Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens
出版年份 2020 全文链接
标题
Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens
作者
关键词
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出版物
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 117, Issue 36, Pages 22341-22350
出版商
Proceedings of the National Academy of Sciences
发表日期
2020-08-28
DOI
10.1073/pnas.2005102117
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Characterizing the Diversity of the CDR-H3 Loop Conformational Ensembles in Relationship to Antibody Binding Properties
- (2019) Monica L. Fernández-Quintero et al. Frontiers in Immunology
- Stabilization of the V2 loop improves the presentation of V2 loop–associated broadly neutralizing antibody epitopes on HIV-1 envelope trimers
- (2019) Steven W. de Taeye et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cooperation between somatic mutation and germline-encoded residues enables antibody recognition of HIV-1 envelope glycans
- (2019) Nelson R. Wu et al. PLoS Pathogens
- Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens
- (2018) Robert K. Abbott et al. IMMUNITY
- Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination
- (2018) Deborah L. Burnett et al. SCIENCE
- Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity
- (2018) Julie Prigent et al. Cell Reports
- Role of framework mutations and antibody flexibility in the evolution of broadly neutralizing antibodies
- (2018) Victor Ovchinnikov et al. eLife
- Poly- and autoreactivity of HIV-1 bNAbs: implications for vaccine design
- (2018) Joel Finney et al. Retrovirology
- Crystal structure of duck egg lysozyme isoform II (DEL-II)
- (2018) David B. Langley et al. BMC STRUCTURAL BIOLOGY
- Murine LRBA deficiency causes CTLA-4 deficiency in Tregs without progression to immune dysregulation
- (2017) Deborah L Burnett et al. IMMUNOLOGY AND CELL BIOLOGY
- Transient expression of human antibodies in mammalian cells
- (2017) Rodrigo Vazquez-Lombardi et al. Nature Protocols
- Structural basis of antigen recognition: crystal structure of duck egg lysozyme
- (2017) David Brent Langley et al. Acta Crystallographica Section D-Structural Biology
- Antibody Recognition of Disordered Antigens
- (2016) Christopher A. MacRaild et al. STRUCTURE
- Crystal Structure of the Conserved Amino Terminus of the Extracellular Domain of Matrix Protein 2 of Influenza A Virus Gripped by an Antibody
- (2015) Ki Joon Cho et al. JOURNAL OF VIROLOGY
- Conformational Dynamics and Antigenicity in the Disordered Malaria Antigen Merozoite Surface Protein 2
- (2015) Christopher A. MacRaild et al. PLoS One
- Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy
- (2014) Anthony P. West et al. CELL
- Host Controls of HIV Neutralizing Antibodies
- (2014) B. F. Haynes et al. SCIENCE
- How good are my data and what is the resolution?
- (2013) Philip R. Evans et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization
- (2013) Florian Klein et al. CELL
- Vaccine-induced monoclonal antibodies targeting circumsporozoite protein prevent Plasmodium falciparum infection
- (2013) Lander Foquet et al. JOURNAL OF CLINICAL INVESTIGATION
- Elimination of Germinal-Center-Derived Self-Reactive B Cells Is Governed by the Location and Concentration of Self-Antigen
- (2012) Tyani D. Chan et al. IMMUNITY
- Antigenic Characterization of an Intrinsically Unstructured Protein, Plasmodium falciparum Merozoite Surface Protein 2
- (2012) Christopher G. Adda et al. INFECTION AND IMMUNITY
- Expression of high-affinity human antibody fragments in bacteria
- (2012) Romain Rouet et al. Nature Protocols
- An introduction to data reduction: space-group determination, scaling and intensity statistics
- (2011) Philip R. Evans ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- iMOSFLM: a new graphical interface for diffraction-image processing withMOSFLM
- (2011) T. Geoff G. Battye et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- REFMAC5 for the refinement of macromolecular crystal structures
- (2011) Garib N. Murshudov et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Overview of theCCP4 suite and current developments
- (2011) Martyn D. Winn et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Efficacy of RTS,S/AS01E malaria vaccine and exploratory analysis on anti-circumsporozoite antibody titres and protection in children aged 5–17 months in Kenya and Tanzania: a randomised controlled trial
- (2011) Ally Olotu et al. LANCET INFECTIOUS DISEASES
- XDS
- (2010) Wolfgang Kabsch ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Elicitation of structure-specific antibodies by epitope scaffolds
- (2010) G. Ofek et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Association Energetics of Cross-Reactive and Specific Antibodies†
- (2009) S. Mohan et al. BIOCHEMISTRY
- Light chain somatic mutations change thermodynamics of binding and water coordination in the HyHEL-10 family of antibodies
- (2009) Mauro Acchione et al. MOLECULAR IMMUNOLOGY
- Comprehensive secondary-structure analysis of disulfide variants of lysozyme by synchrotron-radiation vacuum-ultraviolet circular dichroism
- (2009) Koichi Matsuo et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- The Intrinsic Contributions of Tyrosine, Serine, Glycine and Arginine to the Affinity and Specificity of Antibodies
- (2008) Sara Birtalan et al. JOURNAL OF MOLECULAR BIOLOGY
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