Article
Immunology
Yiwen Liang, Jingyi Shen, Qiu Lan, Kexin Zhang, Yan Xu, Maxwell Duah, Kailin Xu, Bin Pan
Summary: This research found that PD-1 expression on T cells increased in mice with chronic graft-versus-host disease (cGVHD). Intervention of the PD-1/PD-L1 pathway showed a significant impact on the occurrence of cGVHD and graft-versus-tumor effect.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Yusuke Meguri, Takeru Asano, Takanori Yoshioka, Miki Iwamoto, Shuntaro Ikegawa, Hiroyuki Sugiura, Yuriko Kishi, Makoto Nakamura, Yasuhisa Sando, Takumi Kondo, Yuichi Sumii, Yoshinobu Maeda, Ken-ichi Matsuoka
Summary: After HSCT, the response of T cell subsets to exogenous IL-2 depends on the host's immune environment, with implications for the balance of GVHD and GVL.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Daria Briukhovetska, Javier Suarez-Gosalvez, Cornelia Voigt, Anamarija Markota, Anastasios D. Giannou, Maryam Schuebel, Jakob Jobst, Tao Zhang, Janina Doerr, Florian Maerkl, Lina Majed, Philipp Jie Mueller, Peter May, Adrian Gottschlich, Nicholas Tokarew, Juran Luecke, Arman Oner, Melanie Schwerdtfeger, David Andreu-Sanz, Ruth Gruenmeier, Matthias Seifert, Stefanos Michaelides, Michael Hristov, Lars M. Koenig, Bruno Loureiro Cadilha, Oleg Mikhaylov, Hans-Joachim Anders, Simon Rothenfusser, Richard A. Flavell, Daniela Cerezo-Wallis, Cristina Tejedo, Maria S. Soengas, Tobias Bald, Samuel Huber, Stefan Endres, Sebastian Kobold
Summary: Although T cells producing interleukin-22 (IL-22) in breast and lung tumors are associated with poor patient outcomes, deletion of IL-22 or its receptor reduces metastasis in mouse models. IL-22 induces high expression of CD155, which impairs the function of NK cells and increases metastatic burden. The findings suggest an immunosuppressive circuit activated by T cell-derived IL-22 that promotes lung metastasis.
Article
Biochemistry & Molecular Biology
Jianing Chen, Xuehui Li, Ping Zeng, Xujun Zhang, Kefan Bi, Chenhong Lin, Jingjing Jiang, Hongyan Diao
Summary: The involvement of IL-17A in immune-mediated hepatitis was investigated using a mice model with intestine exposed to Salmonella typhimurium. The study found that IL-17A overactivation of NKT cells contributed to severe liver injury in Con A-induced immune-mediated hepatitis. Additionally, MAIT-cell-derived IL-17A was identified as the original driver of NKT cell overactivation. This axis could potentially serve as a therapeutic target in autoimmune liver disease.
Article
Immunology
Lingzhen Hu, Jingyi Hu, Liheng Chen, Yi Zhang, Qingqing Wang, Xuyan Yang
Summary: Our study demonstrated that IL-22 overexpression in LN activated the STAT3 signaling pathway, increased chemokine secretion, promoted macrophage infiltration, and thus aggravated LN in lupus-prone mice. This suggests that IL-22 may play a pathogenic role in LN and serve as a potential therapeutic target for LN.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Alexandra Berger, Sarah J. Colpitts, Morgan Zych, Christopher J. Paige
Summary: We explored the use of IL-21 cell-based anti-leukemia treatment in a mouse model of acute lymphoblastic leukemia. Injection of IL-21-secreting 70Z/3 leukemia cells induced a strong anti-leukemia response and led to 100% survival rate. IL-21 secretion correlated with improved survival and the expansion of IL-21-secreting cells. The delivery of IL-21 showed the potential to induce a potent immune response and long-term immunity, making it an attractive candidate for cancer immunotherapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Review
Immunology
David Y. Oh, Lawrence Fong
Summary: Cytotoxic CD4(+) T cells play important roles in both cancer and non-cancer environments, where they can directly kill cancer cells. They are also found in situations like infection and autoimmunity. The cytolytic mechanisms of cytotoxic CD4(+) T cells vary across different disease states.
