The TWEAK/Fn14 pathway as an aggravating and perpetuating factor in inflammatory diseases; focus on inflammatory bowel diseases

Update on biologic pathways in inflammatory bowel disease and their therapeutic relevance

(2012) Matthew J. Hamilton et al.   JOURNAL OF GASTROENTEROLOGY

TWEAK (tumor necrosis factor–like weak inducer of apoptosis) activates CXCL16 expression during renal tubulointerstitial inflammation

(2012) María Concepción Izquierdo et al.   KIDNEY INTERNATIONAL

Fecal HMGB1 Is a Novel Marker of Intestinal Mucosal Inflammation in Pediatric Inflammatory Bowel Disease

(2011) Roberta Vitali et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Intestinal myofibroblasts: targets for stem cell therapy

(2011) R. C. Mifflin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Macrophages and Tissue Injury: Agents of Defense or Destruction?

(2011) Debra L. Laskin et al.   Annual Review of Pharmacology and Toxicology

Interleukin-13 Damages Intestinal Mucosa via TWEAK and Fn14 in Mice—A Pathway Associated With Ulcerative Colitis

(2011) Rei Kawashima et al.   GASTROENTEROLOGY

Regulation of Homeostasis and Inflammation in the Intestine

(2011) Thomas T. MacDonald et al.   GASTROENTEROLOGY

Proinflammatory Cytokines in the Pathogenesis of Inflammatory Bowel Diseases

(2011) Warren Strober et al.   GASTROENTEROLOGY

Interactions Between the Host Innate Immune System and Microbes in Inflammatory Bowel Disease

(2011) Clara Abraham et al.   GASTROENTEROLOGY

RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome

(2011) Linde Duprez et al.   IMMUNITY

TWEAK/Fn14 pathway: an immunological switch for shaping tissue responses

(2011) Linda C. Burkly et al.   IMMUNOLOGICAL REVIEWS

TNF-like weak inducer of apoptosis (TWEAK) and TNF-α cooperate in the induction of keratinocyte apoptosis

(2011) Maya Zimmermann et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TWEAK Induces Apoptosis through a Death-signaling Complex Comprising Receptor-interacting Protein 1 (RIP1), Fas-associated Death Domain (FADD), and Caspase-8

(2011) Aminah Ikner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TWEAK causes myotube atrophy through coordinated activation of ubiquitin-proteasome system, autophagy, and caspases

(2011) Shephali Bhatnagar et al.   JOURNAL OF CELLULAR PHYSIOLOGY

TWEAK, a multifunctional cytokine in kidney injury

(2011) Ana Belen Sanz et al.   KIDNEY INTERNATIONAL

Development of an Fn14 agonistic antibody as an anti-tumor agent

(2011) Jennifer S. Michaelson et al.   mAbs

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

Genetics and pathogenesis of inflammatory bowel disease

(2011) Bernard Khor et al.   NATURE

TWEAK/Fn14 promotes apoptosis of human endometrial cancer cells via caspase pathway

(2010) Dengfeng Wang et al.   CANCER LETTERS

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

(2010) C. Bauer et al.   GUT

Tumor necrosis factor-like weak inducer of apoptosis is a mitogen for liver progenitor cells

(2010) Janina E. E. Tirnitz-Parker et al.   HEPATOLOGY

The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis

(2010) Md. Hasan Zaki et al.   IMMUNITY

Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases

(2010) Jeremy Dupaul-Chicoine et al.   IMMUNITY

Epithelium: the interplay between innate and Th2 immunity

(2010) Katarzyna Bulek et al.   IMMUNOLOGY AND CELL BIOLOGY

Full-length, Membrane-anchored TWEAK Can Function as a Juxtacrine Signaling Molecule and Activate the NF-κB Pathway

(2010) Sharron A. N. Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The TWEAK–Fn14 system is a critical regulator of denervation-induced skeletal muscle atrophy in mice

(2010) Ashwani Mittal et al.   JOURNAL OF CELL BIOLOGY

Inflammatory bowel disease in Asia

(2010) Rupert W L Leong et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Soluble and Transmembrane TNF-Like Weak Inducer of Apoptosis Differentially Activate the Classical and Noncanonical NF- B Pathway

(2010) C. Roos et al.   JOURNAL OF IMMUNOLOGY

The Role of Matrix Metalloproteinases in Intestinal Epithelial Wound Healing During Normal and Inflammatory States

(2010) Dana M. Hayden et al.   JOURNAL OF SURGICAL RESEARCH

Direct targeting of fibroblast growth factor-inducible 14 protein protects against renal ischemia reperfusion injury

(2010) Kiyohiko Hotta et al.   KIDNEY INTERNATIONAL

TWEAK regulates proliferation and differentiation of adult neural progenitor cells

(2010) Marion N. Schölzke et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tumor necrosis factor-like weak inducer of apoptosis and fibroblast growth factor-inducible 14 mediate cerebral ischemia-induced poly(ADP-ribose) polymerase-1 activation and neuronal death

