Article
Immunology
Arturo Gonzalez de la Aleja, Cristina Herrero, Monica Torres-Torresano, Juan Vladimir de la Rosa, Barbara Alonso, Enrique Capa-Sardon, Ittai B. Muller, Gerrit Jansen, Amaya Puig-Kroeger, Miguel A. Vega, Antonio Castrillo, Angel L. Corbi
Summary: LXR activation limits the anti-inflammatory polarization of human macrophages and promotes the acquisition of an inflammatory profile, which is associated with the expression of specific genes and the release of activin A.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Konda Kumaraswami, Christoph Arnholdt, Elisabeth Deindl, Manuel Lasch
Summary: Increasing evidence suggests that lymphocytes play distinct roles in inflammation-induced tissue remodeling and tissue damage. Arteriogenesis describes the growth of natural bypasses from pre-existing collateral arteries. The role of innate immune cells is widely understood in the process of arteriogenesis, whereas the role of lymphocytes remains unclear and is the subject of the present study.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pediatrics
Wei Han, Ya'nan Pan, Ziyao Han, Li Cheng, Li Jiang
Summary: This study aims to evaluate the effects of advanced maternal age (AMA) on the development of myelin sheaths in offspring. The results indicate that AMA impairs memory function and myelin formation in offspring, with the ERK signaling pathway potentially playing a significant role.
FRONTIERS IN PEDIATRICS
(2022)
Review
Chemistry, Multidisciplinary
Jiayi Mao, Lu Chen, Zhengwei Cai, Shutong Qian, Zhimo Liu, Binfan Zhao, Yuguang Zhang, Xiaoming Sun, Wenguo Cui
Summary: The review discusses the use of macrophage immunotherapy in promoting wound healing, as well as the importance of biomaterials in regulating macrophage signaling for tissue regeneration.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Amy L. Wooldridge, Mazhar Pasha, Palehswan Chitrakar, Raven Kirschenman, Anita Quon, Floor Spaans, Tamara Saez, Christy-Lynn M. Cooke, Sandra T. Davidge
Summary: The study found that advanced maternal age is associated with pregnancy complications and impairs uterine artery adaptations to pregnancy. Aged dams had worse pregnancy outcomes, with altered myogenic behavior and vascular structure in their arteries during pregnancy. These changes may affect fetal growth and development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Behavioral Sciences
Wei Han, Ya' Nan Pan, Ziyao Han, Dishu Huang, Siqi Hong, Xiaojie Song, Li Cheng, Li Jiang
Summary: Advanced maternal age may have negative effects on offspring's neurodevelopment, including impaired synaptic plasticity.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Nataliya V. Mushenkova, Nikita G. Nikiforov, Alexandra A. Melnichenko, Vladislav Kalmykov, Nikolay K. Shakhpazyan, Varvara A. Orekhova, Alexander N. Orekhov
Summary: This review discusses the functional phenotypes of intraplaque macrophages and their distinct contribution to atherosclerosis inflammation.
Article
Biology
Ana C. G. Salina, Douglas dos-Santos, Tamara S. Rodrigues, Marlon Fortes-Rocha, Edismauro G. Freitas-Filho, Daniel L. Alzamora-Terrel, Icaro M. S. Castro, Thais F. C. Fraga da Silva, Mikhael H. F. de Lima, Daniele C. Nascimento, Camila M. Silva, Juliana E. Toller-Kawahisa, Amanda Becerra, Samuel Oliveira, Diego B. Caetite, Leticia Almeida, Adriene Y. Ishimoto, Thais M. Lima, Ronaldo B. Martins, Flavio Veras, Natalia B. do Amaral, Marcela C. Giannini, Leticia P. Bonjorno, Maria I. F. Lopes, Maira N. Benatti, Sabrina S. Batah, Rodrigo C. Santana, Fernando C. Vilar, Maria A. Martins, Rodrigo L. Assad, Sergio C. L. de Almeida, Fabiola R. de Oliveira, Eurico Arruda Neto, Thiago M. Cunha, Jose C. Alves-Filho, Vania L. D. Bonato, Fernando Q. Cunha, Alexandre T. Fabro, Helder Nakaya, Dario S. Zamboni, Paulo Louzada-Junior, Rene D. R. Oliveira, Larissa D. Cunha
Summary: This study reveals that the engulfment of SARS-CoV-2-infected apoptotic cells by macrophages exacerbates inflammatory cytokine production and impairs the ability of macrophages to perform continual efferocytosis. Lung monocytes and macrophages from severe COVID-19 patients also show compromised efferocytic capacity.
