The role of mitochondrial DNA mutations and free radicals in disease and ageing

Vitamin E Paradox in Alzheimer's Disease: It Does Not Prevent Loss of Cognition and May Even Be Detrimental

(2017) Ana Lloret et al.   JOURNAL OF ALZHEIMERS DISEASE

ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy

(2012) Yuqing Wang et al.   Autophagy

SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging

(2012) Albert Giralt et al.   BIOCHEMICAL JOURNAL

Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner

(2012) Magdalena Frank et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice

(2012) Kati J. Ahlqvist et al.   Cell Metabolism

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

Superoxide dismutase is dispensable for normal animal lifespan

(2012) J. M. Van Raamsdonk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Genome Instability and ROS Enhance Intestinal Tumorigenesis in APCMin/+ Mice

(2011) Dong Kyun Woo et al.   AMERICAN JOURNAL OF PATHOLOGY

Antioxidant clinical trials in mild cognitive impairment and Alzheimer's disease

(2011) Patrizia Mecocci et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Old Enzymes, New Tricks: Sirtuins Are NAD+-Dependent De-acylases

(2011) Matthew D. Hirschey   Cell Metabolism

Measurement of H2O2 within Living Drosophila during Aging Using a Ratiometric Mass Spectrometry Probe Targeted to the Mitochondrial Matrix

(2011) Helena M. Cochemé et al.   Cell Metabolism

Fine Tuning Our Cellular Factories: Sirtuins in Mitochondrial Biology

(2011) Lei Zhong et al.   Cell Metabolism

In Vivo Mapping of Hydrogen Peroxide and Oxidized Glutathione Reveals Chemical and Regional Specificity of Redox Homeostasis

(2011) Simone C. Albrecht et al.   Cell Metabolism

Unraveling the Biological Roles of Reactive Oxygen Species

(2011) Michael P. Murphy et al.   Cell Metabolism

Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS

(2011) Yaohui Chen et al.   EMBO REPORTS

Extending life span by increasing oxidative stress

(2011) Michael Ristow et al.   FREE RADICAL BIOLOGY AND MEDICINE

The SirT3 Divining Rod Points to Oxidative Stress

(2011) Eric L. Bell et al.   MOLECULAR CELL

Ageing theories unified

(2011) Daniel P. Kelly   NATURE

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

(2011) Camilla Burnett et al.   NATURE

Mitochondria: The Next (Neurode)Generation

(2011) Eric A. Schon et al.   NEURON

Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA

(2011) C. Kukat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Taking a “good” look at free radicals in the aging process

(2011) Siegfried Hekimi et al.   TRENDS IN CELL BIOLOGY

Tracing the Trail of Protons through Complex I of the Mitochondrial Respiratory Chain

(2011) Arnaud Mourier et al.   PLOS BIOLOGY

Ultra-Deep Sequencing of Mouse Mitochondrial DNA: Mutational Patterns and Their Origins

(2011) Adam Ameur et al.   PLoS Genetics

Somatic Mitochondrial DNA Mutations in Mammalian Aging

(2010) Nils-Göran Larsson   Annual Review of Biochemistry

The Interplay Between Mitochondrial Dynamics and Mitophagy

(2010) Gilad Twig et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial ROS Generation and Its Regulation: Mechanisms Involved in H2O2 Signaling

(2010) Michel Rigoulet et al.   ANTIOXIDANTS & REDOX SIGNALING

DNA repair in organelles: Pathways, organization, regulation, relevance in disease and aging

(2010) Pierre Boesch et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial sirtuins

(2010) Jing-Yi Huang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

(2010) Shinichi Someya et al.   CELL

SnapShot: Reactive Oxygen Intermediates (ROI)

(2010) Carl Nathan et al.   CELL

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

(2010) Michael Ristow et al.   EXPERIMENTAL GERONTOLOGY

Hydroethidine- and MitoSOX-derived red fluorescence is not a reliable indicator of intracellular superoxide formation: Another inconvenient truth

(2010) Jacek Zielonka et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial myopathy induces a starvation-like response

(2010) Henna Tyynismaa et al.   HUMAN MOLECULAR GENETICS

Mitochondrial dysfunction as a cause of ageing

(2010) A. Trifunovic et al.   JOURNAL OF INTERNAL MEDICINE

Methods for detection and measurement of hydrogen peroxide inside and outside of cells

(2010) Sue Goo Rhee et al.   MOLECULES AND CELLS

A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease

(2010) Barry J. Snow et al.   MOVEMENT DISORDERS

Regulation of autophagy by ROS: physiology and pathology

(2010) Ruth Scherz-Shouval et al.   TRENDS IN BIOCHEMICAL SCIENCES

Phase II trial of CoQ10 for ALS finds insufficient evidence to justify phase III

(2009) Petra Kaufmann et al.   ANNALS OF NEUROLOGY

Is the oxidative stress theory of aging dead?

(2009) Viviana I. Pérez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Is there more to aging than mitochondrial DNA and reactive oxygen species?

(2009) Mikhail F. Alexeyev   FEBS Journal

Reversal of the Mitochondrial Phenotype and Slow Development of Oxidative Biomarkers of Aging in Long-livedMclk1+/−Mice

(2009) Jérôme Lapointe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mice Deficient in Both Mn Superoxide Dismutase and Glutathione Peroxidase-1 Have Increased Oxidative Damage and a Greater Incidence of Pathology but No Reduction in Longevity

(2009) Y. Zhang et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans

(2009) Jeremy M. Van Raamsdonk et al.   PLoS Genetics

The overexpression of major antioxidant enzymes does not extend the lifespan of mice

(2008) Viviana I. Pérez et al.   AGING CELL

The human SIRT3 protein deacetylase is exclusively mitochondrial

(2008) Helen M. Cooper et al.   BIOCHEMICAL JOURNAL

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans

(2008) R. Doonan et al.   GENES & DEVELOPMENT

Age-associated mosaic respiratory chain deficiency causes trans-neuronal degeneration

(2008) E. Dufour et al.   HUMAN MOLECULAR GENETICS