Review
Biochemistry & Molecular Biology
Jian Zhang, Haochun Zhou, He Li, Zhiwei Ying, Xinqi Liu
Summary: Selenium is an essential nutrient with antioxidant and immune properties, and its deficiency is linked to various diseases and dysfunctions in humans. Organic selenium is recommended over inorganic selenium due to its higher bioavailability and lower toxicity. Selenium is present in various selenoproteins that play important roles in the immune and oxidation systems of the human body.
Article
Chemistry, Applied
Zhongqiu Hu, Yuanxi Yao, Meng Lv, Yiqian Zhang, Lin Zhang, Yahong Yuan, Tianli Yue
Summary: Selenoproteins PR-Se-1, PR-Se-2, and PR-Se-3 were isolated from Agaricus blazei Murrill (ABM) and identified as isoenzymes of isocitrate dehydrogenase, dihydrolipoyl dehydrogenase, and n-proline reductase, respectively. ABM is a promising source of selenium in selenium-poor regions, with organic selenium comprising about 81% of its total selenium content.
Review
Food Science & Technology
Dan Xiao, Tong Li, Xin Huang, Kongdi Zhu, Zimeng Li, Yulan Dong, Lianshun Wang, Jiaqiang Huang
Summary: This review discusses the novel development of Se-enriched probiotics and the bioactivities of SeNPs, emphasizing their potential applications as nutritional additives in food. The paper highlights the significant role of SeNPs in anti-oxidation and explains the mechanisms by which they improve Se deficiency and boost animal health. Selenium deficiency remains a major worldwide nutritional challenge and studying the influencing factors and enrichment mechanisms of Se-enriched probiotics is essential for exploiting more potent Se-enriched probiotics.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Barbara Rita Cardoso, Larissa Lago, Aimee Linda Dordevic, Eugene Anthony Kapp, Anna M. Raines, Roger A. Sunde, Blaine Russel Roberts
Summary: The study identified candidate proteins in the liver regulated by dietary selenium intake, ranging from deficiency to toxic levels, and found a U-shaped dose-response relationship between selenium status and health outcomes. The results suggest that changes in selenium levels can impact the metabolism of glutathione, xenobiotics, and amino acids in the body.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Plant Sciences
Maila Adriely Silva, Gustavo Ferreira de Sousa, Ana Paula Branco Corguinha, Josimar Henrique de Lima Lessa, Guilherme Soares Dinali, Cynthia Oliveira, Guilherme Lopes, Douglas Amaral, Patrick Brown, Luiz Roberto Guimaraes Guilherme
Summary: This study evaluated the effects of different strategies for biofortifying soybean grains with selenium through soil application. The results showed that selenium application via C-MAP and E-MAP significantly increased soybean yield and selenium content in grains, and improved grain quality.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Food Science & Technology
Maila Adriely Silva, Gustavo Ferreira de Sousa, Gary Banuelos, Douglas Amaral, Patrick H. Brown, Luiz Roberto Guimaraes Guilherme
Summary: This study aimed to evaluate the effect of different selenium application methods (soil or foliar) and sources (organic or inorganic) on the total selenium content and speciation in selenium-enriched soybean grains. The results showed that all treatments with inorganic selenium increased the selenium content in grains compared to the control. More than 80% of the total selenium was present as selenomethionine (SeMet), and the speciation was influenced by the selenium source and application method. The treatments using inorganic selenium, applied via soil or foliar, produced the highest content of SeMet in soybean grains. Finally, the preservation of selenium species in products derived from soybean grains should be evaluated.
Article
Multidisciplinary Sciences
Fengxiu Sun, Zhenzhen Zhao, Mathilda M. Willoughby, Shuaiqi Shen, Yu Zhou, Yiyan Shao, Jing Kang, Yongtian Chen, Mengying Chen, Xiaojing Yuan, Iqbal Hamza, Amit R. Reddi, Caiyong Chen
Summary: This study identifies HRG-9 as an intracellular haem chaperone that plays a crucial role in transporting haem within cells. Loss of HRG-9 leads to haem accumulation in different cellular compartments and is associated with symptoms resembling certain genetic disorders.
