Article
Biochemistry & Molecular Biology
Jessica Correa Bezerra Bellei, Nicolas Glanzmann, Barbara Albuquerque Carpinter, Daniela Chaves Renhe, Carolina Brandi Marques, Marina Rocha Azevedo, Livia Maria Barreto, Vinicius Novaes Rocha, Isabelle Karine da Costa Nunes, Henrique Marcelo Gualberto Pereira, Elaine Soares Coimbra, Eduardo Antonio Ferraz Coelho, Adilson David da Silva, Fernando de Pilla Varotti, Kezia Katiani Gorza Scopel
Summary: Chloroquine remains the most effective drug for malaria treatment, although resistance to it has emerged. This study focuses on the synthesis of quinoline derivatives to develop new antimalarials. Compound 3 showed promising activity against malaria, inhibiting parasite growth and protecting against severe malaria development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemical Research Methods
Aleena Das, Welka Sahu, Deepak Kumar Ojha, K. Sony Reddy, Mrutyunjay Suar
Summary: An untargeted metabolomics approach was used to identify the changes in metabolic pathways and metabolites in the serum of mice with different pathological stages of malaria. The study provides insights into the host biology during malaria and could be helpful for the selection of animal models for evaluating diagnostic and therapeutic interventions against malaria.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Immunology
Athina Georgiadou, Praveena Naidu, Sophie Walsh, Steve Kamiza, Valentina Barrera, Simon P. Harding, Christopher A. Moxon, Aubrey J. Cunnington
Summary: Our study found that MMP8 was extensively expressed in retinal capillaries of Malawian children with malarial retinopathy and strongly associated with vascular leak, suggesting MMP8 may be one of the causes of vascular endothelial barrier disruption in CM.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)
Article
Cell Biology
Qihui Liu, Quanli Yang, Zengfeng Wu, Yanfang Chen, Miaomiao Xu, Hua Zhang, Jiliang Zhao, Zonghua Liu, Zerong Guan, Jing Luo, Zhi-yong Li, Guodong Sun, Qiong Wen, Yan Xu, Zhenhua Li, Kebing Chen, Xiaosong Ben, Wanchun He, Xueshi Li, Zhinan Yin, Jianlei Hao, Ligong Lu
Summary: This study reveals the accumulation of gamma delta T cells in fibrotic liver and their role in alleviating liver fibrosis. The activation of mTOR signaling in gamma delta T cells is observed during CCl4 treatment. IL-1 beta activation promotes the upregulation of CXCR3 expression through the mTORC2 signaling pathway in gamma delta T cells, leading to their migration into the liver and improvement of liver fibrosis.
CELL DEATH & DISEASE
(2022)
Article
Medicine, Research & Experimental
Michael Brandon Ware, Maggie Phillips, Christopher McQuinn, Mohammad Y. Zaidi, Hannah M. Knochelmann, Emily Greene, Brian Robinson, Cameron J. Herting, Thomas A. Mace, Zhengjia Chen, Chao Zhang, Matthew R. Farren, Amanda N. Ruggieri, Jacob S. Bowers, Reena Shakya, Alton B. Farris, Gregory Young, William E. Carson III, Bassel El-Rayes, Chrystal M. Paulos, Gregory B. Lesinski
Summary: This study demonstrates that anti-IL-6 and anti-CTLA-4 antibodies can enhance antitumor immune responses to pancreatic cancer. Dual blockade of IL-6 and CTLA-4 inhibits tumor growth by inducing T cell infiltrations and secretion of IFN-gamma by CD4+ T cells. The efficacy of this combination therapy is dependent on the CXCR3 axis and the presence of both CD4+ and CD8+ T cells.
Article
Ophthalmology
Kexin Li, Xue Feng, Kenji Hikosaka, Kazumi Norose
Summary: A murine model of primary acquired ocular toxoplasmosis was successfully established through peroral infection with Toxoplasma gondii. After infection, various immune mediators in the aqueous humor showed significant increase, providing new insights into the immunopathogenesis of ocular toxoplasmosis.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Biology
Veethika Pandey, Alicia Fleming-Martinez, Ligia Bastea, Heike R. Doeppler, Jillian Eisenhauer, Tam Le, Brandy Edenfield, Peter Storz
Summary: This study highlights the importance of CXCL10/CXCR3 signaling in the early phase of murine pancreatic cancer, demonstrating its role in mediating chemotaxis, proliferation, and maintenance of inflammatory identity in macrophages within the pancreas. Inhibition of CXCL10/CXCR3 signaling shifts macrophage populations to a tumor-promoting phenotype, increasing fibrosis and lesion progression.
