Letter
Immunology
Leon Caly, Ashleigh F. Porter, Joanna Chua, James P. Collet, Julian D. Druce, Michael G. Catton, Sebastian Duchene
Summary: During a mouse plague in early 2021, a farmer from New South Wales, Australia, was diagnosed with locally acquired lymphocytic choriomeningitis virus infection. Whole-genome sequencing revealed a divergent and geographically distinct strain of lymphocytic choriomeningitis virus compared to other published sequences.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Mark J. G. Bakkers, Alex Moon-Walker, Rasmus Herlo, Vesna Brusic, Sarah Hulsey Stubbs, Kathryn M. Hastie, Erica Ollmann Saphire, Tomas L. Kirchhausen, Sean P. J. Whelan
Summary: LCMV is a virus that enters cells by binding to different receptors and causes severe health problems. This study found that LCMV first binds to CD164 before entering cells, providing new targets for therapeutic interventions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Virology
Daniel Grupel, Yaniv Lustig, Tal Brosh-Nissimov
Summary: Lymphocytic choriomeningitis virus (LCMV) is an often-overlooked virus that can have severe consequences. We present the first documented infection by LCMV in Israel, and the epidemiology of LCMV is evolving with the potential for a worldwide endemicity, highlighting the need for increased awareness and testing.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Immunology
Young Rock Chung, Tanushree Dangi, Nicole Palacio, Sarah Sanchez, Pablo Penaloza-MacMaster
Summary: Adoptive B cell therapy can effectively treat chronic infections, and the combination of antibody effector functions and virus-specific CD4 T cells can enhance the therapeutic effect.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Thomas Ferenc, Mateja Vujica, Anna Mrzljak, Tatjana Vilibic-Cavlek
Summary: This study summarizes the epidemiological, clinical, and diagnostic features of reported patients with congenital LCMV infection. A total of 27 studies with 86 patients were included, and the results showed that 52.73% of the patients were males. Common clinical manifestations included chorioretinitis, hydrocephalus, and psychomotor retardation or developmental delay. The diagnosis was most often confirmed serologically, and computed tomography and/or magnetic resonance imaging revealed ventriculomegaly, periventricular calcifications, and microcephaly. Mothers of congenitally infected infants were often exposed to mice during pregnancy, with flu-like symptoms occurring primarily in the first two trimesters.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Fisheries
Lin Huang, Xiaowen Zhu, Jihui Kuang, Bohuan Li, Qing Yu, Mingzhu Liu, Bingzheng Li, Hui Guo, Pengfei Li
Summary: In this study, a viperin homolog named To-viperin was cloned and characterized from golden pompano, and its role in response to SGIV and NNV infection was investigated. The expression of To-viperin was induced by viral infection and overexpression of To-viperin significantly reduced the viral titer of SGIV and NNV.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Malgorzata Wachowska, Alicja Wojciechowska, Angelika Muchowicz
Summary: Tumor-associated neutrophils play a crucial role in the tumor microenvironment, influencing cancer development and patient survival. In chronic lymphocytic leukemia, disturbances in neutrophil functions impede immune defense, highlighting the importance of understanding the underlying mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Jamin Liu, Kristeene A. Knopp, Elze Rackaityte, Chung Yu Wang, Matthew T. Laurie, Sara Sunshine, Andreas S. Puschnik, Joseph L. DeRisi
Summary: This study identifies novel host factors associated with Lymphocytic choriomeningitis virus (LCMV) infection of human tissues, highlighting the importance of CD164 in viral entry and suggesting it as a potential therapeutic target for congenital infection.
Article
Immunology
Jonathan Dyal, Shiv Gandhi, Caitlin M. Cossaboom, Austin Leach, Ketan Patel, Marjorie Golden, Joseph Canterino, Marie-Louise Landry, Debi Cannon, Mary Choi, Inna Krapiunaya, John D. Klena, Trevor Shoemaker
Summary: Lymphocytic choriomeningitis virus is an underreported cause of miscarriage and neurologic disease. Surveillance remains challenging due to nonspecific symptomatology, inconsistent case reporting, and difficulties with diagnostic testing.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Yuri Ushijima, Haruka Abe, Takehiro Ozeki, Georgelin N. Ondo, Marien J. V. M. Mbadinga, Rodrigue Bikangui, Chimene Nze-Nkogue, Etienne F. Akomo-Okoue, Ghislain W. E. Ella, Lilian B. M. Koumba, Branly C. B. B. Nso, Rodrigue Mintsa-Nguema, Patrice Makouloutou-Nzassi, Boris K. Makanga, Fred L. M. Nguelet, Vahid R. Zadeh, Shuzo Urata, Armel V. N. Mbouna, Marguerite Massinga-Loembe, Selidji T. Agnandji, Bertrand Lell, Jiro Yasuda
Summary: The study revealed a seroprevalence of 21.5% for LCMV in Gabon, with higher rates in males and adults. Local rodents, shrews, and porcupines around semi-urban areas posed an infection risk.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Biology
Onruedee Khantisitthiporn, Byron Shue, Nicholas S. Eyre, Colt W. Nash, Lynne Turnbull, Cynthia B. Whitchurch, Kylie H. Van der Hoek, Karla J. Helbig, Michael R. Beard
Summary: The study found that viperin interacts with ISG Pex19, and is associated with peroxisomes and lipid droplets. The enhancement of the RLR signaling pathway by viperin is lost when Pex19 expression is reduced. Viperin requires the combined action of mitochondria and peroxisome MAVS to optimally induce IFN-beta.
