Article
Chemistry, Inorganic & Nuclear
Pravinkumar Selvam, Sourav De, Priyankar Paira, S. K. Ashok Kumar, Selva R. Kumar, Anbalagan Moorthy, Arjita Ghosh, Yung-Chih Kuo, Subhasis Banerjee, Shantha Kumar Jenifer
Summary: In recent years, Ru(II) complexes have gained high importance in medicinal chemistry due to their significant anti-cancer activities, which are directly related to their DNA binding ability. This report discusses the chemistry and cytotoxicity of two new Ru(II) complexes and analyzes their structural and photophysical properties, as well as their binding abilities with DNA and BSA. The results show that these Ru(II) complexes exhibit superior cytotoxicity to cisplatin against cancer cells and have minimal impact on normal cells.
DALTON TRANSACTIONS
(2022)
Article
Pharmacology & Pharmacy
Klaudia Cseh, Heiko Geisler, Kristina Stanojkovska, Julia Westermayr, Philipp Brunmayr, Dominik Wenisch, Natalie Gajic, Michaela Hejl, Martin Schaier, Gunda Koellensperger, Michael A. A. Jakupec, Philipp Marquetand, Wolfgang Kandioller
Summary: The main purpose of this study was to synthesize a new set of naphthoquinone-based ruthenium(II) arene complexes and understand their mode of action. The chemical structures and biological activities of these compounds were examined, and a positive correlation was found between cytotoxicity, lipophilicity, and cellular accumulation. This study provides important insights into the effects of these arene complexes.
Article
Biochemistry & Molecular Biology
Marta G. Fuster, Imane Moulefera, Mercedes G. Montalban, Jose Perez, Gloria Villora, Gabriel Garcia
Summary: In this study, four compounds were synthesized by reacting [Ru(p-cymene)(mu-Cl)Cl](2) complex with different ligands. The compounds were characterized and their structures were analyzed. MTT assay was performed to evaluate the cytotoxicity of the complexes on cervical cancer cells, and the results showed low cytotoxicity.
Article
Chemistry, Inorganic & Nuclear
Oscar A. Lenis-Rojas, M. Paula Robalo, Ana Isabel Tomaz, Alexandra R. Fernandes, Catarina Roma-Rodrigues, Ricardo G. Teixeira, Fernanda Marques, Monica Folgueira, Julian Yanez, Anabel Alba Gonzalez, Martin Salamini-Montemurri, Dawrin Pech-Puch, Digna Vazquez-Garcia, Margarita Lopez Torres, Alberto Fernandez, Jesus J. Fernandez
Summary: Ruthenium(II) complexes, considered as attractive alternatives to platinum-based drugs, demonstrated significant cytotoxicity against breast cancer cells with lower toxicity towards normal cells, possibly through induction of reactive oxygen species and interaction with protein targets.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Binoy Kar, Priyankar Paira
Summary: We have developed a synthetic protocol for selective cancer therapy using half-sandwich Ru(II)-p-cymene dipyrido[3,2-a:2',3'-clphenazine analogues. Under irradiation, the cytotoxicity of all complexes is doubled and they exhibit significant selectivity against cancer cells. One complex (RuL4) shows the best phototoxicity. These complexes also have strong binding capacity to serum albumin and DNA, and display good stability.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Amalyn Nain-Perez, Luiz C. A. Barbosa, Maria H. Araujo, Joao P. A. Martins, Jacqueline A. Takahashi, Geane Oliveira, Renata Diniz, Lucie Heller, Sophie Hoenke, Rene Csuk
Summary: New ruthenium complexes were synthesized with some showing potent anticancer and antimicrobial activities, with the most effective compound acting through apoptosis. Molecular docking studies indicated key amino acid interactions with a protein from S. aureus, in agreement with the inhibitory potential against this bacterium.
Article
Chemistry, Applied
Rais Ahmad Khan, Amal AlFawaz, Nida N. Farshori, Anup Paul, Mohammed H. Jaafar, Ali Alsalme
Summary: Two organometallic ruthenium (II) complexes containing analogs of aminobenzimidazole were synthesized and characterized. Their binding affinity with human serum albumin and cytotoxic potential against cancer cells were evaluated. One of the complexes showed promising cytotoxic properties, indicating its potential as an anticancer therapeutic.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Francesco Caruso, Gottumukkala Subbaraju, Modukuri Ramani, Marzia Gariboldi, Emanuela Marras, Carmen Kloer, Aron Sulovari, Sarjit Kaur, Miriam Rossi
Summary: This study synthesized three [(eta(6)-p-cymene)Ru(L)Cl] neutral complexes and evaluated their antiproliferative activity against lung cancer, colon cancer, and glioblastoma. The results showed that complexation significantly increased the antitumor activity of hispolon derivatives in glioblastoma, and the inhibitory ability towards aldehyde dehydrogenase was determined.
