Article
Chemistry, Multidisciplinary
Feng Gao, Ziqi Dai, Tong Zhang, Yuhao Gu, Desheng Cai, Mingjun Lu, Zijie Zhang, Qi Zeng, Bingxian Shang, Bing Xu, Haimin Lei
Summary: In this study, a series of novel sinomenine derivatives were designed and synthesized. Compound 17 exhibited excellent anti-inflammatory and analgesic activities, indicating its potential as a drug.
Article
Biochemistry & Molecular Biology
Takashi Nawata, Hiroki Sakai, Takeshi Honda, Marina Otsuka, Hina Fujita, Hitoshi Uchinoumi, Shigeki Kobayashi, Takeshi Yamamoto, Masataka Asagiri, Masafumi Yano
Summary: Dantrolene inhibits Ca2+ leakage from destabilized ryanodine receptors and shows potential as a therapeutic agent against endoplasmic reticulum stress-associated diseases. In a mouse model of collagen-induced arthritis, oral administration of dantrolene significantly reduces arthritic scores, suppresses bone and chondral destruction, and inhibits the production of serum anti-type II collagen IgG. These findings suggest that dantrolene may be a potential anti-rheumatic drug.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Immunology
David Achudhan, Shan-Chi Liu, Yen-You Lin, Chien-Chung Huang, Chun-Hao Tsai, Chih-Yuan Ko, I-Ping Chiang, Yueh-Hsiung Kuo, Chih-Hsin Tang
Summary: The study demonstrates that Antcin K, a compound isolated from Antrodia cinnamomea, shows anti-inflammatory effects by inhibiting proinflammatory cytokine production in human rheumatoid synovial fibroblasts. This indicates the potential of Antcin K in treating rheumatoid arthritis by reducing inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, Research & Experimental
Jamshid Gholizadeh Navashenaq, Arezoo Gowhari Shabgah, Mahdiyeh Hedayati-Moghadam, Nazila Ariaee, Hamed Mohammadi, Maryam Hemmatzadeh, Sara Azhdari, Tannaz Jamialahmadi, Thozhukat Sathyapalan, Amirhossein Sahebkar
Summary: Rheumatoid arthritis (RA) is an autoimmune disease affecting joints, with unclear etiology but involving immune mechanisms. Immune cells migrate to the joints during disease onset, and the shift to Th1 and Th17 immune responses is crucial in RA development. Myeloid-derived suppressor cells (MDSCs) regulate immune system, their specific functions in RA need further investigation.
Article
Immunology
Zhen-Yi Long, Yi-Feng Zhou, Hao Yuan, Ya-Meng Peng, Si-Xian Wu, Fang Peng
Summary: The study revealed that the levels of IgG4 and IL-21 in the serum increased with disease progression in collagen-induced arthritis (CIA) rats, and the expression of IgG4 and IL-21 receptors in the ankle joint was significantly higher in the CIA model group. These proteins were closely related to the pathological score, indicating that IL-21 may promote rheumatoid arthritis development by regulating IgG4 content.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Zhengyu Fang, Yiping Hu, Jiajing Dai, Lianhua He, Juan He, Bihua Xu, Xinle Han, Fubo Zhong, Huiyao Lan, Qingwen Wang
Summary: The combination treatment with CS12192 and MTX is shown to have a better therapeutic effect on collagen-induced arthritis (CIA) in rats, with a stronger suppressive effect on T cells and macrophage-mediated joint inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Samuel Garcia-Arellano, Luis Alexis Hernandez-Palma, Sergio Cerpa-Cruz, Gabriela Athziri Sanchez-Zuno, Melva Guadalupe Herrera-Godina, Jose Francisco Munoz-Valle
Summary: The study demonstrated that in rheumatoid arthritis patients, rhMIF stimulation can promote the secretion of IL-25, IL-31, and IL-33, with different stimuli having a significant impact on this secretion. However, the effect of treatments on the immune factor secretion was relatively minimal.
Review
Biotechnology & Applied Microbiology
Jeevithan Elango, Camilo Zamora-Ledezma, Baolin Ge, Chunyu Hou, Zhilin Pan, Bin Bao, Carlos Perez Albacete Martinez, Jose Manuel Granero Marin, Jose Eduardo Mate Sanchez de Val, Chunling Bao, Wenhui Wu
Summary: Collagen plays a significant role in regulating signaling mechanisms in bone and immune cells. Imbalance in collagen turnover can lead to complications and affect cellular homeostasis. While collagen has been widely explored for its beneficial effects, such as in the treatment of cartilage-related disorders, its potentially immunogenic properties have also been a subject of research and debate. This review aims to bridge the gap between the arthritogenic and anti-arthritogenic effects of collagen and provide insight into its mechanisms in arthritis.
