Article
Pediatrics
Viktoria Engert, Celine Siauw, Annika Stock, Monika Rehn, Achim Woeckel, Christoph Haertel, Johannes Wirbelauer
Summary: The current evidence suggests that neonatal SARS-coronavirus-2 infections tend to be mild, but data on the impact of maternal infection during pregnancy on fetal development are limited. We present a unique case of a moderately preterm infant with intracranial bleeding and periventricular leukomalacia potentially as a consequence of post-COVID-19 hyperinflammation during pregnancy.
Article
Pediatrics
Gustavo Rocha, Filipa Flor de Lima, Ana P. Machado, Hercilia Guimaraes
Summary: There is a significant association between a maternal age of 35 years or older and cystic periventricular leukomalacia in very preterm infants.
MINERVA PEDIATRICS
(2023)
Review
Acoustics
Glenda McLean, Atul Malhotra, Paul Lombardo, Michal Schneider
Summary: This review examines screening protocols and recommendations for the timing of cranial ultrasound examinations in preterm neonates born before 32 weeks of gestation. The recommended timing for the examinations varied, with at least one examination in the first week of life universally recommended. Further studies are needed to establish an optimal protocol for improving detection and monitoring of brain injuries in very preterm neonates.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Neurosciences
Sarah B. Scheinman, Dhavamani Sugasini, Monay Zayed, Poorna C. R. Yalagala, Felecia M. Marottoli, Papasani V. Subbaiah, Leon M. Tai
Summary: Research suggests that LPC-DHA/EPA-enriched krill oil can increase brain DHA and improve memory-related behavior in mice with the APOE4 gene. Therefore, long-term use of LT-krill oil supplements may provide some level of protection against age-related neurodegeneration.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Christopher A. Lear, Benjamin A. Lear, Joanne O. Davidson, Jialin Sae-Jiw, Johanna M. Lloyd, Simerdeep K. Dhillon, Alistair J. Gunn, Laura Bennet
Summary: Lear et al. demonstrate that delaying the blockade of the tumour necrosis factor (TNF) pathway can help attenuate cystic white matter injury and improve brain maturation in preterm foetal sheep. TNF blockade could be used as an effective strategy to reduce disability after preterm birth, with a wide therapeutic window.
Article
Medicine, General & Internal
Ja-Hye Ahn, Hyun Ju Lee, Kyeongmi Lee, Jean Lim, Jae Kyoon Hwang, Chang-Ryul Kim, Hyun A. Kim, Han-Suk Kim, Hyun-Kyung Park
Summary: The study revealed that repetitive LPS stimulation significantly inhibited brain cell development by impairing oligodendrocyte differentiation, while brain cell development was not affected in the late LPS group. Inflammation during the early developmental stage of oligodendrocytes increases the susceptibility of the preterm brain to inflammation-induced injury.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Jinping Sun, Wei Wang, Quanrui Ma, Xiaoli Pan, Hualiang Zhai, Junyan Wang, Yong Han, Yunhong Li, Yin Wang
Summary: PVL is a common brain injury in preterm survivors, and RIPK1 plays an important role in its pathogenesis. Inhibition of RIPK1 can effectively alleviate brain injury and long-term neurobehavioral abnormalities in PVL by reducing neural cell necroptosis and reversing neuroinflammation.
NEUROCHEMICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Andrea Tapia-Bustos, Carolyne Lespay-Rebolledo, Valentina Vio, Ronald Perez-Lobos, Emmanuel Casanova-Ortiz, Fernando Ezquer, Mario Herrera-Marschitz, Paola Morales
Summary: Perinatal asphyxia affects oligodendrocytes, neuroinflammation, and cell viability in the telencephalon of rats, with the most significant impact observed at postnatal day 7. Treatment with mesenchymal stem cells (MSCs) can prevent the detrimental effects of perinatal asphyxia on myelination and oligodendrocyte survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pediatrics
Mohsin Raj Mantoo, Ashok K. Deorari, Manisha Jana, Ramesh Agarwal, M. Jeeva Sankar, Anu Thukral
Summary: The study aimed to determine the incidence and risk factors of preterm white matter injury in preterm neonates. The results showed that preterm WMI occurred in 37.1% of neonates, with PIVH occurring in 17.8% and PVL in 24.3%. Risk factors were not associated with PIVH, but hemodynamically significant patent ductus arteriosus and apnea of prematurity were significantly associated with increased risk of PVL.
