Article
Polymer Science
Benedict Jose Chellathurai, Ramyadevi Anburose, Mohammad H. H. Alyami, Mohan Sellappan, Mohammad F. F. Bayan, Balakumar Chandrasekaran, Kumarappan Chidambaram, Mohamed Rahamathulla
Summary: The present study aimed to develop and evaluate a polyherbal gel for treating acne by formulating a mixture of Aloe barbadensis pulp and Vigna radiata extract using Carbopol 940, triethanolamine, and propylene glycol as gelling, viscosity modifying, and pH modifying agents respectively. The developed gel exhibited significant antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Candida albicans, with promising inhibition zones. The gel formulation also showed beneficial effects on acne, with the additional benefit of Aloe barbadensis on the skin.
Article
Pharmacology & Pharmacy
Yuan-Shuo Hsueh, Yan-Jye Shyong, Hsiu-Ching Yu, Shu-Jhen Jheng, Shang-Wen Lin, Hua-Lin Wu, Jui-Chen Tsai
Summary: The study developed NLC formulations containing rhTM, which effectively promoted chronic wound healing with high encapsulation efficiency and sustained release. In diabetic mouse models, it showed significant improvement in wound healing and cell migration, with lower plasma concentrations compared to rhTM solution.
Article
Biotechnology & Applied Microbiology
Eleesha Sana, Mahira Zeeshan, Qurat Ul Ain, Ashraf Ullah Khan, Irshad Hussain, Salman Khan, Elise Lepeltier, Hussain Ali
Summary: The study successfully delivered curcumin loaded transfersomes to arthritic tissues, with in vitro and in vivo evaluations demonstrating promising therapeutic efficacy by significantly alleviating symptoms of rheumatoid arthritis.
Article
Polymer Science
Ayesha Mahmood, Asif Mahmood, Mohamed A. Ibrahim, Zahid Hussain, Muhammad Umar Ashraf, Mounir M. Salem-Bekhit, Ibrahim Elbagory
Summary: This research aimed to develop a pH-responsive polymeric system for targeted drug delivery of Diloxanide furoate. Sodium alginate (Na-Alg) and Carbopol 934P were used as building blocks and SCH1-SCH12 were created with different polymer ratios. Positive outcomes were observed in swelling and release profiles at higher pH levels. Hydrogel formation, component compatibility, thermal stability, and Diloxanide furoate loading were all validated. The results showed the potential of this polymeric system for pH-dependent localized and regulated drug delivery.
Article
Polymer Science
K. Reeta Vijaya Rani, Sruthi Rajan, Mullaicharam Bhupathyraaj, R. Krishna Priya, Nirmala Halligudi, Mohammad Abobakr Al-Ghazali, Sathvik B. Sridhar, Javedh Shareef, Sabin Thomas, Saleem M. Desai, Pandurang D. Pol
Summary: A novel ophthalmic pH-induced nanoemulsion in situ gel of Timolol maleate (NEI5) was developed in this study, which demonstrated continuous drug release and decreased intraocular pressure (IOP) in glaucoma patients.
Article
Polymer Science
Anam Asghar, Muhammad Naeem Aamir, Fatima Akbar Sheikh, Naveed Ahmad, Nasser F. Alotaibi, Syed Nasir Abbas Bukhari
Summary: This study investigates the comparative effects of nanogel using Withania coagulans extract, pregabalin alone, and a co-combination gel on burn wound healing. The results indicate that the co-combination gel is more effective in promoting wound healing and reducing inflammation.
Article
Medicine, Research & Experimental
Bianca da Costa Bernardo Port, Gabriela Schneider-Rauber, Debora Fretes Argenta, Mihails Arhangelskis, Carlos Eduardo Maduro de Campos, Adailton Joao Bortoluzzi, Thiago Caon
Summary: This study investigates the effect of formulation composition on the crystal form of drugs in topical products. Different solvent variations result in different particulate matter. Microscopic analysis shows heterogeneous particles in the gels. Interestingly, different formulations seem to accumulate in different regions of the skin.
