Article
Multidisciplinary Sciences
Claire E. Depew, Jordan A. Rixon, Stephen J. McSorley
Summary: Hepatic CD4 tissue-resident memory T cells (TRM) are crucial for protection against Salmonella infection, and a study has found that local inflammation in the liver enhances the formation of CD4 TRM. The researchers developed a system to directly visualize the formation of hepatic TRM and found that liver inflammation also boosts the effectiveness of a subunit Salmonella vaccine. Surprisingly, IL-2 and IL-1 were found to play a role in enhancing CD4 TRM formation. This knowledge is important for developing a more effective vaccine against invasive nontyphoidal salmonellosis (iNTS).
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell Biology
Bojana Jakic, William J. Olson, Kerstin Siegmund, Victoria Klepsch, Janine Kimpel, Verena Labi, Dietmar Zehn, Gottfried Baier, Natascha Hermann-Kleiter
Summary: The loss of nuclear orphan receptor NR2F6 enhances antigen-specific CD8(+) memory formation and boosts inflammatory cytokine responses in mice after bacterial infection. The enhanced memory formation is intrinsic to CD8(+) T cells and is established early in the antibacterial immune response, mediated by IFN-gamma. Blocking IFN-gamma normalizes the memory precursor cell formation, indicating potential therapeutic benefits of NR2F6 manipulation for memory CD8(+) T cell functionality.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Kathryn M. LaPorte, Rosmely Hernandez, Alicia Santos Savio, Thomas R. Malek
Summary: Researchers tested an IL-2 biologic, mIL-2/CD25, which preferentially stimulates the high-affinity IL-2R, and found that it can effectively support antitumor responses to immunogenic tumors as a monotherapy or in combination with a PD-1 checkpoint blockade. This treatment increases the frequency and function of tumor-specific CD8(+) T effector cells and induces long-term antitumor memory responses in the tumor microenvironment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Dermatology
Pawit Phadungsaksawasdi, Toshiharu Fujiyama, Kazuo Kurihara, Taisuke Ito, Tetsuya Honda, Yoshiki Tokura
Summary: In human psoriasis, PD-1 expressing CD8(+) CD103(+) T cells in the skin are associated with disease severity and histopathology, indicating a potential pathogenic subset that may play a role in psoriasis pathogenesis.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Immunology
Konjit Getachew Muleta, Isabel Ulmert, Kedir Hussen Hamza, Sharne van Dijl, Joy Nakawesi, Katharina Lahl
Summary: Rotavirus (RV) infection induces strong adaptive immunity, with initial clearance depending on cytotoxic CD8 T cells. Type I classical dendritic cells (cDC1) play a key role in CD8 T cell induction and RV cytotoxicity. This study found that the individual Toll-like receptor 3 (TLR3) and MyD88-mediated signaling pathways were not required for CD8 T cell response or RV clearance. Surprisingly, absence of type I interferon (IFN) signaling did not alter the accumulation of RV-specific CD8 T cells, but it impaired their ability to produce IFN gamma and granzyme.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Lara Gerhardt, Megan M. Y. Hong, Yeganeh Yousefi, Rene Figueredo, Saman Maleki Vareki
Summary: Tumor-specific CD8+ T cells play a critical role in antitumor immunity, but the factors that regulate their phenotype and function are not fully understood. IL-12 and IL-27 are cytokines known to promote CD8+ T cell function and antitumor responses. This study investigates the role of IL-12 and IL-27 in modulating CD39 expression on CD8+ T cells and highlights the differential impact of CD39-inducing factors on the phenotype and effector functions of CD8+ T cells.
JOURNAL OF IMMUNOLOGY
(2023)
Editorial Material
Immunology
Tiani L. Louis, John T. Chang
Summary: In this study, Hirai et al. demonstrate the competition for the cytokine TGF beta as a key factor in regulating the persistence and occupancy of CD8(+) tissue-resident memory T cells in the skin epidermal niche.
