Contribution of Alternatively Activated Macrophages to Allergic Lung Inflammation: A Tale of Mice and Men

Macrophage Chitinase 1 Stratifies Chronic Obstructive Lung Disease

(2012) Eugene Agapov et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Adoptive transfer of IL-4Rα+ macrophages is sufficient to enhance eosinophilic inflammation in a mouse model of allergic lung inflammation

(2012) Andrew Q Ford et al.   BMC IMMUNOLOGY

Dendritic cells and airway epithelial cells at the interface between innate and adaptive immune responses

(2011) H. Hammad et al.   ALLERGY

Transfer of in vivo primed transgenic T cells supports allergic lung inflammation and FIZZ1 and Ym1 production in an IL-4Rα and STAT6 dependent manner

(2011) Preeta Dasgupta et al.   BMC IMMUNOLOGY

Alternative activation of macrophages by IL-4 requires SHIP degradation

(2011) Shelley B. Weisser et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Increased arginase activity contributes to airway remodelling in chronic allergic asthma

(2011) H. Maarsingh et al.   EUROPEAN RESPIRATORY JOURNAL

Potential role for alternatively activated macrophages in the secondary bacterial infection during recovery from influenza

(2011) Wilbur H. Chen et al.   IMMUNOLOGY LETTERS

The historical milestones in the understanding of leukocyte biology initiated by Elie Metchnikoff

(2011) Jean-Marc Cavaillon   JOURNAL OF LEUKOCYTE BIOLOGY

Nuocytes: expanding the innate cell repertoire in type-2 immunity

(2011) Jillian L. Barlow et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Innate lymphoid cells wield a double-edged sword

(2011) Marsha Wills-Karp et al.   NATURE IMMUNOLOGY

Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity

(2011) Ya-Jen Chang et al.   NATURE IMMUNOLOGY

Rapid Host Defense against Aspergillus fumigatus Involves Alveolar Macrophages with a Predominance of Alternatively Activated Phenotype

(2011) Shikha Bhatia et al.   PLoS One

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

Orchestrating house dust mite-associated allergy in the lung

(2011) Lisa G. Gregory et al.   TRENDS IN IMMUNOLOGY

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Interactions between innate and adaptive immunity in asthma pathogenesis: New perspectives from studies on acute exacerbations

(2010) Patrick G. Holt et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

In vivo regulation of the allergic response by the IL-4 receptor α chain immunoreceptor tyrosine-based inhibitory motif

(2010) Raffi Tachdjian et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

More alternative activation of macrophages in lungs of asthmatic patients

(2010) Barbro N. Melgert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Hypoxia-Induced Mitogenic Factor (HIMF/FIZZ1/RELM ) Increases Lung Inflammation and Activates Pulmonary Microvascular Endothelial Cells via an IL-4-Dependent Mechanism

(2010) K. Yamaji-Kegan et al.   JOURNAL OF IMMUNOLOGY

Control of RSV-induced lung injury by alternatively activated macrophages is IL-4Rα-, TLR4- and IFN-β-dependent

(2010) K A Shirey et al.   Mucosal Immunology

Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma

(2009) Michelle L. North et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Macrophages

(2009) Barbro N. Melgert et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice

(2009) Kathryn A Niese et al.   BMC IMMUNOLOGY

Innate Cells and T Helper 2 Cell Immunity in Airway Inflammation

(2009) Nora A. Barrett et al.   IMMUNITY

Genetic variants in the mannose receptor gene (MRC1) are associated with asthma in two independent populations

(2009) Takeshi Hattori et al.   IMMUNOGENETICS

Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice

(2009) Denis Bedoret et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13–induced tissue responses and apoptosis

(2009) Chun Geun Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation

(2009) M. Kurowska-Stolarska et al.   JOURNAL OF IMMUNOLOGY

Ym1/2 Promotes Th2 Cytokine Expression by Inhibiting 12/15(S)-Lipoxygenase: Identification of a Novel Pathway for Regulating Allergic Inflammation

(2009) Y. Cai et al.   JOURNAL OF IMMUNOLOGY

Interactions between Innate Antiviral and Atopic Immunoinflammatory Pathways Precipitate and Sustain Asthma Exacerbations in Children

(2009) L. S. Subrata et al.   JOURNAL OF IMMUNOLOGY

Chitin, Chitinases and Chitinase-like Proteins in Allergic Inflammation and Tissue Remodeling

(2009) Chun Geun Lee   YONSEI MEDICAL JOURNAL

Retnla (Relmα/Fizz1) Suppresses Helminth-Induced Th2-Type Immunity

(2009) John T. Pesce et al.   PLoS Pathogens

Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis

(2009) John T. Pesce et al.   PLoS Pathogens

Alternative Activation of Macrophages: An Immunologic Functional Perspective

(2008) Fernando O. Martinez et al.   Annual Review of Immunology

Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance

(2008) Justin I. Odegaard et al.   Cell Metabolism

Immunology's foundation: the 100-year anniversary of the Nobel Prize to Paul Ehrlich and Elie Metchnikoff

(2008) Stefan H E Kaufmann   NATURE IMMUNOLOGY

Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease

(2008) Edy Y Kim et al.   NATURE MEDICINE

Effect of Variation inCHI3L1on Serum YKL-40 Level, Risk of Asthma, and Lung Function

(2008) Carole Ober et al.   NEW ENGLAND JOURNAL OF MEDICINE

Distinct roles for IL-13 and IL-4 via IL-13 receptor  1 and the type II IL-4 receptor in asthma pathogenesis

(2008) A. Munitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA