Article
Neurosciences
Jose Antonio Noriega-Prieto, Laura Eva Maglio, Jonathan A. Zegarra-Valdivia, Jaime Pignatelli, Ana M. Fernandez, Laura Martinez-Rachadell, Jansen Fernandes, Angel Nunez, Alfonso Araque, Ignacio Torres-Aleman, David Fernandez de Sevilla
Summary: This study demonstrates that IGF-I signaling induces long-term potentiation of brain synapses in mice by activating astrocytic IGF-I receptors, resulting in changes in synaptic plasticity and animal behavior. The research reveals a novel mechanism of how IGF-I impacts cortical inhibitory synaptic plasticity and animal behavior through astrocytes.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Ecology
Christyn Bailey, Nicole Strepparava, Albert Ros, Thomas Wahli, Heike Schmidt-Posthaus, Helmut Segner, Carolina Tafalla
Summary: The study revealed that hosts of different ages and infection life history stages have varying responses to Tetracapsuloides bryosalmonae infection and proliferative kidney disease (PKD). Older fish showed a decline in susceptibility, and re-exposure to the parasite resulted in a concomitant immunity that did not intensify infection severity. These findings highlight the importance of infection life history heterogeneity on disease outcome and immune responses.
JOURNAL OF ANIMAL ECOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
M. Monteiro, A. S. Lavrador, R. Santos, F. Rangel, P. Iglesias, M. Tarraga, A. Couto, C. R. Serra, C. Tafalla, E. Da Costa, M. R. Domingues, A. Oliva-Teles, A. P. Carvalho, P. Enes, P. Diaz-Rosales
Summary: This study demonstrates the potential of algae extracts as immunotherapeutic agents with antiviral and antibacterial activities. Extracts from brown and green algae showed promising results in inhibiting viruses and bacteria, and were found to enhance zebrafish immune response and intestinal morphology.
MARINE BIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Pedro Perdiguero, Esther Morel, Patricia Diaz-Rosales, Carolina Tafalla
Summary: B cells express a unique antibody protein with diverse antigen binding regions. The transcription of different rearranged VLJLCL genes in single rainbow trout B cells suggests a more relaxed isotype exclusion in teleosts.
Article
Biology
Pedro Perdiguero, Esther Morel, Carolina Tafalla
Summary: The study utilized the newly developed 10x Genomics single-cell RNA sequencing technology to analyze the transcriptional patterns of individual B cells in the peripheral blood of teleost fish, revealing different subsets and maturation stages. The results offer valuable insights into the biology of teleost B cells and provide potential markers for differentiating trout B cell subsets in the future.
Article
Fisheries
Yehfang Hu, Ayham Alnabulsi, Abdo Alnabulsi, Callum Scott, Carolina Tafalla, Christopher J. Secombes, Tiehui Wang
Summary: IFN-gamma is a key cytokine in Th1 immune responses, playing a crucial role in protection against infections. Monoclonal antibodies developed in this study were able to monitor IFN-gamma expression, revealing that various cells in trout can produce IFN-gamma and increase following infection or vaccination. Monitoring IFN-gamma production may be important in assessing the effectiveness of Th1 responses and cell mediated immunity in fish.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
M. Estrella Fernandez de Sevilla, Jaime Pignatelli, Jonathan A. Zegarra-Valdivia, Pablo Mendez, Angel Nunez, Ignacio Torres Aleman
Summary: This study reveals that mice lacking functional insulin-like growth factor I (IGF-I) receptors in orexin neurons exhibit PTSD-like behavior and are unresponsive to the anxiolytic effects of IGF-I, while inhibition of orexin neurons improves this behavior. Systemic IGF-I treatment also ameliorates PTSD-like behavior in mice, and IGF-I modulates the GABA/Glutamate synaptic structure in orexin neurons to achieve this effect.