Article
Microbiology
Hanna Abberger, Matthias Hose, Anne Ninnemann, Christopher Menne, Mareike Eilbrecht, Karl S. Lang, Kai Matuschewski, Robert Geffers, Josephine Herz, Jan Buer, Astrid M. Westendorf, Wiebke Hansen
Summary: Neuropilin-1 (Nrp-1) expression on CD8(+) T cells is associated with neurological deficits and liver damage in Plasmodium and viral infections. Nrp-1(+)CD8(+) T cells exhibit a highly activated phenotype during infections. T cell-specific Nrp-1 deficiency alleviates the severity of the diseases. The reduced blood-brain barrier leakage and parasite sequestration may contribute to the protective effects.
Article
Biology
Sanket V. Rege, Arnaud Teichert, Juliet Masumi, Onkar S. Dhande, Reema Harish, Brett W. Higgins, Yesenia Lopez, Lily Akrapongpisak, Hannah Hackbart, Sofia Caryotakis, Dino P. Leone, Balazs Szoke, Jonas Hannestad, Karoly Nikolich, Steven P. Braithwaite, S. Sakura Minami
Summary: Targeting immune-mediated, age-related biology can be a transformative therapeutic strategy. In this study, inhibition of CCR3 shows pro-cognitive benefits in mice by modulating peripheral T cells and reducing neuroinflammation. These findings highlight the therapeutic potential of CCR3 inhibition in neuroinflammatory diseases of aging.
COMMUNICATIONS BIOLOGY
(2023)
Review
Cell Biology
Travis Yui Hei Chan, Jenny Sum Yee Wong, Karrie Mei-Yee Kiang, Cherry Won Yuet Sun, Gilberto Ka-Kit Leung
Summary: The CXCR3 receptor and its ligands play important roles in promoting GBM, and targeting CXCR3 may be a promising therapeutic approach for GBM. Despite controversies in this field, the CXCR3 pathway could serve as a key strategy to overcome the limitations of existing immunotherapies for GBM.
CELL DEATH & DISEASE
(2023)
Article
Behavioral Sciences
Chunlan Song, Wanyu Jia, Shengli Shi, Peng Li
Summary: The prevalence of diabetes in China has been increasing in recent years, and glibenclamide is commonly used as a hypoglycemic drug. However, there have been incidents of children accidentally ingesting glibenclamide in grassroots areas, leading to serious consequences. This article reports a case of a child who died from cerebral herniation caused by hypoglycemia induced by mistakenly taking glibenclamide. This highlights the importance for clinicians to consider hypoglycemic seizures and coma when dealing with unknown causes of convulsions in children and to promptly administer high concentrations of glucose to normalize blood sugar levels. Pediatricians should also be alert to the possibility of accidental medication in unexplained seizures and coma in children.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Immunology
Angelo Ferreira Chora, Sofia Marques, Joana Lisboa Goncalves, Priscila Lima, Daniel Gomes da Costa, Daniel Fernandez-Ruiz, Maria Ines Marreiros, Pedro Ruivo, Tania Carvalho, Ruy M. Ribeiro, Karine Serre, William R. Heath, Bruno Silva-Santos, Ann T. Tate, Maria M. Mota
Summary: During malaria infection, Plasmodium replicates in the liver and later infects red blood cells. It has been commonly believed that liver infection does not affect disease pathology as clinical manifestations only occur during the blood stage. However, a study using a mouse model uncoupling liver and blood stages of infection revealed that signals from both stages determine mortality outcomes. This finding was mediated by the activation of Vy4+ y8 T cells during the liver stage, which subsequently influenced cytokine profiles during the blood stage. The study also suggested that IL-17 produced by y8 T cells played a role in protecting mice from lethal cerebral malaria.
Article
Multidisciplinary Sciences
Maide Ozen, Hui Zhao, Flora Kalish, Yang Yang, Lauren L. Jantzie, Ronald J. Wong, David K. Stevenson
Summary: Our study reveals that exposure to systemic inflammation late in gestation can alter HO homeostasis in fetal liver and spleen, leading to sustained dysregulation of innate immune cell populations and intracellular myeloid HO-1 expression in the spleen through young adolescence in mice.
Article
Agriculture, Dairy & Animal Science
Emma Gulliver, Stuart Hunter, Laryssa Howe, Fernanda Castillo-Alcala
Summary: Avian malaria caused by Plasmodium species is a known cause of mortality in avifauna worldwide. Through analyzing the pathology of kiwi birds, this study reveals the impact of this disease on New Zealand's endemic avian species.
