Article
Pharmacology & Pharmacy
Hongxing Wang, Hui Wu, Kehua Fang, Xiaotian Chang
Summary: The study showed significantly increased levels of uridine diphosphate (UDP) in the synovial fluid of rheumatoid arthritis (RA) patients, positively correlated with disease markers. UDP was found to promote RA pathogenesis by stimulating P2Y6 activity to increase IL-6 production.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Melanie Fouesnard, Johanna Zoppi, Melanie Petera, Lea Le Gleau, Carole Migne, Fabienne Devime, Stephanie Durand, Alexandre Benani, Samuel Chaffron, Veronique Douard, Gaelle Boudry
Summary: The study revealed that early consumption of a Western diet rapidly affected hypothalamic metabolites in rats, while reducing the diversity of caecal microbiota and shifting its composition towards a pro-inflammatory profile. Data integration indicated strong correlations between gut microbiota sub-networks and hypothalamic oxidative stress.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Article
Biochemistry & Molecular Biology
Yukari Suda, Toshihisa Nakashima, Hiroaki Matsumoto, Daisuke Sato, Satoshi Nagano, Haruka Mikata, Sara Yoshida, Kenichi Tanaka, Yusuke Hamada, Naoko Kuzumaki, Minoru Narita
Summary: The study found that aging in the hypothalamus contributes to increased anxiety, impaired motor coordination, and reduced muscle strength in mice. Aging leads to the production of PD-1-enriched exhausted microglia and neuroinflammatory A1-like reactive astrocytes in the hypothalamus.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Jacob M. Dundee, Mar Puigdellivol, Richard Butler, Thomas O. J. Cockram, Guy C. Brown
Summary: Aging leads to loss of brain synapses and memory, possibly due to microglial phagocytosis of synapses. Activation of P2Y(6) receptor (P2Y(6)R) by UDP released from stressed neurons induces microglial phagocytosis. Inactivation of P2Y(6)R decreases microglial phagocytosis of synapses and prevents age-induced synaptic loss and memory impairment.
Article
Biochemistry & Molecular Biology
Fernando Cruz-Mendoza, Sonia Luquin, Joaquin Garcia-Estrada, David Fernandez-Quezada, Fernando Jauregui-Huerta
Summary: This study investigated the effects of acoustic stress on hippocampal proliferation and glial cytoarchitecture in adult male rats using environmental noise as a stress model. The results showed abnormal cellular proliferation in the hippocampus after 21 days of noise exposure, with an inverse effect on the proliferation ratios of astrocytes and microglia. Both cell lineages also displayed atrophic morphologies with fewer processes and lower densities in the noise-stressed animals. These findings suggest that stress not only affects neurogenesis and neuronal death in the hippocampus, but also the proliferation ratio, cell density, and morphology of glial cells, potentially triggering an inflammatory-like response that compromises their homeostatic and repair functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
You Jung Kang, Hsih-Yin Tan, Charles Y. Lee, Hansang Cho
Summary: PM2.5 particulate matter, a major air pollutant, has been linked to neurological disorders like Alzheimer's disease. Studies show that PM2.5 exposure can lead to neuronal damage and neuroinflammation in the brain.