MOLECULAR PHARMACEUTICS
(2022)
Article
Polymer Science
Asif Nawaz, Muhammad Shahid Latif, Maha Abdallah Alnuwaiser, Shafi Ullah, Muhammad Iqbal, Mulham Alfatama, Vuanghao Lim
Summary: The results suggest that chitosan-coated nanoemulsion gel is safe and can potentially be used to promote 5-FU skin retention, which is ideal for skin diseases such as melanoma. Incorporating nanoemulsion into gel has resulted in higher T-max, longer half-life, and greater skin drug retention.
Article
Pharmacology & Pharmacy
Cristina Scomoroscenco, Mircea Teodorescu, Cristina Lavinia Nistor, Ioana Catalina Gifu, Cristian Petcu, Daniel Dumitru Banciu, Adela Banciu, Ludmila Otilia Cinteza
Summary: This study aimed to develop new microemulsion systems for topical use and identify a suitable water-soluble polymer for gel microemulsions. The efficacy of the developed microemulsion and gel microemulsion systems in delivering curcumin into the skin was also studied. A pseudo-ternary phase diagram was developed using specific ingredients, and physicochemical characterization and in vitro permeation studies were conducted.
Article
Pharmacology & Pharmacy
Vanessa Marcia Vaz, Srinivas Reddy Jitta, Ruchi Verma, Lalit Kumar
Summary: The present study aimed to formulate and evaluate hesperetin-loaded proposomal gel for topical antioxidant activity. The proposomal gel showed enhanced in vitro drug release compared to hesperetin dispersion and demonstrated good properties with sustained drug release. Both hesperetin and hesperetin-loaded proposomes exhibited comparable in vitro antioxidant activities.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Navni Sharma, Sandeep Kumar, Garima Joshi, Deepak Choudhary
Summary: This study aimed to prepare and characterize Nano-Structured Lipid Carriers (NLCs) of Febuxostat (FB) incorporated in a gel for the treatment of Gout. The hot high-pressure homogenization technique was used to improve the physicochemical property of FB. Results showed that NLCs (1:3) had high entrapment and drug content, with 87% of the drug released in a controlled manner within 6 hours. This indicates that the NLCs gel formulation can modify drug release, increase bioavailability, and reduce side effects.
RECENT PATENTS ON NANOTECHNOLOGY
(2022)
Article
Polymer Science
Ghayal Sachin Ramesh, Nazir Hussain, Subhadeep Roy, Santanu Kaity
Summary: Topical delivery of medicaments in a controlled manner is still a promising area of research. Researchers developed a drug-loaded microsponge-loaded gel formulation for controlled topical delivery of mupirocin. The formulation was optimized in terms of drug content, particle size, pH, viscosity, and skin penetration, and showed promising results in prolonging the drug's delivery.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Parinbhai Shah, Benjamin Goodyear, Nirali Dholaria, Vinam Puri, Bozena Michniak-Kohn
Summary: Psoriasis is a chronic autoimmune skin disease that poses challenges in drug delivery due to low bioavailability. This study explores the use of niosomes to improve drug bioavailability of corticosteroids for topical treatment of skin conditions, showing promise for potential use in treating diseases like psoriasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Cristina Scomoroscenco, Mircea Teodorescu, Adina Raducan, Miruna Stan, Sorina Nicoleta Voicu, Bodgan Trica, Claudia Mihaela Ninciuleanu, Cristina Lavinia Nistor, Catalin Ionut Mihaescu, Cristian Petcu, Ludmila Otilia Cinteza
Summary: This study aimed to develop and characterize new gel microemulsions for topical cosmetic applications, using grape seed oil and three different water-soluble polymers. Physico-chemical characterization and cytotoxicity evaluation showed that the gel microemulsions could effectively incorporate and control the release of hydrophobic active ingredients.
Article
Polymer Science
Md. Shabbir Alam, Niha Sultana, Md. Abdur Rashid, Yahya Alhamhoom, Asad Ali, Ayesha Waheed, Mo. Suheb Ansari, Mohd. Aqil, Mohd Mujeeb
Summary: Sunburn is a skin condition caused by prolonged exposure to UV rays from the sun. Rutin, with its antioxidant and anti-inflammatory effects, shows potential for soothing sunburned skin. This study aimed to develop carbopol gel-encased glycerosomes for sunburn treatment and optimize the formulation using DoE. The optimized formulation showed sustained release, good permeation into the skin, and high antioxidant activity.
