Article
Microbiology
Hongyu Zhang, Mengying Xia, Bin Zhang, Yue Zhang, Hong Chen, Yalan Deng, Yingming Yang, Lei Lei, Tao Hu
Summary: In this study, it was found that GcrR interacts with VicR to regulate sucrose-selective polysaccharide metabolism in Streptococcus mutans. By constructing different mutant strains and analyzing experimental data, the regulatory mechanism and mode of action of GcrR under sucrose induction were revealed.
ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Microbiology
Joao Felipe Besegato, Priscila Borges Gobbo de Melo, Adilson Cesar Abreu Bernardi, Marina Trevelin Souza, Edgar Dutra Zanotto, Vanderlei Salvador Bagnato, Alessandra Nara de Souza Rastelli
Summary: This study evaluates the combined use of experimental ultrasound, aPDT, and bioactive glasses for the removal, decontamination, and remineralization of dentin caries lesions. The results suggest that the combination of ultrasound, aPDT, and bioactive glasses can be a promising minimally invasive treatment for caries lesions.
Article
Nutrition & Dietetics
Meng Guo, Jianmin Wu, Weilian Hung, Zhe Sun, Wen Zhao, Hanglian Lan, Zhi Zhao, Guna Wuri, Bing Fang, Liang Zhao, Ming Zhang
Summary: This study found that L. paracasei ET-22 has a significant preventive effect on dental caries in mice. It was also found that ET-22 acts by regulating the microbiota of dental plaques and inhibiting biofilm formation.
Article
Dentistry, Oral Surgery & Medicine
Mariele Vertuan, Paula Fontana Machado, Beatriz Martines de Souza, Aline Silva Braga, Ana Carolina Magalhaes
Summary: The experimental solution containing TiF4/NaF and chitosan showed no antimicrobial effect but significantly reduced enamel caries development compared to the control group under this model.
JOURNAL OF DENTISTRY
(2021)
Article
Microbiology
Muna Aqawi, Ronit Vogt Sionov, Ruth Gallily, Michael Friedman, Doron Steinberg
Summary: The study demonstrated that Cannabigerol (CBG) can effectively prevent the formation of Streptococcus mutans biofilms, reduce biofilm thickness and metabolic activity, and alter the surface roughness of the biofilms. CBG also decreased the expression of genes related to S. mutans biofilm formation, indicating its potential as a preventive treatment for dental caries.
Review
Biochemistry & Molecular Biology
Leena Ibraheem Bin-Jardan, Dalal Ibrahim Almadani, Leen Saleh Almutairi, Hadi A. Almoabid, Mohammed A. Alessa, Khalid S. Almulhim, Rasha N. AlSheikh, Yousif A. Al-Dulaijan, Maria S. Ibrahim, Afnan O. Al-Zain, Abdulrahman A. Balhaddad
Summary: Secondary caries, a major cause of resin-based dental restoration failure, occurs at the interface between an existing restoration and the restored tooth surface due to an imbalance between demineralization and remineralization. Incorporating bioactive compounds into resin-based materials, such as nano-sized amorphous calcium phosphate (NACP), calcium fluoride (CaF2), and bioactive glass (BAG), has shown promising results in preventing bacterial biofilm attachment and promoting remineralization. The effectiveness of these compounds depends on their structure, amount, and intended application. To enhance remineralization outcomes and antibacterial action, inorganic remineralizing compounds are often combined with other bioactive agents, such as quaternary ammonium compounds (QACs). However, more clinical testing is needed to validate the performance of these compounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biophysics
Wenjing Guo, Yang Li, Siyuan Wang, Yueying Wang, Chenhui Li, Yangye Jin, Yuanyuan Li, Xu Chen, Wenjun Miao
Summary: In this study, a novel photodynamic nano hydroxyapatite (nHAP) named Ce6 @QCS/nHAP was developed, which exhibited good biocompatibility and potent photodynamic activity. The Ce6 @QCS/nHAP effectively associated with cariogenic Streptococcus mutans (S. mutans) and showed a significant antibacterial effect through photodynamic killing and physical inactivation. The nanosystem also demonstrated excellent biofilm penetration capacity and effectively eradicated dental plaque.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Tahreem Tanweer, Nosheen Fatima Rana, Iqra Saleem, Iqra Shafique, Sultan M. Alshahrani, Hanadi A. Almukhlifi, Amenah S. Alotaibi, Sohad Abdulkaleg Alshareef, Farid Menaa
