Article
Chemistry, Applied
Hideaki Tokuyama, Ryo Aoyagi, Kazuto Fujita, Yuki Maekawa, Shohei Riya
Summary: Ethanol fermentation using a hybrid system containing free and immobilized yeast cells in macroporous hydrogel scaffold was studied, with immobilization achieved through NIPA and MTGA hydrogels. The hybrid system showed higher ethanol productivity than the control system, with macroporous hydrogel allowing stable growth of immobilized yeast cells. In steady-state fermentation, the hybrid system had significantly higher cell densities and ethanol productivities compared to the control system.
REACTIVE & FUNCTIONAL POLYMERS
(2021)
Article
Food Science & Technology
Arslan Ahmad, Summar A. Naqvi, Muhammad J. Jaskani, Muhammad Waseem, Ehsan Ali, Iqrar A. Khan, Muhammad Faisal Manzoor, Azhari Siddeeg, Rana Muhammad Aadil
Summary: Dates are rich in sugars and can be used for bioethanol production through anaerobic fermentation. Researchers have found that date palm waste in Pakistan, the largest agricultural waste, can be a cost-effective source for bioethanol production. By fermenting the waste with Saccharomyces cerevisiae, researchers have successfully produced 15% ethanol with the presence of glucose, fructose, and sucrose in the date waste, showing the potential for industrial ethanol production. Additionally, the proximate analysis of date fruit revealed various nutrients suitable for microbial growth for ethanol production.
FOOD SCIENCE & NUTRITION
(2021)
Article
Energy & Fuels
Hamidreza Shafaei, Ahmad Taghizadeh-Alisaraei, Ahmad Abbaszadeh-Mayvan, Aliasghar Tatari
Summary: In this study, the use of giant reed as a substrate for bioethanol production was investigated. The effects of sodium hydroxide concentration, temperature, and pretreatment duration on bioethanol concentration and yield were studied and optimized using response surface methodology. The results showed significant effects of the variables on bioethanol production, and the optimal conditions for bioethanol production were determined. These findings highlight the potential of giant reed biomass as a suitable raw material for bioethanol production.
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Article
Energy & Fuels
Sabah Abada, Latifa Tebbouche, Rahma Bessah, Madina Kechkar, Abdessalam Berrached, Meryem Saber, Majda Aziza, Abdeltif Amrane
Summary: Potato waste, a major concern in the potato processing industry, can be a valuable resource for biofuel production due to its high organic content. This study successfully converted the waste into bioethanol through chemical pretreatment and yeast fermentation, achieving a high yield of bioethanol. The results indicate the great potential of potato starch for bioethanol production.
BIOMASS CONVERSION AND BIOREFINERY
(2022)
Article
Biotechnology & Applied Microbiology
Jana Fees, Jonas J. Christ, Sabine Willbold, Lars M. Blank
Summary: A biotechnological process using Saccharomyces cerevisiae to upgrade phosphate-containing wastewater into pure sodium polyphosphate was developed in this study. The quality of polyphosphate was independent of the composition of the wash water and can be reused in various applications, contributing to the sustainable utilization of phosphate and reducing the need for phosphate rock.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
Article
Biotechnology & Applied Microbiology
Thais O. Secches, Carla F. Santos Viera, Thaynara K. E. Pereira, Victor T. O. Santos, Jade Ribeirodos Santos, Goncalo A. G. Pereira, Marcelo F. Carazzolle
Summary: This article introduces the combination of sugarcane and corn ethanol production methods in Brazil, and analyzes the performance of Brazilian industrial strains in corn ethanol production. The results show that certain strains demonstrate good tolerance and productivity under high temperature and high solids concentration conditions.
BIORESOURCES AND BIOPROCESSING
(2022)
Article
Microbiology
Agnese Kokina, Kristel Tanilas, Zane Ozolina, Karlis Pleiko, Karlis Shvirksts, Ilze Vamza, Janis Liepins
Summary: Purine starvation affects cellular morphology, metabolism, and transcriptome in budding yeast, leading to cell cycle arrest, trehalose accumulation, and tolerance to environmental stresses. It also results in significant downregulation of ribosomal biosynthesis genes. The expression of new proteins during purine starvation is critical for cells to attain stress tolerance phenotype.
