Article
Medical Laboratory Technology
Hao Yang, Fang Guo, Qin Guo, Yifei Wang, Ping He, Hongbo Zhang, Shuaiyu Wang
Summary: The sFlt1/PlGF ratio is a useful parameter for the diagnosis of preeclampsia, showing good performance in distinguishing preeclampsia from other hypertensive disorders of pregnancy and predicting adverse outcomes. PlGF and sFlt1/PlGF ratio are worth implementing in the clinical management of women with preeclampsia.
CLINICA CHIMICA ACTA
(2022)
Article
Biochemistry & Molecular Biology
Lucia Perez-Roque, Elena Nunez-Gomez, Alicia Rodriguez-Barbero, Carmelo Bernabeu, Jose M. Lopez-Novoa, Miguel Pericacho
Summary: Preeclampsia is a pregnancy-specific disease characterized by hypertension, with its etiopathogenesis related to abnormal placentation and the release of soluble factors. High plasma levels of soluble endoglin (sEng) may serve as an early diagnostic and prognostic biomarker for the disease, impacting the pathophysiology of preeclampsia significantly.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jin Zhang, Wei Hua, Xinyuan Zhao, Fan Yang, Ting Guo, Jianhua Zhang, Xuerong Zheng, Wanqi Liang
Summary: This study confirmed the protective effects of paeoniflorin against preeclampsia-related endothelial damage by upregulating VEGFA to alleviate the injury caused by overexpression of sFlt-1 and sEng.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2021)
Article
Peripheral Vascular Disease
Francesca Gaccioli, Ulla Sovio, Sungsam Gong, Emma Cook, D. Stephen Charnock-Jones, Gordon C. S. Smith
Summary: This study aimed to investigate the relationship between protein levels of sFLT1 and PlGF in maternal serum and placental tissue lysates. The findings showed that the sFLT1:PlGF ratio is increased in both preeclampsia and FGR, but in preeclampsia, it is primarily driven by increased placental sFLT1 levels, while in FGR, it is primarily driven by decreased placental PlGF levels.
Article
Multidisciplinary Sciences
Anna Maria Nuzzo, Domenica Giuffrida, Laura Moretti, Paola Re, Giorgio Grassi, Guido Menato, Alessandro Rolfo
Summary: This study compared the expression of anti-angiogenic sFlt1 and pro-angiogenic PlGF in placenta and maternal blood in GDM, GDM-PE, CTRL, and PE cases. The results showed higher sFlt1/PlGF values in GDM-PE maternal blood, decreased PlGF gene expression in GDM, PE, and GDM-PE placentae, and increased PlGF protein levels in GDM and GDM-PE placentae. Additionally, sFlt1 gene expression was higher in PE placentae, while sFlt1 protein expression was lower in GDM-PE placentae. These findings suggest a potential link between sFlt1 overproduction and PE onset in GDM pregnancies.
SCIENTIFIC REPORTS
(2021)
Article
Peripheral Vascular Disease
Brooke Armistead, Leena Kadam, Emily Siegwald, Fergus P. McCarthy, John C. Kingdom, Hamid-Reza Kohan-Ghadr, Sascha Drewlo
Summary: Preeclampsia is a severe hypertensive disorder of pregnancy caused by placental villi pathology leading to widespread maternal endothelial dysfunction. Modulating trophoblast differentiation pathway through PPAR gamma-GCM1 axis may reduce excessive sFLT1 production and improve clinical outcomes. Pharmacological manipulation of PPAR gamma activity shows potential to rescue the antiangiogenic state of preeclampsia.