BIOENGINEERING-BASEL
(2022)
Article
Immunology
Xiaolei Liu, Li Li, Qian Wang, Fengchao Jiang, Pei Zhang, Fei Guo, Hongjun Liu, Jian Huang
Summary: A new humanized anti-IL-6 mAb HZ-0408b with potent binding and neutralizing activity to human IL-6 has been developed. It showed a high species specificity and lower cross-reactivity compared to other anti-IL-6 mAbs. HZ-0408b exhibited a stronger inhibitory effect on IL-6 signaling and effectively reduced joint swelling and plasma CRP levels in a monkey CIA model.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Jing He, Yanan Chu, Jing Li, Qingren Meng, Yudong Liu, Jiayang Jin, Yifan Wang, Jian Wang, Bo Huang, Lianjie Shi, Xing Shi, Jiayi Tian, Yunzhi Zhufeng, Ruiling Feng, Wenjing Xiao, Yuzhou Gan, Jianping Guo, Changjun Shao, Yin Su, Fanlei Hu, Xiaolin Sun, Jun Yu, Yu Kang, Zhanguo Li
Summary: This study reveals the imbalance between butyrate-producing and butyrate-consuming species in rheumatoid arthritis patients. It shows that butyrate promotes the production of T-regs and reduces inflammation. Butyrate supplementation can alleviate inflammation by rebalancing immune cells and reducing antibody production.
Article
Immunology
Haiyan Xu, Li Cai, Zijian Li, Lili Zhang, Guojue Wang, Rongli Xie, Yongshuai Jiang, Yuanyang Yuan, Hong Nie
Summary: The IL-7/IL-7R pathway has a dual effect on osteoclastogenesis in RA, by inhibiting osteoclast formation and inducing inflammatory remission, making it a potential novel therapeutic target for autoimmune diseases like RA.
Article
Immunology
Tae Sung M. Kim, Lakmali Silva, Vasileios Ionas Theofilou, Teresa Greenwell-Wild, Lu Li, Drake Winslow Williams, Tomoko Ikeuchi, Laurie H. Brenchley, Thomas I. Bugge, Patricia J. Diaz, Mariana Kaplan, Carmelo M. Carmona-Rivera, Niki Moutsopoulos
Summary: Neutrophil extracellular traps (NETs) are early triggers of pathogenic inflammation in periodontitis, a prevalent oral inflammatory disease. NETs promote IL-17/Th17 immune response and contribute to bone destruction. Human findings support the role of NET-mediated pathology in periodontitis.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Immunology
Qiong Wang, Qinbin Ye, Xiaoyu Xi, Xiaoxue Cao, Xing Wang, Mengxiao Zhang, Yuan Xu, Tingting Deng, Xiaobing Deng, Guoqiang Zhang, Cheng Xiao
Summary: This study explored the association between RIPK1-dependent necroptosis and the pathogenesis of rheumatoid arthritis (RA), and identified a potential new treatment option. The plasma levels of RIPK1 and MLKL were found to be higher in RA patients and positively correlated with disease severity. Treatment with KW2449, a small molecule inhibitor targeting RIPK1, reduced joint inflammation and tissue damage in an animal model of RA. These findings suggest that RIPK1-dependent necroptosis could be a therapeutic target for RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Ehsan Nourbakhsh, Ali Mohammadi, Mohammad Salemizadeh Parizi, Atena Mansouri, Farnoosh Ebrahimzadeh
Summary: Myeloid suppressor cells play a crucial role in autoimmune diseases by regulating T cell function, making them a potential target for therapy. Despite significant progress in understanding their involvement in autoimmune diseases, many questions surrounding MDSC activation and functions remain unanswered.