Article
Food Science & Technology
Lin Lin, Rubing Du, Yuqiao Wang, Qun Wu, Yan Xu
Summary: This study revealed the cross-feeding of amino acids between Saccharomyces cerevisiae and two lactobacilli species in Chinese liquor fermentation. A predictive model was established to regulate the growth of lactobacilli species.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2022)
Article
Microbiology
Gabriela Muller, Victor R. de Godoy, Marcelo G. Dario, Eduarda H. Duval, Sergio L. Alves-Jr, Augusto Bucker, Carlos A. Rosa, Barbara Dunn, Gavin Sherlock, Boris U. Stambuk
Summary: By studying the genetic characteristics of different industrial yeast strains used in Brazil for fuel ethanol and cachaca production, it was found that invertase activity may not limit sucrose fermentation. A modified industrial yeast strain with altered sucrose metabolism was able to consume the disaccharide directly and achieve higher ethanol production.
Article
Environmental Sciences
Niyam Dave, Thivaharan Varadavenkatesan, Raja Selvaraj, Ramesh Vinayagam
Summary: The study investigated the predictive ability of an integrated artificial neural network with genetic algorithm for bioethanol production from marine macroalgae. The results showed that the developed model can effectively predict the effects of fermentative parameters on bioethanol production and achieve a maximum bioethanol yield close to the predicted value in experiments.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Sathish Kumar Rajamanickam, Sureshkumar Kasinathan
Summary: This study successfully produced renewable biofuel from Manilkara zapota fruit and seed oil, with bioethanol and ethyl ester displaying potential as substitutes for fossil diesel and gasoline. Optimal production parameters were determined through experimentation, highlighting the promise of these biofuels as sustainable alternatives.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Olga N. Tsolcha, Vasiliki Patrinou, Christina N. Economou, Marianna Dourou, George Aggelis, Athanasia G. Tekerlekopoulou
Summary: Bioethanol production potential from different biomasses derived from a cyanobacteria-based microbial consortium grown on chemical medium and wastewaters was examined in this study, with the best results obtained using sulfuric acid 2.5 N for acid hydrolysis. After optimizing sugar release, alcoholic fermentation using Saccharomyces cerevisiae was performed, achieving up to 85.9% of the theoretical ethanol yield when a raisin residue extract was added to the biomass broth.
Article
Biochemistry & Molecular Biology
Juergen J. Heinisch, Andrea Murra, Kai Juergens, Hans-Peter Schmitz
Summary: Hanseniaspora uvarum is a yeast that dominates the early stages of wine fermentation and has a significant impact on aroma compound production. In this study, researchers developed a comprehensive toolset for genetic manipulation of this yeast, including the construction of self-replicating cloning vectors and the creation of deletion markers for gene deletion strategies. They also established dominant markers for selection and developed recyclable deletion cassettes. Additionally, a chemical transformation procedure using freeze-competent cells was reported. These techniques and constructs provide efficient and targeted methods for manipulating H. uvarum.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mrinal Sharma, Prranshu Yadav, Ankita Doshi, Hemang D. Brahmbhatt, C. Ratna Prabha
Summary: The study examined the effects of six double mutants derived from the ubiquitin mutant UbEP42 on cell functions, finding that the double mutation L50P-I61T had the most detrimental impact. Overall, these double mutations made cells more sensitive, and the negative effects under certain conditions could be compensated for by each other.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biotechnology & Applied Microbiology
Letitia Minnaar, Riaan den Haan
Summary: This study evaluates the potential of natural and industrial strains of Saccharomyces cerevisiae to secrete cellulases. The results show that natural isolates have better secretion capacities for cellulases under high temperature and acetic acid conditions, and exhibit tolerance to various fermentation-associated stresses. These isolates could serve as promising chassis organisms for consolidated bioprocessing bioethanol production.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Immunology
