Article
Immunology
Ziling Zhong, Xueying Huang, Shaojie Zhang, Shaochuan Zheng, Xiqiao Cheng, Rongrong Li, Di Wu, Liping Mo, Shenhong Qu
Summary: Recent studies have shown that the Notch signalling pathway induces the production of Th2-related immune factors, but the exact mechanism through which Notch signalling exacerbates allergic rhinitis (AR) remains unknown. In this study, serum, nasal mucosa, and spleen samples were isolated to investigate the roles of Notch in AR. The results demonstrated that blocking the Notch pathway may alleviate miR-155-mediated inflammation via the regulation of immune homeostasis in AR.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medical Laboratory Technology
Wenyan Tian, Xueqin Pang, Fujuan Luan
Summary: The study aimed to find a useful disease marker for early diagnosis of gastric cancer. The results showed that serum miR-181, miR-652, and CA72-4 were closely linked to the occurrence and development of gastric cancer. The combination of these three indicators has diagnostic value for early gastric cancer.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Clinical Neurology
Huiping Li, Shu Li, Hongxi Yang, Yuan Zhang, Fusheng Xu, Zhi Cao, Yue Ma, Yabing Hou, Yan Borne, Yaogang Wang
Summary: The study found that poor mental health status in participants of the UK Biobank was associated with a higher risk of cardiovascular disease. Each of the mental factors studied individually showed a positive association with CVD risk, and the composite score of these factors was positively correlated with CVD, CHD, and stroke risk in a dose-response manner.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Cell Biology
Abigail Edwards, Keith Brennan
Summary: The Notch signaling pathway plays crucial roles in development and disease, particularly in breast cancer, affecting various aspects like proliferation, apoptosis, invasion, and metastasis, as well as cancer stem cell phenotype and therapy resistance. Therapeutic targeting of Notch signaling holds promise for breast cancer treatment, with considerations of both potential benefits and drawbacks.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Meyer Elbaz, Julien Faccini, Clemence Laperche, Marie-Helene Grazide, Jean-Bernard Ruidavets, Cecile Vindis
Summary: Circulating miR-223 and miR-186 are promising predictive biomarkers for long-term mortality after MI.
Article
Physiology
Jian Han, Xiaogang Cui, Tianqi Yuan, Zhiming Yang, Yue Liu, Yajuan Ren, Changxin Wu, Yunfei Bian
Summary: Circulating exosomal miRNAs have potential as biomarkers for diagnosis of cardiovascular diseases. In this study, the differentially expressed miRNAs in exosomes from plasma of SCAD patients were analyzed and their diagnostic potential for SCAD was investigated.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wei Chen, Junnan Ru, Tong Wu, Da Man, Jingbang Wu, Lijuan Wu, Yujing Sun, Hanxi Yu, Min Li, Gangwei Zhang, Xingxin Zhu, Rongliang Tong, Heng Xiao, Yanhua Li, Beng Yang
Summary: MiR-652-3p is upregulated in hepatocellular carcinoma (HCC), especially in metastatic HCC patients. It promotes HCC metastasis by regulating the EMT pathway and inhibiting TNRC6A expression. MiR-652-3p and TNRC6A may serve as potential biomarkers for predicting prognosis in HCC patients with metastasis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Clinical Neurology
Rukiye Tekdemir, Yavuz Selvi, Kursat Altinbas, Nadir Kocak
Summary: This study found that miRNAs play an important role in the pathogenesis of bipolar disorder and may serve as biomarkers for diagnosis and screening of the disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
James A. Roberts, Richard D. Rainbow, Parveen Sharma
Summary: Cardiovascular toxicity and diseases have a detrimental impact on morbidity and mortality. The dysregulation of the NRF2 transcription factor can lead to susceptibility to toxicity and subsequent tissue dysfunction in the cardiovascular system. Stimulation of the NRF2 signalling pathway has shown potential in alleviating cardiotoxicity and cardiovascular disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Yanjing He, Yin Cai, Pearl Mingchu Pai, Xinling Ren, Zhengyuan Xia
Summary: microRNAs (miRs) are short non-coding RNAs that regulate gene expression, and miR-503, a member of the miR-16 family, has been extensively studied in cardiovascular disease and cancer. Studies have shown that miR-503 may serve as a potential diagnostic marker or therapeutic target in cardiovascular disease or cancer by regulating gene expression through various pathological processes.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Joanna Kalafut, Arkadiusz Czerwonka, Karolina Czapla, Alicja Przybyszewska-Podstawka, Justyna Magdalena Hermanowicz, Adolfo Rivero-Muller, Lidia Borkiewicz
Summary: Notch1 signaling plays a diverse role in tissue development and homeostasis. The relationship between NOTCH1 expression and the development of health disorders, especially cancers, is intensively studied. Control of Notch1 signaling involves not only transcriptional regulation but also various post-translational events, including ligand-dependent mechanical activation and interaction with other signaling molecules, such as long non-coding RNAs (lncRNAs).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Xuan Wang, Jun Cai, Lei Zhao, Dejun Zhang, Guojie Xu, Jianli Hu, Tao Zhang, Min Jin
Summary: Research has shown that miR-9-5p directly targets NUMB, affecting the growth and migration properties of CD44(+) PCSCs, while overexpression of NUMB can overcome the effects of miR-9-5p, providing new insights into treating PCSCs and PCa metastasis.