Article
Cell Biology
Georgia Margioula-Siarkou, Chrysoula Margioula-Siarkou, Stamatios Petousis, Kosmas Margaritis, Eleftherios Vavoulidis, Giuseppe Gullo, Maria Alexandratou, Konstantinos Dinas, Alexandros Sotiriadis, Georgios Mavromatidis
Summary: Preeclampsia, a leading cause of maternal and fetal morbidity and mortality, involves dysfunction of the placenta leading to imbalance of angiogenic and anti-angiogenic factors. Endoglin and soluble endoglin play significant roles in the pathophysiology of preeclampsia by interfering with signaling pathways that regulate angiogenesis and endothelial function. Further research is needed to explore the potential prognostic, diagnostic, and therapeutic implications of these molecules in clinical management of preeclampsia.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Physiology
Shunping Gui, Shengping Zhou, Min Liu, Yanping Zhang, Linbo Gao, Tao Wang, Rong Zhou
Summary: In patients with severe preeclampsia (sPE), the upregulation of soluble Axl (sAxl) in maternal plasma is positively correlated with elevated levels of sFlt-1 and negatively correlated with placental NO synthase (eNOS). Elevated sAxl levels suppress proliferation and tube formation of endothelial cells, and promote cytotoxicity. The study also demonstrates that sAxl plays a role in systemic vascular injury through the regulation of key molecules of angiogenesis, contributing to the development of sPE.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Nataliia Sergeevna Karpova, Olga Pavlovna Dmitrenko, Tatyana Sergeevna Budykina
Summary: One of the main causes of maternal and neonatal morbidity and mortality is pre-eclampsia, characterized by a high sFlt1/PlGF ratio. Pregestational diseases in mothers may increase the risk, but few studies have looked at the connection between maternal comorbidities and the sFlt1/PlGF ratio. This review summarizes the latest information on the association between maternal pregestational diseases and the ratio of sFlt1/PlGF, as well as the link between changes in pregnancy hormones/metabolites and a high sFlt1/PlGF ratio. Debate remains on the association between the ratio and maternal disorders, calling for further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Haiyan Chu, Anastasia Sacharidou, An Nguyen, Chun Li, Ken L. Chambliss, Jane E. Salmon, Yu-Min Shen, Julie Lo, Gustavo W. Leone, Joachim Herz, David Y. Hui, Denise K. Marciano, Vikki M. Abrahams, Bryony Natale, Alina P. Montalbano, Xue Xiao, Lin Xu, David R. Natale, Philip W. Shaul, Chieko Mineo
Summary: In this study, it was found that antiphospholipid antibodies (aPL) can induce preeclampsia by influencing placental trophoblast function and endangering the fetus. The results suggest that aPL affect preeclampsia by altering gene expression related to preeclampsia through the regulation of PP2A protein phosphatase activity. Overall, the findings indicate that the impact of aPL on trophoblast cells is crucial for the development of preeclampsia, involving modulation of various signaling pathways.
CIRCULATION RESEARCH
(2021)
Article
Medical Laboratory Technology
Pacifique Levy, Safouane Hamdi, Jean Guiboudenche, Marie Clothilde Haguet, Sophie Bailleul, Guillaume Lefevre
Summary: The study evaluated the uncertainties in the sFlt-1/PlGF ratio using the theory of error propagation. Results showed that uncertainties increased linearly with ratio values and were lower for Elecsys assays compared to Kryptor assays. While uncertainties cannot eliminate differences in ratio values from different immunoassays, they can impact the interpretation of sFlt-1/PlGF ratio results, especially near predefined PE diagnosis or prognosis cut-offs.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Article
Peripheral Vascular Disease
Ana G. Nolasco-Leanos, Karla L. Ramirez-Valenzuela, Reyes Carrillo-Juarez, Carlos J. Molina-Perez, Irma Isordia-Salas, Alfredo Leanos-Miranda
Summary: In women with gestational hypertension, imbalance of angiogenic factors is associated with adverse maternal and perinatal outcomes as well as progression to preeclampsia. Circulating concentrations of sEng and the soluble fms-like tyrosine kinase-1/placental growth factor ratio can be used as suitable markers to assess the risk of adverse outcomes.
JOURNAL OF HYPERTENSION
(2021)
Article
Medicine, General & Internal
Antonella Iannaccone, Beatrix Reisch, Rainer Kimmig, Boerge Schmidt, Laven Mavarani, Marvin Darkwah Oppong, Bartosz Tyczynski, Mark Dzietko, Michael Jahn, Alexandra Gellhaus, Angela Koeninger
Summary: This study evaluated the feasibility of therapeutic plasma exchange (TPE) compared to standard-of-care treatment in delaying preterm delivery in early-onset preeclampsia (eoPE). The results showed that TPE could prolong the duration of pregnancy and reduce the levels of sFlt-1 and sEng in maternal serum without impairing neonatal outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Kazuya Mimura, Takuji Tomimatsu, Masayuki Endo, Tadashi Kimura
Summary: Four pregnant women without underlying diseases developed atypical preeclampsia before 20 weeks with elevated sFlt-1/PlGF ratios. Pregnancy termination led to normalization of clinical findings within 3 months.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Article
Medicine, General & Internal
Thanaphan Thitivichienlert, Chadakarn Phaloprakarn, Thananda Trakarnvanich
Summary: Preeclampsia can lead to renal function impairment, but the currently available biomarkers do not provide predictive value for long-term renal function, blood pressure, and urine albumin/creatinine ratio in patients with preeclampsia.
ANNALS OF MEDICINE AND SURGERY
(2022)