(2010) W.B. Haile et al.   NEUROSCIENCE

TWEAK Activates the Non-Canonical NFκB Pathway in Murine Renal Tubular Cells: Modulation of CCL21

(2010) Ana B. Sanz et al.   PLoS One

Innate immune cell populations function as initiators and effectors in Th2 cytokine responses

(2010) Steven A. Saenz et al.   TRENDS IN IMMUNOLOGY

Fn14-Fc Fusion Protein Regulates Atherosclerosis in ApoE −/− Mice and Inhibits Macrophage Lipid Uptake In Vitro

(2009) Kitty Schapira et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Tumor Necrosis Factor–Like Weak Inducer of Apoptosis (TWEAK) Enhances Vascular and Renal Damage Induced by Hyperlipidemic Diet in ApoE-Knockout Mice

(2009) Begoña Muñoz-García et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

TWEAK promotes ovarian cancer cell metastasis via NF-κB pathway activation and VEGF expression

(2009) Lan Dai et al.   CANCER LETTERS

TWEAK is a positive regulator of cardiomyocyte proliferation

(2009) Tatyana Novoyatleva et al.   CARDIOVASCULAR RESEARCH

TNF-like weak inducer of apoptosis inhibits proinflammatory TNF receptor-1 signaling

(2009) A Wicovsky et al.   CELL DEATH AND DIFFERENTIATION

A Novel Role for Tumor Necrosis Factor–Like Weak Inducer of Apoptosis (TWEAK) in the Development of Cardiac Dysfunction and Failure

(2009) Mohit Jain et al.   CIRCULATION

TNF-like weak inducer of apoptosis (TWEAK) induces inflammatory and proliferative effects in human kidney cells

(2009) Hua-Xin Gao et al.   CYTOKINE

Matrix metalloproteinase-9 inhibition ameliorates pathogenesis and improves skeletal muscle regeneration in muscular dystrophy

(2009) H. Li et al.   HUMAN MOLECULAR GENETICS

Welcome to the neighborhood: epithelial cell-derived cytokines license innate and adaptive immune responses at mucosal sites

(2009) Steven A. Saenz et al.   IMMUNOLOGICAL REVIEWS

Pro-Inflammatory Cytokines TNF-Related Weak Inducer of Apoptosis (TWEAK) and TNFα Induce the Mitogen-Activated Protein Kinase (MAPK)-Dependent Expression of Sclerostin in Human Osteoblasts*

(2009) Cristina Vincent et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Tweak induces proliferation in renal tubular epithelium: a role in uninephrectomy induced renal hyperplasia

(2009) Ana B. Sanz et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Prevalence of ulcerative colitis and Crohn’s disease in Japan

(2009) Keiko Asakura et al.   JOURNAL OF GASTROENTEROLOGY

TNF-Like Weak Inducer of Apoptosis (TWEAK) Activates Proinflammatory Signaling Pathways and Gene Expression through the Activation of TGF- -Activated Kinase 1

(2009) M. Kumar et al.   JOURNAL OF IMMUNOLOGY

Fibroblast growth factor-inducible 14 (Fn14) is expressed in the lower genital tract and may play a role in amplifying inflammation during infection

(2009) Eugene S. Han et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

TWEAK/Fn14 Pathway: A Nonredundant Role in Intestinal Damage in Mice Through a TWEAK/Intestinal Epithelial Cell Axis

(2008) Taeko Dohi et al.   GASTROENTEROLOGY

Gut, inflammation and osteoporosis: basic and clinical concepts

(2008) H. Tilg et al.   GUT

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα

(2008) James E. Vince et al.   JOURNAL OF CELL BIOLOGY

NF-κB in inflammatory bowel disease

(2008) I. Atreya et al.   JOURNAL OF INTERNAL MEDICINE

No end in site: TWEAK/Fn14 activation and autoimmunity associated- end-organ pathologies

(2008) Timothy S. Zheng et al.   JOURNAL OF LEUKOCYTE BIOLOGY

TNF superfamily member TWEAK exacerbates inflammation and demyelination in the cuprizone-induced model

(2008) Heather A. Iocca et al.   JOURNAL OF NEUROIMMUNOLOGY

The Cytokine TWEAK Modulates Renal Tubulointerstitial Inflammation

(2008) A. B. Sanz et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Fibroblast Growth Factor-Inducible 14 Receptor Is Highly Expressed in HER2-Positive Breast Tumors and Regulates Breast Cancer Cell Invasive Capacity

(2008) A. L. Willis et al.   MOLECULAR CANCER RESEARCH

Epithelial apoptosis is a prominent feature of the epithelial barrier disturbance in intestinal inflammation: effect of pro-inflammatory interleukin-13 on epithelial cell function

(2008) F Heller et al.   Mucosal Immunology

The TWEAK–Fn14 cytokine–receptor axis: discovery, biology and therapeutic targeting

(2008) Jeffrey A. Winkles   NATURE REVIEWS DRUG DISCOVERY

Oxidative stress in ulcerative colitis-associated carcinogenesis

(2008) A. Roessner et al.   PATHOLOGY RESEARCH AND PRACTICE