MOLECULAR PSYCHIATRY
(2022)
Article
Immunology
Beatriz Abos, Elena Perez-Fernandez, Esther Morel, Pedro Perdiguero, Carolina Tafalla
Summary: In rainbow trout, TWEAK 1 plays a role in response to pathogens by modulating the transcription of antimicrobial and pro-inflammatory genes in different leukocyte subsets. Additionally, TWEAK has been established as a B cell differentiation factor in this species.
FRONTIERS IN IMMUNOLOGY
(2021)
Correction
Immunology
Ottavia Benedicenti, Tiehui Wang, Esther Morel, Christopher J. Secombes, Irene Soleto, Patricia Diaz-Rosales, Carolina Tafalla
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jaime Pignatelli, M. Estrella Fernandez de Sevilla, Jacob Sperber, Daniel Horrillo, Gema Medina-Gomez, Ignacio Torres Aleman
Summary: The uncoupling of metabolism and circadian activity increases the risk of various pathologies. Insulin and IGF-I have been found to regulate feeding patterns and circadian rhythms. IGF-I modulates orexin neurons to align metabolism and circadian rhythms, which is essential in preventing metabolic disorders and diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Jonathan A. Zegarra-Valdivia, Jansen Fernandes, Maria Estrella Fernandez de Sevilla, Angel Trueba-Saiz, Jaime Pignatelli, Kentaro Suda, Laura Martinez-Rachadell, Ana Maria Fernandez, Julio Esparza, Miguel Vega, Angel Nunez, Ignacio Torres Aleman
Summary: Sleep disturbances in aging mice are related to impaired IGF-I signaling onto orexin neurons, and modulation of the activity of orexin neurons in the lateral hypothalamus can improve sleep patterns.
Article
Neurosciences
Inmaculada Crespo, Jaime Pignatelli, Veena Kinare, Hector R. Mendez-Gomez, Miriam Esgleas, Maria Jose Roman, Josep M. Canals, Shubha Tole, Carlos Vicario
Summary: This study investigates the impact of misexpression of the Tbr1 transcription factor on mouse neural progenitor cells. The results suggest that Tbr1 misexpression delays or disrupts neuronal migration, specification, and dendrite development, potentially leading to brain malformations.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Ana M. Fernandez, Laura Martinez-Rachadell, Marta Navarrete, Julia Pose-Utrilla, Jose Carlos Davila, Jaime Pignatelli, Sonia Diaz-Pacheco, Santiago Guerra-Cantera, Emilia Viedma-Moreno, Rocio Palenzuela, Samuel Ruiz de Martin Esteban, Ricardo Mostany, Cristina Garcia-Caceres, Matthias Tschop, Teresa Iglesias, Maria L. de Ceballos, Antonia Gutierrez, Ignacio Torres Aleman
Summary: Insulin receptors in astrocytes play a role in neurovascular coupling by modulating glucose uptake and angiogenesis. Lack of insulin receptors in astrocytes leads to uncoupling of brain blood flow with glucose uptake, disturbed mitochondrial function, and abnormal angiogenesis. Treatment with the antioxidant N-acetylcysteine can normalize these effects.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Francisco J. Fernandez Acosta, Inma Luque-Molina, Rebeca Vecino, Eva Diaz-Guerra, Cagla Defterali, Jaime Pignatelli, Carlos Vicario
Summary: This study found that neural stem cells in the olfactory bulb of adult mice can generate CalR(+) neurons, and these adult cells exhibit different morphologies when migrating to different layers of the olfactory bulb. The study also revealed that altering the expression of the transcription factor Tbr1 can affect the migration and morphology of these newly generated neurons.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Fisheries
Rocio Simon, Patricia Martinez, Lucia Gonzalez, M. Camino Ordas, Carolina Tafalla
Summary: Mucosal surfaces are the main route for pathogens to enter the host. This study investigated the immune response of mucosal epithelial cells from the gastrointestinal tract and gills of rainbow trout to a viral mimic and two important viral pathogens. The results provide valuable information on the different responses of these cell lines to viral stimuli and their usefulness in studying mucosal responses in fish.
JOURNAL OF FISH DISEASES
(2023)