Review
Immunology
Erica M. Orsini, Apostolos Perelas, Brian D. Southern, Lisa M. Grove, Mitchell A. Olman, Rachel G. Scheraga
Summary: Innate immune cells are able to sense and respond to their physical environment through mechanical signals transmitted via mechanosensitive ion channels and cell adhesion molecules, which then activate intracellular signaling pathways to regulate gene expression and cellular function. Understanding how immune cells interpret mechanical information may provide potential targets for treating human diseases. Areas of future studies include autoimmune, allergic, infectious, and malignant conditions.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Andreas Margraf, Mauro Perretti
Summary: This article discusses the importance of inflammation for immune response and its potential role in chronic diseases and organ damage. The mechanisms triggering, hindering, or resolving inflammation have been studied, but precise therapeutic interventions are not yet fully understood. The article highlights the role of cellular phenotypes, particularly neutrophils, macrophages, and platelets, in inflammation research and suggests implications for diagnostics and therapeutics.
Article
Biochemistry & Molecular Biology
Ryota Tanida, Hironobu Tsubouchi, Shigehisa Yanagi, Yusuke Saito, Koji Toshinai, Taiga Miyazaki, Toshinari Takamura, Masamitsu Nakazato
Summary: This study investigated the role of endogenous ghrelin in LPS-induced ARDS model. The results showed that ghsr(-/-) mice had better survival rates, lower levels of inflammatory cytokines, and higher oxygenation levels. Peritoneal macrophages isolated from ghsr(-/-) mice also had lower cytokine production and oxygen consumption rate. These findings suggest that endogenous ghrelin plays a crucial role in the initiation and continuation of acute inflammatory response in ARDS by modulating macrophage activity.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Guzel Rafikova, Svetlana Piatnitskaia, Elena Shapovalova, Svyatoslav Chugunov, Victor Kireev, Daria Ialiukhova, Azat Bilyalov, Valentin Pavlov, Julia Kzhyshkowska
Summary: The immuno-compatibility of ceramic implants, which depends on the interaction with immune cells, is still insufficiently understood and requires intensive experimental research. This review summarizes the state of the art in ceramic implants, including their mechanical properties, chemical modifications, surface structures, and shapes. The gaps in knowledge are identified, and the possibilities for further research using advanced quantitative technologies are outlined.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Holly J. Hulsebus, Kevin M. Najarro, Rachel H. McMahan, Devin M. Boe, David J. Orlicky, Elizabeth J. Kovacs
Summary: Alcohol consumption increases the risk of infections, particularly pneumococcal pneumonia. Pneumonia patients with alcohol use require more intensive treatment and longer hospital stays. Alcohol consumption affects the immune response in the respiratory tract.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ozge Erdogan, Jingya Xia, Jennifer L. Gibbs, Isaac M. Chiu
Summary: This study investigated the kinetics of the immune response, bacterial invasion, and immune cell types in dental pulp during pulpitis. The results showed that macrophages, neutrophils, and monocytes were the predominant immune cell populations during pulpitis, with signs of transitioning to an adaptive immune response over time.
JOURNAL OF ENDODONTICS
(2023)
Article
Biochemistry & Molecular Biology
Gareth B. Kitchen, Thomas Hopwood, Thanuja Gali Ramamoorthy, Polly Downton, Nicola Begley, Tracy Hussell, David H. Dockrell, Julie E. Gibbs, David W. Ray, Andrew S. Loudon
Summary: Robust inflammatory responses are crucial for survival after respiratory infections, and Epigenetic factors are increasingly being recognized as important determinants of immune responses. EZH2 acts differently in macrophages and neutrophils, affecting inflammatory responses and chemotaxis. Targeting EZH2 may have implications for mucosal immunity and conditions driven by pulmonary neutrophil influx.