Review
Immunology
Mariame Mohamed Ahamada, Yang Jia, Xiaochuan Wu
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease that primarily affects adults, especially females and non-Caucasian individuals. Despite numerous studies on SLE, the exact pathogenesis remains unclear and there is no specific drug for effective treatment. The involvement of macrophages in the development of SLE is increasingly recognized, suggesting a potential for macrophage-centered therapeutic approaches.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Food Science & Technology
Yaozhong Hu, Jiaxin Gu, Jing Lin, Yi Wang, Feier Yang, Jia Yin, Zhenting Yu, Sihao Wu, Huan Lv, Xuemeng Ji, Shuo Wang
Summary: The intervention of EGCG on macrophage polarization was found to promote M2 polarization and inhibit M1 polarization, particularly in liver, colon, spleen, and brain.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Oncology
Cesar Oyarce, Ana Vizcaino-Castro, Shipeng Chen, Annemarie Boerma, Toos Daemen
Summary: The study demonstrates that targeting macrophage cell metabolism can repolarize them from an immunosuppressive M2 phenotype to an anti-tumoral M1-like phenotype. Additionally, it can also prevent M0-to-M2 polarization.
Article
Immunology
Fulvio Massaro, Florent Corrillon, Basile Stamatopoulos, Nathan Dubois, Achille Ruer, Nathalie Meuleman, Dominique Bron, Laurence Lagneaux
Summary: Mesenchymal stromal cells (MSC) play a critical role in aging and inflammaging, and studying them is important for understanding the mechanisms of diseases in the elderly.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Food Science & Technology
Nanaka Arimura, Hiroshi Watanabe, Hiromasa Kato, Tadashi Imafuku, Takehiro Nakano, Miyu Sueyoshi, Mayuko Chikamatsu, Kai Tokumaru, Taisei Nagasaki, Hitoshi Maeda, Motoko Tanaka, Kazutaka Matsushita, Toru Maruyama
Summary: Fat atrophy and adipose tissue inflammation can lead to metabolic symptoms in chronic kidney disease (CKD). The relationship between fat atrophy/adipose tissue inflammation and advanced oxidation protein products (AOPPs) is unclear. This study investigated the involvement of AOPPs in adipose tissue inflammation and established the underlying molecular mechanism.
Review
Engineering, Biomedical
Yinfeng Zhang, Tingting Wang, Meng Sun, Yueyue Song, Xinyuan Huang, Shutian Zhang, Jun Yang, Jinfeng Zhang
Summary: Inflammatory bowel disease (IBD) is a chronic and recurrent gastrointestinal inflammatory disorder with a rapidly increasing incidence, posing a global healthcare challenge. Efficient cure for IBD is lacking due to its elusive etiology and pathogenesis. Nanotherapeutic strategies utilizing advanced nanomaterials show promise in achieving positive clinical efficacy and reduced side effects. This review provides an overview of the characteristics of healthy and inflammatory intestinal microenvironments, discusses different administration routes and targeting strategies of nanotherapeutics for IBD treatment, explores nanotherapeutic treatments based on different IBD pathogenesis, and presents future challenges and perspectives.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Immunology
Tingting Xia, Meng Zhang, Wei Lei, Ruilin Yang, Shengping Fu, Zhenhai Fan, Ying Yang, Tao Zhang
Summary: Cell growth, proliferation, differentiation, and apoptosis are influenced by STAT3, and aberrant STAT3 expression affects the development of inflammatory immunological disorders, fibrotic diseases, and malignancies. Macrophages (M0) can be polarized into pro-inflammatory (M1) and anti-inflammatory (M2) types, and STAT3 signaling plays a role in this polarization. This review compiles the relevant signaling pathways associated with STAT3 and macrophage polarization for the treatment and investigation of disorders related to macrophage polarization.
FRONTIERS IN IMMUNOLOGY
(2023)