Carolyn Saylor Hawk, Carolina Coelho, Diane Sthefany Lima de Oliveira, Verenice Paredes, Patricia Albuquerque, Anamelia Lorenzetti Bocca, Ananesia Correa dos Santos, Victoria Rusakova, Heather Holemon, Ildinete Silva-Pereira, Maria Sueli Soares Felipe, Hideo Yagita, Andre Moraes Nicola, Arturo Casadevall
JOURNAL OF IMMUNOLOGY
(2019)
Article
Microbiology
Tiago Benoliel, Marciano Regis Rubini, Carolina de Souza Baptistello, Christiane Ribeiro Janner, Vanessa Rodrigues Vieira, Fernando Araripe Torres, Adrian Walmsley, Lidia Maria Pepe de Moraes
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2020)
Article
Infectious Diseases
Patricia Albuquerque, Andre Moraes Nicola, Diogo Almeida Gomes Magnabosco, Lorena da Silveira Derengowski, Luana Soares Crisostomo, Luciano Costa Gomes Xavier, Stefania de Oliveira Frazao, Fernanda Guilhelmelli, Marco Antonio de Oliveira, Jhones do Nascimento Dias, Fabian Andres Hurtado, Marcus de Melo Teixeira, Allan Jefferson Guimaraes, Hugo Costa Paes, Eduardo Bagagli, Maria Sueli Soares Felipe, Arturo Casadevall, Ildinete Silva-Pereira
PLOS NEGLECTED TROPICAL DISEASES
(2019)
Article
Multidisciplinary Sciences
Luiza Cesca Piva, Janice Lisboa De Marco, Lidia Maria Pepe de Moraes, Viviane Castelo Branco Reis, Fernando Araripe Goncalves Torres
Article
Microbiology
Stefania de Oliveira Frazao, Herdson Renney de Sousa, Lenise Goncalves da Silva, Jessica dos Santos Folha, Kaio Cesar de Melo Gorgonha, Getulio Pereira de Oliveira Jr, Maria Sueli Soares Felipe, Ildinete Silva-Pereira, Arturo Casadevall, Andre Moraes Nicola, Patricia Albuquerque
Article
Microbiology
Agata Nogueira D'Aurea Moura, Diane Sthefany Lima de Oliveira, Verenice Paredes, Leticia Barboza Rocha, Fabiana Freire Mende de Oliveira, Gustavo Meirell Lessa, Juan Fernando Riasco-Palacios, Arturo Casadevall, Patricia Albuquerque, Maria Sueli Soares Felipe, Roxane Maria Fontes Piazza, Andre Moraes Nicola
Article
Microbiology
Calliandra M. de-Souza-Silva, Fabian Andres Hurtado, Aldo Henrique Tavares, Getulio P. de Oliveira Jr, Taina Raiol, Christiane Nishibe, Daniel Paiva Agustinho, Nalvo Franco Almeida, Maria Emilia Machado Telles Walter, Andre Moraes Nicola, Anamelia Lorenzetti Bocca, Patricia Albuquerque, Ildinete Silva-Pereira
Article
Oncology
Onita Bhattasali, Fernando A. Torres, Hyung K. Kang, Lester D. R. Thompson, Iman A. Abdalla, Michael P. McNicoll, Alice Lin, Joan J. Ryoo, Jergin Chen, Shawn Iganej
Summary: This study analyzed the prognostic impact of retropharyngeal lymphadenopathy (RPL) in stage I node-positive HPV-associated oropharyngeal squamous cell carcinoma (OPSCC). RPL was associated with increased locoregional recurrence (LRR) and distant metastasis (DM), as well as inferior progression-free survival (PFS) and overall survival (OS). The negative impact of RPL on outcomes was less pronounced in patients who received high-dose cisplatin (HDC). Incorporation of RPL into future disease staging may help optimize risk-stratification and treatment decisions.
Article
Immunology
Diane Sthefany Lima de Oliveira, Verenice Paredes, Adrielle Veloso Caixeta, Nicole Moreira Henriques, Maggie P. Wear, Patricia Albuquerque, Maria Sueli Soares Felipe, Arturo Casadevall, Andre Moraes Nicola
Summary: Decades of studies on antibody structure have shown that while the V region binds antigens, the C region can affect affinity and specificity. This study identified the molecular basis of how the constant region impacts antigen binding, and how engineering antibodies with different constant regions can result in different binding patterns.
Article
Multidisciplinary Sciences
Rodrigo B. Aires, Alexandre A. de S. M. Soares, Ana Paula M. Gomides, Andre M. Nicola, Andrea Teixeira-Carvalho, Dayde Lane M. da Silva, Eliana T. de Gois, Flavia D. Xavier, Francielle P. Martins, Gabriela P. J. Santos, Heidi Luise Schulte, Isabelle S. Luz, Laila S. Espindola, Laurence R. do Amaral, Liza F. Felicori, Luciana A. Naves, Maira R. M. de Carvalho, Matheus de S. Gomes, Otavio T. Nobrega, Patricia Albuquerque, Wagner Fontes, Ciro M. Gomes, Patricia S. Kurizky, Cleandro P. Albuquerque, Olindo A. Martins-Filho, Licia Maria H. da Mota
Summary: Thromboelastometry parameters are useful in differentiating the coagulation profile between severe and non-severe COVID-19 patients, which is important for therapeutic intervention.