Article
Immunology
Haoan Yi, Weiyang Jiang, Fang Yang, Fan Li, Yirong Li, Wenjing Zhu, Qing Li, Syed Hassam Fakhar, Yaming Cao, Lan Luo, Wen Zhang, Yongshu He
Summary: Studies show that G6pd-deficient mice have a survival advantage, less severe ECM, and mild liver injury when combating malaria. This protection is related to proinflammatory responses, where Th1 differentiation and dendritic cell maturation in the liver and spleen are inhibited in G6pd-deficient mice. Our findings reveal a novel understanding of how G6PD deficiency protects against malaria in vivo.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Mireia Recasens, Beatriz Almolda, Jeus Perez-Clausell, Iain L. Campbell, Berta Gonzalez, Bernardo Castellano
Summary: Chronic exposure to IL-6 induces a desensitized phenotype of microglia, which may lead to decreased axonal sprouting.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Genetics & Heredity
Maxwell T. Stevens, Bernadette M. Saunders
Summary: miR-652-3p plays diverse roles in various disease states, functioning as an important regulator of gene expression. It modulates cell polarity mechanisms by targeting LLGL1 and ZEB1, impacting cancer metastasis and cell division. Additionally, miR-652-3p has different effects on angiogenesis and immune cell regulation, demonstrating its potential across multiple cellular systems.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Review
Cell Biology
Felix M. D. Marsh-Wakefield, Andrew J. Mitchell, Samuel E. Norton, Thomas Myles Ashhurst, Julia K. H. Leman, Joanna M. Roberts, Jessica E. Harte, Helen M. McGuire, Roslyn A. Kemp
Summary: High-dimensional cytometry represents a new exciting era in immunology research, requiring a shift in users' thinking towards experimental design and data analysis to maximize data quality.
IMMUNOLOGY AND CELL BIOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Shiyao Li, Yi Ju, Jiajing Zhou, Ka Fung Noi, Andrew J. Mitchell, Tian Zheng, Stephen J. Kent, Christopher J. H. Porter, Frank Caruso
Summary: By engineering polymer nanocapsules of different sizes and conducting experiments in cell, blood, and rat models, it was found that decreasing the size of the nanocapsules from 150 to 50 nm reduces their association with phagocytic cells and prolongs systemic exposure in vivo. These findings provide insights into bio-nano interactions and can serve as a platform for further research in this field.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Cell Biology
Maxwell T. Stevens, Beatrice D. Nagaria, Warwick J. Britton, Bernadette M. Saunders
Summary: Macrophages exhibit plasticity and their phenotypes and antimicrobial responses are influenced by the local microenvironment and tissue origin. The study found that macrophages from alveolar and peritoneal origins respond differently to mycobacterial infection, with varying expression levels of proinflammatory cytokines and chemokines.
IMMUNOLOGY AND CELL BIOLOGY
(2021)
Article
Immunology
Alanna G. Spiteri, Rachel L. Terry, Claire L. Wishart, Thomas M. Ashhurst, Iain L. Campbell, Markus J. Hofer, Nicholas J. C. King
Summary: A novel gating strategy was developed to distinguish microglia and infiltrating myeloid cells during West Nile virus infection, revealing significant phenotypic changes in the cells. Four distinct microglia subsets were identified, with two additional populations of macrophages recruited from the bone marrow during infection. Detailed kinetic analysis showed alterations in microglia subsets and their phenotypes in response to infection, providing valuable insights for potential therapeutic approaches targeting these cells.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Immunology
Deborah L. Burnett, Katherine J. L. Jackson, David B. Langley, Anupria Aggrawal, Alberto Ospina Stella, Matt D. Johansen, Harikrishnan Balachandran, Helen Lenthall, Romain Rouet, Gregory Walker, Bernadette M. Saunders, Mandeep Singh, Hui Li, Jake Y. Henry, Jennifer Jackson, Alastair G. Stewart, Franka Witthauer, Matthew A. Spence, Nicole G. Hansbro, Colin Jackson, Peter Schofield, Claire Milthorpe, Marianne Martinello, Sebastian R. Schulz, Edith Roth, Anthony Kelleher, Sean Emery, Warwick J. Britton, William D. Rawlinson, Rudolfo Karl, Simon Schaefer, Thomas H. Winkler, Robert Brink, Rowena A. Bull, Philip M. Hansbro, Hans-Martin Jaeck, Stuart Turville, Daniel Christ, Christopher C. Goodnow
Summary: Viral mutations pose a challenge to the efficacy of COVID-19 vaccines, but research has shown that antibodies targeting conserved sites can generate effective neutralization.
