Article
Medicine, Research & Experimental
Yi Wu, Suwen Lu, Xuan Huang, Yuanyuan Liu, Kuiyuan Huang, Ziying Liu, Weikang Xu, Wei Zhu, Jinlin Hou, Hongyan Liu, Xiaoyong Zhang
Summary: The study revealed that increased expression of cIAP2 was associated with severity of liver fibrosis in liver tissues. Deletion of cIAP2 from hepatocytes or degrading cIAPs using APG-1387 ameliorated liver fibrosis. Targeting cIAPs represented a promising therapeutic strategy for liver fibrosis by increasing MMP9 expression induced by CCL5 chemotactic neutrophils.
Article
Biochemistry & Molecular Biology
Hanh Hong Chu, Yoshiki Kobayashi, Dan Van Bui, Yasutaka Yun, Linh Manh Nguyen, Akitoshi Mitani, Kensuke Suzuki, Mikiya Asako, Akira Kanda, Hiroshi Iwai
Summary: Eosinophilic chronic rhinosinusitis (ECRS) is a refractory airway disease accompanied by eosinophilic inflammation. In this study, researchers investigated the role of CCL4, a specific ligand for CCR5 receptors, in eosinophil activation and recruitment in ECRS patients. The findings suggest that CCL4, derived from airway epithelial cells, plays a crucial role in the accumulation and activation of eosinophils at inflammatory sites.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Rong Li, Jing Zhang, Qiong Wang, Meng Cheng, Bin Lin
Summary: TPM1 plays a crucial role in regulating pro-inflammatory phenotype of microglia, mediating LPS-induced inflammation through the PKA/CREB signaling pathway. TPM1 also regulates inflammation downstream of TREM2 and in a microglia-dependent manner.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Oncology
Katarzyna Augoff, Anita Hryniewicz-Jankowska, Renata Tabola, Kamilla Stach
Summary: MMP9, a protease with diverse functions, plays a crucial role in tumorigenesis by regulating cancer cell migration, epithelial-to-mesenchymal transition, immune response, angiogenesis, and tumor microenvironment formation. However, the complicated regulation mechanism and high homology with other MMP family members make it difficult to develop effective and safe MMP9 inhibitors as anticancer drugs. The recent development of blocking antibodies shows promise, but further research is needed to fully understand the mechanisms of MMP9 in tumorigenesis and develop new therapies targeting MMP9.
Article
Biochemistry & Molecular Biology
Yoshiki Kobayashi, Hanh Hong Chu, Akira Kanda, Yasutaka Yun, Masami Shimono, Linh Manh Nguyen, Akitoshi Mitani, Kensuke Suzuki, Mikiya Asako, Hiroshi Iwai
Summary: Eosinophilic airway inflammatory disease is associated with bronchial asthma, and eosinophilic chronic rhinosinusitis (ECRS) is a typical refractory type 2 airway inflammation. CCL4, produced at local inflammatory sites, is involved in the accumulation and activation of type 2 inflammatory cells, including eosinophils. However, the detailed mechanism of CCL4 production and its potential as a biomarker for type 2 airway inflammation remain unclear. In this study, the researchers evaluated the expression and production of CCL4 mRNA via TSLP receptor, toll-like receptors (TLRs), and proteinase-activated receptor-2 (PAR2) in bronchial epithelial cells co-incubated with purified eosinophils or eosinophil peroxidase (EPX). They also examined the levels of serum chemokines (CCL4, CCL11, CCL26, and CCL17), total IgE, and fractionated exhaled nitrogen oxide (FENO), as well as CCL4 expression in nasal polyps of patients with severe ECRS and asthma. The results indicated that CCL4 was induced by TSLP in eosinophilic inflammation. Furthermore, CCL4 was released via TLR3 signaling, which was enhanced by TSLP. CCL4 was mainly found in nasal polyp epithelial cells, and its serum levels decreased after dupilumab treatment. Serum CCL4 levels were positively correlated with FENO, serum IgE, and CCL17 levels. Therefore, CCL4 released from epithelial cells through the innate immune system during type 2 airway inflammation may serve as a useful biomarker for this condition.
