Article
Multidisciplinary Sciences
Ruopeng Feng, Thiyagaraj Mayuranathan, Peng Huang, Phillip A. Doerfler, Yichao Li, Yu Yao, Jingjing Zhang, Lance E. Palmer, Kalin Mayberry, Georgios E. Christakopoulos, Peng Xu, Chunliang Li, Yong Cheng, Gerd A. Blobel, M. Celeste Simon, Mitchell J. Weiss
Summary: In this study, it was found that depletion of the VHL E3 ligase stabilizes its ubiquitination target HIF1α, inducing the transcription of the gamma-globin gene and increasing HbF expression in red blood cell precursors. Similar induction of HbF can be achieved with hypoxia or inhibition of prolyl hydroxylase domain enzymes that target HIF1α.
Article
Chemistry, Multidisciplinary
Huiti Li, Yali Liu, Zian Xue, Li Zhang, Xiaoxue Ruan, Jintong Yang, Zhongjiao Fan, Hongfang Zhao, Yu Cao, Guoqiang Chen, Ying Xu, Lu Zhou
Summary: HIF-1 alpha plays a critical role in cellular adaptation to hypoxia and a small molecule HI-101 effectively reduces its expression. By further modifications, compounds HI-104 and HI-105 with good pharmacokinetic properties and potent antitumor activity are developed.
Article
Oncology
Chao Fang, Lei Dai, Cun Wang, Chuanwen Fan, Yongyang Yu, Lie Yang, Hongxin Deng, Zongguang Zhou
Summary: Research showed that SCG2 expression was associated with the survival of CRC patients, and it exhibited anti-tumor and anti-angiogenesis effects by inhibiting HIF-1 alpha/VEGF activity.
MOLECULAR ONCOLOGY
(2021)
Review
Oncology
Kenneth N. Huynh, Sriram Rao, Bradley Roth, Theodore Bryan, Dayantha M. Fernando, Farshid Dayyani, David Imagawa, Nadine Abi-Jaoudeh
Summary: Hypoxia-inducible factor 1 alpha (HIF-1a) is a transcription factor that regulates the cellular response to hypoxia and is upregulated in all types of solid tumor. Hepatocellular carcinoma (HCC) is a highly vascular and hypoxic tumor, and treatments like TACE and TAE can exacerbate hypoxia in HCC. Hypoxia-activated prodrugs (HAPs) have potential as a targeted treatment for hypoxic HCC, but more research is needed to understand their effects in combination with embolization.
Article
Multidisciplinary Sciences
Junjun Chen, Dong Liu, Jingpu Yang, Chengxun Jin, Chang Zhao, Jinzhang Cheng
Summary: In this study, the researchers found that epidermal growth factor (EGF) regulates a hypoxia-inducible factor 1 alpha (HIF-1 alpha)-microRNA-21 (miR-21)-aquaporin 4 (AQP4) axis in nasal epithelial cells from patients with chronic rhinosinusitis (CRS). EGF upregulates HIF-1 alpha and miR-21 expression, inhibiting AQP4 expression and promoting the proliferation of nasal epithelial cells and the development of CRS.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Ophthalmology
Bing X. Ross, Lin Jia, Dejuan Kong, Tiantian Wang, Jingyu Yao, Heather M. Hager, Steven F. Abcouwer, David N. Zacks
Summary: The study aimed to determine the necessity of HIF-1a on PR cell survival after RD. The findings suggest that rod-derived HIF-1a plays a key role in promoting PR cell survival.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Surgery
Yunfei Zhang, Xiao Zhang, Bing Tian, Qin Deng, Chunbao Guo
Summary: This study demonstrates the crucial role of HIF-1 alpha in regulating the intestinal microcirculation during the pathogenesis of NEC. Targeting HIF-1 alpha may be a promising strategy for the treatment of NEC.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Tripti Singh, Pallabi Banerjee, Uditi, Sarita Kumari, Anita Chopra, Nagendra Singh, Imteyaz Qamar
Summary: Regucalcin regulates intracellular Ca2+ homeostasis and intracellular signaling pathways. Its expression in hypoxia is upregulated by HIF-1α through direct binding to the HRE binding motifs within the Regucalcin promoter.