Article
Chemistry, Multidisciplinary
Xueying Kang, Haojie Huang, Chenyang Jiang, Longhuai Cheng, Yueqian Sang, Xuekang Cai, Yalun Dong, Lu Sun, Xin Wen, Zhen Xi, Long Yi
Summary: The importance of selenium in biology and health is becoming increasingly clear. This study demonstrates that selenocyclopropenones and selenoamides can release hydrogen selenide (H2Se) upon reaction with cysteine, and the rate of release can be tuned through structural modifications. The researchers developed a quantitative assay for direct H2Se trapping and quantification. Additionally, they found that arylselenoamide can release H2Se in cellular environments. Mechanistic investigations and density functional theory calculations provide insight into the possible pathways of Cys-activated H2Se release. The well-defined chemistries of Cys-activated H2Se donor motifs have potential for studying selenium biology and developing new H2Se donors and bioconjugate techniques.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Applied
Yuning Liu, Xiaohui Feng, Qingshi Meng, Jiawei Zhu, Xueting Jia, Qingyu Zhao, Chaohua Tang, Yanan Yu, Junmin Zhang
Summary: Nap-DNB, an off-on fluorescent probe based on naphthimide, was developed for the detection of biological selenols in vitro. It can rapidly and sensitively respond to selenocysteine, with a detection limit of 92 nM. By adopting a low-pH detection environment and robust reaction sites, Nap-DNB successfully detected selenols in selenium-enriched Tan sheep's serum, liver, and longissimus dorsi.
Review
Biochemistry & Molecular Biology
Leonardo Warzea Lima, Serenella Nardi, Veronica Santoro, Michela Schiavon
Summary: Selenium is an essential element for human metabolism, acting as antioxidants, protecting cells, and preventing metabolic disorders. It can enhance the catalytic activity of selenoproteins, strengthen antioxidant capacity, and help prevent viral infections. For SARS-CoV-2, selenium supplementation can serve as a complementary treatment.
Review
Food Science & Technology
John-Nelson Ekumah, Yongkun Ma, Nelson Dzidzorgbe Kwaku Akpabli-Tsigbe, Emmanuel Kwaw, Shengmei Ma, Jie Hu
Summary: Selenium is a necessary micronutrient with health benefits, but accessing organic selenium in nature is challenging due to uneven global distribution. Various methods such as genetic engineering, selenium fertilizer, and microorganisms can help address this issue. There are also unexplored opportunities to convert inorganic selenium from selenium-rich soil into organic forms for human consumption.
Article
Chemistry, Organic
Li Sun, Liwei Wang, Hesham Alhumade, Hong Yi, Hu Cai, Aiwen Lei
Summary: A novel electrochemical radical selenylation reaction was reported for the transformation of alkenes and activated arenes without the need for external oxidants. This method successfully yielded a variety of selenoethers with potential applications in biological chemistry, showcasing regioselectivity and atom-economic features.
Article
Materials Science, Multidisciplinary
A. Q. Li, N. Lin, L. W. Xu, W. J. Zhang, X. C. Zhang, Z. Y. Wang, C. Ma
Summary: The effects of Al doping on the oxidation kinetics and oxidation mechanism of Ti(C,N)-based cermets were systematically investigated. Al derived from decomposed AlN powders promoted the precipitation of (Ni,Co)3Al nanoparticles in the binder phase, and the presence of (Ni,Co)3Al nanoparticles improved oxidation resistance by forming a (Ni,Co)(Ti,Al)O3 layer.