SCIENTIFIC REPORTS
(2021)
Article
Public, Environmental & Occupational Health
Cother Hajat, Yakir Siegal, Amalia Adler-Waxman
Summary: The study shows that over 57% of insured patients in the US may have multiple chronic conditions (MCCs). Clustering of MCCs is common and associated with healthcare utilization.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Pediatrics
Biplab Kumar Datta, Ashwini Tiwari, Elinita Pollard, Havilah Ravula
Summary: This study assessed the association between cardiovascular disease (CVD) among parents and child mental health. The results showed that children of parents with CVD were more likely to face mental health difficulties, indicating the need for the development or adaptation of public health interventions to support the mental health of children with parents with CVD.
Article
Public, Environmental & Occupational Health
Richard C. Sadler, Thomas W. Wojciechowski, Zachary Buchalski, Mieka Smart, Megan Mulheron, David Todem
Summary: This study integrated community voice into the development of a healthfulness index and combined it with self-reported chronic disease and health outcomes data. While there were associations between the healthfulness index and cardiovascular disease and mental health outcomes, overall the healthfulness index did not increase predictive strength for the relationship between health and sociodemographic covariates.
SOCIAL SCIENCE & MEDICINE
(2022)
Article
Cell Biology
Bernadette M. Saunders, Caroline Rudnicka, Aleksandra Filipovska, Stefan Davies, Natalie Ward, Jana Hricova, Markus P. Schlaich, Vance B. Matthews
IMMUNOLOGY AND CELL BIOLOGY
(2018)
Article
Infectious Diseases
Simone E. Barry, Magda Ellis, YuRong Yang, Guangyu Guan, Xiaolin Wang, Warwick J. Britton, Bernadette M. Saunders
JOURNAL OF INFECTION
(2018)
Review
Immunology
Kathryn Wright, Karren Plain, Auriol Purdie, Bernadette M. Saunders, Kumudika de Silva
INFECTION AND IMMUNITY
(2020)
Review
Immunology
Jessica L. Pedersen, Nilesh J. Bokil, Bernadette M. Saunders
Article
Infectious Diseases
Jennifer Ho, Nilesh J. Bokil, Phuong Thi Bich Nguyen, Thu Anh Nguyen, Michael Y. Liu, Nathan Hare, Greg J. Fox, Bernadette M. Saunders, Guy B. Marks, Warwick J. Britton
JOURNAL OF INFECTION
(2020)
Review
Immunology
M. D. Johansen, A. Irving, X. Montagutelli, M. D. Tate, I Rudloff, M. F. Nold, N. G. Hansbro, R. Y. Kim, C. Donovan, G. Liu, A. Faiz, K. R. Short, J. G. Lyons, G. W. McCaughan, M. D. Gorrell, A. Cole, C. Moreno, D. Couteur, D. Hesselson, J. Triccas, G. G. Neely, J. R. Gamble, S. J. Simpson, B. M. Saunders, B. G. Oliver, W. J. Britton, P. A. Wark, C. A. Nold-Petry, P. M. Hansbro
MUCOSAL IMMUNOLOGY
(2020)
Article
Cell Biology
Maxwell T. Stevens, Beatrice D. Nagaria, Warwick J. Britton, Bernadette M. Saunders
Summary: Macrophages exhibit plasticity and their phenotypes and antimicrobial responses are influenced by the local microenvironment and tissue origin. The study found that macrophages from alveolar and peritoneal origins respond differently to mycobacterial infection, with varying expression levels of proinflammatory cytokines and chemokines.
