Elovl5 regulates the mTORC2-Akt-FOXO1 pathway by controlling hepaticcis-vaccenic acid synthesis in diet-induced obese mice

Red Blood Cell Membrane Concentration of cis-Palmitoleic and cis-Vaccenic Acids and Risk of Coronary Heart Disease

(2012) Luc Djoussé et al.   AMERICAN JOURNAL OF CARDIOLOGY

Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c

(2012) Asami Hagiwara et al.   Cell Metabolism

Menhaden Oil Decreases High-Fat Diet–Induced Markers of Hepatic Damage, Steatosis, Inflammation, and Fibrosis in Obese Ldlr−/− Mice

(2012) Christopher M. Depner et al.   JOURNAL OF NUTRITION

Palmitoleate Induces Hepatic Steatosis but Suppresses Liver Inflammatory Response in Mice

(2012) Xin Guo et al.   PLoS One

Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling

(2012) C. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fatty acids in the de novo lipogenesis pathway and risk of coronary heart disease: the Cardiovascular Health Study

(2011) Jason HY Wu et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Targeting PI3K/mTOR Signaling in Cancer

(2011) B. M. Emerling et al.   CANCER RESEARCH

Rictor/mTORC2 Is Essential for Maintaining a Balance Between β-Cell Proliferation and Cell Size

(2011) Yanyun Gu et al.   DIABETES

mTORC2 Protein-mediated Protein Kinase B (Akt) Serine 473 Phosphorylation Is Not Required for Akt1 Activity in Human Platelets

(2011) Samantha F. Moore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance

(2011) Rui-Hong Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Chronic administration of palmitoleic acid reduces insulin resistance and hepatic lipid accumulation in KK-Ay Mice with genetic type 2 diabetes

(2011) Zhi-Hong Yang et al.   Lipids in Health and Disease

ER Stress Inhibits mTORC2 and Akt Signaling Through GSK-3 -Mediated Phosphorylation of Rictor

(2011) C.-H. Chen et al.   Science Signaling

Adipose tissue palmitoleic acid and obesity in humans: does it behave as a lipokine?

(2010) Jian Gong et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation

(2010) Donald B. Jump et al.   BIOCHEMICAL PHARMACOLOGY

Fatty acid regulation of hepatic lipid metabolism

(2010) Donald B Jump   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Uncoupling of Acetylation from Phosphorylation Regulates FoxO1 Function Independent of Its Subcellular Localization

(2010) Li Qiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elevated hepatic fatty acid elongase-5 activity corrects dietary fat-induced hyperglycemia in obese BL/6J mice

(2010) Sasmita Tripathy et al.   JOURNAL OF LIPID RESEARCH

Role of fatty acid elongases in determination of de novo synthesized monounsaturated fatty acid species

(2010) Christopher D. Green et al.   JOURNAL OF LIPID RESEARCH

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis

(2010) Y. Ohno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR and cancer: many loops in one pathway

(2009) Alejo Efeyan et al.   CURRENT OPINION IN CELL BIOLOGY

Characterization of Rictor Phosphorylation Sites Reveals Direct Regulation of mTOR Complex 2 by S6K1

(2009) C. C. Dibble et al.   MOLECULAR AND CELLULAR BIOLOGY

mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling

(2009) L.-A. Julien et al.   MOLECULAR AND CELLULAR BIOLOGY

Increased AKT S473 phosphorylation after mTORC1 inhibition is rictor dependent and does not predict tumor cell response to PI3K/mTOR inhibition

(2009) M. Breuleux et al.   MOLECULAR CANCER THERAPEUTICS

Rictor is a novel target of p70 S6 kinase-1

(2009) C Treins et al.   ONCOGENE

Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism

(2008) Haiming Cao et al.   CELL

Docosahexaenoic acid (DHA) and hepatic gene transcription

(2008) Donald B. Jump et al.   CHEMISTRY AND PHYSICS OF LIPIDS

N-3 polyunsaturated fatty acid regulation of hepatic gene transcription

(2008) Donald B Jump   CURRENT OPINION IN LIPIDOLOGY

O-GlcNAc Regulates FoxO Activation in Response to Glucose

(2008) Michael P. Housley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin Resistance in Striated Muscle-specific Integrin Receptor β1-deficient Mice

(2008) Haihong Zong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elevated hepatic fatty acid elongase-5 activity affects multiple pathways controlling hepatic lipid and carbohydrate composition

(2008) Yun Wang et al.   JOURNAL OF LIPID RESEARCH

Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice

(2008) Young-Ah Moon et al.   JOURNAL OF LIPID RESEARCH