Article
Food Science & Technology
Yuanyuan Ye, Wei Yan, Lijun Peng, Jiangling He, Na Zhang, Jiaojiao Zhou, Shuiyuan Cheng, Jie Cai
Summary: This study investigates the elemental and chemical profiles of green tea with different selenium levels. Significant differences were found in the contents of minerals and bioactive components. Selenium was found to be synergistic with zinc and antagonistic with magnesium, aluminum, chromium, iron, and arsenic. Furthermore, selenium showed positive correlations with certain gallic acid and gallated catechins, while negatively correlated with some non-gallated catechins.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
T. Castel, K. Leon, C. Gandubert, B. Gueguen, A. Amerand, A. Guernec, M. Theron, K. Pichavant-Rafini
Summary: Selenium contributes to physiological functions through selenoproteins and plays a role in oxidative stress defense. A deficiency of selenium can lead to the onset or worsening of pathologies. The study aimed to determine the effects of sodium selenite or selenium-enriched spirulina supplementation.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jingzeng Cai, Jiaqiang Huang, Jie Yang, Xiaoming Chen, Haoran Zhang, Yue Zhu, Qi Liu, Ziwei Zhang
Summary: This study reveals the role of selenoprotein M (SELENOM) in maintaining mitophagy in high-fat diet-induced non-alcoholic fatty liver disease (NAFLD). SELENOM downregulation aggravates hepatic steatosis, inflammation, and fibrosis, while reducing mitophagy and increasing mitochondrial apoptosis. SELENOM overexpression activates Parkin-mediated mitophagy, reducing mitochondrial apoptosis and removing damaged mitochondria.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Chemistry, Physical
Jiaqiang Huang, Zongxue Yu, Junlei Tang, Pingquan Wang, Qiuyue Tan, Juan Wang, Xianzhang Lei
Summary: This paper reviews the performance, synthesis and modification methods, and alkaline stability protection of anion-exchange polyelectrolytes (AEPs) in alkaline fuel cells, and summarizes the current research and development status. The evaluation and comparison of different types of AEPs and AEMs deepen the understanding of AEPs in AEMFC.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2022)
Review
Nutrition & Dietetics
Kongdi Zhu, Shihui Yang, Tong Li, Xin Huang, Yulan Dong, Pengjie Wang, Jiaqiang Huang
Summary: Selenium and selenoproteins play important roles in regulating the immune system, and have a certain effect in preventing food allergies.
Article
Biochemistry & Molecular Biology
Qi Liu, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Chen
Summary: Light pollution, especially the dim blue light at night, has been found to have a negative impact on cognitive function. This study investigated the effects of exposure to dim blue light on mice and found that it impaired spatial learning and memory, increased plasma corticosterone levels, activated microglia, and caused oxidative stress and neuroinflammation in the hippocampus. These changes ultimately led to neuronal loss and synaptic dysfunction, resulting in impaired spatial learning and memory in mice.
Review
Biochemistry & Molecular Biology
Qi Liu, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Chen
Summary: This article provides an overview of the effect of intranasal insulin administration on memory and its underlying mechanism. It highlights the molecular link between hippocampal insulin resistance and AD and provides a theoretical basis for finding new therapeutic targets for AD in clinical practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chao Song, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Chen
Summary: In order to investigate the influence of monochromatic light on circadian rhythms of plasma insulin level and pancreatic clock gene expression, chicks were raised under different colors of light. The results showed that plasma melatonin, insulin, and the pancreatic clock gene all exhibited rhythmic expression under monochromatic light. Red light reduced plasma melatonin levels and the expression of the pancreatic clock gene, while increasing plasma insulin levels. After the pineal gland was removed, the circadian expressions of plasma melatonin and pancreatic clock gene were reduced, and plasma insulin levels were increased, indicating the importance of melatonin in the effect of monochromatic light on circadian rhythm of plasma insulin level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Qingyun Guan, Yixuan Li, Zixu Wang, Jing Cao, Yulan Dong, Fazheng Ren, Yaoxing Chen
Summary: Light pollution can contribute to obesity, and the effect of environmental light wavelength on mammalian obesity is not fully understood. This study found that exposure to blue light significantly increased weight gain and white adipose tissue (WAT) weight in mice fed with a high-fat diet. Blue light also disrupted glucose homeostasis and upregulated the expression of circadian clocks in WAT. The elevation of plasma corticosterone levels and glucocorticoid receptors in WAT may explain the changes in circadian clocks.