Article
Environmental Sciences
Maher A. Amer, Azza Othman, Mohamed A. El-Missiry, Aya A. Farag, Maggie E. Amer
Summary: The study found that PAs have an anti-fibrotic effect on CCl4-induced liver injury and fibrosis by modulating the interdependence of oxidative stress, inflammation, apoptosis, and DNA integrity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Yun Xing, Saiyang Xie, Wenke Shi, Xiaofeng Zeng, Wei Deng, Qizhu Tang
Summary: This study reveals that IL-21 plays a role in promoting inflammation, apoptosis, and fibrosis in pressure-induced cardiac remodeling, and this effect is mediated through the activation of the TIMP4/MMP9 signaling pathway. These findings provide important insights into the mechanisms of cardiac diseases and offer potential therapeutic strategies.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Immunology
Gangjie Qiao, Wenbin Ji, Zhaonan Sun, Xiulan Wang, Peiyuan Li, Haowen Jia, Lingling Duan, Feng Qi
Summary: Isosteviol, a sweetener derived from Stevia rebaudiana, has been found to have various biological activities. This study investigated the protective mechanism of isosteviol in burn injury and found that it can reduce inflammation by promoting an increase in the M2 macrophage ratio and increasing the expression of MMP9 during acute inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Suvesh Munakarmi, Yamuna Gurau, Juna Shrestha, Prabodh Risal, Ho Sung Park, Geum-Hwa Lee, Yeon Jun Jeong
Summary: Identifying effective biomarker-based phytochemicals from medicinal plants is a promising strategy to protect against liver injury. The combination of Vitis vinifera L. (VE) leaf and Centella asiatica (CE) extract (VCEC) shows synergistic protective effects against CCl4-induced acute liver injury in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Juan-Juan Li, He-Chun Jiang, Ao Wang, Fang-Tian Bu, Peng-Cheng Jia, Sai Zhu, Lin Zhu, Cheng Huang, Jun Li
Summary: This study demonstrates that HD-16 exerts anti-fibrotic effects in liver fibrosis by activating the AMPK/SIRT3 pathway, alleviating liver inflammation and fibrosis induced by CCl4.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ting Chen, Zhigang Huang, Wei Chen, Ru Ding, Na Li, Haiming Cui, Feng Wu, Chun Liang, Xiaoliang Cong
Summary: This study investigated the effect of bupropion on cirrhotic cardiomyopathy induced by carbon tetrachloride. The results showed that bupropion attenuated the inflammatory and oxidative condition, improved liver damage, and enhanced cardiac contractility.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Hanglu Ying, Long Li, Yufen Zhao, Feng Ni
Summary: This study evaluated the function of ivermectin in regulating liver fibrosis. The results showed that ivermectin alleviated histopathological changes, improved liver function, reduced collagen deposition, and downregulated the expression of profibrotic genes. Mechanistically, it inhibited intrahepatic macrophage accumulation and suppressed the production of proinflammatory factors. Importantly, it also promoted HSC deactivation by reducing the protein levels of alpha-smooth muscle actin (alpha-SMA).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Hong Zhu, Huizi Zhao, Songbing Xu, Yuan Zhang, Yuhao Ding, Jun Li, Cheng Huang, Taotao Ma
Summary: The study demonstrates that Sennoside A (SA) attenuates liver fibrosis by enhancing SOCS1 expression, inhibiting fibrogenesis marker expression, and suppressing inflammatory responses. SA also inhibits HSC proliferation by reducing proinflammatory cytokines in macrophages.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Medicine, General & Internal
Zhifeng Zhao, Chihao Zhang, Jiayun Lin, Lei Zheng, Hongjie Li, Xiaoliang Qi, Haizhong Huo, Xiaolou Lou, Bruce D. Hammock, Sung Hee Hwang, Yongyang Bao, Meng Luo
Summary: PTUPB alleviated liver fibrosis and portal hypertension by inhibiting fibrotic deposition, inflammation, angiogenesis, sinusoidal, and SMA remodeling, potentially mediated through the downregulation of sEH/COX-2/TGF-beta.
FRONTIERS IN MEDICINE
(2021)
Article
Cell Biology
Xue Liu, Yan Liu, Rui-xue Yang, Xiang-jiu Ding, Er-shun Liang
Summary: The deficiency of Tsc2 in macrophages exacerbates the progression of aortic aneurysms by upregulating Gpr68 expression, leading to proinflammatory processes and matrix metallopeptidase activation. These findings provide a novel therapeutic strategy to limit the progression of aneurysms caused by Tsc2 mutations.
CELL DEATH & DISEASE
(2022)
Article
Cardiac & Cardiovascular Systems
Alexis Slama, Mohamed Zaatar, Muhittin Demir, Oezlem Okumus, Stefan Mattheis, Sandra Kampe, Kaid Darwiche, Stephan Lang, Clemens Aigner
Summary: The study found that in carefully selected patients, tracheal or laryngotracheal resection after previous interventions provides comparable outcomes to primary surgery.
