Article
Biochemistry & Molecular Biology
Salwa M. El-Sayed, Mona Nossier, Ahmed Ibrahim Nossier
Summary: This study evaluated the antioxidant activity of faba bean seeds pre-treated with selenium, garlic husk extract, and lemon peel extract and their effects in a rat model of ulcerative colitis. The results showed that the pre-treated faba bean seeds had enhanced antioxidant capacity and potential protective and therapeutic effects in experimental colitis.
Review
Cell Biology
Shengjie Ma, Jiaxin Zhang, Heshi Liu, Shuang Li, Quan Wang
Summary: Macrophages play a significant role in the progression of inflammatory bowel disease (IBD) by regulating inflammatory phenotype. Further investigation of the role of macrophages in the pathogenesis of IBD will facilitate the development of novel treatments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Immunology
Maorun Zhang, Xiaoping Li, Qi Zhang, Jiahua Yang, Gang Liu
Summary: Colitis-associated colorectal cancer (CAC) is a severe complication of ulcerative colitis (UC), characterized by multiple lesions, worse pathological type, and poor prognosis. Macrophages, as innate immune cells, play a crucial role in both inflammatory response and tumor immunity. Enhanced macrophage infiltration in UC leads to the production of inflammatory cytokines, promoting UC tumorigenesis. Macrophage polarization into M1 has an anti-tumor effect, while M2 polarization promotes tumor growth. Targeting macrophages has shown effectiveness in preventing and treating CAC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Sarah P. Short, Jennifer M. Pilat, Caitlyn W. Barrett, Vishruth K. Reddy, Yael Haberman, Jared R. Hendren, Benjamin J. Marsh, Cody E. Keating, Amy K. Motley, Kristina E. Hill, Anne E. Zemper, M. Kay Washington, Chanjuan Shi, Xi Chen, Keith T. Wilson, Jeffrey S. Hyams, Lee A. Denson, Raymond F. Burk, Michael J. Rosen, Christopher S. Williams
Summary: Patients with inflammatory bowel disease (IBD) often have nutritional selenium deficiencies and are at higher risk of developing colon cancer. Research has shown that reduction of the antioxidant protein SELENOP can increase tumor development in colitis-associated cancer models, with epithelial-specific deletion of SELENOP leading to elevated oxidative stress and tumor initiation. This suggests that colonic SELENOP levels may serve as a biomarker for disease severity and cancer predisposition in IBD patients.
Review
Biochemistry & Molecular Biology
Siarhei A. Dabravolski, Vasily N. Sukhorukov, Alexandra A. Melnichenko, Victoria A. Khotina, Alexander N. Orekhov
Summary: Selenium is a vital trace element necessary for metabolic processes, protection against oxidative stress, and cardiovascular system functioning. Deficiency in selenium has been linked to various cardiovascular diseases including Keshan's disease, heart failure, coronary heart disease, myocardial infarction, and atherosclerosis. Through selenoenzymes and selenoproteins, selenium is involved in important processes such as regulation of redox homeostasis, oxidative stress, calcium flux, and thyroid hormone metabolism; an imbalance in selenium supply may disrupt these processes.
Article
Immunology
L. Ji, Y. Chen, L. Xie, Z. Liu
Summary: Dock2, an atypical guanine exchange factor expressed on immune cells, plays a crucial role in regulating macrophage migration and antibacterial ability by modulating the expression of chemokines and receptors in response to chemokine stimulation, thus contributing significantly to host defense against enteric bacterial infection.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Review
Biology
Sojit Tomo, Gangam Saikiran, Mithu Banerjee, Sushmita Paul
Summary: The disruption of antioxidant defense in severe acute respiratory syndrome due to SARS-CoV infection has been demonstrated, with selenium playing a major role in reducing reactive oxygen species produced in response to viral infections. Selenium also inhibits NF-kappa B activation, thus alleviating inflammation. In viral infections, selenoproteins have been found to inhibit type I interferon responses and modulate T cell proliferation and oxidative burst in macrophages. Virally encoded selenoproteins have been identified in various viral genomes, and potential selenoproteins in the COVID-19 genome may provide further insights into their role in viral pathogenesis.
Article
Biotechnology & Applied Microbiology
Jing Yan, Wei Yu, Guoliang Wang, Chang Lu, Chen Liu, Lu Jiang, Zizheng Jiang, Zhenghao Liang, Dong Liu
Summary: Lrrk2 deficiency can alleviate the progression of colitis by promoting M2 macrophage transition and facilitating probiotic colonization.