INORGANICA CHIMICA ACTA
(2022)
Article
Chemistry, Inorganic & Nuclear
Rais Ahmad Khan, Seham Suliman Alterary, Ibtisam I. BinSharfan, Huda Alsaeedi, Amal AlFawaz, Mohd. Shahnawaz Khan, Mohammad H. Jaafar, Yanshu Shi, Hadi D. Arman, Ali Alsalme
Summary: In this study, two new p-cymene ruthenium(II) complexes were designed and synthesized, and characterized by spectroscopic techniques and computational studies. The complexes showed good binding affinity towards human serum albumin and exhibited potential cytotoxicity against cancer cells.
INORGANICA CHIMICA ACTA
(2022)
Article
Chemistry, Inorganic & Nuclear
Oscar A. Lenis-Rojas, Rui Cabral, Beatriz Carvalho, Sofia Friaes, Catarina Roma-Rodrigues, Jhonathan A. A. Fernandez, Sabela F. Vila, Laura Sanchez, Clara S. B. Gomes, Alexandra R. Fernandes, Beatriz Royo
Summary: A new series of half-sandwich ruthenium(II) compounds bearing 1,2,3-triazole ligands were synthesized and fully characterized. Compounds 1 and 3 showed good cytotoxic activity against ovarian cancer cells with low toxicity both in vitro and in vivo.
INORGANIC CHEMISTRY
(2021)
Article
Crystallography
Mohd. Muddassir, Abdullah Alarifi, Mohd. Afzal
Summary: A new ruthenium complex with 5-aminosalicylic acid as the ligand was synthesized, characterized, and structurally analyzed. Density functional theory calculations were used to determine important molecular orbital parameters, which were consistent with experimental results. Luminescence analysis showed that the complex is a suitable candidate for photoluminescent material based on its emission properties.
Article
Chemistry, Inorganic & Nuclear
Yu-Feng Wang, Ji-Xia Tang, Zai-Yong Mo, Juan Li, Fu-Pei Liang, Hua-Hong Zou
Summary: In this study, three new cobalt(II) complexes were designed and synthesized, showing strong anti-cancer activity and better inhibitory effects compared to the commonly used drug cisplatin. CoCl and Col could induce cell apoptosis by regulating the expression of autophagy-related proteins.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Ertugrul Gazi Saglam, Senem Akkoc, Yunus Zorlu, Elif Bulat, Aziz Akgun
Summary: In this study, various dithiophosphonato Ni(II) and dithiophosphinato Ni(II) complexes were synthesized and evaluated for their chemical properties and cytotoxic activity against human cell lines. Some of the complexes exhibited significant cytotoxicity, indicating their potential as anticancer agents.
Article
Chemistry, Inorganic & Nuclear
Ivelise Dimbarre Lao Guimaraes, Flavia Marszaukowski, Renan Ribeiro, Sergio Ricardo de Lazaro, Katia Mara de Oliveira, Alzir Azevedo Batista, Patricia Castellen, Ellen Wrobel, Jarem Raul Garcia, Rene T. Boere, Karen Wohnrath
Summary: Neutral Ru(II)-arene complexes with different ligands were synthesized, characterized, and evaluated for cytotoxicity against lung and breast cancer cell lines. The complexes showed varying solubility and cytotoxicity, with one complex displaying high cytotoxicity towards cancer cells but no activity against healthy cells, indicating some degree of selectivity.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Caio Cesar Candido, Henrique Vieira Reis Silva, Bruno Zavan, Marisa Ionta, Marilia Imaculada Frazao Barbosa, Antonio Carlos Doriguetto
Summary: In this study, novel ruthenium(II) complexes with metronidazole as a ligand were synthesized and characterized. The results showed that complexes (1) and (3) exhibited inhibitory effects on the proliferation of MCF-7 cells and induced apoptosis.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Tamara Petrovic, Nevenka Gligorijevic, Ferdinand Belaj, Sandra Arandelovic, Ljiljana E. Mihajlovic-Lalic, Sanja Grguric-Sipka, Jelena Poljarevic
Summary: In this study, three Re(V) complexes were synthesized and characterized, and their cytotoxicity against breast adenocarcinoma and pancreatic adenocarcinoma cells was investigated. One of the complexes, C1, showed dose-dependent cytotoxic potential and enhanced antiproliferative action in combination with an inhibitor of efflux transporter P-glycoprotein. Depletion of glutathione further increased the activity of C1.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Aleksandra Margetic, Stefan Nikolic, Sanja Grguric-Sipka, Miroslava T. Vujcic
Summary: This article investigates the interaction of four arene ruthenium complexes with DNA, revealing their DNA-binding activity, quenching properties, and antimicrobial activity against bacteria.