THORACIC AND CARDIOVASCULAR SURGEON
(2022)
Article
Oncology
Sharareh Bordbari, Britta Morchen, Ekaterina Pylaeva, Elena Siakaeva, Ilona Spyra, Maksim Domnich, Freya Droege, Oliver Kanaan, Karl Sebastian Lang, Dirk Schadendorf, Stephan Lang, Iris Helfrich, Jadwiga Jablonska
Summary: This study reveals that Type I interferon-deficient tumor-associated neutrophils play a significant role in promoting angiogenesis in tumors by releasing pro-angiogenic factors and activating the transcription factor FOXO3a. The post-translational modifications of FOXO3a control its transcriptional activity, which ultimately regulates the expression of pro-angiogenic factors. Targeting FOXO3a activity could be a potential strategy for antiangiogenic targeted therapy in cancer.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Oncology
Irem Ozel, Inga Duerig, Maksim Domnich, Stephan Lang, Ekaterina Pylaeva, Jadwiga Jablonska
Summary: Tumor angiogenesis is a critical step in cancer progression, and neutrophils have been found to play an important role in this process. This review summarizes the pro-angiogenic functions of neutrophils and discusses the potential for targeting these cells in anti-cancer therapy.
Article
Multidisciplinary Sciences
Anna Wrobeln, Tristan Leu, Jadwiga Jablonska, Urban Geisthoff, Stephan Lang, Joachim Fandrey, Freya Droege
Summary: Patients with hereditary haemorrhagic telangiectasia (HHT) suffer from abnormal vessel structures, leading to vessel hemorrhage and shunt effects. This study found significantly decreased expression of HIF-1 alpha in HHT patients, with no effect on the known upstream regulators of HIF-1 alpha. The results highlight the importance of HIF in HHT and suggest an interaction between the known HHT mutation and HIF-1 alpha dysregulation in HHT patients.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Johannes Doescher, Moritz Meyer, Christoph Arolt, Alexander Quaas, Jens Peter Klussmann, Philipp Wolber, Agnes Bankfalvi, Hans-Ulrich Schildhaus, Tobias Bastian, Stephan Lang, Simon Laban, Patrick J. Schuler, Cornelia Brunner, Thomas K. Hoffmann, Stephanie E. Weissinger
Summary: Adenoid cystic carcinoma (ACC) is a rare tumor with late occurring metastases and recurrences. The lack of effective treatment in the palliative situation and unsuccessful trials on immunotherapeutic drugs show the need for prognostic markers and understanding the reasons for the lack of response to immunotherapy. The study found that ACC is not recognized by infiltrating immune cells, suggesting the need for other methods to induce recognition of ACC by the immune system. The low immunogenicity of ACC and the abundance of lymphocytes have no influence on prognosis, explaining the observed lack of response towards immunotherapy.
Article
Cell Biology
Jadwiga Jablonska, Malwina Rist, Ilona Spyra, Luisa Tengler, Maksim Domnich, Benjamin Kansy, Bernd Giebel, Basant Kumar Thakur, Nicole Rotter, Stephan Lang, Sonja Ludwig
Summary: Head and Neck Cancers (HNCs) exhibit highly immunosuppressive properties, and small extracellular vesicles (sEVs) play a role in intercellular communication by carrying immunosuppressive proteins and inhibiting anti-tumor immune responses. This study evaluates immunosuppressive markers on sEVs from HNC patients at different disease stages and follow-up periods. The findings suggest that a combination of immunoregulatory markers should be used to monitor disease progression and therapy response in HNC.
Article
Otorhinolaryngology
L. C. Holtmann, E. Deuss, M. Meyer, F. Kaster, T. Bastian, M. C. Schleupner, E. Hagedorn, S. Lang, D. Arweiler-Harbeck
Summary: This study evaluated the accuracy of using photographs taken by patients to detect skin irritations or complications after cochlear implantation. The results showed that digital evaluators could reliably detect treatment-requiring conditions, indicating that digital photographic assessment could reduce in-person consultations.
