Defective lipid metabolism in neurodegeneration with brain iron accumulation (NBIA) syndromes: not only a matter of iron

Polyunsaturated fatty acids inhibit stimulated coupling between the ER Ca2+ sensor STIM1 and the Ca2+ channel protein Orai1 in a process that correlates with inhibition of stimulated STIM1 oligomerization

(2014) David Holowka et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Plasma phospholipids identify antecedent memory impairment in older adults

(2014) Mark Mapstone et al.   NATURE MEDICINE

Membrane Lipids Tune Synaptic Transmission by Direct Modulation of Presynaptic Potassium Channels

(2014) Mario Carta et al.   NEURON

Efficacy and safety of deferiprone for the treatment of pantothenate kinase-associated neurodegeneration (PKAN) and neurodegeneration with brain iron accumulation (NBIA): Results from a four years follow-up

(2014) Giovanni Cossu et al.   PARKINSONISM & RELATED DISORDERS

Impairment of Drosophila Orthologs of the Human Orphan Protein C19orf12 Induces Bang Sensitivity and Neurodegeneration

(2014) Arcangela Iuso et al.   PLoS One

Exome Sequence Reveals Mutations in CoA Synthase as a Cause of Neurodegeneration with Brain Iron Accumulation

(2013) Sabrina Dusi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

MAM (mitochondria-associated membranes) in mammalian cells: Lipids and beyond

(2013) Jean E. Vance   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Pantethine treatment is effective in recovering the disease phenotype induced by ketogenic diet in a pantothenate kinase-associated neurodegeneration mouse model

(2013) Dario Brunetti et al.   BRAIN

Cell death and diseases related to oxidative stress:4-hydroxynonenal (HNE) in the balance

(2013) S Dalleau et al.   CELL DEATH AND DIFFERENTIATION

Recessive truncatingNALCNmutation in infantile neuroaxonal dystrophy with facial dysmorphism

(2013) Çiğdem Köroğlu et al.   JOURNAL OF MEDICAL GENETICS

Plasma and Erythrocyte Fatty Acids Reflect Intakes of Saturated and n–6 PUFA within a Similar Time Frame

(2013) Leanne Hodson et al.   JOURNAL OF NUTRITION

Iron metabolism in the CNS: implications for neurodegenerative diseases

(2013) Tracey A. Rouault   NATURE REVIEWS NEUROSCIENCE

Proteomic Mapping of Mitochondria in Living Cells via Spatially Restricted Enzymatic Tagging

(2013) H.-W. Rhee et al.   SCIENCE

Mitochondrial lipid trafficking

(2013) Takashi Tatsuta et al.   TRENDS IN CELL BIOLOGY

Interaction of aldehydes derived from lipid peroxidation and membrane proteins

(2013) Stefania Pizzimenti et al.   Frontiers in Physiology

Disturbed brain phospholipid and docosahexaenoic acid metabolism in calcium-independent phospholipase A2-VIA (iPLA2β)-knockout mice

(2012) Yewon Cheon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Severe disturbance in the Ca2+ signaling in astrocytes from mouse models of human infantile neuroaxonal dystrophy with mutated Pla2g6

(2012) M. Strokin et al.   HUMAN MOLECULAR GENETICS

Pantothenate kinase-associated neurodegeneration: altered mitochondria membrane potential and defective respiration in Pank2 knock-out mouse model

(2012) Dario Brunetti et al.   HUMAN MOLECULAR GENETICS

Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases

(2012) F. Lamari et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Mitochondria-associated ER membranes in Alzheimer disease

(2012) Eric A. Schon et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Mitochondrial membrane protein associated neurodegenration: A novel variant of neurodegeneration with brain iron accumulation

(2012) Eva C. Schulte et al.   MOVEMENT DISORDERS

A new phenotype of brain iron accumulation with dystonia, optic atrophy, and peripheral neuropathy

(2012) Rita Horvath et al.   MOVEMENT DISORDERS

Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury

(2012) Jing Ji et al.   NATURE NEUROSCIENCE

Fats and Factors: Lipid Profiles Associate with Personality Factors and Suicidal History in Bipolar Subjects

(2012) Simon J. Evans et al.   PLoS One

Germline Deletion of Pantothenate Kinases 1 and 2 Reveals the Key Roles for CoA in Postnatal Metabolism

(2012) Matthew Garcia et al.   PLoS One

Absence of an Orphan Mitochondrial Protein, C19orf12, Causes a Distinct Clinical Subtype of Neurodegeneration with Brain Iron Accumulation

(2011) Monika B. Hartig et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Neurodegeneration with brain iron accumulation — Clinical syndromes and neuroimaging

(2011) Hyman M. Schipper   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Genetics of Neurodegeneration with Brain Iron Accumulation

(2011) Allison Gregory et al.   Current Neurology and Neuroscience Reports

Lipid peroxidation and neurodegenerative disease

(2011) Tanea T. Reed   FREE RADICAL BIOLOGY AND MEDICINE

Central nervous system dysfunction in a mouse model of Fa2h deficiency

(2011) Kathleen A. Potter et al.   GLIA

Associations of polyunsaturated fatty acids with residual depression or anxiety in older people with major depression

(2011) Ayesha Jadoon et al.   JOURNAL OF AFFECTIVE DISORDERS

Neuroaxonal Dystrophy in Calcium-Independent Phospholipase A2  Deficiency Results from Insufficient Remodeling and Degeneration of Mitochondrial and Presynaptic Membranes

(2011) G. Beck et al.   JOURNAL OF NEUROSCIENCE

2-hydroxylated sphingomyelin profiles in cells from patients with mutated fatty acid 2-hydroxylase