Summary: This study aimed to enhance the antibacterial potential of resin composite by using Magnesium-doped Zinc oxide (Mg-doped ZnO) nanoparticles (NPs) and test their effectiveness in a diabetes model. The results showed that composites with 1% Mg-doped ZnO had significantly improved antibacterial properties, without affecting the mechanical properties and biocompatibility. Moreover, Mg-doped ZnO composites prevented secondary caries formation in diabetic patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Marcin Magacz, Sergio Alatorre-Santamaria, Karolina Kedziora, Kacper Klasa, Pawel Mamica, Wiktoria Pepasinska, Magdalena Lebiecka, Dorota Koscielniak, Elzbieta Pamula, Wirginia Krzysciak
Summary: The LPO system has potential in preventing dental caries by exhibiting antimicrobial properties. Modifying the enzymatic system using different substrates showed varying effects on biofilm growth and lactate synthesis. The LPO-iodide system had the strongest inhibitory effect on biofilm growth, while the LPO-selenocyanate system showed a moderate inhibitory effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Emerson Tavares de Sousa, Aline Tavares Lima-Holanda, Luciana Solera Sales, Marines Nobre-dos-Santos
Summary: The study found that exposure to starch and sucrose (isolated or combined) led to a decrease in CA VI activity in children with early childhood caries in saliva. However, the combination of starch and sucrose did not modify CA VI activity in the biofilm of ECC children.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Microbiology
Nan Liu, Xin Li, Maofeng Wang, Fengyu Zhang, Chuandong Wang, Kundi Zhang, Hongwei Wang, Sujuan Xu, Wei Hu, Lichuan Gu
Summary: Billions of people suffer from dental caries annually due to the resistance of cariogenic bacteria, particularly Streptococcus mutans, which form biofilms that are highly resistant to antimicrobial treatments. A truncated form of the enzyme DexA, known as DexA70, has been found to prevent and disassemble S. mutans biofilms effectively, enhancing their sensitivity to antimicrobial agents and lysozyme, thus offering great potential in combating biofilm-related dental caries.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Infectious Diseases
Aparna Vijayakumar, Hema Bhagavathi Sarveswari, Sahana Vasudevan, Karthi Shanmugam, Adline Princy Solomon, Prasanna Neelakantan
Summary: Baicalein significantly reduced caries-related virulence in Streptococcus mutans by inhibiting biofilm formation and other key phenotypes. It had a greater effect on S. mutans than commensal bacteria. Mechanistic studies showed downregulation of genes related to biofilm formation, surface attachment, quorum sensing, acid production, and competence. Additionally, baicalein showed potential translational value by synergistically interacting with fluoride against S. mutans biofilms.
Article
Biochemistry & Molecular Biology
Hong Chen, Sihong Xie, Jing Gao, Liwen He, Wenping Luo, Yunhao Tang, Michael D. Weir, Thomas W. Oates, Hockin H. K. Xu, Deqin Yang
Summary: This study investigated the effects of using flavonoids to inhibit Streptococcus mutans, Candida albicans, and dual-species biofilms, and to protect enamel hardness in a biofilm-based caries model for the first time. Baicalein showed promising results in reducing biofilm formation and protecting enamel hardness in the model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jingheng Liang, Yan Zhou, Guihua Tang, Ruixue Wu, Huancai Lin
Summary: This study found that the cell-free supernatant of Lactobacillus plantarum has a strong antibiofilm effect on Streptococcus mutans, and the main antibiofilm substance is a mixture of lactic acid and valine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Mariele Vertuan, Julia Franca da Silva, Aline Silva Braga, Beatriz Martines de Souza, Ana Carolina Magalhaes
Summary: The study evaluated the effects of TiF4/NaF and chitosan on bacterial species of microcosm biofilm and dentin demineralization. The results showed that the experimental solution had no antimicrobial effect but was able to reduce dentin caries development under the model. Overall, TiF4/NaF plus chitosan solution showed promising results for reducing mineral loss and preventing caries.
ARCHIVES OF ORAL BIOLOGY
(2021)