Review
Biochemistry & Molecular Biology
Choong-Hyun Koh, Suyoung Lee, Minkyeong Kwak, Byung-Seok Kim, Yeonseok Chung
Summary: CD8 T cells play crucial roles in immune defense, and emerging evidence suggests the existence of distinct subsets with unique functions and therapeutic potential. Understanding these subsets is important for understanding immune responses in different diseases, and developing immunotherapeutic approaches targeting specific CD8 T-cell subsets holds great promise.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Immunology
Tyler G. Normile, Antonella Rella, Maurizio Del Poeta
Summary: The study found that a C. neoformans mutant, Delta sgl1, accumulating sterylglucosides (SGs), can provide complete protection under immunodeficient conditions. The mutant decreases levels of SGs post-fungal clearance.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Nicolle Rakanidis Machado, Beatriz Oliveira Fagundes, Lorena Abreu Fernandes, Augusto Cesar Penalva de Oliveira, Youko Nukui, Jorge Casseb, Fernando Roberto Machado Cunha, Luiz Henrique da Silva Nali, Sabri Saeed Sanabani, Jefferson Russo Victor
Summary: This study found that IgG obtained from HAM/TSP and ATLL patients can differentially modulate the cytokine production by human T and B cells, and elicit distinct effects on target populations.
FRONTIERS IN MEDICINE
(2023)
Article
Allergy
Komal Agrawal, Li Ching Ong, Susan Monkley, Kristofer Thorn, Elisabeth Israelsson, Engin Baturcam, Cassie Rist, Karin Schon, Sophia Blake, Bjorn Magnusson, James Cartwright, Suman Mitra, Abilash Ravi, Nazanin Zounemat-Kermani, Jayendra Kumar Krishnaswamy, Nils Y. Lycke, Ulf Gehrmann, Johan Mattsson
Summary: Patients with asthma experience reduced ability to clear respiratory viral infections due to changes in gene expression in nasal and lung epithelial cells. These changes interfere with the development of lung resident memory T cells, which may contribute to the increased susceptibility of patients with asthma to viral exacerbations.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Andrea Papait, Elsa Vertua, Patrizia Bonassi Signoroni, Anna Cargnoni, Marta Magatti, Francesca Romana Stefani, Jacopo Romoli, Antonietta Rosa Silini, Ornella Parolini
Summary: We found that hAMSCs from human term placenta can affect the development and fate of CD8 T cells through multiple mechanisms, providing new insights into the treatment of diseases characterized by altered activation of memory subsets.
Article
Medicine, General & Internal
Mariela P. Cabral-Piccin, Laura Papagno, Xavier Lahaye, Federico Perdomo-Celis, Stevenn Volant, Eoghann White, Sian Llewellyn-Lacey, David A. Price, Nicolas Chomont, Nicolas Manel, Asier Saez-Cirion, Victor Appay
Summary: HIV-2 primes CD8+ T cells with potent antiviral functionality by activating the cGAS/STING pathway, resulting in enhanced immune control of HIV-1. The use of cGAMP or other STING agonists can enhance CD8+ T cell-mediated immune responses against HIV-1, providing a new direction for HIV-1 therapy.