(2011) Phyllis Dan et al.   Lipids in Health and Disease

Metabolic consequences of mitochondrial coenzyme A deficiency in patients with PANK2 mutations

(2011) Valerio Leoni et al.   MOLECULAR GENETICS AND METABOLISM

Sodium Leak Channels in Neuronal Excitability and Rhythmic Behaviors

(2011) Dejian Ren   NEURON

Genetic Ablation of PLA2G6 in Mice Leads to Cerebellar Atrophy Characterized by Purkinje Cell Loss and Glial Cell Activation

(2011) Zhengshan Zhao et al.   PLoS One

Three faces of the same gene: FA2H links neurodegeneration with brain iron accumulation, leukodystrophies, and hereditary spastic paraplegias

(2010) Susanne A. Schneider et al.   ANNALS OF NEUROLOGY

Defective FA2H leads to a novel form of neurodegeneration with brain iron accumulation (NBIA)

(2010) Michael C. Kruer et al.   ANNALS OF NEUROLOGY

Dystonia in neurodegeneration with brain iron accumulation: outcome of bilateral pallidal stimulation

(2010) L. Timmermann et al.   BRAIN

Protection of Pancreatic β-Cells by Group VIA Phospholipase A2-Mediated Repair of Mitochondrial Membrane Peroxidation

(2010) Zhengshan Zhao et al.   ENDOCRINOLOGY

Mutation of FA2H underlies a complicated form of hereditary spastic paraplegia (SPG35)

(2010) Katherine J. Dick et al.   HUMAN MUTATION

Fatty Acid 2-Hydroxylase Mediates Diffusional Mobility of Raft-associated Lipids, GLUT4 Level, and Lipogenesis in 3T3-L1 Adipocytes

(2010) Lin Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Imaging decreased brain docosahexaenoic acid metabolism and signaling in iPLA2β (VIA)-deficient mice

(2010) Mireille Basselin et al.   JOURNAL OF LIPID RESEARCH

Lipidomics reveals a remarkable diversity of lipids in human plasma,

(2010) Oswald Quehenberger et al.   JOURNAL OF LIPID RESEARCH

Cystamine metabolism and brain transport properties: clinical implications for neurodegenerative diseases

(2010) Mélanie Bousquet et al.   JOURNAL OF NEUROCHEMISTRY

The relevance of iron in the pathogenesis of Parkinson’s disease

(2010) Jeswinder Sian-Hülsmann et al.   JOURNAL OF NEUROCHEMISTRY

Pantethine rescues a Drosophila model for pantothenate kinase-associated neurodegeneration

(2010) A. Rana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Establishment of an Improved Mouse Model for Infantile Neuroaxonal Dystrophy That Shows Early Disease Onset and Bears a Point Mutation in Pla2g6

(2009) Haruka Wada et al.   AMERICAN JOURNAL OF PATHOLOGY

Fatty acid 2-Hydroxylation in mammalian sphingolipid biology

(2009) Hiroko Hama   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Cytochrome c/cardiolipin relations in mitochondria: a kiss of death

(2009) Valerian E. Kagan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Fatty acid 2-hydroxylase regulates cAMP-induced cell cycle exit in D6P2T Schwannoma cells

(2009) Nathan L. Alderson et al.   JOURNAL OF LIPID RESEARCH

Working towards an exegesis for lipids in biology

(2009) H Alex Brown et al.   Nature Chemical Biology

Mutations in the Fatty Acid 2-Hydroxylase Gene Are Associated with Leukodystrophy with Spastic Paraparesis and Dystonia

(2008) Simon Edvardson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Disrupted Membrane Homeostasis and Accumulation of Ubiquitinated Proteins in a Mouse Model of Infantile Neuroaxonal Dystrophy Caused by PLA2G6 Mutations

(2008) Ibrahim Malik et al.   AMERICAN JOURNAL OF PATHOLOGY

Oxidative stress and mitochondrial dysfunction in neurodegeneration; cardiolipin a critical target?

(2008) Simon Pope et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Intracellular phospholipase A2 group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury

(2008) Rubèn López-Vales et al.   BRAIN

Emerging pathways in genetic Parkinson's disease: Potential role of ceramide metabolism in Lewy body disease

(2008) Jose Bras et al.   FEBS Journal

De novo CoA biosynthesis is required to maintain DNA integrity during development of the Drosophila nervous system

(2008) Floris Bosveld et al.   HUMAN MOLECULAR GENETICS

Neuroaxonal Dystrophy Caused by Group VIA Phospholipase A2 Deficiency in Mice: A Model of Human Neurodegenerative Disease

(2008) K. Shinzawa et al.   JOURNAL OF NEUROSCIENCE

Absence of 2-Hydroxylated Sphingolipids Is Compatible with Normal Neural Development But Causes Late-Onset Axon and Myelin Sheath Degeneration

(2008) I. Zoller et al.   JOURNAL OF NEUROSCIENCE

Imaging Neuroinflammation in Alzheimer's Disease with Radiolabeled Arachidonic Acid and PET

(2008) G. Esposito et al.   JOURNAL OF NUCLEAR MEDICINE

Orai, STIM1 and iPLA2β: a view from a different perspective

(2008) Victoria M. Bolotina   JOURNAL OF PHYSIOLOGY-LONDON

Phenotypic spectrum of neurodegeneration associated with mutations in the PLA2G6 gene (PLAN)

(2008) M. A. Kurian et al.   NEUROLOGY

Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2β in pancreatic β-cells and in iPLA2β-null mice

(2007) Shunzhong Bao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM