Article
Environmental Sciences
Qingchao Shi, Zhengyong Wen, Jun Wang, Peng Hu, Yuanchao Zou, Shuqi Wang, Chuanjie Qin
Summary: This study found that dietary supplementation of PQQ improved the growth performance, serum biochemical parameters, antioxidant status, and growth-related gene expressions in juvenile yellow catfish, with the optimal level of 4.92 mg/kg.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Multidisciplinary Sciences
Samiksha Joshi, Saurabh Gangola, Vandana Jaggi, Manvika Sahgal
Summary: In this study, functionally active phosphate solubilizing bacteria (PSB) associated with Shisham plant were screened and 18 bacteria capable of solubilizing tri-calcium phosphate were identified. All 18 isolates showed zinc solubilization, indole acetic acid (IAA), siderophore, and hydrogen cyanide (HCN) production. Phylogenetic analysis identified the bacterial strains as belonging to Pseudomonas, Klebsiella, Streptomyces, Pantoea, Kitasatospora, Micrococcus, and Staphylococcus genera. One isolate, L4 from Lacchiwala region, showed the highest efficiency in phosphate solubilization. The selected PSB strains have potential applications in plant growth promotion, disease suppression, antioxidant activity, and yield enhancement.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Applied
Chikara Kato, Isabella Supardi Parida, Satoshi Maeda, Tsuyoshi Mikekado, Shunji Kato, Susumu Takekoshi, Kiyotaka Nakagawa
Summary: This study investigated the cellular uptake of PQQ using instrumental analysis and found that most PQQ was taken up by cells in its unchanged form, while some reacted with amino acids and was taken up as derivatives. These findings suggest that PQQ derivatives may contribute to the physiological effects of PQQ.
JOURNAL OF OLEO SCIENCE
(2022)
Article
Medicine, Research & Experimental
Xuan Wu, Xuan Zhou, Shuo Liang, Xingyu Zhu, Zhan Dong
Summary: The study showed that PQQ can prevent and protect against delayed bone fracture healing induced by OVX by inhibiting oxidative stress, promoting osteoblastic bone formation, and inhibiting osteoclastic bone resorption. This provides insight into the mechanism of PQQ supplementation in promoting fracture healing and supports its potential clinical application in bone fracture treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Chemistry, Multidisciplinary
Suman Chakrabarty, Evan O. Romero, Joshua B. Pyser, Jessica A. Yazarians, Alison R. H. Narayan
Summary: The total synthesis of structurally complex natural products remains an exciting area of research, with recent advancements in biocatalysis allowing for the application of enzymes in constructing complex molecules. The utilization of enzymes alongside small molecule-based approaches has enabled concise chemoenzymatic routes to natural products, demonstrating the potential for selective oxidation reactions and late-stage diversification of complex scaffolds.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Chemistry, Medicinal
Alberto Boretti
Summary: The spike protein-induced heart inflammation from COVID-19 infection or mRNA vaccines can possibly be reduced by supplementation with pyrroloquinoline quinone (PQQ), although there is currently no evidence supporting this claim.
NATURAL PRODUCT COMMUNICATIONS
(2022)
Article
Food Science & Technology
Hui Gao, Jiafeng Niu, Hua Yang, Zhaoxin Lu, Libang Zhou, Fanqiang Meng, Fengxia Lu, Meirong Chen
Summary: In this study, the Devosia strain A6-243 was identified as a bacteria capable of transforming deoxynivalenol (DON) with the assistance of pyrroloquinoline quinone (PQQ). The strain was able to completely transform 100 μg/mL of DON within 48 hours and produce non-toxic 3-epi-DON. It was also found that the strain could degrade 3-keto-DON and remove DON from contaminated wheat. These findings provide valuable references for the screening of microorganisms with DON transformation abilities and the development of detoxification enzymes for mycotoxins in grain.
Article
Chemistry, Organic
Haochen Zou, Xin Xia, Qiushuang Xu, Haoxin Wang, Yuemao Shen, Yaoyao Li
Summary: The structural diversity of PoTeMs is mainly generated by cyclases and cytochrome P450s. In Saccharopolyspora hirsuta, six new cytotoxic PoTeMs, including the first examples of oxidized one-ring PoTeMs, were discovered through combinatorial reassembling and heterologous expression.
