Article
Multidisciplinary Sciences
Nadine Kamenjarin, Katrin Hodapp, Felix Melchior, Gregory Harms, Ann- Kathrin Hartmann, Joschka Bartneck, Sabine Muth, Verena K. Raker, Christian Becker, Anna Brand, Bjorn E. Clausen, Markus P. Radsak, Hansjorg Schild, Hans Christian Probst
Summary: Tissue-resident memory CD8+ T cells (TRM) in the skin require epidermal Langerhans cells, which cross-present keratinocyte-derived antigens, for their reactivation to provide protection against reinfection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Immunology
Rui Dai, Xiaopei Huang, Yiping Yang
Summary: This study demonstrates the critical role of gamma delta T cells in promoting the CD8(+) T cell response to VV infection. Gamma delta T cells are able to present viral antigens and activate CD8(+) T cells, with MyD88 signaling playing a key role in this process. Understanding the regulation of adaptive T cell response by gamma delta T cells may provide insight for the development of more effective vaccine strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Oncology
Werner Held, Daniel E. Speiser
Summary: Adoptive cell immunotherapy using in vitro expanded autologous tumor-infiltrating lymphocytes shows potential for durable remission in certain cancers, but complete and long-lasting control of metastatic melanoma requires tumor-specific CD8(+) T cells with stem-cell-like properties.
Article
Immunology
W. J. Venema, S. Hiddingh, G. M. C. Janssen, J. Ossewaarde-van Norel, N. Dam van Loon, J. H. de Boer, P. A. van Veelen, J. J. W. Kuiper
Summary: This study identified the naturally presented antigenic SAG peptides through HLA-A29 immunopeptidomics and found that SAG is not a CD8+ T cell autoantigen, suggesting that it is not involved in the pathogenesis of BCR.
CLINICAL IMMUNOLOGY
(2023)
Article
Cell Biology
Anita Sapoznikov, Stav Kozlovski, Nehora Levi, Sara W. Feigelson, Ofer Regev, Natalia Davidzohn, Shifra Ben-Dor, Rebecca Haffner-Krausz, Ester Feldmesser, Noa Wigoda, Ekaterina Petrovich-Kopitman, Moshe Biton, Ronen Alon
Summary: Lymphocyte priming in lymph nodes was believed to require stable immune synapses between T cells and antigen-presenting dendritic cells. The role of ICAM-1 in these synapses was investigated in vivo and it was found that although ICAM-1 is involved in stable conjugates between DCs and CD8 blasts, these conjugates are not essential for proliferation and differentiation of CD8 lymphocytes. The results suggest that firm immune synapses are dispensable for TCR-triggered lymphocyte proliferation and differentiation into effector lymphocytes.
Article
Oncology
Xuedan He, Shiqi Zhou, Melissa Dolan, Yuhao Shi, Jianxin Wang, Breandan Quinn, Dushyant Jahagirdar, Wei-Chiao Huang, Moriya Tsuji, Roberto Pili, Fumito Ito, Joaquin Ortega, Scott Abrams, John M. L. Ebos, Jonathan F. Lovell
Summary: The study successfully predicted and screened MHC-I restricted neoepitopes in a murine renal adenocarcinoma model, converting them into immunogenic nanoparticles which induced antitumor responses. One candidate neoepitope, Nesprin-2 L4492R (Nes2LR), not only induced functional responses within 20-plex or 60-plex particles, but also prevented tumor growth.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Cell Biology
Neda Feizi, Chiara Focaccetti, Ilenia Pacella, Gloria Tucci, Alessandra Rossi, Massimo Costanza, Rosetta Pedotti, John Sidney, Alessandro Sette, Claudia La Rocca, Claudio Procaccini, Giuseppe Matarese, Vincenzo Barnaba, Silvia Piconese
Summary: The study demonstrates that immune responses to cryptic apoptosis-associated epitopes (AEs) may contribute to immunopathology in neuroinflammation, as shown in a mouse model of MS (EAE). The presence of AE-specific CD8(+) T cells, their physiological control, and their exacerbation of disease severity when immunized with AEs during EAE induction were observed, supporting the role of AE-specific autoimmunity in neuroinflammation.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Seong Jin Choi, June-Young Koh, Min-Seok Rha, In-Ho Seo, Hoyoung Lee, Seongju Jeong, Su-Hyung Park, Eui-Cheol Shin
Summary: Subsets of human CD8+ T cells express inhibitory NK cell receptors, KIRs and NKG2A. These receptors are mutually exclusive in their expression and have distinct phenotypic and functional characteristics. KIR+CD8+ T cells are more differentiated, senescent, and responsive to IL2R8, while NKG2A+CD8+ T cells are more responsive to IL12R81, IL12R82, and IL18R8, and exhibit strong IFN-g production and NK-like cytotoxicity in response to IL-15.
