Article
Neurosciences
An-ran Zhao, Jie Li, Si-qi Wang, Li-hua Bian, Wen-jing Li, Jian-you Guo
Summary: This study found a correlation between anxiety-like behavior and mitochondrial energy metabolism, suggesting that the main mechanism of anxiety disorders may be a disturbance of mitochondrial energy metabolism, possibly related to the AMPK/SIRT1 pathway.
BRAIN RESEARCH BULLETIN
(2023)
Article
Pharmacology & Pharmacy
Jiaqin Wu, Yuna Qian, Cheng Chen, Fan Feng, Lianhong Pan, Li Yang, Chunli Wang
Summary: This study demonstrated that Hesperetin (HPT) has chondroprotective and anti-inflammatory effects on chondrocytes through the AMPK signaling pathway, inhibiting TNF-alpha-induced cartilage degradation and promoting chondrocyte proliferation. RNA sequencing identified potential molecular targets, with 549 differentially expressed genes, and highlighted the importance of the AMPK pathway in mediating HPT's protective effects. Overall, HPT shows promise as a natural drug for osteoarthritis treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Xiao-Die Wang, Wei-Li Yu, Yun Sun
Summary: In this study, the role of the AMPK-SIRT1 pathway in acute pancreatitis (AP) was investigated. The results showed that AMPK and SIRT1 were down-regulated in AP, leading to impaired autophagy and increased inflammation. Activation of AMPK restored impaired autophagy and inhibited inflammation by up-regulating SIRT1.
Article
Food Science & Technology
Jiayi Dou, Haozhen Cui, Zhenyu Cui, Meiyan Xuan, Chong Gao, Zhaoxu Li, Lihua Lian, Jixing Nan, Yanling Wu
Summary: Pterostilbene has shown potential in preventing and treating hepatic fibrosis by regulating fibrogenesis, energy metabolism, inflammation, and the interaction between Sirt1 and STAT3. It displayed cytotoxicity on activated hepatic stellate cells and reduced levels of fibrosis markers in mice with hepatic fibrosis induced by thioacetamide.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Plant Sciences
Yan Du, Ding-xiang Li, Dong-yu Lu, Ran Zhang, Qiao-qiao Zhong, Yan-lin Zhao, Xiao-xiao Zheng, Shuai Ji, Liang Wang, Dao-Quan Tang
Summary: This study confirms that mulberry leaf water extract can effectively alleviate lipid accumulation and inflammation by regulating ADPN/AMPK-mediated signaling pathways and relevant metabolic disturbances.
Article
Physiology
Xiu-ying Luo, Ze Zhong, Ai-guo Chong, Wei-wei Zhang, Xin-dong Wu
Summary: The study revealed that trimetazidine (TMZ) can inhibit myocardial apoptosis and energy metabolism disorder induced by myocardial infarction (MI) by activating the SIRT1-AMPK pathway.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Ying Mei, Hui Hu, Liangjun Deng, Xiaoou Sun, Wen Tan
Summary: This study found that STVNa can improve NAFLD by activating autophagy, reducing inflammation and lipid accumulation, and inhibiting hepatic oxidative stress and fibrosis. Therefore, STVNa may be an alternative therapeutic agent for NAFLD.
SCIENTIFIC REPORTS
(2022)
Article
Plant Sciences
Xunzhe Yin, Zuojia Liu, Jin Wang
Summary: This study systematically evaluated the pharmacological functions and underlying mechanisms of the phytochemical tetrahydropalmatine (THP) in nonalcoholic fatty liver disease (NAFLD). The results showed that THP improves hepatic steatosis in NAFLD by switching lipid metabolism via the AMPK-SREBP-1c-Sirt1 pathway. This research provides a promising phytochemical component for the therapy against hepatic steatosis in NAFLD.
Article
Immunology
Zhiqiang Wang, Zhou Lu, Shengli Lin, Jie Xia, Ziwen Zhong, Zhangjuan Xie, Yun Xing, Jingbo Qie, Mengxia Jiao, Yifan Li, Haoyu Wen, Pengyuan Zhao, Dan Zhang, Pinghong Zhou, Jiawen Qian, Feifei Luo, Luman Wang, Hongxiu Yu, Jie Liu, Jie Gu, Ronghua Liu, Yiwei Chu
Summary: A subset of B cells expressing leucine-tRNA-synthase-2 (LARS2) with a transforming growth factor-beta 1 (TGF-beta 1) regulatory feature has been identified in both mouse and human colorectal cancer (CRC). These cells exhibit a leucine nutrient preference and are located outside the tertiary lymphoid structure. They are associated with colorectal hyperplasia and shortened survival in CRC patients. A leucine diet can induce the generation of LARS B cells, while deletion of Lars2 gene or leucine blockage can repress CRC immunoevasion. Mechanistically, LARS2 regulates mitochondrial nicotinamide adenine dinucleotide (NAD(+)) regeneration and oxidative metabolism, involving the NAD-dependent protein deacetylase sirtuin-1 (SIRT1).