Article
Immunology
Huilei Zhang, Shuangqing Liu, Yanan Li, Jianru Li, Chen Ni, Ming Yang, Jun Dong, Zhaoqing Wang, Zhihai Qin
Summary: The study reveals that S100A4 drives dysfunction in CD8(+) T-EM cells, leading to the loss of their protective memory response and promoting asthma worsening. CD8(+) T-EM cells can be divided into dysfunctional subsets and subsets inclined towards apoptosis based on the expression of S100A4. S100A4 affects mitochondrial metabolism, leading to a decrease in acetyl-CoA levels, which impairs the transcription of effector genes (especially IFN-γ), facilitating cell survival, tolerance, and memory potential.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Cell Biology
Yiran Niu, Linlin Ye, Wenbei Peng, Zihao Wang, Xiaoshan Wei, Xu Wang, Yu Li, Siyu Zhang, Xuan Xiang, Qiong Zhou
Summary: IL-26 is a newly discovered member of the IL-10 cytokine family mainly secreted by Th17 cells, and its involvement in malignant pleural effusion (MPE) production and promotion has been reported for the first time in this study. Elevated levels of IL-26, IL-10, and IL-6 were observed in MPE compared to peripheral blood, with the primary cell source of IL-26 being Th17 cells. Additionally, IL-26 was found to impact the proportions of CD4(+) T cells and CD8(+) T cells, influencing their tumor-killing activity and patient survival.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ning Song, Yang Xu, Hans-Joachim Paust, Ulf Panzer, Maria Mercedes de las Noriega, Linlin Guo, Thomas Renne, Jiabin Huang, Xianglin Meng, Mingyan Zhao, Friedrich Thaiss
Summary: Lack of IKK1 in CD4(+)T lymphocytes reduces renal injury caused by IRI by decreasing the ability of CD4 lymphocytes to differentiate into Th1/Th17 cells. This finding suggests that targeting IKK1 in lymphocytes may be a novel therapeutic strategy for IRI.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Mathematical & Computational Biology
Ryan Baker, Raquel Hontecillas, Nuria Tubau-Juni, Andrew J. Leber, Shiv Kale, Josep Bassaganya-Riera
Summary: This study built a computational model to simulate the complex mechanisms of immune and metabolic regulation of CD4+ T cell functions. The model revealed how CD4+ T cells shape the immune response during Clostridioides difficile infection (CDI) and the potential pharmacological targeting to enhance regulatory (Treg) response. Activation of LANCL2 decreased effector response, increased regulatory response, and induced metabolic changes favoring Treg development. Gluconeogenesis via PEPCK-M was identified as a potential factor responsible for increased immunosuppressive behavior in Treg cells.
NPJ SYSTEMS BIOLOGY AND APPLICATIONS
(2022)
Article
Immunology
Carina A. Baeuerlein, Musga Qureischi, Zeinab Mokhtari, Paula Tabares, Christian Brede, Ana-Laura Jordan Garrote, Simone S. Riedel, Martin Chopra, Simone Reu, Anja Mottok, Estibaliz Arellano-Viera, Carolin Graf, Miriam Kurzwart, Katharina Schmiedgen, Hermann Einsele, Matthias Woelfl, Paul-Gerhardt Schlegel, Andreas Beilhack
Summary: Research suggests that the upregulation of alpha 4 beta 7 integrin, CD162E, CD162P, and downregulation of CD62L on peripheral blood T-cells may be correlated with the development of aGvHD after allo-HCT. Other surface markers like CD25, CD69, and CC-chemokine receptors were not found to be predictive markers in this study. Based on preclinical data from mouse models, a panel of surface markers combining alpha 4 beta 7 integrin with CD62L, CD162E, and CD162P is proposed to identify patients at risk for early aGvHD after allo-HCT.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hendrik Stuelb, Malte Bachmann, Sina Gonther, Heiko Muehl
Summary: This study investigates the role of IL-22 in female mice with acetaminophen-induced liver injury, demonstrating that testosterone and dihydrotestosterone can reduce IL-22 production in female splenocytes. The findings suggest a potential explanation for the increased IL-22 in female mice and splenocytes during inflammatory activation, and highlight the immunosuppressive effects of androgens in males.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Srikanth Sadhu, Rajdeep Dalal, Jyotsna Dandotiya, Akshay Binayke, Virendra Singh, Manas Ranjan Tripathy, Vinayaka Das, Sandeep Goswami, Shakti Kumar, Zaigham Abbas Rizvi, Amit Awasthi
Summary: IL-9, primarily produced by helper T cells, plays a critical role in COVID-19 by promoting viral spread and airway inflammation. This study demonstrates that blocking IL-9 can reduce airway inflammation, suggesting IL-9 as a potential therapeutic target for mitigating disease severity in COVID-19.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Andrea M. Amitrano, Brandon J. Berry, Kihong Lim, Kyun-Do Kim, Richard E. Waugh, Andrew P. Wojtovich, Minsoo Kim
Summary: Cancer immunotherapy is more effective against hematological malignancies than solid tumors due to metabolic challenges in the tumor microenvironment. Mitochondria play a key role in CD8(+) T cell activation and effector function. Enhanced mitochondrial function is associated with improved T cell migration and effector function, highlighting the importance of mitochondrial metabolism in T cell responses.
FRONTIERS IN IMMUNOLOGY
(2021)