Article
Multidisciplinary Sciences
Mladen Jergovic, Christopher P. Coplen, Jennifer L. Uhrlaub, David G. Besselsen, Shu Cheng, Megan J. Smithey, Janko Nikolich-Zugich
Summary: Infections can lead to the expansion of a subpopulation of long-lived, Ly6C(+) CD8(+) Tn cells with accelerated effector function, depending on the action of IFN-I. This highlights the significant role of infection-driven IFN-I in regulating Tn homeostasis and function, with potential implications for immunotherapy.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Seon-Hee Kim, Eunjung Cho, Yu Kim, Chungyong Han, Beom K. Choi, Byoung S. Kwon
Summary: The study demonstrates that post-conditioning treatment with anti-CD4 can enhance the anti-tumor efficacy of adoptive T cell therapy (ACT) by promoting the expansion of IL-18R alpha(hi) CD8(+) T cells. This combination treatment accelerates proliferation and differentiation of tumor-reactive CD8(+) T cells and improves tumor suppression and host survival. The enrichment of polyfunctional IL-18R alpha(hi) CD8(+) T cells plays a key role in the induced tumor suppression, mediated by IL-18 signaling and TCR-MHC I interaction.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Emily N. Truckenbrod, Kristina S. Burrack, Todd P. Knutson, Henrique Borges da Silva, Katharine E. Block, Stephen D. O'Flanagan, Katie R. Stagliano, Arthur A. Hurwitz, Ross B. Fulton, Kristin R. Renkema, Stephen C. Jameson
Summary: The study found that self-specific CD8(+) T cells in a physiological setting exhibit similar phenotypic and gene expression profiles, but show differences in function, such as enhanced self-tolerance in mice lacking Dct. This suggests that predicting CD8(+) T cell self-specificity is challenging based on precursor frequency, phenotype, or initial responsiveness, and that certain gene expression characteristics like reduced activation-induced CD25 expression may help identify functionally tolerant cells.
Article
Immunology
Changwei Peng, Matthew A. Huggins, Kelsey M. Wanhainen, Todd P. Knutson, Hanbin Lu, Hristo Georgiev, Kristen L. Mittelsteadt, Nicholas N. Jarjour, Haiguang Wang, Kristin A. Hogquist, Daniel J. Campbell, Henrique Borges da Silva, Stephen C. Jameson
Summary: ICOS signaling pathway plays a critical role in the generation of CD8+ tissue-resident memory (Trm) T cells, promoting their production but not affecting their maintenance. This study reveals the importance of costimulatory signals in the generation of tissue-resident populations.
Article
Immunology
Maximilien Evrard, Erica Wynne-Jones, Changwei Peng, Yu Kato, Susan N. Christo, Raissa Fonseca, Simone L. Park, Thomas N. Burn, Maleika Osman, Sapna Devi, Jerold Chun, Scott N. Mueller, George Kannourakis, Stuart P. Berzins, Daniel G. Pellicci, William R. Heath, Stephen C. Jameson, Laura K. Mackay
Summary: The migratory receptor S1PR5 plays a critical role in T cell infiltration and emigration from peripheral organs, and is specifically downregulated in tissue-resident memory T (TRM) cells. The induction of S1pr5 relies on the transcription factors T-bet and ZEB2, and local TGF-beta signaling is necessary for the coordinated downregulation of Tbx21, Zeb2, and S1pr5. S1PR5-mediated control of tissue residency is conserved across innate and adaptive immune compartments.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Immunology
Trupti Vardam-Kaur, Sarah van Dijk, Changwei Peng, Kelsey M. Wanhainen, Stephen C. Jameson, Henrique Borges da Silva
Summary: This study found that unequal upregulation of P2RX7 in effector CD8+ T cells is a foundational element in the early fate determination of Tcm and Trm cells. P2RX7 negatively regulates the expression of the transcriptional repressor Zeb2, affecting the formation of Tcm and Trm cells.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Kevin Joannou, Dominic P. Golec, Haiguang Wang, Laura M. Henao-Caviedes, Julia F. May, Rees G. Kelly, Rigel Chan, Stephen C. Jameson, Troy A. Baldwin
Summary: This study investigates the relationship between maturation and thymic export of adult-derived gamma delta thymocytes in mice. The findings reveal the existence of two populations of gamma delta T cell recent thymic emigrants (RTEs) in adult mice, with one population maturing outside the thymus and the other population completing maturation within the thymus. Additionally, a heterogeneous population of resident gamma delta thymocytes of unknown functional importance was identified.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Oncology
Kelsey M. Wanhainen, Changwei Peng, Maggie H. Zhou, Bruna de Gois Macedo, Stephen 'Flanagan, Tingyuan Yang, Ameeta Kelekar, Brandon J. Burbach, Henrique Borges da Silva, Stephen C. Jameson
Summary: Expression of the purinergic receptor P2RX7 by CD8(+) T cells promotes memory generation after acute infections, but may limit antitumor responses. In a mouse model of CD8(+) T-cell adoptive transfer, P2RX7 is shown to be beneficial for optimal melanoma control, as P2RX7-deficient CD8(+) T cells exhibit impaired mitochondrial function and decreased frequency within tumors. Furthermore, in vitro stimulation of P2RX7 enhances melanoma control by CD8(+) T cells, suggesting the potential use of P2RX7 stimulation as a novel therapeutic approach for tumor immunotherapy.
