Article
Oncology
Ying Chen, Bailing Tian
Summary: This study investigated the effects of IFN-gamma on autoimmune diseases in SLE patients and mouse models. The results showed that IFN-gamma contributes to the pathogenesis of SLE by regulating inflammation and immune complex formation.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Immunology
Neha Sangewar, Suryakant D. Waghela, Jianxiu Yao, Huldah Sang, Jocelyn Bray, Waithaka Mwangi
Summary: This study identified highly cross-reactive BVDV-specific CD8(+) T cells in cattle and novel IFN-gamma-inducing CD8(+) T cell epitopes from different regions of BVDV polyprotein. These conserved epitopes were found to elicit broadly reactive CD8(+) T cell responses against diverse BVDV strains, suggesting their potential use in developing a more effective CD8(+) T cell-based BVDV vaccine.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Changlin Zhao, Xianlin Wu, Jia Chen, Guoqiang Qian
Summary: The therapeutic effects of IL-21 and IFN-gamma inducing the formation of CD4(+)CXCR5(+)CD57(+)T cells on liver cancer were evaluated in this study. The increase in CD4(+)CXCR5(+)CD57(+)T cells and the elevated expression of IL-21 and IFN-gamma were associated with prolonged survival in liver cancer patients. HBV infection led to a decrease in CD4(+)CXCR5(+)CD57(+)T cells and chronic inflammation.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yunyan Sun, Bing Wang, Qianwen Hu, Haixiao Zhang, Xun Lai, Tier Wang, Chunxiao Zhao, Jiali Wang, Xi Zhang, Qing Niu, Baolin He, Erlie Jiang, Mingxia Shi, Xiaoming Feng, Yuechen Luo
Summary: Adipose tissue CD11c(+) myeloid cell is an independent risk factor for obesity and metabolic disorders. In this study, it was found that liver kinase B1 (Lkb1) plays a role in CD11c(+) cell-mediated immune responses in diet-induced obesity. Loss of Lkb1 in CD11c(+) cells leads to obesity resistance but lower glucose tolerance, accompanied by immune abnormalities. The imbalance of IL-17A and IFN-gamma is observed in fat T cells and CD11c(-) macrophages, contributing to the resistance to weight gain.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Oncology
Shuxin Huang, Yujie Zhao, Wenpu Lai, Jiaxiong Tan, Xue Zheng, Xianfeng Zha, Yangqiu Li, Shaohua Chen
Summary: This study found that T cell exhaustion and immune microenvironment heterogeneity contribute to the limited clinical efficacy of immune checkpoint inhibitors (ICIs) in acute myeloid leukemia (AML) immunotherapy. Blocking PD-1 or Tim-3 can partially restore cytokine secretion, with a synergistic effect observed by co-blocking PD-1 and Tim-3. However, there is heterogeneity in cytokine secretion in ICI-treated T cells in AML patients.
CANCER BIOLOGY & THERAPY
(2023)
Article
Immunology
Faisal Rasheed Anjum, Sidra Anam, Ghazanfar Abbas, Muhammad Shahid Mahmood, Sajjad Ur Rahman, Mohsan Ullah Goraya, Rana Muhammad Abdullah, Muhammad Luqman, Ashiq Ali, Muhammad Kamran Akram, Tamoor Hamid Chaudhry
Summary: This study reviews the protective and immunopathogenic role of type I interferons in the pathogenesis of MERS-CoV, SARS-CoV, and SARS-CoV-2. It emphasizes the potential implications of using type I interferons in combination with IFN-gamma for the treatment of COVID-19.
Review
Oncology
Charles D. Mills, Laurel L. Lenz, Robert A. Harris
Article
Microbiology
Emily M. Eshleman, Christine Delgado, Staci J. Kearney, Rachel S. Friedman, Laurel L. Lenz
Review
Immunology
William J. Crisler, Laurel L. Lenz
CURRENT OPINION IN IMMUNOLOGY
(2018)
Article
Cell Biology
Sarah E. Clark, Rebecca L. Schmidt, Daniel S. McDermott, Laurel L. Lenz
Editorial Material
Immunology
Scott Alper, Laurel L. Lenz
CURRENT OPINION IN IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Taylor K. Soderborg, Sarah E. Clark, Christopher E. Mulligan, Rachel C. Janssen, Lyndsey Babcock, Diana Ir, Dominick J. Lemas, Linda K. Johnson, Tiffany Weir, Laurel L. Lenz, Daniel N. Frank, Teri L. Hernandez, Kristine A. Kuhn, Angelo D'Alessandro, Linda A. Barbour, Karim C. El Kasmi, Jacob E. Friedman
NATURE COMMUNICATIONS
(2018)
Correction
Multidisciplinary Sciences
Taylor K. Soderborg, Sarah E. Clark, Christopher E. Mulligan, Rachel C. Janssen, Lyndsey Babcock, Diana Ir, Bridget Young, Nancy F. Kriebs, Dominick J. Lemas, Linda K. Johnson, Tiffany Weir, Laurel L. Lenz, Daniel N. Frank, Teri L. Hernandez, Kristine A. Kuhn, Angelo D'Alessandro, Linda A. Barbour, Karim C. El Kasmi, Jacob E. Friedman
NATURE COMMUNICATIONS
(2019)
Article
Immunology
Sarah E. Clark, Kristina S. Burrack, Stephen C. Jameson, Sara E. Hamilton, Laurel L. Lenz
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Cell Biology
Chao Yang, Daniel S. McDermot, Shivani Pasricha, Sammy Bedoui, Laurel L. Lenz, Ian R. van Driel, Elizabeth L. Hartland
JOURNAL OF LEUKOCYTE BIOLOGY
(2020)
Review
Immunology
Elizabeth R. Aguilera, Laurel L. Lenz
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Immunology
Melissa M. Walker, Soojin Kim, William J. Crisler, Kimberlie Nguyen, Laurel L. Lenz, John C. Cambier, Andrew Getahun
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Medical Laboratory Technology
Sarah E. Clark, Rebecca L. Schmidt, Elizabeth R. Aguilera, Laurel L. Lenz
TRANSLATIONAL RESEARCH
(2020)
Article
Immunology
Sandy R. Larson, Nikki Bortell, Alysha Illies, William J. Crisler, Jennifer L. Matsuda, Laurel L. Lenz
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Microbiology
Nikki Bortell, Elizabeth R. Aguilera, Laurel L. Lenz
Summary: Pulmonary coinfections can impair the host's ability to control systemic Lm, increasing susceptibility to severe infection. Exposure to microbial products can render hosts more susceptible to severe infection through an increase in IL-10 production. This increase in susceptibility correlates with a dampening of myeloid cell function in infected tissues.
Article
Biology
William J. Crisler, Emily M. Eshleman, Laurel L. Lenz
LIFE SCIENCE ALLIANCE
(2019)