Article
Chemistry, Medicinal
Ajay Mahor, Devesh M. Sawant, Amit K. Goyal
Summary: This study employed Enumeration to modify Amphotericin B at specific sites, resulting in the identification of 14 hits with improved predicted aqueous solubility and cell permeability. These findings suggest that bioavailability can be enhanced, potentially leading to the development of an oral formulation of Amphotericin B.
CURRENT COMPUTER-AIDED DRUG DESIGN
(2023)
Editorial Material
Chemistry, Medicinal
Riccardo Concu, Umesh Gupta, Amit K. Goyal
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2023)
Editorial Material
Chemistry, Medicinal
Srushti Tambe, Rohit Kumar, Purnima Amin, Monalisa Mishra, Madhu Gupta, Kavitha Govarthanan, Ashwin Kumar Narasimhan, Piyush Kumar Gupta
Summary: Organoids offer an opportunity to study the effects of diseases on cellular physiology, human tissues, and organs. They are crucial tools for analyzing biomaterial toxicity, discovering new drugs, and advancing regenerative medicine.
FUTURE MEDICINAL CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Ankaj Kumar, Rishi Paliwal, Arvind Gulbake
Summary: Recently, lentinan (LNT) has been utilized for its diversified potential in research, with an extended role as a novel biomaterial. It is a biocompatible, multifunctional polysaccharide used as a pharmaceutical additive for engineering drug or gene carriers. LNT's triple helical structure offers more binding sites for specific targeting of diseases expressing dectin-1 receptors through LNT-engineered carriers. Gene delivery using poly(dA)-s-LNT complexes has shown greater targetability and specificity.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Pharmacology & Pharmacy
Hemant Joshi, Dhruv Sanjay Gupta, Nosheen Kamruddin Abjani, Ginpreet Kaur, Chakrabhavi Dhananjaya Mohan, Jagjit Kaur, Diwakar Aggarwal, Isha Rani, Seema Ramniwas, Hadi Sajid Abdulabbas, Madhu Gupta, Hardeep Singh Tuli
Summary: Genistein, a commonly occurring isoflavone, has gained popularity for its diverse pharmacological benefits, including improved bone health, reduced postmenopausal complications, and anti-cancer potential. This review provides insights into its usage, chemistry, pharmacokinetics, apoptotic mechanisms in cancer management, opportunities for synergism, and recent clinical trials. Additionally, advancements in nanotechnology for improved safety and efficacy and results from safety and toxicology studies are discussed.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Sumel Ashique, Ashish Garg, Neeraj Mishra, Neha Raina, Long Chiau Ming, Hardeep Singh Tulli, Tapan Behl, Radha Rani, Madhu Gupta
Summary: Lung cancer, the most common type of cancer, has a high incidence and mortality rate, prompting extensive research into nanomaterial-based drug delivery systems. This review focuses on the use of lipid, polymer, and carbon-based nanomaterials for traditional therapies and the potential of stimuli-responsive nanomaterials in lung cancer treatment. Limitations and opportunities for improving nano-based material design for non-small cell lung cancer are also discussed.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Radha Rani, Neha Raina, Ajay Sharma, Pramod Kumar, Hardeep Singh Tulli, Madhu Gupta
Summary: Rheumatoid arthritis is a hyperactive immune disorder that causes severe inflammation in synovial joints, leading to joint immobility. Traditional treatment approaches have limitations, and there is a need for innovative drug delivery carriers for efficient and safe therapeutic delivery. Nanotechnology shows great promise in developing novel carriers for rheumatoid arthritis treatment. This paper covers the pathophysiological aspects of rheumatoid arthritis and discusses future research directions for reducing synovial inflammation.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Review
Surgery
Jatin Chhabra, Hitesh Chopra, Rakesh Pahwa, Neha Raina, Karan Wadhwa, Swati Saini, Poonam Negi, Madhu Gupta, Inderbir Singh, Harish Dureja, Talha Bin Emran
Summary: Wounds are a significant health concern and a major cost to healthcare systems. Nanotechnological advances, especially nanoemulsions, have attracted attention for wound therapy due to their stability and bioavailability. Nanotechnology provides benefits in wound healing such as improved skin permeation and controlled release. This article reviews recent research advancements on the utilization of nanoemulsions in wound treatment.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Multidisciplinary Sciences
Disha Kesharwani, Swarnali Das Paul, Rishi Paliwal, Trilochan Satapathy
Summary: The objective of this study was to develop and optimize DCN loaded nanostructured lipid carrier (NLCs) for topical delivery. NLCs were prepared by hot homogenization followed by sonication method, and the formulation was optimized using central composite design. The optimized formulation exhibited desirable particle size, entrapment efficiency, and drug release profile. The developed DCN-NLCs showed sustained release and enhanced tissue penetration in vitro, indicating their potential for topical application.