INFLAMMOPHARMACOLOGY
(2021)
Article
Rheumatology
Anella Saviano, Adel Abo Manosour, Federica Raucci, Francesco Merlino, Noemi Marigliano, Anna Schettino, Mussarat Wahid, Jenefa Begum, Andrew Filer, Julia E. Manning, Gian Marco Casillo, Marialuisa Piccolo, Maria Grazia Ferraro, Simona Marzano, Pasquale Russomanno, Rosa Bellavita, Carlo Irace, Jussara Amato, Mohammed Alfaifi, Peter Rimmer, Tariq Iqbal, Stefano Pieretti, Valentina Vellecco, Francesco Caso, Luisa Costa, Roberto Giacomelli, Raffaele Scarpa, Giuseppe Cirino, Mariarosaria Bucci, Helen M. McGettrick, Paolo Grieco, Asif Jilani Iqbal, Francesco Maione
Summary: This study identified a novel IL-17A/F-derived peptide and generated a new anti-IL-17 antibody that can effectively reverse the pro-inflammatory actions of IL-17A/F. The antibody showed less off-target effects compared to the current gold-standard biologic. Preclinical and clinical evidence demonstrated the high efficacy and therapeutic potency of the antibody in patients with IMIDs.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Sadiq Umar, Karol Palasiewicz, Katrien Van Raemdonck, Michael V. Volin, Bianca Romay, M. Asif Amin, Ryan K. Zomorrodi, Shiva Arami, Mark Gonzalez, Vikram Rao, Brian Zanotti, David A. Fox, Nadera Sweiss, Shiva Shahrara
Summary: In this study, it was found that the binding of miR-Let7b to TLR7 can enhance synovitis, while IRAK4 inhibitor therapy can treat RA by reducing arthritis activity, especially in miR-Let7b-induced arthritis.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Katrien Van Raemdonck, Sadiq Umar, Karol Palasiewicz, Bianca Romay, Suncica Volkov, Shiva Arami, Nadera Sweiss, Shiva Shahrara
Summary: This study reveals that miR-Let7b activates TLR7 and induces skin inflammation, exacerbating joint inflammation in a PsA-like preclinical model. TLR7 agonist R837 promotes metabolic reprogramming in macrophages and enhances the expression of IL-1 beta, IL-6, and IL-12, facilitating myeloid-to-T-cell crosstalk in mice. Inhibiting glycolysis reverses TLR7-driven inflammation in myeloid and lymphoid cells, suggesting a potential therapeutic target for PsA.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Yunjuan Nie, Teja Srinivas Nirujogi, Ravi Ranjan, Brenda F. Reader, Sangwoon Chung, Megan N. Ballinger, Joshua A. Englert, John W. Christman, Manjula Karpurapu
Summary: Pulmonary macrophages are crucial in lung injury pathogenesis, with NFATc3 and NF-kB being key regulators through PARP-1-mediated polyADP-ribosylation, affecting macrophage function and inflammation expression. Inhibiting polyADP-ribosylation with PARP-1 inhibitors prevents LPS-induced ALI pathogenesis.
JOURNAL OF INNATE IMMUNITY
(2021)
Article
Immunology
Sadiq Umar, Karol Palasiewicz, Katrien Van Raemdonck, Michael V. Volin, Bianca Romay, Imran Ahmad, Chandana Tetali, Nadera Sweiss, M. Asif Amin, Ryan K. Zomorrodi, Shiva Shahrara
Summary: CCL25 and CCR9 enhance the infiltration and inflammatory response of RA FLS and monocytes in RA through p38 and ERK phosphorylation. However, CCL25 is unable to polarize RA PBMCs into effector Th1/Th17 cells.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Rheumatology
Katrien Van Raemdonck, Sadiq Umar, Karol Palasiewicz, Michael V. Volin, Hatem A. Elshabrawy, Bianca Romay, Chandana Tetali, Azam Ahmed, M. Asif Amin, Ryan K. Zomorrodi, Nadera Sweiss, Shiva Shahrara
Summary: IL-34, an endogenous factor, plays a crucial role in rheumatoid arthritis by remodeling hypermetabolic M34 macrophages and facilitating their cross-regulation with T effector cells, ultimately leading to inflammatory bone destruction.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Critical Care Medicine
Sharon Leung, Stephen M. Pastores, John M. Oropello, Craig M. Lilly, Samuel M. Galvagno, Neeraj Badjatia, Judith Jacobi, Daniel L. Herr, Jason David Oliveira
Summary: This article proposes a framework based on expert opinions and survey responses to assist critical care organizations in designing and implementing successful regionalization. The article highlights the need for a critical assessment of administrative and clinical challenges and barriers, and emphasizes the importance of systems thinking, business planning and control, and essential infrastructure development.
CRITICAL CARE MEDICINE
(2022)
Article
Cell Biology
Katrien Van Raemdonck, Sadiq Umar, Karol Palasiewicz, Anja Meyer, Michael V. Volin, Huan J. Chang, Mina Al-Awqati, Ryan K. Zomorrodi, Shiva Shahrara
Summary: The study revealed the significant role of CCL21 in metabolic reprogramming of experimental arthritis and rheumatoid arthritis macrophages, and the mechanism of regulating inflammatory response through 2-DG therapy. The findings suggest that CCL21 promotes inflammation and impacts immune metabolism by modulating glucose uptake and glycolysis pathway.