Article
Chemistry, Multidisciplinary
Wei Fu, Lu Ma, Yan Ju, Jianguo Xu, Hao Li, Sirong Shi, Tao Zhang, Ronghui Zhou, Jianwei Zhu, Ruxiang Xu, Chao You, Yunfeng Lin
Summary: Inhibition of CCR2 expression during the acute phase of ICH polarizes microglia towards a therapeutic subtype, leading to accelerated hematoma absorption, decreased neurological inflammation, and improved neurological function in mice. The nanorobotic tFNA shows promising ability to transfer siCCR2 for treating ICH.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Immunology
Kaira A. Church, Derek Rodriguez, Andrew S. Mendiola, Difernando Vanegas, Irene L. Gutierrez, Ian Tamayo, Abdul Amadu, Priscila Velazquez, Sandra M. Cardona, Stefka Gyoneva, Anne C. Cotleur, Richard M. Ransohoff, Tejbeer Kaur, Astrid E. Cardona
Summary: Diabetic retinopathy is a complication of diabetes with no cure. This study found that polymorphic variants of CX3CR1 exacerbate inflammation, neuronal loss, and vascular damage in diabetic retinas. Pharmacological depletion of microglia reduced neurodegeneration and angiogenesis in wild-type mice, but not in mice with CX3CR1 variants.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Paula Izquierdo-Altarejos, Mar Martinez-Garcia, Vicente Felipo
Summary: Patients with liver cirrhosis may experience cognitive impairment due to hyperammonemia and peripheral inflammation, which can also be replicated in rats with chronic hyperammonemia. Neuroinflammation in the hippocampus, caused by peripheral inflammation, alters neurotransmission and leads to cognitive impairment. Extracellular vesicles (EVs) from peripheral blood are believed to play a role in transmitting these peripheral alterations to the brain.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Clinical Neurology
Xionghui Chen, Xuying He, Feng Xu, Ningbo Xu, Nona Hashem Sharifi, Pengjie Zhang, Jerry J. Flores, Lei Wu, Qiuguang He, Hideki Kanamaru, Shiyi Zhu, Siyuan Dong, Mingyang Han, Ye Yuan, Lei Huang, Liyan Miao, John H. Zhang, Youxin Zhou, Jiping Tang
Summary: This study investigated the therapeutic effects of r-FKN on experimental germinal matrix hemorrhage (GMH) and its underlying mechanisms. The results showed that r-FKN could promote hematoma resolution, attenuate neuroinflammation and neurological deficits, and induce M1/M2 microglial polarization through the AMPK/PPARγ signaling pathway.
Article
Cell Biology
Hongyun Wang, Junrui Ye, Ye Peng, Wenyu Ma, Haodong Chen, Hongshuo Sun, Zhongping Feng, Wenbin He, Gang Li, Shifeng Chu, Zhao Zhang, Naihong Chen
Summary: This study investigated the role of microglial mitophagy in CKLF-induced microglial activation and neuroinflammation. The findings suggest that CKLF treatment leads to an increase in mitophagy markers and autophagosome formation, but impairs lysosomal function, resulting in the accumulation of damaged mitochondria in microglial cells. Pharmacological blocking or gene-silencing of mitophagy inhibits CKLF-mediated microglial activation and inflammation.
Article
Cell Biology
Qinjie Zhou, Diego F. Nino, Yukihiro Yamaguchi, Sanxia Wang, William B. Fulton, Hongpeng Jia, Peng Lu, Thomas Prindle, David Pamies, Meaghan Morris, Liam L. Chen, Chhinder P. Sodhi, David J. Hackam
Summary: Necrotizing enterocolitis (NEC) can lead to acute intestinal necrosis in premature infants and severe neurological impairment. The activation of toll-like receptor 4 in the intestinal epithelium is associated with NEC-related brain injury, which may be induced by gut-derived IFN-gamma-releasing CD4(+) T cells. Early intervention to manage intestinal inflammation in children with NEC could potentially improve neurological outcomes.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Neurosciences
Chikage Kijima, Toshiki Inaba, Kenichiro Hira, Nobukazu Miyamoto, Kazuo Yamashiro, Takao Urabe, Nobutaka Hattori, Yuji Ueno
Summary: This study investigates whether astrocytic extracellular vesicles (AEVs) regulated by microglia can modulate glial scars and improve stroke recovery. The researchers found that the peri-infarct glial scars consisted of reactive astrocytes and that administering AEVs led to functional recovery in rats subjected to middle cerebral artery occlusion.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ji-Yun Kang, Dong-Cheol Baek, Chang-Gue Son, Jin-Seok Lee