Article
Gastroenterology & Hepatology
David Dora, Szilamer Ferenczi, Rhian Stavely, Viktoria E. Toth, Zoltan V. Varga, Tamas Kovacs, Ildiko Bodi, Ryo Hotta, Krisztina J. Kovacs, Allan M. Goldstein, Nandor Nagy
Summary: The study revealed the presence of a blood-myenteric barrier (BMB) in the gut, which is similar to the blood-brain barrier (BBB) and protects the enteric nervous system from inflammation. Disruption of the BMB in colitis leads to increased inflammatory stimuli access to the myenteric plexus, potentially causing neuroinflammation in gastrointestinal diseases.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Immunology
Tingting Xia, Meng Zhang, Wei Lei, Ruilin Yang, Shengping Fu, Zhenhai Fan, Ying Yang, Tao Zhang
Summary: Cell growth, proliferation, differentiation, and apoptosis are influenced by STAT3, and aberrant STAT3 expression affects the development of inflammatory immunological disorders, fibrotic diseases, and malignancies. Macrophages (M0) can be polarized into pro-inflammatory (M1) and anti-inflammatory (M2) types, and STAT3 signaling plays a role in this polarization. This review compiles the relevant signaling pathways associated with STAT3 and macrophage polarization for the treatment and investigation of disorders related to macrophage polarization.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yan-Ting Wu, Li-Shan Zhong, Chen Huang, Yu-Ying Guo, Fu-Jun Jin, Yu-Ze Hu, Zi-Bo Zhao, Zhe Ren, Yi-Fei Wang
Summary: Macrophage ferroptosis is a potential therapeutic target for ulcerative colitis (UC), and beta-caryophyllene (BCP) has been identified as an effective inhibitor of macrophage lipid peroxidation and inflammation. BCP activates the type 2 cannabinoid receptor (CB2R) to inhibit macrophage ferroptosis and its induced inflammatory response both in vivo and in vitro.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Environmental
Liwen Zhang, Dong Cheng, Jing Zhang, Hui Tang, Fenghua Li, Yi Peng, Xinglan Duan, En Meng, Cuili Zhang, Tao Zeng, Fuyong Song, Jia-Sheng Wang, Xiulan Zhao, Jun Zhou
Summary: We found that the macrophage AHR/TLR/STAT signaling axis is involved in colon colitis induced by the non-canonical AHR ligand aflatoxin B1 (AFB1). In mice exposed to AFB1, there was severe colitis characterized by increased recruitment of myeloid immune cells and tissue damage. In human macrophage models, the exposure to AFB1 resulted in functional changes, overall inflammation, disruption of mitochondrial function, and perturbation of the AHR/TLR/STAT3 signaling axis. Our study suggests that targeting this signaling axis may be a potential intervention for colitis caused by AFB1 exposure.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Ruihua Ye, Jiaqiang Huang, Zixu Wang, Yaoxing Chen, Yulan Dong
Summary: Selenium is an essential trace element that plays a vital biological role in the body through selenoproteins. Selenoproteins are involved in various biological processes such as oxidative stress regulation, immune response, and antioxidant defense. Both deficiency and excess selenium can cause damage to the body. Selenium intake is mainly through dietary supplements. This paper reviews the synthesis and mechanism of selenoproteins, as well as their role and mechanism in disease regulation, and prospects the future development of selenium-enriched products.
Article
Nutrition & Dietetics
Song Yu, Haixiang Guo, Zhonghao Ji, Yi Zheng, Bingbing Wang, Qingqing Chen, Hongyu Tang, Bao Yuan
Summary: Sea cucumber peptide (SCP) can protect against colitis by modulating the intestinal microbiota composition and the intestinal barrier, as well as inhibiting the polarization of M1 macrophages.
Article
Pharmacology & Pharmacy
Lin-Kong Gong, Xiaodong Yang, Juan Yang, Shu Wu, Yue Chen, Jiang-Tao Zhang, Zhi-Hong Wang, Li-Hua Chen, Chungen Xing, Tong Liu
Summary: This study found that ganciclovir can improve DSS-induced ulcerative colitis by inhibiting the STING signaling pathway. The therapeutic effect of this drug on UC in mice is promising.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Ramanpreet Kaur, Dhimant Desai, Shantu Amin, Kaisar Raza, Aman Bhalla, Pooja Yadav, Naveen Kaushal
Summary: This study demonstrates the translational applicability of a novel class of COX inhibitors containing Selenium for efficiently managing inflammatory disorders such as Ulcerative Colitis (UC). Selenocoxib-3 shows promising pharmacokinetics, therapeutic potential, and safety margins compared to its parent NSAID Celecoxib. It effectively resolves the symptoms of DSS-induced colitis and mitigates inflammation and colon damage.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Microbiology
Stephanie L. Collins, Jonathan C. Stine, Jordan E. Bisanz, C. Denise Okafor, Andrew D. Patterson
Summary: This Review discusses host-microbiota interactions and their impact on bile acid metabolism and composition. The gut microbiota plays a crucial role in bile acid metabolism, with diverse biological roles for bile acids being discovered. External factors such as antibiotics and diet also influence bile acid composition. Understanding the impact of bile acid signaling networks in different organs is increasingly important for the development of targeted therapeutics.