Article
Biochemistry & Molecular Biology
Mohammed Alshareef, Devin Hatchell, Tyler Vasas, Khalil Mallah, Aakash Shingala, Jonathan Cutrone, Ali Alawieh, Chunfang Guo, Stephen Tomlinson, Ramin Eskandari
Summary: Germinal matrix hemorrhage (GMH) is a common pathology in infants, with long-term consequences. This study found that the complement pathway plays a critical role in the acute and chronic outcomes of GMH. Inhibiting the complement pathway can reduce hemorrhage, improve survival, and alleviate structural changes associated with brain injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Maria Rachele Ceccarini, Veronica Ceccarelli, Michela Codini, Katia Fettucciari, Mario Calvitti, Samuela Cataldi, Elisabetta Albi, Alba Vecchini, Tommaso Beccari
Summary: In this study, the potential role of EPA and DHA on BDNF and GDNF expression was investigated, and it was found that EPA can reduce neurotoxicity and increase BDNF and GDNF expression through epigenetic mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Cheong-Jun Moon, Tae Hee Kwon, Kyung Sang Lee, Hyun-Seung Lee
Summary: This case highlights the association of WMI with GBS bacteremia without central nervous system invasion and suggests that intrauterine GBS infection in premature infants without interventions may lead to extensive and persistent GBS colonization, early-onset and recurrent GBS disease, and WMI. Controlling postnatal as well as intrauterine infection/inflammation with maternal prophylaxis may be crucial for preventing and limiting neurological injury.
Article
Biotechnology & Applied Microbiology
Liufang He, Hui Yang, Jinxing Feng, Tingyan Wei, Yong Huang, Xueli Zhang, Zhangxing Wang
Summary: In a neonatal rat model of periventricular leukomalacia, upregulation of GPR17 was associated with decreased myelin sheath formation, while downregulation of GPR17 led to increased myelin sheath formation by inducing Olig1 expression. This study suggests that targeting GPR17 may be a potential therapeutic strategy for white matter injury.
Article
Nutrition & Dietetics
Danielle N. Christifano, Kathleen M. Gustafson, Susan E. Carlson, Nasrin Sultanna, Alexandra Brown, Scott A. Sands, John Colombo, Byron J. Gajewski
Summary: Achieving maternal-newborn docosahexaenoic acid (DHA) equilibrium (EQ) is important for optimizing newborn DHA status. This study aimed to determine the daily DHA intake during pregnancy most likely to result in EQ. The results suggest that an intake of 650mg DHA/day is necessary to increase the potential for EQ at delivery.
Article
Pediatrics
Po-Ming Wu, Chen-Yu Wu, Chung- Li, Chao-Ching Huang, Yi-Fang Tu
Summary: Cystic periventricular leukomalacia (PVL) is a common white matter injury in preterm infants. This study aimed to validate the contribution of cystic PVL to postnatal epilepsy and demonstrate its seizure characteristics in very preterm infants.
Article
Obstetrics & Gynecology
Funda Tuzun, Yagmur Akcura, Nuray Duman, Hasan Ozkan
Summary: This study compared the use of isotonic and hypotonic fluids for hospitalized term newborns and found that hypotonic fluids may lead to unsafe decreases in plasma sodium levels. However, larger studies are still needed to determine the safety of using hypotonic fluids in term newborns.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Hematology
Leylagul Kaynar, Emre Tekgunduz, Ilknur Kozanoglu, Hasan Atilla Ozkan, Salih Aksu, Fahir Ozkalemkas, Fatih Demirkan
Summary: Graft versus host disease (GVHD) is a significant cause of mortality and morbidity after allogeneic stem cell transplantation. Steroids are the first-line treatment, but there is no standard approach for second-line therapy. ECP, with its immunomodulatory effect, is favored for treating GVHD as it has a low risk of relapse or infection. However, it requires specific conditions and equipment.
TRANSFUSION AND APHERESIS SCIENCE
(2022)
Editorial Material
Hematology
Emre Tekgunduz, Hasan Atilla Ozkan
TRANSFUSION AND APHERESIS SCIENCE
(2022)
Article
Hematology
Sidika Gulkan Ozkan, Cengiz Pata, Alphan Sekuri, Yasemin Cinar, Hasan Atilla Ozkan
Summary: Hepatic veno-occlusive disease, a rare and life-threatening complication of transplantation, can be diagnosed and monitored early using liver stiffness measurement. This non-invasive imaging method shows promise in improving patient outcomes and survival rates.
TRANSFUSION AND APHERESIS SCIENCE
(2022)
Article
Hematology
Hasan Atilla Ozkan, Sidika Gulkan Ozkan
Summary: Hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a rare and potentially life-threatening complication of hematopoietic stem cell transplantation (HSCT). Diagnosis is based on clinical criteria, and imaging techniques are not yet routinely used. The only approved drug for treatment is defibrotide.
TRANSFUSION AND APHERESIS SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Orhan Sahin, Gozde Akturk, Serap Cilaker Micili, Ozlem Gursoy Doruk, Fazilet Karapinar, Nil Hocaoglu, Bekir Ugur Ergur, Pinar Akan, Yesim Tuncok, Sule Kalkan
Summary: This study evaluated the protective effect of nicorandil on QT prolongation and myocardial damage induced by amitriptyline. The results showed that nicorandil could prevent the electrophysiological changes and myocardial damage caused by amitriptyline.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Article
Genetics & Heredity
Meral Kayikcioglu, Hasan Selcuk Ozkan, Burcu Yagmur, Selen Bayraktaroglu, Asli Tetik Vardarli
Summary: This article reports two cases of homozygous familial hypercholesterolemia with different treatment responses to lomitapide. The study aims to clarify the possibility of preventing the progression of atherosclerotic burden in patients with homozygous familial hypercholesterolemia through effective and safe reduction of LDL-C with low-dose lomitapide, and emphasizes the role of treatment adherence in therapy success.