Article
Medicine, General & Internal
Pere Domingo, Maria Gracia Mateo, Joan Villarroya, Ruben Cereijo, Ferran Torres, Joan C. Domingo, Laura Campderros, Jose M. Gallego-Escuredo, Maria del Mar Gutierrez, Isabel Mur, Noemi Corbacho, Francesc Vidal, Francesc Villarroya, Marta Giralt
Summary: People living with HIV, especially those on cART, have increased levels of GDF15, which are associated with dyslipidemia, insulin resistance, metabolic syndrome, HALS, and inflammation. However, GDF15 is not correlated with cardiovascular risk after adjusting for age.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Andrea B. Troxel, Eva Petkova, Keith Goldfeld, Mengling Liu, Thaddeus Tarpey, Yinxiang Wu, Danni Wu, Anup Agarwal, Cristina Avendano-Sola, Emma Bainbridge, Katherine J. Bar, Timothy Devos, Rafael F. Duarte, Arvind Gharbharan, Priscilla Y. Hsue, Gunjan Kumar, Annie F. Luetkemeyer, Geert Meyfroidt, Andre M. Nicola, Aparna Mukherjee, Mila B. Ortigoza, Liise-anne Pirofski, Bart J. A. Rijnders, Casper Rokx, Arantxa Sancho-Lopez, Pamela Shaw, Pablo Tebas, Hyun-Ah Yoon, Corita Grudzen, Judith Hochman, Elliott M. Antman
Summary: This meta-analysis found no association of CCP with better clinical outcomes for the typical patient, and it provides a model for conducting real-time individual patient data pooling and meta-analysis during a pandemic.
Article
Medicine, General & Internal
Hyung Park, Thaddeus Tarpey, Mengling Liu, Keith Goldfeld, Yinxiang Wu, Danni Wu, Yi Li, Jinchun Zhang, Dipyaman Ganguly, Yogiraj Ray, Shekhar Ranjan Paul, Prasun Bhattacharya, Artur Belov, Yin Huang, Carlos Villa, Richard Forshee, Nicole C. Verdun, Hyun Ah Yoon, Anup Agarwal, Ventura Alejandro Simonovich, Paula Scibona, Leandro Burgos Pratx, Waldo Belloso, Cristina Avendano-Sola, Katharine J. Bar, Rafael F. Duarte, Priscilla Y. Hsue, Anne F. Luetkemeyer, Geert Meyfroidt, Andre M. Nicola, Aparna Mukherjee, Mila B. Ortigoza, Liise-anne Pirofski, Bart J. A. Rijnders, Andrea Troxel, Elliott M. Antman, Eva Petkova
Summary: This study aimed to develop an index for predicting the relative treatment benefit from COVID-19 convalescent plasma (CCP) compared to treatment without CCP. The study found that CCP treatment may be most effective for patients with preexisting conditions and those in the early stages of COVID-19.
Article
Health Care Sciences & Services
Patricia Kurizky, Otavio Nobrega, Alexandre Anderson De Sousa Munhoz Soares, Rodrigo Barbosa Aires, Cleandro Pires De Albuquerque, Andre Moraes Nicola, Patricia Albuquerque, Andrea Teixeira-Carvalho, Luciana Ansaneli Naves, Wagner Fontes, Isabelle Souza Luz, Liza Felicori, Ana Paulo Monteiro Gomides, Dayde Lane Mendonca-Silva, Laila Salmen Espindola, Olindo Assis Martins-Filho, Sheila Maria Barbosa de Lima, Licia Maria Henrique Mota, Ciro Martins Gomes
Summary: This study aims to compare the effects of excessive cytokine release on the immune system, inflammation, and hemostasis between mild and severe forms of COVID-19. Various parameters will be analyzed, blood samples collected, and more clinical information provided for future studies.
JMIR RESEARCH PROTOCOLS
(2021)
Meeting Abstract
Clinical Neurology
Hyung K. Kang, Raffi Ourfalian, Emilie T. Nguyen, Fernando A. Torres, Lei T. Feng, Navdeep S. Sangha