Article
Multidisciplinary Sciences
Ji Eun Park, Sook Min Hwang, Ji-Young Hwang, Jin Hee Moon, Ik Yang, Ji Young Woo, Hye Jin Lee
Summary: The study showed an association between decreased echogenicity and heterogeneity on thyroid ultrasound and thyroid dysfunction in pediatric and adolescent AITD patients. Severe thyroid dysfunction was significantly associated with higher ultrasound grade, and levels of TSH differed significantly according to ultrasound grades in hyperthyroid and hypothyroid states.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Syed Morshed, Rauf Latif, Terry F. Davies
Summary: This study found that TSH or antioxidants can rescue thyroid cells from N-TSHR-mAb-induced apoptosis by enhancing autophagy. These results suggest that N-TSHR-mAb under low TSH conditions in Graves' disease patients may be detrimental to thyroid cell survival.
JOURNAL OF AUTOIMMUNITY
(2022)
Article
Multidisciplinary Sciences
Jae Hwan Choi, Hoon Noh, Yoon-Duck Kim, Kyung In Woo
Summary: This study revealed that the initial concentration of TSAb is a factor affecting the recovery of restrictive myopathy in patients with TED. Age, sex, smoking status, CAS, thyroid status, and muscle thickness on the CT scan did not significantly differ between the improved and not-improved groups.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Terry F. Davies, Syed A. Morshed, Mihaly Mezei, Rauf Latif
Summary: TSH receptor antibodies play an important role in Graves' disease and Hashimoto's thyroiditis, and their measurement is useful for diagnosis and prognosis. However, it is not possible to accurately detect blocking TSH receptor antibodies in patients with Graves' disease due to potential interference from stimulating antibodies.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Ruben Pampin-Sanchez, Cristina Martinez-Mugica-Barbosa, Eva Maria Fonseca-Aizpuru, Francisco Javier Barbazan-Vazquez, Beatriz Fernandez-Gonzalez, Loreto Buznego-Suarez
Summary: This study retrospectively analyzed the experience and outcomes of 11 adult patients with thyroid eye disease (TED) who were treated with intravenous tocilizumab. The results showed that tocilizumab treatment can effectively control TED, improve the quality of life of patients, and has no serious adverse effects.
Article
Medicine, General & Internal
Deborah J. W. Lee, Soon Kieng Phua, Yali Liang, Claire Chen, Tar-Choon Aw
Summary: We evaluated the performance of the Abbott thyroid-stimulating hormone receptor antibody chemiluminescent microparticle immunoassay (CMIA) on the Alinity i. The results showed that the Abbott CMIA met the requirements for precision, linearity, analytical measuring range, limit of blank, limit of detection, limit of quantitation and diagnostic cut offs for Graves' disease. Thus, it is suitable for clinical use.
Article
Multidisciplinary Sciences
Nadia Sawicka-Gutaj, Paulina Ziolkowska, Klaudia Wojciechowska, Sara Shawkat, Agata Czarnywojtek, Wojciech Warchol, Jerzy Sowinski, Ewelina Szczepanek-Parulska, Marek Ruchala
Summary: This study used the ThyPROpl questionnaire to investigate the self-reported influence of benign thyroid diseases on patients' eyes and vision. The results showed that eye complaints are common in patients with benign thyroid diseases, impacting their overall quality of life. Patients with thyroid diseases experienced more ocular complaints compared to controls, except for swelling around the lower eyelids.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Marius Nicolae Stan, Alicia Algeciras-Schimnich, Vishakantha Murthy, Prabin Thapa, Naohiro Araki
Summary: The new OTS-TSI assay showed excellent performance in differential diagnosis of GD and thyroiditis, with a sensitivity and specificity of 100%, superior to ROC-TBII. It also demonstrated high sensitivity for TED diagnosis and has a short turnaround time without the need for cell culture equipment. Larger studies in U.S. populations are needed for validation.
Article
Endocrinology & Metabolism
Masayoshi Nakano, Hiroe Konishi, Masahiro Koshiba
Summary: The thyroid-stimulating antibody/TSH receptor antibody ratio is a highly sensitive and specific indicator for active GO, especially in patients without T3 predominance, and serves as a good screening test for active GO in primary care settings.