Article
Pharmacology & Pharmacy
Katarina Komatovic, Ana Matosevic, Natasa Terzic-Jovanovic, Suzana Zunec, Sandra Segan, Mario Zlatovic, Nikola Marakovic, Anita Bosak, Dejan M. Opsenica
Summary: This study investigated the inhibitory activity of 22 structurally distinct 4-aminoquinolines bearing an adamantane moiety on AChE and BChE, and their ability to cross the BBB. Compound 5 and compound 8 showed the best inhibition and potential as structural scaffolds for designing novel central nervous system drugs.
Article
Chemistry, Inorganic & Nuclear
Irina Kuznetcova, Marija Ostojic, Nevenka Gligorijevic, Sandra Arandelovic, Vladimir B. Arion
Summary: A newly synthesized ring system compound, 5,6,7,9-tetrahydro-8H-indolo[3,2-e]benzazocin-8-one, along with its ligands and metal complexes, exhibits significant anticancer activity, surpassing cisplatin.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Boris M. Popovic, Nevenka Gligorijevic, Sandra Arandelovic, Ana Catarina Macedo, Tatjana Juric, Denis Uka, Karolina Mocko-Blazek, Ana Teresa Serra
Summary: This study investigated the cytotoxic profile of twelve choline chloride-based deep eutectic solvents (NADES) on HT-29, Caco-2, MCF-7, and MRC-5 cell lines. The cytotoxic effect was found to depend on the structure of the hydrogen bond donor (HBD). Acidic systems with organic acids as HBDs showed the highest cytotoxic effects, especially on the HT-29 cell line. The cytotoxicity was influenced by the concentration of the NADES system in the cell medium and the chemical constitution of the systems.
Article
Polymer Science
Simonida Lj. Tomic, Jovana S. S. Vukovic, Marija M. Babic M. Radic, Vuk. V. Filipovic, Dubravka P. P. Zivanovic, Milos M. Nikolic, Jasmina Nikodinovic-Runic
Summary: Scaffolding biomaterials that combine different material types can be engineered to create hybrid scaffolds with advantageous properties for biomedical applications. In this research, a combination of Manuka honey and 2-hydroxyethyl methacrylate/gelatin hydrogel scaffolds was developed as a bioactive platform. The hybrid scaffolds showed desirable properties such as high porosity, pH- and temperature-dependent swelling, and good absorption capacity. In vitro studies demonstrated that the scaffolds had controlled degradation rates and exhibited biocompatibility with fibroblast and keratinocyte cell lines, with the highest Manuka honey content resulting in the best biocompatibility. These findings suggest that the synergy of Manuka honey and 2-hydroxyethyl methacrylate/gelatin hydrogel scaffolds holds promise for biomedical applications.
Article
Chemistry, Inorganic & Nuclear
Christopher Wittmann, Tim Gruene, Alexander Prado-Roller, Sandra Arandelovic, Johannes Reynisson, Vladimir B. B. Arion
Summary: A series of latonduine derivatives were synthesized and characterized using spectroscopic and mass spectrometry techniques. The molecular structures of some compounds were confirmed by X-ray diffraction or electron diffraction. The antiproliferative activity of these compounds in different cancer cells and normal cells was evaluated by MTT assays.
Article
Chemistry, Inorganic & Nuclear
Marija V. Dimitrijevic, Ljiljana E. Mihajlovic-Lalic, Sanja Grguric-Sipka, Tatjana M. Mihajlov-Krstev, Dragoljub L. Miladinovic, Jelena M. Poljarevic
Summary: Eleven new and three reported half-sandwich Ru(II) arene complexes were synthesized and evaluated for their in vitro antibacterial and antifungal activity. The structures and purity of the compounds were confirmed using various spectroscopic and analytical techniques. The ligands exhibited better inhibitory effect against Gram-positive bacteria compared to the metal complexes, while all synthesized complexes showed similar activity against Candida albicans.