Review
Biochemistry & Molecular Biology
Robert A. Hill, Andrew Sutherland
Summary: This paper presents a personal selection of 32 recent papers covering various aspects of current developments in bioorganic chemistry and novel natural products, including eurysoloid A from Eurysolen gracilis.
NATURAL PRODUCT REPORTS
(2021)
Article
Agriculture, Dairy & Animal Science
Dongxu Ming, Caiyun Huang, Wenhui Wang, Zijie Wang, Chenyu Shi, Xindi Yin, Linlin Sun, Youjun Gao, Fenglai Wang
Summary: The supplementation of weaned pigs with PQQ·Na-2 post-weaning can improve growth performance, reduce diarrhea incidence, and enhance antioxidant status without harmful effects on the pigs.
Article
Biology
Saad Alkahtani, Saud Alarifi, Abdullah A. Alkahtane, Gadah Albasher, Mohammed AL-Zharani, Norah M. Alhoshani, Norah S. AL-Johani, Nada H. Aljarba, Md Saquib Hasnain
Summary: Hyperglycemia, a common metabolic disorder in diabetes, causes oxidative stress, which can be alleviated by antioxidants like pyrroloquinoline quinine (PQQ). PQQ inhibits AGEs formation and reduces oxidative damage during hyperglycemia, showing potential as a therapeutic antioxidant.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Alexa M. Schmitz, Brooke Pian, Sean Medin, Matthew C. Reid, Mingming Wu, Esteban Gazel, Buz Barstow
Summary: Researchers developed a whole-genome knockout collection of mutants for Gluconobacter oxydans, identifying genes influencing the efficacy of rare earth element bioleaching. Disruption of genes related to Pyrroloquinoline Quinone synthesis and glucose dehydrogenase significantly reduces bioleaching, while disruption of phosphate-specific transport system genes enhances bioleaching efficiency. This study offers a roadmap for engineering G. oxydans' genome to improve bioleaching efficiency.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Jie Li, Jing Zhang, Qi Xue, Boyang Liu, Ran Qin, Yiping Li, Yue Qiu, Rong Wang, David Goltzman, Dengshun Miao, Renlei Yang
Summary: Age-related osteoporosis is associated with increased oxidative stress and cellular senescence. Pyrroloquinoline quinone (PQQ) is a water-soluble vitamin-like compound that has strong antioxidant capacity. This study found that dietary PQQ supplementation can prevent age-related osteoporosis in mice by inhibiting osteoclastic bone resorption and stimulating osteoblastic bone formation. PQQ appears to bind to MCM3 and reduces its ubiquitination-mediated degradation, thereby activating Nrf2-antioxidant response element signaling and inhibiting bone resorption. The study reveals the underlying mechanism of PQQ's strong antioxidant capacity and presents PQQ as a potential agent for clinical prevention and treatment of natural aging-induced osteoporosis.
Article
Biotechnology & Applied Microbiology
Changle Zhao, Yinping Wan, Xiaojie Cao, Huili Zhang, Xin Bao
Summary: The Methylobacterium CLZ strain, isolated from soil contaminated with chemical wastewater, showed the smallest genome size and lowest number of proteins among five Methylobacterium strains, making it an ideal model for genetic engineering and biological process studies. The discovery of the pqqL gene in the Methylobacterium CLZ strain, which is crucial for PQQ synthesis but absent in other strains, was surprising. Random mutagenesis resulted in the generation of the NI91 strain with significantly increased PQQ yield, with the upregulation of the mxaJ gene identified as a potential factor for the high production of PQQ.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2021)
Article
Fisheries
Chao-Qun Li, Yong-Jun Cao, Long-Fei Cui, Chun-Yang Zhang, Bei-Li Zhang, Qin-Yuan Ma
Summary: This study investigated the effects of dietary PQQ on growth, intestinal health, and liver oxidative stress in zebrafish. The results showed that PQQ improved growth performance and intestinal health, and alleviated the oxidative stress induced by TDCPP in the liver of zebrafish.