ENDOCRINE PRACTICE
(2022)
Article
Endocrinology & Metabolism
Shuhei Morita, Tomoyuki Takagi, Hidefumi Inaba, Yasushi Furukawa, Shohei Kishimoto, Shinsuke Uraki, Naoki Shimo, Ken Takeshima, Saya Uraki, Kei Doi, Mitsuyo Imagawa, Mika Kokawa, Tomomi Konami, Hitomi Hara, Yoshihiro Hara, Emiko Sone, Hiroto Furuta, Masahiro Nishi, Asako Doi, Shinobu Tamura, Taka-aki Mastuoka
Summary: This study investigated the impact of the SARS-CoV-2 vaccine on thyroid autoimmunity and found that the vaccine may disrupt thyroid autoimmunity. Clinicians should consider this possibility.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Dennis Freuer, Christa Meisinger
Summary: Schizophrenia is a chronic psychiatric disorder with unclear causal relationship with thyroid function. A bidirectional two-sample Mendelian randomization study using genome-wide association studies data on Europeans showed that hypothyroidism is inversely associated with schizophrenia. Further research is needed to understand the role of thyroid function in the development of schizophrenia.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Immunology
Tanja Diana, Martin Ungerer, Christian Wuster, Julia Fassbender, Zhongmin Li, Andreas Reimann, Hans-Peter Holthoff, Michael Kanitz, George J. Kahaly
Summary: BALB/c mice receiving long-term immunizations of adenovirus expressing TSHR developed Graves' disease. P19 treatment significantly improved thyroid function, reduced anti-TSHR antibodies and thyroid hormone levels, and had beneficial effects on acidic mucins and collagen content in orbital tissue. This study suggests P19 as a potential novel therapeutic approach for GD and associated orbitopathy.
JOURNAL OF AUTOIMMUNITY
(2021)
Review
Medicine, General & Internal
Swan Kang, Shirin Hamed Azzam, Neda Minakaran, Daniel G. Ezra
Summary: This review assesses the efficacy and safety of using RTX for the treatment of TAO. The results show that there is currently insufficient evidence to support the use of RTX in people with TAO. The study suggests that RTX may improve the clinical activity score of TAO, but the evidence for other outcomes is limited, and the RTX group experiences more adverse events.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Mirjana Babic Leko, Iva Juresko, Iva Rozic, Nikolina Pleic, Ivana Gunjaca, Tatijana Zemunik
Summary: Vitamin D is important for the normal functioning of organs, including the thyroid. Vitamin D deficiency is considered a risk factor for thyroid disorders, but the interaction between vitamin D and thyroid function is not fully understood. Studies comparing vitamin D status with thyroid function and the effect of vitamin D supplementation show inconsistent results, making it difficult to draw a definite conclusion. Additional studies with larger sample sizes are needed to fully understand the effect of vitamin D on thyroid function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medical Laboratory Technology
Yao Hu, Jiajin Ni, Yi Cen, Buyue Zhang, Wenqing Wu, Wei Cheng, Mingying Huang, Ming Guan
Summary: The TSI assay demonstrated excellent analytical performance and high positive predictive value for GD. There was a high correlation between the quantitative results of the two methods, with a cutoff value of 0.7 IU/L obtained through ROC analysis for the TSI assay.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Multidisciplinary Sciences
Deborah L. Burnett, Peter Schofield, David B. Langley, Jennifer Jackson, Katherine Bourne, Emily Wilson, Benjamin T. Porebski, Ashley M. Buckle, Robert Brink, Christopher C. Goodnow, Daniel Christ
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Biochemistry & Molecular Biology
Peter G. Chandler, Li Lynn Tan, Benjamin T. Porebski, James S. Green, Blake T. Riley, Sebastian S. Broendum, David E. Hoke, Robert J. Falconer, Trent P. Munro, Malcolm Buckle, Colin J. Jackson, Ashley M. Buckle
Summary: The FN3Con monobody is explored as a potential alternative to antibodies for therapeutic applications, due to its extreme stability and binding capabilities to therapeutic targets. Grafting binding loops from Adnectin-anti-VEGFR2 onto the prestabilized FN3Con scaffold resulted in a construct with high affinity binding to VEGFR2, maintaining both stability and activity. This strategy offers promise for the development of monobody domains with desirable biophysical characteristics.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Immunology
Chantal E. Hargreaves, Silvia Salatino, Sarah C. Sasson, James E. G. Charlesworth, Elizabeth Bateman, Arzoo M. Patel, Consuelo Anzilotti, John Broxholme, Julian C. Knight, Smita Y. Patel
Summary: CVID is an immunodeficiency disorder characterized by low serum immunoglobulins and susceptibility to bacterial infection. This study suggests that deficient DNA repair mechanisms in some patients may lead to antibody deficiencies, susceptibility to inflammation, and cancer. Targeted sequencing and gene expression analysis identified rare genetic variants in DNA repair pathways in CVID patients, distinguishing them from controls and complex patients.
