CXCR4 Chemokine Receptor Signaling Induces Apoptosis in Acute Myeloid Leukemia Cells via Regulation of the Bcl-2 Family Members Bcl-XL, Noxa, and Bak

High Expression of CXCR4 and CXCR7 Predicts Poor Survival in Gallbladder Cancer

(2013) X Yao et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process

(2012) M. Rahmani et al.   BLOOD

Phosphatidylserine exposure during apoptosis reflects bidirectional trafficking between plasma membrane and cytoplasm

(2012) S-H Lee et al.   CELL DEATH AND DIFFERENTIATION

Pertussis Toxin, an Inhibitor of Gαi PCR, Inhibits Bile Acid- and Cytokine-Induced Apoptosis in Primary Rat Hepatocytes

(2012) Golnar Karimian et al.   PLoS One

Hypoxia-Induced Modulation of Apoptosis and BCL-2 Family Proteins in Different Cancer Cell Types

(2012) Audrey Sermeus et al.   PLoS One

CXCR7 impact on CXCL12 biology and disease

(2012) Lorena Sánchez-Martín et al.   TRENDS IN MOLECULAR MEDICINE

Dual mTORC1/mTORC2 inhibition diminishes Akt activation and induces Puma-dependent apoptosis in lymphoid malignancies

(2011) M. Gupta et al.   BLOOD

CXCR7 mediated Giα independent activation of ERK and Akt promotes cell survival and chemotaxis in T cells

(2011) Romsha Kumar et al.   CELLULAR IMMUNOLOGY

High Cell Surface Death Receptor Expression Determines Type IVersusType II Signaling

(2011) Xue Wei Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization

(2011) Haiming Dai et al.   JOURNAL OF CELL BIOLOGY

Leukemia Stem Cells and Microenvironment: Biology and Therapeutic Targeting

(2011) Marina Y. Konopleva et al.   JOURNAL OF CLINICAL ONCOLOGY

G i2 and ZAP-70 Mediate RasGRP1 Membrane Localization and Activation of SDF-1-Induced T Cell Functions

(2011) K. N. Kremer et al.   JOURNAL OF IMMUNOLOGY

Stromal Cell-Derived Factor-1 Signaling via the CXCR4-TCR Heterodimer Requires Phospholipase C- 3 and Phospholipase C- 1 for Distinct Cellular Responses

(2011) K. N. Kremer et al.   JOURNAL OF IMMUNOLOGY

How to manage high-risk acute myeloid leukemia

(2011) E H Estey   LEUKEMIA

MEK inhibition enhances ABT-737-induced leukemia cell apoptosis via prevention of ERK-activated MCL-1 induction and modulation of MCL-1/BIM complex

(2011) M Konopleva et al.   LEUKEMIA

The vascular niche: home for normal and malignant hematopoietic stem cells

(2011) P L Doan et al.   LEUKEMIA

The Role of CXCR4 in the Prediction of Bone Metastases from Breast Cancer: A Pilot Study

(2011) Emanuele Sacanna et al.   ONCOLOGY

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

(2011) Michelle C. Mendoza et al.   TRENDS IN BIOCHEMICAL SCIENCES

MicroRNA-146a and AMD3100, two ways to control CXCR4 expression in acute myeloid leukemias

(2011) I Spinello et al.   Blood Cancer Journal

BH3-only proteins: Orchestrators of apoptosis

(2010) Aisha Shamas-Din et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Exploiting cellular pathways to develop new treatment strategies for AML

(2010) Amir T. Fathi et al.   CANCER TREATMENT REVIEWS

CXCL12 (SDF-1)/CXCR4 Pathway in Cancer

(2010) B. A. Teicher et al.   CLINICAL CANCER RESEARCH

Update on clinical experience with AMD3100, an SDF-1/CXCL12–CXCR4 inhibitor, in mobilization of hematopoietic stem and progenitor cells

(2010) Iskra Pusic et al.   CURRENT OPINION IN HEMATOLOGY

CXCR7: a new SDF-1-binding receptor in contrast to normal CD34+ progenitors is functional and is expressed at higher level in human malignant hematopoietic cells

(2010) Maciej Tarnowski et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Role of the CXCR4/CXCL12 Axis in Lymphangioleiomyomatosis and Angiomyolipoma

(2010) D. Clements et al.   JOURNAL OF IMMUNOLOGY

G 13 and Rho Mediate Endosomal Trafficking of CXCR4 into Rab11+ Vesicles upon Stromal Cell-Derived Factor-1 Stimulation

(2010) A. Kumar et al.   JOURNAL OF IMMUNOLOGY

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

CXCL12 Chemokine Expression and Secretion Regulates Colorectal Carcinoma Cell Anoikis through Bim-Mediated Intrinsic Apoptosis

(2010) Luke J. Drury et al.   PLoS One

ERK and cell death: Mechanisms of ERK-induced cell death - apoptosis, autophagy and senescence

(2009) Sebastien Cagnol et al.   FEBS Journal

Mobilization of PML/RAR  negative peripheral blood stem cells with a combination of G-CSF and CXCR4 blockade in relapsed acute promyelocytic leukemia pre-treated with arsenic trioxide

(2009) F. Stolzel et al.   HAEMATOLOGICA

Context-dependent Bcl-2/Bak Interactions Regulate Lymphoid Cell Apoptosis

(2009) Haiming Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elucidation of CXCR7-Mediated Signaling Events and Inhibition of CXCR4-Mediated Tumor Cell Transendothelial Migration by CXCR7 Ligands

(2009) B. A. Zabel et al.   JOURNAL OF IMMUNOLOGY

Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML

(2008) Z. Zeng et al.   BLOOD

BH3 Mimetic Obatoclax Enhances TRAIL-Mediated Apoptosis in Human Pancreatic Cancer Cells

(2008) S. Huang et al.   CLINICAL CANCER RESEARCH

Human Immunodeficiency Virus-Induced Apoptosis of Human Breast Cancer Cells Via CXCR4 is Mediated by the Viral Envelope Protein But Does Not Require CD4

(2008) Shogo Misumi et al.   CURRENT HIV RESEARCH