FRONTIERS IN GENETICS
(2023)
Article
Medicine, General & Internal
Coskun Armagan, Tugba Ucuncu Egeli, Can Akyildiz, Kadri Murat Erdogan, Funda Erdogan, Nuray Duman, Hasan Ozkan
Summary: This article presents a rare condition called Bosma-Arhinia-Microphthalmia (BAM) syndrome, which is characterized by eye defects, complete absence of nose, and hypogonadotropic hypogonadism. The symptoms and severity of the disorder can vary in different patients, and the majority of reported cases have unknown etiology. The article shares a case report of a female baby born through vaginal delivery with features including midface hypoplasia, nasal aplasia, hypertelorism, and other anomalies associated with BAM syndrome, along with challenges faced during the follow-up period.
JOURNAL OF DR BEHCET UZ CHILDRENS HOSPITAL
(2023)
Article
Gastroenterology & Hepatology
Muhammed Fatih Karakaya, Erdem Er, Onur Kirimker, Mesut Gumussoy, Emin Bodakci, Mubin Ozercan, Beyza Doganay Erdogan, Hale Gokcan, Meltem Kologlu, Kaan Karayalcin, Cihan Yurdaydin, Acar Tuzuner, Selcuk Haznedaroglu, Kubilay Cinar, Hasan Ozkan, Ramazan Idilman
Summary: This study aimed to investigate biliary complications in liver transplant recipients with choledochocholedocho stomy anastomosis, identify the risk factors for the development of such complications, and evaluate the success of endoscopic approaches. The study found that biliary strictures and leakages were the most common biliary complications after liver transplantation, and endoscopic treatment was successful in most recipients.
TURKISH JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Business
Hasan Ozkan, Murat Adil Salapcioglu
Summary: This study examines the relationships between organizational agility (OA), sustainable quality perception (SQP), and innovation orientation (IO), and tests the mediating role of innovation orientation between the other two variables. The findings show a significant positive correlation between OA and SQP, OA and IO, and IO and SQP. Additionally, the study reveals that innovation orientation plays a partial and strong mediating role between OA and SQP.
INTERNATIONAL JOURNAL OF BUSINESS
(2022)
Article
Computer Science, Information Systems
Onur Ayan, Polina Kutsevol, Hasan Yagiz Ozkan, Wolfgang Kellerer
Summary: Networked control systems utilize communication networks to form closed feedback control loops. Information sharing and preventing information staleness are crucial for achieving desired control tasks. In this study, we conducted experimental research on multiple heterogeneous NCSs, focusing on MAC protocols. We proposed a novel contention-free algorithm and introduced a new metric called normalized mean squared error. Our results demonstrate the benefits of value-aware prioritization and the adverse effects of information staleness on control performance.
Review
Pediatrics
Hasan Ozkan, Nuray Duman, Funda Tuzun
Summary: The optimal ventilation strategy has not been clarified yet for infants with severe bronchopulmonary dysplasia. Ventilating these infants as if they were in the acute phase of respiratory distress syndrome and attempting early extubation can lead to errors. Considering the heterogeneous nature of the disease, a combined mode of volume-guaranteed synchronized intermittent mechanical ventilation and pressure support ventilation may be the most physiologically appropriate ventilation mode.
TURKISH ARCHIVES OF PEDIATRICS
(2022)
Article
Pediatrics
Yinying Zhang
Summary: This article presents a case of congenital bone marrow failure that was successfully treated with haploidentical bone marrow transplantation (BMT) and identifies a novel, de novo pathogenic variant in the MECOM gene.
TURKISH JOURNAL OF PEDIATRICS
(2022)
Article
Pediatrics
Bermal Hasbay, Tuba Canpolat, Elif Aktekin, Hasan Ozkan, Senay Demir Kekec
Summary: This study evaluated 38 cases of sacrococcygeal germ cell tumors diagnosed in the hospital between 2006 and June 2021. Type 4 cases were observed more frequently in the series. Routine ultrasonography is recommended for patients presenting with constipation and inability to urinate, with further alpha-fetoprotein testing if a mass is detected. The disease can be successfully treated with a multidisciplinary approach.
TURKISH ARCHIVES OF PEDIATRICS
(2022)
Review
Medicine, General & Internal
Meral Kayikcioglu, Hasan Selcuk Ozkan, Burcu Yagmur
Summary: Myocardial infarction in young individuals often presents with atypical signs and symptoms and has different risk factors compared to older individuals. In addition to traditional risk factors, non-traditional factors also contribute to the risk profile of young individuals. However, the scarcity of studies and lack of guidelines make it challenging for these individuals to receive accurate medical care.
BALKAN MEDICAL JOURNAL
(2022)