IMMUNOLOGY AND CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sadiq Umar, Karol Palasiewicz, Anja Meyer, Prabhakaran Kumar, Bellur S. Prabhakar, Michael V. Volin, Rani Rahat, Mina Al-Awqati, Huan J. Chang, Ryan K. Zomorrodi, Jalees Rehman, Shiva Shahrara
Summary: Inflammatory and glycolytic responses in severe COVID-19 patients may be counter-regulated by targeting IRAK4, which plays a critical role in the molecular mechanism driven by SARS-CoV-2 Spike protein. Inhibition of IRAK4 rescues SARS-CoV-2-induced cytotoxic effects and reduces inflammatory markers and metabolic imprints, offering a promising therapeutic strategy.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Medicine, Research & Experimental
Sonal R. Pannu, Tyler Haddad, Matthew Exline, John W. Christman, Jeffrey C. Horowitz, Jonathan Peters, Guy Brock, Philip Diaz, Elliott D. Crouser
Summary: This study aims to improve targeted oxygenation in mechanically ventilated patients by reducing excessive FiO(2) exposure. The use of algorithm-based FiO(2) titration and electronic alert system aims to curb hyperoxemia and prevent hypoxemia by shortening the time spent with high FiO(2) levels.
CONTEMPORARY CLINICAL TRIALS
(2022)
Article
Immunology
Teja Srinivas Nirujogi, Sainath R. Kotha, Sangwoon Chung, Brenda F. Reader, Anita Yenigalla, Liwen Zhang, John P. Shapiro, Jon Wisler, John W. Christman, Krishnarao Maddipati, Narasimham L. Parinandi, Manjula Karpurapu
Summary: This study reveals the presence of diverse lipid mediators in extracellular vesicles (EVs) during acute lung injury (ALI), which are correlated with the inflammatory status of lung macrophages. These EVs modulate the function of macrophages and alveolar epithelial cells during ALI.
JOURNAL OF INNATE IMMUNITY
(2022)
Review
Immunology
Anja Meyer, Prashant J. Parmar, Shiva Shahrara
Summary: While physiological levels of IL-7 are essential for T cell function, elevated levels of IL-7 in Rheumatoid arthritis (RA) can contribute to disease activity and joint inflammation. IL-7 promotes immune cell differentiation and secretion of inflammatory factors, aggravating the inflammatory response. Blocking IL-7/IL-7R signaling can effectively suppress joint inflammation, osteoclast formation, and neovascularization.
AUTOIMMUNITY REVIEWS
(2022)
Article
Critical Care Medicine
Jon R. Wisler, Kanhaiya Singh, Adara McCarty, Ryan Harkless, Manjula Karpurapu, Edward Hernandez, Debasmita Mukherjee, Ahmed S. Abouhashem, John W. Christman, Chandan K. Sen
Summary: Exosome-mediated transfer of DNMT mRNA may result in methylation and gene silencing during sepsis-induced immunosuppression. Inhibition of exosome uptake or targeted siRNA-mediated DNMT gene silencing can prevent the transfer of DNMT mRNA and maintain host immune response. This highlights the therapeutic potential of targeting these exosome-mediated epigenetic events during sepsis.
Editorial Material
Rheumatology
Nadera J. Sweiss, Robert Baughman
Summary: Limited understanding of the immunology of sarcoidosis has hindered therapeutic progress. However, evidence from a small open-label trial suggests that treatment with the Janus kinase inhibitor tofacitinib can improve sarcoidosis symptoms, primarily by inhibiting type 1 immunity.
NATURE REVIEWS RHEUMATOLOGY
(2022)
Article
Allergy
Hyung-Geun Moon, Jacob D. Eccles, Seung-jae Kim, Ki-Hyun Kim, Young-Mee Kim, Jalees Rehman, Hyun Lee, Pinal Kanabar, John W. Christman, Steven J. Ackerman, Christian Ascoli, Homan Kang, Hak Soo Choi, Minhyung Kim, Sungyong You, Gye Young Park
Summary: C1q is selectively enriched in the CSF1R+cDC2 subset among conventional DCs, and it plays a critical role in allergen sensing and allergic lung inflammation. The C1q receptor CD91 (LRP1) is required for lung CSF1R+cDC2s to recognize the C1q-allergen complex and induce allergic lung inflammation.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Respiratory System
Jaleel Jerry G. Sweis, Nabil William G. Sweis, Christian Ascoli, Benjamin Levin, Boaz Avitall, Israel Rubinstein, George Kondos, Daniel A. Culver, Marc Judson, Robert Baughman, Dawood Darbar, Wonder Drake, Shiva Shahrara, Leslie T. Cooper, Nadera J. Sweiss
Summary: This study retrospectively evaluated patients with cardiac sarcoidosis who received adalimumab treatment at the University of Illinois Health between 2011 and 2022. Adalimumab showed positive clinical response in all seven patients and had corticosteroid-sparing effects.
RESPIRATORY MEDICINE CASE REPORTS
(2022)