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Medicine, Research & Experimental
Xiaoliang Zhou, Debopriya Chakraborty, Iain A. Murray, Denise Coslo, Zoe Kehs, Anitha Vijay, Carolyn Ton, Dhimant Desai, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew
Summary: Intestinal homeostasis is maintained through balanced cellular turnover, proliferation, differentiation, and self-renewal, but can be influenced by the aryl hydrocarbon receptor (AHR). The AHR plays a role in small intestinal gene expression and cellular repertoire remodeling, promoting intestinal resilience. Genetic ablation of Ahr impairs lineage commitment and differentiation, while exposure to AHR ligands reverses these effects.
LABORATORY INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Sougat Misra, Tai-Jung Lee, Aswathy Sebastian, John McGuigan, Chang Liao, Imhoi Koo, Andrew D. Patterson, Randall M. Rossi, Molly A. Hall, Istvan Albert, K. Sandeep Prabhu
Summary: Macrophages play a crucial role in inflammation and its resolution. Selenium and selenoproteins, which contain the amino acid selenocysteine, are essential for the functions of macrophages. In this study, the researchers investigated the role of SELENOW, a highly expressed selenoprotein, in inflammation using Selenow knock-out macrophages. The results suggest that SELENOW is involved in redox processes and bioenergetics during inflammation and its resolution.
Article
Biochemistry & Molecular Biology
Jonathan A. A. Young, Silvana Duran-Ortiz, Stephen Bell, Kevin Funk, Yuan Tian, Qing Liu, Andrew D. D. Patterson, Edward O. O. List, Darlene E. E. Berryman, John J. J. Kopchick
Summary: Growth hormone (GH) affects protein metabolism and alters circulating levels of glycine and hydroxyproline. GH abnormality, such as increased GH action or GH resistance, leads to changes in amino acid concentrations in plasma and feces. Acute GH treatment decreases liver gene expression of glycine metabolism genes and serum glycine in mice.
Article
Environmental Sciences
Rajbinder K. Virk, Roobee Garla, Naveen Kaushal, Mohinder P. Bansal, Mohan L. Garg, Biraja P. Mohanty
Summary: Long term exposure to arsenic through consumption of contaminated groundwater is a global issue, but arsenic compounds are also emerging as potential chemotherapeutic drugs. Arsenic speciation studies have significantly contributed to our understanding of the biological behavior of arsenic in humans, but there are limitations and challenges in interpreting arsenic metabolism. Various technologies have identified hundreds of metabolic arsenic conjugates, but the relationship between these species and the metabolic pathway of arsenic remains unclear. New experimental methodologies have revealed novel biorelevant arsenic species, but there is still a need to focus on identifying and characterizing different types of arsenicals in a comprehensive manner.
Article
Biochemistry & Molecular Biology
Fangcong Dong, Iain A. Murray, Andrew Annalora, Denise M. Coslo, Dhimant Desai, Krishne Gowda, Jian Yang, Dingbowen Wang, Imhoi Koo, Fuhua Hao, Shantu G. Amin, Andrew D. Patterson, Craig Marcus, Gary H. Perdew
Summary: A certain diet can enhance the activity of the aryl hydrocarbon receptor (AHR) in the intestinal tract, which is responsible for maintaining intestinal barrier homeostasis. This is possibly achieved through the role of certain dietary substrates as CYP1A1/1B1 substrates, which increase the half-life of potent AHR ligands. The gut bacterial metabolite urolithin A (UroA) has been identified as one of these substrates, and its intake can lead to increased AHR activity in key barrier tissues.
Article
Multidisciplinary Sciences
Dari Shalon, Rebecca Neal Culver, Jessica A. Grembi, Jacob Folz, Peter V. Treit, Handuo Shi, Florian A. Rosenberger, Les Dethlefsen, Xiandong Meng, Eitan Yaffe, Andres Aranda-Diaz, Philipp E. Geyer, Johannes B. Mueller-Reif, Sean Spencer, Andrew D. Patterson, George Triadafilopoulos, Susan P. Holmes, Matthias Mann, Oliver Fiehn, David A. Relman, Kerwyn Casey Huang
Summary: This study developed an ingestible device that can collect samples from multiple regions of the human intestinal tract during normal digestion. Multi-omics analysis of the collected samples revealed significant differences in bacteria, phages, host proteins, and metabolites between the intestines and stool. The study provides insights into the roles of the gut microbiome and metabolome in human physiology and disease through non-invasive longitudinal profiling of microorganisms, proteins, and bile acids along the intestinal tract.