Article
Critical Care Medicine
Matt D. Johansen, Rashad M. Mahbub, Sobia Idrees, Duc H. Nguyen, Stefan Miemczyk, Prabuddha Pathinayake, Kristy Nichol, Nicole G. Hansbro, Linden J. Gearing, Paul J. Hertzog, David Gallego-Ortega, Warwick J. Britton, Bernadette M. Saunders, Peter A. Wark, Alen Faiz, Philip M. Hansbro
Summary: Patients with COPD are more susceptible to SARS-CoV-2 infection and develop severe viral infection and inflammation. COPD pBECs are more susceptible to viral infection possibly due to increased co-receptor expression and protease imbalances. A prominent cluster of IFN-responsive club/goblet cells emerges during infection, which may contribute to immune responses. Therapeutic interventions can suppress viral replication and inflammation.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Immunology
Taylor E. Syme, Magdalena Grill, Emina Hayashida, Barney Viengkhou, Iain L. Campbell, Markus J. Hofer
Summary: This study demonstrates that SBNO2 acts as a novel negative feedback regulator of IL-6 in the brain, restraining its excessive inflammatory actions and providing protection against neuroinflammation and neurodegeneration.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Immunology
Phillip K. West, Andrew N. McCorkindale, Boris Guennewig, Thomas M. Ashhurst, Barney Viengkhou, Emina Hayashida, So Ri Jung, Oleg Butovsky, Iain L. Campbell, Markus J. Hofer
Summary: Our study demonstrates that microglia exhibit stimulus-specific and wide-ranging responses to IL-6 and IFN-alpha, resulting in divergent phenotypes that modulate microglia responses in neuroinflammatory and neurodegenerative diseases.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Immunology
Alanna G. Spiteri, Duan Ni, Zheng Lung Ling, Laurence Macia, Iain L. Campbell, Markus J. Hofer, Nicholas J. C. King
Summary: PLX5622, a widely used inhibitor of CSF-1R, has been shown to not only deplete microglia, but also mature monocytes in a mouse model of severe neuroinflammation induced by WNE. Its protective effect is mediated by the inhibition of CSF-1R, and it also has potential therapeutic applications in CNS viral infection and other monocyte-mediated diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Helen J. Ball, Lakshmi Santanam, Suresh Senan, James A. Tanyi, Marcel van Herk, Paul J. Keall
Summary: A survey was conducted to assess the clinical practice of respiratory motion management in radiation oncology. The results showed that 84% of respondents used deep inspiration breath hold for left-sided breast cancer. 83% of respondents considered respiratory motion management very important or required for thoracic and abdominal cancer patients. 95% of respondents used respiratory motion management for thoracic and abdominal sites.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2022)
Article
Immunology
Phillip K. West, Barney Viengkhou, Iain L. Campbell, Markus J. Hofer
Summary: This study demonstrates that sustained production of IL-6 and IFN-alpha in the central nervous system is detrimental and contributes to the pathogenesis of neurological diseases. The researchers also found that microglia play a significant role in responding to these cytokines and protecting against neurotoxicity and calcification.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jessica L. Pedersen, Simone E. Barry, Nilesh J. Bokil, Magda Ellis, YuRong Yang, Guangyu Guan, Xiaolin Wang, Alen Faiz, Warwick J. Britton, Bernadette M. Saunders
Summary: This study examined the biomarker capacity of a panel of plasma proteins alone and in conjunction with a previously identified miRNA signature to identify active TB disease. The combination of miRNA and proteins significantly improved the sensitivity and specificity as a biosignature over single biomarker candidates, showing potential for the development of a non-sputum test to aid the diagnosis of active TB disease.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)
Article
Immunology
Jim Qin, Michael D. Lovelace, Andrew J. Mitchell, Tania de Koning-Ward, Georges E. R. Grau, Saparna Pai
Summary: The study revealed that in early ECM, antigen-specific CD8(+) T cells interact with endothelial cells and perivascular macrophages on post-capillary venules. In later stages of infection, CD8(+) T cells increase in number and change their behavior, actively crawling along the endothelium and interacting with the inner vessel wall at hotspots. This suggests an active interaction between PVM and CD8(+) T cells across the blood-brain barrier may be the initiating event in the inflammatory cascade leading to BBB alteration and neuropathology.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)