LIFE SCIENCE ALLIANCE
(2021)
Review
Immunology
Yongbo Wang, Xingyu Liu, Panpan Xia, Zhangwang Li, Xinxi FuChen, Yunfeng Shen, Peng Yu, Jing Zhang
Summary: An effective acute inflammatory response is crucial for eliminating infectious microorganisms and transitioning to the resolution and repair phase. Neutrophils play a key role in antimicrobial defense during inflammation, but their removal is necessary for the subsiding of inflammation. Macrophages help clear neutrophils and promote inflammation towards resolution. Recent attention has been given to the potential of microRNAs (miRNAs) as targeted therapy in chronic diseases by regulating various cellular processes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Marco Kunzli, Peter Reuther, Daniel D. Pinschewer, Carolyn G. King
Summary: The strength of TCR signal has different effects on the balance of Th1 and Tfh cells during acute versus persistent infection. Strong TCR signal favors Th1 generation during acute infection but hinders it during chronic infection. Weakly activated T cells show resistance to functional inactivation and display lower levels of markers associated with chronic T cell stimulation.
Article
Virology
Fanny Tevaearai, Laureline Moser, Leo Pomar
Summary: This article presents a case report of congenital LCMV infection, which was confirmed by fetal imaging and laboratory testing.
Article
Virology
Peter Pankovics, Arnold Nagy, Zoltan Nyul, Annamaria Juhasz, Karoly Takats, Akos Boros, Gabor Reuter
Summary: This retrospective study aimed to detect lymphocytic choriomeningitis virus (LCMV) RNA in cerebrospinal fluid samples from patients with unknown central nervous system infections in Hungary. Two LCMV cases were identified, belonging to different genetic lineages. This is the first publication of confirmed human LCMV infections in Hungary using molecular methods.
ARCHIVES OF VIROLOGY
(2023)
Article
Immunology
Nikhil S. Joshi, Elliot H. Akama-Garren, Yisi Lu, Da-Yae Lee, Gregory P. Chang, Amy Li, Michel DuPage, Tuomas Tammela, Natanya R. Kerper, Anna F. Farago, Rebecca Robbins, Denise M. Crowley, Roderick T. Bronson, Tyler Jacks
Article
Immunology
Claudia X. Dominguez, Robert A. Amezquita, Tianxia Guan, Heather D. Marshall, Nikhil S. Joshi, Steven H. Kleinstein, Susan M. Kaech
JOURNAL OF EXPERIMENTAL MEDICINE
(2015)
Review
Immunology
Nicholas M. Adams, Timothy E. O'Sullivan, Clair D. Geary, Jenny M. Karo, Robert A. Amezquita, Nikhil S. Joshi, Susan M. Kaech, Joseph C. Sun
JOURNAL OF IMMUNOLOGY
(2016)
Article
Multidisciplinary Sciences
Elliot H. Akama-Garren, Nikhil S. Joshi, Tuomas Tammela, Gregory P. Chang, Bethany L. Wagner, Da-Yae Lee, William M. Rideout, Thales Papagiannakopoulos, Wen Xue, Tyler Jacks
SCIENTIFIC REPORTS
(2016)
Article
Multidisciplinary Sciences
Tuomas Tammela, Francisco J. Sanchez-Rivera, Naniye Malli Cetinbas, Katherine Wu, Nikhil S. Joshi, Katja Helenius, Yoona Park, Roxana Azimi, Natanya R. Kerper, R. A. Lexander Wesselhoeft, Xin Gu, Leah Schmidt, Milton Cornwall-Brady, Omer H. Yilmaz, Wen Xue, Pekka Katajisto, Arjun Bhutkar, Tyler Jacks
Article
Multidisciplinary Sciences
Gang Xin, David M. Schauder, Weiqing Jing, Aimin Jiang, Nikhil S. Joshi, Bryon Johnson, Weiguo Cui
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Immunology
Nikhil S. Joshi, Weiguo Cui, Claudia X. Dominguez, Jonathan H. Chen, Timothy W. Hand, Susan M. Kaech
JOURNAL OF IMMUNOLOGY
(2011)
Article
Immunology
Weiguo Cui, Nikhil S. Joshi, Ying Liu, Hailong Meng, Steven H. Kleinstein, Susan M. Kaech
JOURNAL OF IMMUNOLOGY
(2014)
Article
Multidisciplinary Sciences
Francisco J. Sanchez-Rivera, Thales Papagiannakopoulos, Rodrigo Romero, Tuomas Tammela, Matthew R. Bauer, Arjun Bhutkar, Nikhil S. Joshi, Lakshmipriya Subbaraj, Roderick T. Bronson, Wen Xue, Tyler Jacks
Article
Multidisciplinary Sciences
Wen Xue, Sidi Chen, Hao Yin, Tuomas Tammela, Thales Papagiannakopoulos, Nikhil S. Joshi, Wenxin Cai, Gillian Yang, Roderick Bronson, Denise G. Crowley, Feng Zhang, Daniel G. Anderson, Phillip A. Sharp, Tyler Jacks
Editorial Material
Multidisciplinary Sciences
Nikhil S. Joshi, Tyler Jacks
Editorial Material
Immunology
Kelli A. Connolly, Brittany Fitzgerald, Nikhil S. Joshi
Editorial Material
Immunology
Martina Damo, Nikhil S. Joshi
Review
Gastroenterology & Hepatology
John George, Divyansh Bajaj, Kesavan Sankaramangalam, Jin Woo Yoo, Nikhil S. Joshi, Scott Gettinger, Christina Price, James J. Farrell
Article
Multidisciplinary Sciences
Leah Schmidt, Banu Eskiocak, Ryan Kohn, Celeste Dang, Nikhil S. Joshi, Michel DuPage, Da-Yae Lee, Tyler Jacks
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)