JOURNAL OF COORDINATION CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Tanja V. Soldatovic, Biljana Smit, Emina M. Mrkalic, Sanja Lj. Matic, Ratomir M. Jelic, Marina Cendic Serafinovic, Nevenka Gligorijevic, Milena Cavic, Sandra Arandelovic, Sanja Grguric-Sipka
Summary: Novel Pt-Zn complexes were synthesized and characterized. The complexes showed strong binding to DNA through groove binding, hydrogen bonds, and hydrophobic or electrostatic interaction. Among them, C2 exhibited highly selective cytotoxicity and induced cell cycle arrest and expression of apoptotic related genes.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Review
Chemistry, Medicinal
Simonida L. J. Tomic, Marija M. Babic M. Radic, Jovana S. Vukovic, Vuk V. Filipovic, Jasmina Nikodinovic-Runic, Marija Vukomanovic
Summary: This review paper discusses the multifunctional biomedical applications of alginate-based hydrogels and scaffolds, highlighting the influence of alginate on the essential properties of these applications. The first part reviews the scientific achievements of alginate in dermal tissue regeneration, drug delivery systems, cancer treatment, and antimicrobials. The second part presents the author's research on hydrogel materials for scaffolds based on alginate in synergy with different materials. The study shows that alginate plays a crucial role in achieving the desired properties of these materials.
Article
Polymer Science
Marija Babic M. Radic, Vuk V. Filipovic, Jovana S. Vukovic, Marija Vukomanovic, Tatjana Ilic-Tomic, Jasmina Nikodinovic-Runic, Simonida Lj. Tomic
Summary: The aim of this study was to create a new scaffolding system for the controlled release of curcumin. The scaffolds were composed of 2-hydroxyethyl methacrylate, gelatin, alginate, and titanium(IV) oxide nanoparticles. The hybrid scaffolds showed favorable properties such as high porosity, swelling capacity, hydrophilicity, degradation rate, curcumin loading efficiency, and controlled release profiles. The cytotoxicity test results indicated satisfactory cell growth on the hybrid scaffold surfaces. These hybrid scaffolds have potential for further in vivo and clinical studies.
Article
Chemistry, Multidisciplinary
Milos Ognjanovic, Zeljko Jacimovic, Milica Kosovic-Perutovic, Irina Besu Zizak, Tatjana Stanojkovic, Zeljko Zizak, Biljana Dojcinovic, Dalibor M. Stankovic, Bratislav Antic
Summary: Partial cation substitution can change the physical properties of compounds, and in this study, yttrium-substituted iron oxide nanoconstructs (YIONs) were prepared. The Y3+ substitution in maghemite (γ-Fe2O3) crystal structures was limited to 1.5%. The YIONs showed excellent heating efficiency and low toxicity, making them suitable for potential medical and technological applications such as magnetic hyperthermia cancer treatment and catalysis.
Article
Horticulture
Milica Fotiric Aksic, Zivoslav Tesic, Milica Kalaba, Ivanka Ciric, Lato Pezo, Biljana Loncar, Uros Gasic, Biljana Dojcinovic, Tomislav Tosti, Mekjell Meland
Summary: The aim of this study was to identify the chemical parameters for distinguishing plum cultivars grown in different regions of Norway. Chemical analysis of 68 plum cultivars revealed variations in the contents of elements, sugars, organic acids, phenolic compounds, and antioxidant activity. These differences have implications for human health and future breeding efforts.
Article
Biochemistry & Molecular Biology
Aleksandar Mijatovic, Nevenka Gligorijevic, Dusan Cocic, Snezana Spasic, Aleksandar Lolic, Sandra Arandelovic, Milan Nikolic, Rada Baosic
Summary: The biological activity of six structurally similar tetradentate Schiff base copper(II) complexes was investigated. One of the complexes, CuAA, showed superior antioxidant activity than Trolox, as well as antimicrobial, antifungal, and antiproliferative properties. The complexes also interacted with human serum albumin and DNA fragments.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Marijana Pavlovic, Emira Kahrovic, Sandra Arandelovic, Sinisa Radulovic, Predrag-Peter Ilich, Sanja Grguric-Sipka, Nevzeta Ljubijankic, Dijana Zilic, Jurica Jurec
Summary: Novel ruthenium(III) complexes were synthesized and characterized. These complexes showed potential cytoselective activity and exhibited high cytotoxicity against breast cancer cells.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
(2023)