Article
Immunology
Laurent Vidard
Summary: This study compares the costimulatory molecules and cytokines required for the activation and proliferation of different immune cells. The results demonstrate that three signals are necessary for optimal proliferation of CD8(+) T cells, NK cells, and gamma delta T cells. The findings challenge the notion of anergy and support the danger signal theory proposed by Polly Matzinger.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Immunology
Niels C. Lory, Mikolaj Nawrocki, Martina Corazza, Joanna Schmid, Valea Schumacher, Tanja Bedke, Stephan Menzel, Friedrich Koch-Nolte, Andreas H. Guse, Samuel Huber, Hans-Willi Mittruecker
Summary: This study investigates the function of TRPM2 in T-cell activation and differentiation using TRPM2-deficient mice. The results suggest that TRPM2 does not play a major role in T-cell activation and differentiation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Andreas Walker, Tatjana Schwarz, Janine Brinkmann-Paulukat, Karin Wisskirchen, Christopher Menne, Elahe Salimi Alizei, Helenie Kefalakes, Martin Theissen, Daniel Hoffmann, Julian Schulze zur Wiesch, Mala K. K. Maini, Markus Cornberg, Anke R. M. Kraft, Verena Keitel, Hans H. H. Bock, Peter A. A. Horn, Robert Thimme, Heiner Wedemeyer, Falko M. M. Heinemann, Tom Luedde, Christoph Neumann-Haefelin, Ulrike Protzer, Joerg Timm
Summary: This study performed a high-resolution analysis of the core(18-27) specific CD8+ T cell and the selected escape pathways in patients with chronic HBV infection. The results demonstrate the promiscuous presentation of the core(18-27) epitope and the selection pressure on the epitope in the context of different HLA class I molecules. Some epitope variants showed evidence for impaired antigen processing and reduced presentation. These findings suggest the importance of considering epitope variants in T cell-based therapy strategies for chronic HBV infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Hematology
Livius Penter, Yang Liu, Jacquelyn O. Wolff, Lin Yang, Len Taing, Aashna Jhaveri, Jackson Southard, Manishkumar Patel, Nicole M. Cullen, Kathleen L. Pfaff, Nicoletta Cieri, Giacomo Oliveira, Seunghee Kim-Schulze, Srinika Ranasinghe, Rebecca Leonard, Taylor Robertson, Elizabeth A. Morgan, Helen X. Chen, Minkyung H. Song, Magdalena Thurin, Shuqiang Li, Scott J. Rodig, Carrie Cibulskis, Stacey Gabriel, Pavan Bachireddy, Jerome Bitz, Howard Streicher, Donna S. Neuberg, F. Stephen Hodi, Matthew S. Davids, Sacha Gnjatic, Kenneth J. Livak, Jennifer Altreuter, Franziska Michor, Robert J. Soffier, Jacqueline S. Garcia, Catherine J. Wu
Summary: The combination of decitabine and ipilimumab shows promising results in reducing AML cells and activating the immune system in AML/MDS patients, but is less effective in targeting leukemia cells outside the lymphoid tissues. Further development of novel approaches to eliminate leukemic progenitors is needed for long-lasting responses.
Article
Oncology
Sabaria Shah, Katherine W. Cook, Peter Symonds, Juliane Weisser, Anne Skinner, Abdullah Al Omari, Samantha J. Paston, Ian Pike, Lindy G. Durrant, Victoria A. Brentville
Summary: This study discovers that homocitrullinated peptides can be processed and presented via MHC-I for tumor therapy. The modified peptides show enhanced binding to HLA-A2 and induce high avidity homocitrulline-specific CD8 T-cell responses, which can kill target cells expressing the peptide.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Binglin Wang, Yi Wang, Xiaofan Sun, Guoliang Deng, Wei Huang, Xingxin Wu, Yanghong Gu, Zhigang Tian, Zhimin Fan, Qiang Xu, Hongqi Chen, Yang Sun
Summary: This study revealed that CXCR6 is exclusively expressed on intratumoral CD8(+) T cells, which are more immunocompetent and possess stronger antitumor activity. Additionally, CXCR6 may serve as a biomarker for tumor immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Immunology
Roshni Roy Chowdhury, John R. Valainis, Megha Dubey, Lotta von Boehmer, Elsa Sola, Julie Wilhelmy, Jing Guo, Oliver Kask, Mane Ohanyan, Meng Sun, Huang Huang, Xianxi Huang, Patricia K. Nguyen, Thomas J. Scriba, Mark M. Davis, Sean C. Bendall, Yueh-hsiu Chien
Summary: Examined the response of gamma delta T cells in acute versus chronic phases of tuberculosis infection and found an expansion of CD8+ gamma delta T cells with memory inflation features in chronic infection. These cells are hyporesponsive to T cell receptor signaling but can mount cytotoxic responses mediated by CD16. Furthermore, CD8+ gamma delta T cells also expand in other chronic inflammatory conditions, suggesting similar effector programs and differentiation fates driven by persistent antigen exposure.