CANCER IMMUNOLOGY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Nicholas N. Jarjour, Kelsey M. Wanhainen, Changwei Peng, Noah V. Gavil, Nicholas J. Maurice, Henrique Borges da Silva, Ryan J. Martinez, Talia S. Dalzell, Matthew A. Huggins, David Masopust, Sara E. Hamilton, Stephen C. Jameson
Summary: Interleukin-15 (IL-15) is a central regulator of memory CD8+ T cells and can stimulate their proliferation and expansion. IL-15 sensitivity is an important feature of memory CD8+ T cell populations, with therapeutic potential.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Nicholas J. Maurice, Stephen C. Jameson
Summary: Human resident memory T cells segregate in different tissues and have gene expression patterns specific to those tissues, suggesting the acquisition of site-specific immunity beyond shared residency traits.
Article
Immunology
Katharine E. Block, Koji Iijima, Mark J. Pierson, Daniel A. Walsh, Rinna Tei, Tamara A. Kucaba, Julie Xu, Mohammad Haneef Khan, Christopher Staley, Thomas S. Griffith, Henry J. McSorley, Hirohito Kita, Stephen C. Jameson
Summary: This study shows that mice initially have impaired innate type 2 responses to lung allergens after exposure to various pathogens, but reactivity resets over time. Cohousing mice for 2 months can restore immune responses to allergens, with interferons playing a regulatory role.
Meeting Abstract
Immunology
Henrique Borges Da Silva, Trupti Vardam-Kaur, Maggie Zhou, Bruna De Gois Macedo, Sarah Van Dijk, Stephen C. Jameson
JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Immunology
Nicholas N. Jarjour, Kelsey M. Wanhainen, Changwei M. Peng, Henrique Borges da Silva, Ryan J. Martinez, Talia S. Dalzell, Matthew A. Huggins, Joseph F. Urban, Sara E. Hamilton Hart, Stephen C. Jameson
JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Immunology
Katharine E. Block, Koji Iijima, Mark Pierson, Daniel A. Walsh, Hirohito Kita, Stephen C. Jameson
JOURNAL OF IMMUNOLOGY
(2021)
Meeting Abstract
Immunology
Henrique Borges da Silva, Trupti Vardam-Kaur, Igor Santiago Carvalho, Changwei Peng, Kelsey M. Wanhainen, Stephen C. Jameson
JOURNAL OF IMMUNOLOGY
(2021)
Meeting Abstract
Immunology
Matthew A. Huggins, Changwei Peng, Kelsey M. Wanhainen, Abigail R. Gress, Stephen C. Jameson, Sara E. Hamilton
JOURNAL OF IMMUNOLOGY
(2021)
Meeting Abstract
Immunology
Nicholas N. Jarjour, Kelsey M. Wanhainen, Henrique Borges da Silva, Changwei Peng, Ryan J. Martinez, Matthew A. Huggins, Joseph F. Urban, Sara E. Hamilton, Stephen C. Jameson
JOURNAL OF IMMUNOLOGY
(2021)