JOURNAL OF RADIATION RESEARCH AND APPLIED SCIENCES
(2023)
Review
Chemistry, Medicinal
Neel Parekh, Ashish Garg, Renuka Choudhary, Madhu Gupta, Ginpreet Kaur, Seema Ramniwas, Moyad Shahwan, Hardeep Singh Tuli, Gautam Sethi
Summary: Cancer is a complex disease characterized by uncontrolled growth and spread of abnormal cells. Telomerase, an enzyme overexpressed in cancer cells, plays a critical role in cell proliferation and survival. Naturally occurring flavonoids can inhibit telomerase expression through various mechanisms, making them potential therapeutic agents for cancer. Numerous studies support the anti-cancer activity of flavonoids and their ability to deactivate telomerase in different cancer types.
Editorial Material
Biotechnology & Applied Microbiology
Neha Raina, Parvaiz Ahmad Shiekh, Akhilesh Kumar, Manu Smriti Singh, Piyush Kumar Gupta, Madhu Gupta
Editorial Material
Biotechnology & Applied Microbiology
Mohini Sikarwar, Vaishali Sunil Mishra, Preeti Tiwari, Madhu Gupta, Sunny Dholpuria, Piyush Kumar Gupta
Summary: Unveiling the potential of polyester nanomedicines in revolutionizing the treatment of visceral leishmaniasis through enhanced drug loading and precise targeting.
Article
Biotechnology & Applied Microbiology
Balak Das Kurmi, Preeti Patel, Rishi Paliwal, Pramod Kumar, Shivani Rai Paliwal
Summary: This study developed a liposomal formulation with desired characteristics for nonimmunogenic, site-specific drug delivery to targeted cancer sites and reduced cardiac toxicity associated with DOX.
Article
Chemistry, Multidisciplinary
Neha Raina, Shafiul Haque, Hardeep Singh Tuli, Atul Jain, Petr Slama, Madhu Gupta
Summary: This study aimed to develop a drug-loaded hydrogel system for chronic wound treatment in type-2 diabetes patients. Results from in vitro and in vivo experiments demonstrated that the hydrogel promoted wound healing and exhibited enhanced antimicrobial and antioxidant properties.
Article
Multidisciplinary Sciences
Junyu Ma, Chen Ma, Xiaoyu Huang, Pedro Henrique Hermes de Araujo, Amit Kumal Goyal, Guolin Lu, Chun Feng
Summary: In this study, uniform fiber-like micelles composed of a pi-conjugated oligo(p-phenylenevinylene) core and a crosslinking silica shell with grafted poly(ethylene glycol) (PEG) chains were generated using living crystalline-driven self-assembly. These micelles exhibited excellent dispersity and colloidal stability, even in different aqueous solutions and elevated temperatures. Furthermore, the micelles showed low cytotoxicity and demonstrated length-dependent cellular uptake behaviors. These findings provide a promising approach for the preparation of uniform, colloidally stable fiber-like nanostructures with tunable length and functions for biomedical applications.
FUNDAMENTAL RESEARCH
(2023)