SCIENCE IMMUNOLOGY
(2023)
Article
Immunology
Kristin R. Renkema, June-Yong Lee, You Jeong Lee, Sara E. Hamilton, Kristin A. Hogquist, Stephen C. Jameson
JOURNAL OF EXPERIMENTAL MEDICINE
(2016)
Article
Immunology
Maria Bettini, Lori Blanchfield, Ashley Castellaw, Qianxia Zhang, Maki Nakayama, Matthew P. Smeltzer, Hui Zhang, Kristin A. Hogquist, Brian D. Evavold, Dario A. A. Vignali
JOURNAL OF IMMUNOLOGY
(2014)
Article
Immunology
Keli L. Holzapfel, Aaron J. Tyznik, Mitchell Kronenberg, Kristin A. Hogquist
JOURNAL OF IMMUNOLOGY
(2014)
Article
Immunology
Deborah W. Hendricks, Henry H. Balfour, Samantha K. Dunmire, David O. Schmeling, Kristin A. Hogquist, Lewis L. Lanier
JOURNAL OF IMMUNOLOGY
(2014)
Article
Immunology
Ross B. Fulton, Sara E. Hamilton, Yan Xing, J. Adam Best, Ananda W. Goldrath, Kristin A. Hogquist, Stephen C. Jameson
Article
Immunology
Shawn A. Mahmud, Luke S. Manlove, Heather M. Schmitz, Yan Xing, Yanyan Wang, David L. Owen, Jason M. Schenkel, Jonathan S. Boomer, Jonathan M. Green, Hideo Yagita, Hongbo Chi, Kristin A. Hogquist, Michael A. Farrar
Article
Multidisciplinary Sciences
Samantha K. Dunmire, Oludare A. Odumade, Jean L. Porter, Juan Reyes-Genere, David O. Schmeling, Hatice Bilgic, Danhua Fan, Emily C. Baechler, Henry H. Balfour, Kristin A. Hogquist
Article
Biology
Haiguang Wang, Kristin A. Hogquist
Article
Multidisciplinary Sciences
Yan Xing, Kristin A. Hogquist
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2014)
Article
Immunology
Maria Sawicka, Gretta L. Stritesky, Joseph Reynolds, Niloufar Abourashchi, Grant Lythe, Carmen Molina-Paris, Kristin A. Hogquist
FRONTIERS IN IMMUNOLOGY
(2014)
Review
Immunology
Roland Ruscher, Kristin A. Hogquist
CURRENT OPINION IN IMMUNOLOGY
(2019)
Article
Immunology
S. Thera Lee, Hristo Georgiev, Elise R. Breed, Roland Ruscher, Kristin A. Hogquist
Summary: CD8 α α intestinal intraepithelial lymphocytes (IEL) mainly originate from thymic precursors, with development inhibited by CD80 and CD86, and conventional DCs playing a significant role. Thymic hematopoietic APC show heterogeneity in expression, but exhibit functional redundancy, with no specialized APC subset promoting the CD8 α α IEL fate.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Hristo Georgiev, Changwei Peng, Matthew A. Huggins, Stephen C. Jameson, Kristin A. Hogquist
Summary: Conventional T cell subsets are selected in the thymus by peptide bearing MHC expressed by cortical epithelial cells, while cortical thymocytes express non-peptide bearing MHC molecules including CD1d and MR1 and select iNKT and MAIT cell populations respectively. The authors have generated a novel inducible MHC class-I transactivator murine system and suggest the absence of peptide-MHC on thymocytes is involved in the selection of non-peptide specific lymphocytes.
NATURE COMMUNICATIONS
(2021)
Correction
Immunology
K. Maude Ashby, Kristin A. Hogquist
NATURE REVIEWS IMMUNOLOGY
(2023)
Review
Immunology
K. Maude Ashby, Kristin A. Hogquist
Summary: This Review summarizes the processes of thymic selection that ensure the functionality and safety of the T cell repertoire. Thymocytes undergo positive or negative selection based on T cell receptor signal strength and stromal cues. The thymus supports T cell development and provides a unique niche for the selection of appropriate T cell clones. Thymic selection ensures a useful (MHC-restricted) and self-tolerant repertoire of available T cells.
NATURE REVIEWS IMMUNOLOGY
(2023)