing machine learning to analyze HSPs in urine, cancer can be predicted with approximately 90% accuracy. Coupling machine learning with understanding of HSP operation may lead to future discoveries of novel HSP-based cancer biomarkers.
FRONTIERS IN MEDICINE
(2021)
Article
Plant Sciences
Anthony Guihur, Bruno Fauvet, Andrija Finka, Manfredo Quadroni, Pierre Goloubinoff
Summary: In the scorching summer dawn, land plants establish molecular defenses to prepare for extreme midday temperatures, inducing heat-shock proteins for acquired thermotolerance. Despite high protein crowding, heat priming did not accumulate HSP chaperones in chloroplasts, while HSP20s accumulated in the cytosol, suggesting their role in preventing heat-labile protein aggregation.
PLANT CELL AND ENVIRONMENT
(2021)
Review
Cell Biology
Francisco Tustumi, Gabriel Andrade Agareno, Ricardo Purchio Galletti, Rafael Benjamim Rosa da Silva, Julia Grams Quintas, Lucas de Abreu Sesconetto, Daniel Jose Szor, Nelson Wolosker
Summary: Heat-shock proteins play important roles in the pathogenesis, prognosis, and treatment of esophagogastric cancer.
Article
Multidisciplinary Sciences
Ahmed Barakat, Even Birkeland, Melissa D. Jorstad, Magalie El Hajj, Msafiri Marijani, Anne Doskeland, Olav Mjaavatten, Frode S. Berven, Tehmina Mustafa
Summary: This study investigated the proteomic profile of PBMCs in pulmonary tuberculosis (PTB) patients to predict treatment response. Blood samples were collected from 8 adult PTB patients in Tanzania at baseline, 2 months of treatment, and treatment completion. Proteins extracted from PBMCs were quantified and analyzed using LC-MS/MS. The results identified differentially expressed proteins involved in cellular processes, metabolic processes, binding, and catalytic activity, suggesting that proteome analysis of PBMCs can be used as a novel technique to monitor anti-tuberculosis treatment response and gain insights into PTB.
Review
Biochemistry & Molecular Biology
Laura Secli, Federica Fusella, Lidia Avalle, Mara Brancaccio
Summary: Heat shock proteins play crucial roles in cellular homeostasis and stress response, with extracellular heat shock proteins potentially contributing to cancer development and metastasis by supporting cancer hallmarks and modulating the tumor microenvironment.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Materials Science, Biomaterials
Huanhuan Zhu, Yunchun Li, Zunzhen Ming, Weiwei Liu
Summary: The development of a biomimetic multifunctional nanoreactor for the synergistic treatment of colon cancer by combining glucose oxidase-based starvation with AuNR-based photothermal therapy is a promising strategy with excellent therapeutic effects on tumors.
BIOMATERIALS SCIENCE
(2021)
Article
Computer Science, Interdisciplinary Applications
Maciej Cytowski, Zuzanna Szymanska
COMPUTING IN SCIENCE & ENGINEERING
(2015)
Editorial Material
Biology
Miroslaw Lachowicz, Zuzanna Szymanska
PHYSICS OF LIFE REVIEWS
(2015)
Article
Mathematics, Applied
Miroslaw Lachowicz, Martin Parisot, Zuzanna Szymanska
DISCRETE AND CONTINUOUS DYNAMICAL SYSTEMS-SERIES B
(2016)
Article
Computer Science, Software Engineering
Maciej Cytowski, Zuzanna Szymanska, Piotr Uminski, Grzegorz Andrejczuk, Krzysztof Raszkowski
SCIENTIFIC PROGRAMMING
(2017)
Article
Computer Science, Interdisciplinary Applications
Maciej Cytowski, Zuzanna Szymanska
COMPUTING IN SCIENCE & ENGINEERING
(2014)
Article
Biology
Zuzanna Szymanska, Martin Parisot, Miroslaw Lachowicz
JOURNAL OF THEORETICAL BIOLOGY
(2014)
Article
Mathematics, Applied
Mateusz Debowski, Miroslaw Lachowicz, Zuzanna Szymanska
APPLIED MATHEMATICS AND COMPUTATION
(2019)
Article
Biology
Grzegorz Dudziuk, Weronika Wronowska, Anna Gambin, Zuzanna Szymanska, Mikolaj Rybinski
JOURNAL OF THEORETICAL BIOLOGY
(2019)
Article
Cell Biology
Mateusz Debowski, Zuzanna Szymanska, Jacek Z. Kubiak, Miroslaw Lachowicz
Article
Mathematics, Applied
Piotr Gwiazda, Blazej Miasojedow, Jakub Skrzeczkowski, Zuzanna Szymanska
Summary: This paper investigates the EBT algorithm (a particle method) for the nonlocal equation with a discontinuous interaction kernel. The main challenge lies in the low regularity of the kernel, which prevents the use of standard arguments. Instead, the radial symmetry of the problem is utilized and transformed using spherical coordinates. The resulting equation has a Lipschitz kernel with a singularity at zero. A new weighted flat norm is introduced, and the convergence of the particle method is proved in this norm. The two-dimensional case is also discussed, which requires the application of the theory of measure spaces on general metric spaces, and numerical simulations are provided to support the theoretical results.
IMA JOURNAL OF NUMERICAL ANALYSIS
(2023)
Article
Multidisciplinary Sciences
Zuzanna Szymanska, Jakub Skrzeczkowski, Blazej Miasojedow, Piotr Gwiazda
Summary: This paper aims to improve cancer models by proposing a new non-local model of cell proliferation, performing Bayesian inference for unknown parameters, and providing proof of stability of posterior distributions. Further research on well-posedness and convergence of the EBT algorithm is provided in a companion paper.
ROYAL SOCIETY OPEN SCIENCE
(2021)
Article
Mathematics, Applied
Jose Antonio Carrillo, Martin Parisot, Zuzanna Szymanska
Summary: This study introduces a new model for tendon healing, describing the rearrangement of collagen fibers during the healing process. The simplified model allows for parameter estimation and showcases the qualitative properties as well as the time for tendon fibers to align. The research suggests the potential importance of tendon cell size in patient recovery based on numerical experiments.
KINETIC AND RELATED MODELS
(2021)
Article
Mathematics, Applied
Grzegorz Dudziuk, Miroslaw Lachowicz, Henryk Leszczynski, Zuzanna Szymanska
DISCRETE AND CONTINUOUS DYNAMICAL SYSTEMS-SERIES B
(2019)
Proceedings Paper
Computer Science, Theory & Methods
Maciej Cytowski, Zuzanna Szymanska
WORKSHOP ON MULTISCALE AND HYBRID MODELLING IN CELL AND CELL POPULATION BIOLOGY
(2015)
Article
Biology
Zuzanna Szymanska, Maciej Cytowski, Elaine Mitchell, Cicely K. Macnamara, Mark A. J. Chaplain
BULLETIN OF MATHEMATICAL BIOLOGY
(2018)