Summary: Microglia are important targets for treating neuropsychiatric disorders. Pinus spp. succinum extract (PSE) has strong antineuroinflammatory and antidepressant properties, potentially involving the regulation of NF-κB translocation and the CX3CR1/Nrf2 pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Debashis Dutta, Malabendu Jana, Moumita Majumder, Susanta Mondal, Avik Roy, Kalipada Pahan
Summary: Targeting the TLR2/MyD88/NF-kappa B pathway can reduce alpha-synuclein spreading, decrease neuroinflammation, and protect dopaminergic neurons.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Lu Wang, Lin Yuan, Xian Zeng, Juanjuan Peng, Yong Ni, Jun Cheng Er, Wang Xu, Bikram Keshari Agrawalla, Dongdong Su, Beomsue Kim, Young-Tae Chang
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2016)
Article
Chemistry, Multidisciplinary
Juanjuan Peng, Wang Xu, Chai Lean Teoh, Sanyang Han, Beomsue Kim, Animesh Samanta, Jun Cheng Er, Lu Wang, Lin Yuan, Xiaogang Liu, Young-Tae Chang
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2015)
Article
Multidisciplinary Sciences
Insup Choi, Beomsue Kim, Ji-Won Byun, Sung Hoon Baik, Hyun Huh, Jong-Hyeon Kim, Inhee Mook-Jung, Woo Keun Song, Joo-Ho Shin, Hyemyung Seo, Young Ho Suh, Ilo Jou, Sang Myun Park, Ho Chul Kang, Eun-Hye Joe
NATURE COMMUNICATIONS
(2015)
Article
Biochemistry & Molecular Biology
Beomsue Kim, Suihan Feng, Seong-Wook Yun, Cheryl Leong, Rudrakanta Satapathy, Si Yan Diana Wan, Young-Tae Chang
Article
Chemistry, Multidisciplinary
Lu Wang, Jingye Zhang, Beomsue Kim, Juanjuan Peng, Stuart N. Berry, Yong Ni, Dongdong Su, Jungyeol Lee, Lin Yuan, Young-Tae Chang
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2016)
Article
Neurosciences
Insup Choi, Jun Kim, Hey-Kyeong Jeong, Beomsue Kim, Ilo Jou, Sang Myun Park, Linan Chen, Un-Jung Kang, Xiaoxi Zhuang, Eun-hye Joe
Article
Immunology
Kyoung-Jin Min, Hey-Kyeong Jeong, Beomsue Kim, Dong Hoon Hwang, Hae Young Shin, An Tran Nguyen, Jong-hyeon Kim, Ilo Jou, Byung G. Kim, Eun-hye Joe
JOURNAL OF NEUROINFLAMMATION
(2012)
Article
Multidisciplinary Sciences
Beomsue Kim, Myung-Soon Yang, Dongjoo Choi, Jong-Hyeon Kim, Hye-Sun Kim, Wongi Seol, Sangdun Choi, Ilo Jou, Eun-Young Kim, Eun-Hye Joe
Article
Multidisciplinary Sciences
Sangwook Park, Seulki Han, Insup Choi, Beomsue Kim, Seung Pyo Park, Eun-Hye Joe, Young Ho Suh
Article
Cell & Tissue Engineering
Cheryl Leong, Duanting Zhai, Beomsue Kim, Seong-Wook Yun, Young-Tae Chang
STEM CELL RESEARCH
(2013)
Article
Multidisciplinary Sciences
Sung-Jin Park, Beomsue Kim, Sejong Choi, Sivaraman Balasubramaniam, Sung-Chan Lee, Jung Yeol Lee, Heon Seok Kim, Jun-Young Kim, Jong-Jin Kim, Yong-An Lee, Nam-Young Kang, Jin-Soo Kim, Young-Tae Chang
NATURE COMMUNICATIONS
(2019)
Article
Chemistry, Multidisciplinary
Beomsue Kim, Masahiro Fukuda, Jung-Yeol Lee, Dongdong Su, Srikanta Sanu, Aymeric Silvin, Audrey T. T. Khoo, Taejoon Kwon, Xiao Liu, Weijie Chi, Xiaogang Liu, Sejong Choi, Diana S. Y. Wan, Sung-Jin Park, Jin-Soo Kim, Florent Ginhoux, H. Shawn Je, Young-Tae Chang
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2019)
Article
Cell Biology
Beomsue Kim, Young Ho Suh, Eunhye Joe
Summary: LRRK2, a primary familial Parkinson's disease-associated gene, negatively regulates microglia's actin dynamics by directly binding to or inhibiting microglia's Rac-PAK signaling. Knockdown of LRRK2 alters microglia's physiological activity, leading to vigorous migration toward damaged cells.
ANIMAL CELLS AND SYSTEMS
(2022)
Article
Biochemistry & Molecular Biology
Naoki Miyamoto, Young-Hyun Go, Larissa Miasiro Ciaramicoli, Haw-Young Kwon, Heon Seok Kim, Xuezhi Bi, Young Hyun Yu, Beomsue Kim, Hyung-Ho Ha, Nam-Young Kang, Seong-Wook Yun, Jin-Soo Kim, Hyuk-Jin Cha, Young-Tae Chang
Summary: The molecular targets of CDy1, ALDH2 and ABCB1, were identified through live-cell affinity-matrix and ABC transporter CRISPRa library screening, revealing the potential for multi-dimensional cellular distinction of specific cell types.
RSC CHEMICAL BIOLOGY
(2021)