COCHLEAR IMPLANTS INTERNATIONAL
(2022)
Article
Otorhinolaryngology
Timon Hussain, Kruthika Thangavelu, Cornelius Kurten, Lisa Galland, Benedikt Hoing, Eric Deuss, Stefan Mattheis, Stephan Lang, Cornelius Deuschl, Michael Forsting, Nils Doerner
Summary: The results show a considerable inaccuracy of clinical neck staging in all OPSCC patients, and these findings need to be taken into consideration during therapy planning. For p16-positive patients, these findings warrant attention in the context of therapy deintensification.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Cell Biology
Ekaterina Pylaeva, Georg Korschunow, Ilona Spyra, Sharareh Bordbari, Elena Siakaeva, Irem Ozel, Maksim Domnich, Anthony Squire, Anja Hasenberg, Kruthika Thangavelu, Timon Hussain, Moritz Goetz, Karl S. Lang, Matthias Gunzer, Wiebke Hansen, Jan Buer, Agnes Bankfalvi, Stephan Lang, Jadwiga Jablonska
Summary: In this study, researchers found that tumor-associated neutrophils migrate to lymph nodes during head and neck cancer progression and play a dual role in shaping anti-tumor responses. In metastasis-free stages, neutrophils stimulate T cells, while in metastatic stages, they suppress T cell responses. The accumulation of neutrophils in lymph nodes can predict the survival rate of head and neck cancer patients.
Article
Immunology
Timon Hussain, Maksim Domnich, Sharareh Bordbari, Ekaterina Pylaeva, Elena Siakaeva, Ilona Spyra, Irem Ozel, Freya Droege, Anthony Squire, Stefan Lienenklaus, Kathrin Sutter, Anja Hasenberg, Matthias Gunzer, Stephan Lang, Jadwiga Jablonska
Summary: Tumor-draining lymph nodes (TDLNs) are the first organs where metastatic spread of cancer occurs, and myeloid cells such as neutrophils play a crucial role in the activation of effector lymphocytes. The availability of type I interferon (IFN) influences the tumor-supportive or tumor-inhibiting activity of neutrophils. Defective type I IFN signaling leads to an impaired immunoregulatory capacity of neutrophils, resulting in enhanced tumor growth. Stimulation of IFN signaling may provide a therapeutic opportunity in head and neck cancer patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Audiology & Speech-Language Pathology
Laura Christine Holtmann, Amadea Strahlenbach, Stefan Hans, Stephan Lang, Diana Arweiler-Harbeck
Summary: The medial olivocochlear reflex (MOCR) may affect bimodal hearing in some individuals, but it is not observable in all cases. Threshold changes observed in acoustic brainstem response (ABR) measurements were reproducible in a specific subgroup, potentially due to a reactivated MOCR.
AUDIOLOGY AND NEURO-OTOLOGY
(2023)
Article
Otorhinolaryngology
Benedikt Hoeing, L. Wittig, L. Weber, B. A. Stuck, S. Mattheis, T. Hussain, S. Lang, J. M. Theysohn, Y. Li, S. Hansen
Summary: This retrospective study aimed to investigate the use of abdominal ultrasound as a staging procedure in head and neck squamous cell carcinoma (HNSCC). Out of 426 patients who received abdominal ultrasound, 7% were suspected of metastasis, with the majority being liver masses. The study found that abdominal ultrasound had a negative predictive value of 99.03% and a positive predictive value of 5.88% in HNSCC patients with N2/N3 cervical lymph node status.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Otorhinolaryngology
Eric Deuss, Saskia Schieder, Stephan Lang, Stefan Mattheis, Orlando Guntinas-Lichius, Moritz Friedo Meyer
Summary: This survey aimed to assess the diagnostic workup and therapeutic strategies for salivary gland diseases in German otorhinolaryngology departments. The results showed diversity in the diagnosis and treatment methods, with variations in different locations.
Review
Immunology
Benedict Boateng Antuamwine, Rebeka Bosnjakovic, Francisca Hofmann-Vega, Xi Wang, Theodosios Theodosiou, Ioannis Iliopoulos, Sven Brandau
Summary: Research on tumor-associated neutrophils (TAN) is currently booming due to the strong clinical relevance of these neutrophils in tumor progression. Recent high-dimensional analysis of murine neutrophils has revealed their unexpected plasticity in cancer and other inflammatory diseases. However, the functional validation of different transcriptional states and phenotypes of neutrophils in cancer is still lacking, calling for the refinement of current concepts in order to bridge the gap between experimental insight and clinical translation.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Oncology
Antonio Hrvat, Mathias Schmidt, Bernd Wagner, Denise Zwanziger, Rainer Kimmig, Lothar Volbracht, Sven Brandau, Nina Mallmann-Gottschalk
Summary: This study discovered that malignant ascites has inhibitory effects on the antitumor activity of healthy donor NK and T cells. Imbalanced electrolytes in ascites were identified as crucial factors causing immunosuppression of NK and T cells. Selective inhibition of sodium electrolyte channels can restore intracellular calcium flux and signaling pathways, thereby enhancing immune cell activity. The findings were correlated with poor patient prognosis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)