IMMUNOLOGY AND CELL BIOLOGY
(2021)
Article
Immunology
Deborah L. Burnett, Katherine J. L. Jackson, David B. Langley, Anupria Aggrawal, Alberto Ospina Stella, Matt D. Johansen, Harikrishnan Balachandran, Helen Lenthall, Romain Rouet, Gregory Walker, Bernadette M. Saunders, Mandeep Singh, Hui Li, Jake Y. Henry, Jennifer Jackson, Alastair G. Stewart, Franka Witthauer, Matthew A. Spence, Nicole G. Hansbro, Colin Jackson, Peter Schofield, Claire Milthorpe, Marianne Martinello, Sebastian R. Schulz, Edith Roth, Anthony Kelleher, Sean Emery, Warwick J. Britton, William D. Rawlinson, Rudolfo Karl, Simon Schaefer, Thomas H. Winkler, Robert Brink, Rowena A. Bull, Philip M. Hansbro, Hans-Martin Jaeck, Stuart Turville, Daniel Christ, Christopher C. Goodnow
Summary: Viral mutations pose a challenge to the efficacy of COVID-19 vaccines, but research has shown that antibodies targeting conserved sites can generate effective neutralization.
Article
Immunology
Claudio Counoupas, Matt D. Johansen, Alberto O. Stella, Duc H. Nguyen, Angela L. Ferguson, Anupriya Aggarwal, Nayan D. Bhattacharyya, Alice Grey, Owen Hutchings, Karishma Patel, Rezwan Siddiquee, Erica L. Stewart, Carl G. Feng, Nicole G. Hansbro, Umaimainthan Palendira, Megan C. Steain, Bernadette M. Saunders, Jason K. K. Low, Joel P. Mackay, Anthony D. Kelleher, Warwick J. Britton, Stuart G. Turville, Philip M. Hansbro, James A. Triccas
Summary: This study demonstrates the potential of a BCG-based vaccine to provide protection against major SARS-CoV-2 variants by inducing potent virus-specific immune responses. Pre-treatment with BCG:CoVac followed by a heterologous vaccine boosts SARS-CoV-2-specific antibody responses effectively neutralizing key variants.
Article
Critical Care Medicine
Matt D. Johansen, Rashad M. Mahbub, Sobia Idrees, Duc H. Nguyen, Stefan Miemczyk, Prabuddha Pathinayake, Kristy Nichol, Nicole G. Hansbro, Linden J. Gearing, Paul J. Hertzog, David Gallego-Ortega, Warwick J. Britton, Bernadette M. Saunders, Peter A. Wark, Alen Faiz, Philip M. Hansbro
Summary: Patients with COPD are more susceptible to SARS-CoV-2 infection and develop severe viral infection and inflammation. COPD pBECs are more susceptible to viral infection possibly due to increased co-receptor expression and protease imbalances. A prominent cluster of IFN-responsive club/goblet cells emerges during infection, which may contribute to immune responses. Therapeutic interventions can suppress viral replication and inflammation.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Immunology
Jessica L. Pedersen, Simone E. Barry, Nilesh J. Bokil, Magda Ellis, YuRong Yang, Guangyu Guan, Xiaolin Wang, Alen Faiz, Warwick J. Britton, Bernadette M. Saunders
Summary: This study examined the biomarker capacity of a panel of plasma proteins alone and in conjunction with a previously identified miRNA signature to identify active TB disease. The combination of miRNA and proteins significantly improved the sensitivity and specificity as a biosignature over single biomarker candidates, showing potential for the development of a non-sputum test to aid the diagnosis of active TB disease.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hannes Hinneburg, Jessica L. Pedersen, Nilesh J. Bokil, Alexander Pralow, Falko Schirmeister, Rebeca Kawahara, Erdmann Rapp, Bernadette M. Saunders, Morten Thaysen-Andersen