Article
Immunology
Arturo Gonzalez de la Aleja, Cristina Herrero, Monica Torres-Torresano, Juan Vladimir de la Rosa, Barbara Alonso, Enrique Capa-Sardon, Ittai B. Muller, Gerrit Jansen, Amaya Puig-Kroeger, Miguel A. Vega, Antonio Castrillo, Angel L. Corbi
Summary: LXR activation limits the anti-inflammatory polarization of human macrophages and promotes the acquisition of an inflammatory profile, which is associated with the expression of specific genes and the release of activin A.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Marietta M. Ravesloot-Chavez, Erik Van Dis, Sarah A. Stanley
Summary: Infection with Mycobacterium tuberculosis causes a significant number of deaths annually worldwide, where the role of innate immune cells and the inflammatory response in the infection process are crucial yet complex.Understanding the balance of cell-intrinsic control and inflammation regulation is essential for developing effective therapeutics and vaccines.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 39
(2021)
Review
Microbiology
Haoning Li, Aoxue Wang, Yuying Zhang, Fanhua Wei
Summary: Influenza viruses are a major cause of human respiratory infections and pose a significant threat to global public health systems. Lung macrophages play an important role in controlling the severity of influenza by limiting viral replication, but this replication is strain- and macrophage type-dependent.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Cell Biology
Brian Dobosh, Keivan Zandi, Diego Moncada Giraldo, Shu Ling Goh, Kathryn Musall, Milagros Aldeco, Julia LeCher, Vincent D. Giacalone, Junkai Yang, Devon J. Eddins, Manoj Bhasin, Eliver Ghosn, Vikas Sukhatme, Raymond F. Schinazi, Rabindra Tirouvanziam
Summary: This study reveals the role of lung-infiltrating monocytes in COVID-19 pathogenesis and highlights their significance as a therapeutic target. The researchers found that monocytes acquire SARS-CoV-2 from lung epithelial cells and upregulate inflammatory mediator expression and secretion. Combination therapy with baricitinib and remdesivir enhances antiviral signaling and viral clearance while reducing the secretion of proneutrophilic mediators associated with acute respiratory distress syndrome.
Article
Immunology
Liangfei Niu, Geyang Luo, Rui Liang, Chenli Qiu, Jianwei Yang, Lingling Xie, Kaile Zhang, Yu Tian, Decheng Wang, Shu Song, Howard E. Takiff, Ka-Wing Wong, Xiaoyong Fan, Qian Gao, Bo Yan
Summary: This study reveals the important role of nlrc3-like in the regulation of macrophage homeostasis, early bacterial burden control, and inflammation response. Overexpression or deficiency of nlrc3-like leads to abnormal inflammation response and bacterial burden, highlighting the importance of balanced innate immune response during mycobacterial infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Microbiology
Ebrima Bojang, Harlene Ghuman, Pizga Kumwenda, Rebecca A. Hall
Summary: Infections caused by Candida albicans vary from superficial to systemic and are a major cause of nosocomial infections. The host environment plays a key role in modulating the host-pathogen interaction. Phagocytes play a crucial role in clearing C. albicans through PAMP-PRR interactions.
Article
Pharmacology & Pharmacy
Shumei He, Hongyan Fan, Bin Sun, Meipan Yang, Hongxu Liu, Jianwei Yang, Jianxin Liu, Sizhu Luo, Zihan Chen, Jing Zhou, Lu Xia, Shulin Zhang, Bo Yan
Summary: This study demonstrates the bacteriostatic effect of Salidroside (SAL) from Tibetan medicine Rhodiola rosea on tuberculosis using an in vivo zebrafish model. It also shows increased immune cell recruitment and improved survival rates with SAL treatment, suggesting a potential novel strategy for TB treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Jiarong Gu, Hao Xu, Yandong Chen, Na Li, Xin Hou
Summary: This article reviews the biosynthesis and functions of miR-223 in innate immunity, highlighting its key role in inflammatory diseases and cancers. Furthermore, it discusses the potential role of miR-223 in liver physiopathology and therapeutic prospects.
FRONTIERS IN IMMUNOLOGY
(2022)