JOURNAL OF CLINICAL IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Matthew A. Spence, Matthew D. Mortimer, Ashley M. Buckle, Bui Quang Minh, Colin J. Jackson
Summary: This study used a structural alignment of diverse serpins to generate a comprehensive 6,000-sequence phylogeny, showing extensive diversification of the superfamily into many novel functional clades. Analysis indicated that the hub proteins are ancient and similar due to convergent evolution, rather than horizontal gene transfer as previously speculated. This work clarifies longstanding questions in the evolution of serpins and provides new directions for research in the field of serpin biology.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Article
Biochemistry & Molecular Biology
Sebastian S. Broendum, Daniel E. Williams, Brooke K. Hayes, Felix Kraus, James Fodor, Ben E. Clifton, Anne Geert Volbeda, Jeroen D. C. Codee, Blake T. Riley, Nyssa Drinkwater, Kylie A. Farrow, Kirill Tsyganov, Ryan D. Heselpoth, Daniel C. Nelson, Colin J. Jackson, Ashley M. Buckle, Sheena McGowan
Summary: The study identified the polyrhamnose backbone of Group A streptococcal cell wall as the binding target of PlyC, and characterized the putative rhamnose binding groove of PlyC with critical residues. The interaction between PlyC and the cell wall may be a high avidity one rather than a high-affinity one, contributing to PlyC's remarkable lytic activity.
MOLECULAR MICROBIOLOGY
(2021)
Article
Immunology
Alexander Stewart, Joseph Chi-Fung Ng, Gillian Wallis, Vasiliki Tsioligka, Franca Fraternali, Deborah K. Dunn-Walters
Summary: The separation of B cells into different subsets has provided insights into their diverse functions in immune responses. Advances in single-cell techniques have enabled a deeper understanding of B cell characteristics and functions, though challenges remain. This study offers a reference single-cell dataset for better classification of functional B cell subsets in peripheral blood, highlighting the complexity and diversity of B cell populations.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Hematology
Jonathan C. Strefford, Malgorzata Nowicka, Chantal E. Hargreaves, Cathy Burton, Andrew Davies, Rosalind Ganderton, Wolfgang Hiddemann, Chisako Iriyama, Wolfram Klapper, Kate Latham, Maurizio Martelli, Farheen Mir, Helen Parker, Kathleen N. Potter, Matthew J. J. Rose-Zerilli, Laurie H. Sehn, Marek Trneny, Umberto Vitolo, Christopher R. Bolen, Christian Klein, Andrea Knapp, Mikkel Z. Oestergaard, Mark S. Cragg
Summary: This study demonstrates that Fc gamma R genotype is not associated with response to rituximab/obinutuzumab plus chemotherapy in treatment-naive patients with advanced FL or DLBCL.
Article
Hematology
Malgorzata Nowicka, Laura K. Hilton, Margaret Ashton-Key, Chantal E. Hargreaves, Chern Lee, Russell Foxall, Matthew J. Carter, Stephen A. Beers, Kathleen N. Potter, Christopher R. Bolen, Christian Klein, Andrea Knapp, Farheen Mir, Matthew Rose-Zerilli, Cathy Burton, Wolfram Klapper, David W. Scott, Laurie H. Sehn, Umberto Vitolo, Maurizio Martelli, Marek Trneny, Christopher K. Rushton, Graham W. Slack, Pedro Farinha, Jonathan C. Strefford, Mikkel Z. Oestergaard, Ryan D. Morin, Mark S. Cragg
Summary: The study suggests that higher FCGR2B expression in DLBCL patients can reduce drug efficacy and is associated with shorter progression-free survival in R-CHOP treatment. High FCGR2B expression may promote responsiveness to R-CHOP treatment compared to G-CHOP treatment.