Article
Plant Sciences
Chenghong Sun, Hongbao Liang, Yun Zhao, Shirong Li, Xiangzi Li, Xiaomei Yuan, Guoliang Cheng, Yongkang Zhang, Mingfei Liu, Yongxia Guan, Jingchun Yao, Guimin Zhang
Summary: JFG effectively treats OVA/aluminum hydroxide-induced skin lesions and inflammation in mice through modulating the LKB1/AMPK/SIRT1 axis.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Cheng-Yin Liu, Yi Zhou, Tao Chen, Jing-Chao Lei, Xue-Jun Jiang
Summary: Our study demonstrated that Arctigenin alleviated cardiomyocytes apoptosis, inflammation, and oxidative stress induced by OGD through activating the AMPK/SIRT1 pathway and downregulating NF-kappa B phosphorylation. In animal experiments, Arctigenin improved heart functions and decreased infarct size in AMI/R-rats by reducing oxidative stress, inflammation, and apoptotic levels in heart tissues while enhancing the AMPK/SIRT1 pathway and repressing the NF-kappa B pathway activation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ziyin Lu, Haozhen Wang, Muhammad Ishfaq, Yufang Han, Xiujin Zhang, Xiang Li, Baoqi Wang, Xiuli Lu, Bing Gao
Summary: This study reveals that quercetin, as an AMPK agonist, can counteract inflammatory damage caused by MG infection, highlighting the potential significance of the AMPK cascade signaling pathway as an important target for anti-inflammatory drug research in avian respiratory diseases.
Article
Medicine, Research & Experimental
Yiping Li, Yang Liu, Zhiwei Chen, Kaiyue Tang, Lili Yang, Yuwei Jiang, Jue Wang, Ping Huang, Jianyi Wang, Peiyong Zheng, Haiyan Song
Summary: In this study, researchers found that Protopanaxadiol (PPD), an active compound derived from Gynostemma pentaphyllum, can improve lipid accumulation in hepatocytes induced by free fatty acids and has a therapeutic effect on Non-alcoholic fatty liver disease (NAFLD). The results showed that PPD can reduce liver weight, serum aminotransferase levels, hepatosteatosis, and inflammatory cell infiltration in liver tissues of mice with NAFLD. PPD also improves lipid accumulation in hepatocytes.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Agriculture, Multidisciplinary
Nan Gao, Yang Yang, Siqi Liu, Chunyang Fang, Xiujing Dou, Licong Zhang, Anshan Shan
Summary: Tryptophan modulates metabolic pathways to maintain gut immune defense, reduce inflammation, and protect intestinal mucosal barrier and gut microbiota composition. These effects are mainly mediated through the regulation of the AMPK-SIRT1-autophagy pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Yuan Liu, Michael J. Jurczak, Travis B. Lear, Bo Lin, Mads B. Larsen, Jason R. Kennerdell, Yanwen Chen, Brydie R. Huckestein, Matthew K. Nguyen, Ferhan Tuncer, Yu Jiang, Satdarshan P. Monga, Christopher P. O'Donnell, Toren Finkel, Bill B. Chen, Rama K. Mallampalli
Summary: A newly discovered compound, BC1618, inhibits the degradation of phosphorylated Ampk alpha by targeting the protein Fbxo48, thereby enhancing Ampk biological activity and promoting mitochondrial fission, autophagy, and improved insulin sensitivity in obese mice. This study reveals a novel pathway for regulating Ampk activity.
NATURE CHEMICAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Liang-Yu Chen, Martin Lotz, Robert Terkeltaub, Ru Liu-Bryan
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Orthopedics
L-Y Chen, Y. Wang, R. Terkeltaub, R. Liu-Bryan
OSTEOARTHRITIS AND CARTILAGE
(2018)
Article
Rheumatology
Paulo Gil Alabarse, Liang-Yu Chen, Patricia Oliveira, Huaping Qin, Ru Liu-Bryan
Summary: This study aims to determine the role of CD38 in osteoarthritis (OA) development. The expression of CD38 was up-regulated in knee OA cartilage and stimulated chondrocytes. Overexpression of CD38 in chondrocytes resulted in reduced cellular NAD(+):NADH ratio and enhanced catabolic responses. CD38 deficiency exerted disease-modifying effects in OA and inhibiting CD38 may be a potential novel therapeutic approach for OA treatment.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Khaled Elsaid, Tony R. Merriman, Leigh-Ana Rossitto, Ru Liu-Bryan, Jacob Karsh, Amanda Phipps-Green, Gregory D. Jay, Sandy Elsayed, Marwa Qadri, Marin Miner, Murray Cadzow, Talia J. Dambruoso, Tannin A. Schmidt, Nicola Dalbeth, Ashika Chhana, Jennifer Hoglund, Majid Ghassemian, Anaamika Campeau, Nancy Maltez, Niclas G. Karlsson, David J. Gonzalez, Robert Terkeltaub
Summary: In this study, they found that gout can occur even without hyperuricemia. They discovered that the lack of lubricin activity may contribute to the incidence and progression of gout, and is associated with inflammatory signaling pathways.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Charles McWherter, Yun-Jung Choi, Ramon L. Serrano, Sushil K. Mahata, Robert Terkeltaub, Ru Liu-Bryan
ARTHRITIS RESEARCH & THERAPY
(2018)