Article
Biochemistry & Molecular Biology
Zaozao Pan, Jiaqiang Huang, Ting Hu, Yonghong Zhang, Lingyu Zhang, Jiaxi Zhang, Defeng Cui, Lu Li, Jing Wang, Qiong Wu
Summary: In this study, the protective effects of chitosan-coated selenium nanoparticles (SeNPs) and inorganic selenium (Na2SeO3) on bisphenol A (BPA)-induced toxicity in porcine intestinal epithelial cells (IPEC-J2) were compared. The results showed that SeNPs and Na2SeO3 both attenuated the cellular damage caused by BPA. SeNPs were more effective than Na2SeO3 in protecting against BPA-induced tight junction function injury, proinflammatory response, oxidative stress, apoptosis, and endoplasmic reticulum stress. These findings suggest that selenium nanoparticles may be an effective tool for preventing BPA toxicity in animals and humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
He Yang, Bing Fang, Zixu Wang, Yaoxing Chen, Yulan Dong
Summary: The world is facing an increasing aging population and there is a pressing need to find a safe and effective way to delay the aging process. This study focuses on the aging of endocrine glands, which play a crucial role in the regulation of aging. By analyzing genes and pathways related to endocrine gland aging, this research provides insights into the changes in structure and function of aging endocrine glands as well as the underlying mechanisms.
Article
Biochemistry & Molecular Biology
Wenji Ren, Zixu Wang, Jing Cao, Yulan Dong, Tuanjie Wang, Yaoxing Chen
Summary: Excessive illumination is a severe environmental factor that impacts organisms. Obesity contributes to chronic kidney disease. The effect of continuous light on the kidney and the specific color that produces a noticeable phenomenon are still unknown.
Review
Biochemistry & Molecular Biology
Wei Wang, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Chen
Summary: Animals must process large amounts of information in order to adapt to a changing environment, and their memories and experiences play a crucial role in their survival and development. Intrinsic forgetting, the active deletion of irrelevant information, is equally important for memory acquisition and consolidation. Recent research has shown that Rac1 activity is a key player in intrinsic forgetting, maintaining the balance of the brain's memory management system. Dysfunctions in Rac1-dependent intrinsic forgetting may contribute to memory deficits in neurological and neurodegenerative diseases. These findings provide insights into the neurobiology of memory and forgetting, as well as potential therapies for brain disorders that affect intrinsic forgetting mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yuanyuan Li, Huayun Wan, Ruiqin Ma, Tianya Liu, Yaoxing Chen, Yulan Dong
Summary: Chronic psychological stress affects pregnant mice by increasing norepinephrine, corticosterone, and estradiol levels in the plasma. This stress-induced model resulted in colonic mucosal injury, decreased diversity and richness of the colonic microbiota, and an imbalance in the composition of beneficial and harmful bacteria. Additionally, the study found that estradiol provides better protection for the intestinal barrier after chronic stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Food Science & Technology
Dan Xiao, Tong Li, Xin Huang, Kongdi Zhu, Zimeng Li, Yulan Dong, Lianshun Wang, Jiaqiang Huang
Summary: This review discusses the novel development of Se-enriched probiotics and the bioactivities of SeNPs, emphasizing their potential applications as nutritional additives in food. The paper highlights the significant role of SeNPs in anti-oxidation and explains the mechanisms by which they improve Se deficiency and boost animal health. Selenium deficiency remains a major worldwide nutritional challenge and studying the influencing factors and enrichment mechanisms of Se-enriched probiotics is essential for exploiting more potent Se-enriched probiotics.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Weitian Li, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Chen
Summary: The ubiquity of biological rhythms in life suggests that they are the result of natural selection in evolution. The origin of the biological clock has two possible hypotheses: the selective pressure hypothesis of the oxidative stress cycle and the light evasion hypothesis. Furthermore, the biological clock enhances the adaptability of organisms. Two mechanisms of biological clocks have been discovered: the negative feedback loop of transcription-translation (TTFL) and the post-translational oscillation mechanism (PTO). The TTFL mechanism is commonly found in eukaryotes and is considered the most classic and conservative circadian clock oscillation mechanism. The PTO mechanism, based on the Peroxiredoxin (PRX or PRDX) protein, is the oscillation mechanism of the biological clock in prokaryotes and is widely present in both eukaryotic and prokaryotic life. The coexistence of the PTO and TTFL mechanisms in eukaryotes raises the question of their relationship. Finally, it is speculated that there may be a driving force for the evolution of biological clocks, with a possible evolutionary trend from the PTO mechanism to the TTFL mechanism as organisms adapt to their environment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