Article
Immunology
Chantal E. Hargreaves, Fatima Dhalla, Arzoo M. Patel, Andres Caballero Garcia De Oteyza, Elizabeth Bateman, Joanne Miller, Consuelo Anzilotti, Lisa Ayers, Bodo Grimbacher, Smita Y. Patel
Summary: Genetic variants in PIK3CD, PIK3R1, and NFKB1 are known to cause primary immune deficiencies. This study identified a family with variations in NFKB1, TNFRSF13B, and PIK3R1, and aimed to describe their associated immune and cellular characteristics. The findings showed that mutant PIK3R1 resulted in increased basal pS6 signaling, while mutant NFKB1 did not have this effect.
CLINICAL IMMUNOLOGY
(2022)
Editorial Material
Immunology
Veerle Somers, Deborah K. Dunn-Walters, Mirjam van der Burg, Judith Fraussen
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Xiyuan Bai, Ashley M. Buckle, Eszter K. Vladar, Edward N. Janoff, Reeti Khare, Diane Ordway, David Beckham, Lorelenn B. Fornis, Abraham Majluf-Cruz, Randolph Fugit, Brian M. Freed, Soohyun Kim, Robert A. Sandhaus, Edward D. Chan
Summary: This study found that enoxaparin enhances the inhibition of TMPRSS2 activity by alpha-1-antitrypsin, leading to the inhibition of coronavirus infection. Molecular modeling revealed the specific conformation of AAT and the role of negatively-charged heparin in this process.
SCIENTIFIC REPORTS
(2022)
Correction
Multidisciplinary Sciences
Xiyuan Bai, Ashley M. Buckle, Eszter K. Vladar, Edward N. Janoff, Reeti Khare, Diane Ordway, David Beckham, Lorelenn B. Fornis, Abraham Majluf-Cruz, Randolph V. Fugit, Brian M. Freed, Soohyun Kim, Robert A. Sandhaus, Edward D. Chan
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Cecile F. Frampas, Katie Longman, Matt Spick, Holly-May Lewis, Catia D. S. Costa, Alex Stewart, Deborah Dunn-Walters, Danni Greener, George Evetts, Debra J. Skene, Drupad Trivedi, Andy Pitt, Katherine Hollywood, Perdita Barran, Melanie J. Bailey
Summary: Saliva metabolomics, particularly amino acids, can differentiate between high severity and low severity COVID-19 patients, expanding the understanding of COVID-19 metabolic dysregulation and potentially providing a non-invasive means of sampling patients for timely treatment.
Article
Chemistry, Multidisciplinary
Meri Ayurini, Peter G. Chandler, Paul D. O'Leary, Ruoxin Wang, David Rudd, Karen D. Milewska, Lara R. Malins, Ashley M. Buckle, Joel F. Hooper
Summary: Cobalt-mediated radical polymerizations (CMRPs) have been achieved through the radical decarboxylation of tetrachlorophthalimide activated esters. This method allows for controlled radical polymerization of activated monomers across a wide temperature range using a single cobalt species, while incorporating polymer end groups derived from simple carboxylic acid derivatives and terminating with an organozinc reagent.
Article
Medicine, General & Internal
Matt Spick, Katherine Longman, Cecile Frampas, Holly Lewis, Catia Costa, Deborah Dunn Walters, Alex Stewart, Michael Wilde, Danni Greener, George Evetts, Drupad Trivedi, Perdita Barran, Andy Pitt, Melanie Bailey
Summary: The study revealed lower lipid levels in COVID-19 positive patients, indicating dyslipidemia. Sebum sampling showed potential for distinguishing between COVID-19 positive and negative patients based on lipidomic analysis.