Article
Cardiac & Cardiovascular Systems
Zhiyu Dai, Jianding Cheng, Bin Liu, Dan Yi, Anlin Feng, Ting Wang, Lingling An, Chen Gao, Yibin Wang, Maggie M. Zhu, Xianming Zhang, You-Yang Zhao
Summary: The study reveals the unexpected role of endothelial PHD2 deficiency in inducing cardiac hypertrophy and fibrosis in an HIF-2 alpha-dependent manner, suggesting it as a potential novel therapeutic approach for treating pathological cardiac hypertrophy and heart failure.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biotechnology & Applied Microbiology
Xin Tang, Cheng Chang, Michelle Hao, Mei Chen, David T. Woodley, Axel H. Schonthal, Wei Li
Summary: HIF-1 and Hsp90 play critical roles in spermatogenesis and tumorigenesis, with Hsp90 alpha affecting the levels of HIF-1 alpha in testis, and Hsp90 beta providing protection for signaling molecules responsible for cellular homeostasis.
CANCER GENE THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Lingchun Kong, Jingjing Li, Yuqin Yang, Huixin Tang, Hong Zou
Summary: This study found that Paeoniflorin (PF) can alleviate the progression of retinal vein occlusion (RVO) by inhibiting the HIF-1 alpha/VEGF/STAT3 pathway. The results of this study may provide theoretical knowledge for exploring novel treatments for RVO patients.
Article
Biotechnology & Applied Microbiology
Xiaoyu Hu, Luyuan Li, Josiane E. Eid, Chao Liu, Jinming Yu, Jinbo Yue, Jonathan C. Trent
Summary: In this study, the association between IDH mutation and HIF-1 alpha in chondrosarcoma was investigated. The results suggest that IDH1 mutation confers angiogenic and tumorigenic properties to chondrosarcoma cells by inducing HIF-1 alpha. Therefore, the HIF pathway represents a promising candidate for combinatorial regimens to target IDH1 mutated chondrosarcomas.
Article
Biochemistry & Molecular Biology
Jie Zheng, Su-Jung Kim, Soma Saeidi, Seong Hoon Kim, Xizhu Fang, Yeon-Hwa Lee, Yanymee N. Guillen-Quispe, Hoang Kieu Chi Ngo, Do-Hee Kim, Doojin Kim, Young-Joon Surh
Summary: Hypoxia-inducible factor-1 alpha (HIF-1 alpha) is highly expressed in hypoxic tumors, including hepato-cellular carcinoma (HCC). Another key transcription factor, nuclear factor erythroid 2-related factor 2 (NRF2), is also overactivated in HCC. The interaction between NRF2 and HIF-1 alpha contributes to HCC growth and progression.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Peter A. C. Wing, Peter Jianrui Liu, James M. Harris, Andrea Magri, Thomas Michler, Xiaodong Zhuang, Helene Borrmann, Rosalba Minisini, Nicholas R. Frampton, Jochen M. Wettengel, Laurent Mailly, Valentina D'Arienzo, Tobias Riedl, Luis Nobre, Michael P. Weekes, Mario Pirisi, Mathias Heikenwalder, Thomas F. Baumert, Ester M. Hammond, David R. Mole, Ulrike Protzer, Peter Balfe, Jane A. McKeating
Summary: HIFs play a crucial role in regulating HBV replication, revealing an evolutionary mechanism by which HBV exploits the HIF signaling pathway to persist in the low oxygen environment of the liver.
JOURNAL OF HEPATOLOGY
(2021)
Review
Immunology
Qianyan He, Yinzhong Ma, Jie Liu, Dianhui Zhang, Jiaxin Ren, Ruoyu Zhao, JunLei Chang, Zhen-Ni Guo, Yi Yang
Summary: Ischemic stroke, caused by inadequate cerebrovascular blood and oxygen supply, poses a significant global health burden. HIF-1α, a key regulator of oxygen homeostasis, plays a critical role in various aspects of stroke pathophysiology and is an important target for potential therapeutic interventions. Further research into the differential regulation of HIF-1α in different cell types during ischemic stroke is crucial for understanding the disease mechanism and identifying novel treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2021)