Article
Toxicology
Anitha Vijay, Nina R. Boyle, Supriya M. Kumar, Gary H. Perdew, Shanthi Srinivasan, Andrew D. Patterson
Summary: This study investigates the effects of a persistent organic pollutant on the enteric nervous system, finding that it leads to delayed intestinal motility and neuronal damage, thereby affecting gastrointestinal function.
TOXICOLOGICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Lulu Sun, Yi Zhang, Jie Cai, Bipin Rimal, Edson R. Rocha, James P. Coleman, Chenran Zhang, Robert G. Nichols, Yuhong Luo, Bora Kim, Yaozong Chen, Kristopher W. Krausz, Curtis C. Harris, Andrew D. Patterson, Zhipeng Zhang, Shogo Takahashi, Frank J. Gonzalez
Summary: Bile salt hydrolase (BSH) in Bacteroides is associated with the development of colorectal cancer (CRC) by activating the beta-catenin/CCL28 pathway and promoting the generation of immunosuppressive T-reg cells. Inhibition of BSH activity could slow down CRC progression and serve as a potential target for CRC prevention and treatment.
NATURE COMMUNICATIONS
(2023)
Article
Food Science & Technology
Xiaoling Chen, Andrew D. Patterson, Gary H. Perdew, Iain A. Murray, Joshua J. Kellogg
Summary: A novel AHR modulator, 2-amino-4-methyl-benzothiazole, was predicted, identified, and characterized in white button mushrooms using a molecular networking approach. Cell-based assays showed that this compound has agonistic activity and upregulates CYP1A1 expression. These findings demonstrate the potential of molecular networking in identifying novel receptor modulators from natural products.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Xiaoyang Zhu, Qing Liu, Andrew D. Patterson, Arun K. Sharma, Shantu G. Amin, Samuel M. Cohen, Frank J. Gonzalez, Jeffrey M. Peters
Summary: Long-term ligand activation of PPARa in mice causes hepatocarcinogenesis, while hepatocarcinogenesis is diminished in Ppara-null and PPARA-humanized mice. Lipidomic analyses showed elevated levels of hepatic linoleic acid and overall fatty liver in Ppara-null and PPARA-humanized mice. The accumulation of linoleic acid and loss of CD4+ T cells suggest a new role for PPARa in age-associated hepatocarcinogenesis.
Review
Biochemistry & Molecular Biology
Shamprasad Varija Raghu, Avinash Kundadka Kudva, Rajanikant Golgodu Krishnamurthy, Jayesh Mudgal, Thomas George, Manjeshwar Shrinath Baliga
Summary: Exposure to ionizing radiation can harm the brain, leading to increased blood-brain barrier permeability, neuronal apoptosis, reduced neurogenesis, impaired synaptic plasticity, and cognitive dysfunction. Dietary plants and phytochemicals, such as vitamin E, corilagin, curcumin, resveratrol, and ursolic acid, have shown potential in mitigating radiation-induced damage to the central nervous system. Furthermore, alpha-tocopherol and the micronutrient selenium have neuroprotective effects in cancer survivors previously treated with brain radiation.
Article
Gastroenterology & Hepatology
Alexis Bretin, Jun Zou, Beng San Yeoh, Vu L. Ngo, Shawn Winer, Daniel A. Winer, Lavanya Reddivari, Michael Pellizzon, William A. Walters, Andrew D. Patterson, Ruth Ley, Benoit Chassaing, Matam Vijay-Kumar, Andrew T. Gewirtz
Summary: Psyllium protects against experimental colitis by altering bile acid metabolism and activating FXR, which suppresses pro-inflammatory signaling.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Gary H. Perdew, Charlotte Esser, Megan Snyder, David H. Sherr, Ellen H. van den Bogaard, Karen McGovern, Pedro M. Fernandez-Salguero, Xavier Coumoul, Andrew D. Patterson
Summary: The aryl hydrocarbon receptor (AHR) senses low-molecular-weight molecule signals from environmental exposures, the microbiome, and host metabolism. It plays important roles in host homeostasis, chronic disease development, and responses to toxic insults. Recent research has shown that AHR is a promising target for cancer, metabolic diseases, skin conditions, and autoimmune disease. This meeting aimed to explore the potential therapeutic applications based on our understanding of this receptor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
