Article
Multidisciplinary Sciences
Georg Petkau, Twm J. Mitchell, Krishnendu Chakraborty, Sarah E. Bell, Vanessa D. Angeli, Louise Matheson, David J. Turner, Alexander Saveliev, Ozge Gizlenci, Fiamma Salerno, Peter D. Katsikis, Martin Turner
Summary: RNA binding proteins ZFP36 and ZFP36L1 limit the rate of differentiation and the potency of activated CD8(+) T cells by directly binding mRNA of transcription factors and cytokines, enforcing dependency on costimulation for full T cell activation and effector differentiation.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Ryan Zander, Moujtaba Y. Kasmani, Yao Chen, Paytsar Topchyan, Jian Shen, Shikan Zheng, Robert Burns, Jennifer Ingram, Can Cui, Nikhil Joshi, Joseph Craft, Allan Zajac, Weiguo Cui
Summary: This study found that CD4(+) T cells consist of three distinct subsets during chronic viral infection, and IL-21 derived from Tfh cells is critical for sustaining CD8(+) T cell responses and viral control.
Article
Immunology
Andrea C. Pichler, Nadege Carrie, Marine Cuisinier, Samira Ghazali, Allison Voisin, Pierre-Paul Axisa, Marie Tosolini, Celine Mazzotti, Dominic P. Golec, Sabrina Maheo, Laura do Souto, Ruchan Ekren, Eve Blanquart, Lea Lemaitre, Virginie Feliu, Marie-Veronique Joubert, Jennifer L. Cannons, Camille Guillerey, Herve Avet-Loiseau, Tania H. Watts, Benoit L. Salomon, Olivier Joffre, Yenkel Grinberg-Bleyer, Pamela L. Schwartzberg, Liliana E. Lucca, Ludovic Martinet
Summary: CD137 (4-1BB) is a promising target for cancer immunotherapy. It modulates the infiltration of CD8+ exhausted T cells expressing inhibitory receptors into tumors. CD137 signaling stimulates the proliferation and differentiation of Tex precursor cells through NF-KB subunits RelA and cRel and Tox-dependent chromatin remodeling. Understanding T cell exhaustion is crucial for cancer and infectious disease treatment. CD137 is identified as a critical regulator of Tex cell expansion and differentiation with broad therapeutic potential.
Article
Cell Biology
Melissa G. Lechner, Zikang Zhou, Aline T. Hoang, Nicole Huang, Jessica Ortega, Lauren N. Scott, Ho -Chung Chen, Anushi Y. Patel, Rana Yakhshi-Tafti, Kristy Kim, Willy Hugo, Pouyan Famini, Alexandra Drakaki, Antoni Ribas, Trevor E. Angell, Maureen A. Su
Summary: Autoimmune toxicity is an increasing challenge in using immune checkpoint inhibitors for cancer treatment. This study investigated the immune infiltrates in ICI-thyroiditis patients and identified a dominant population of cytotoxic CD8+ T cells. The researchers also found that interleukin-21 played a crucial role in the formation of these thyrotoxic CD8+ T cells and validated the findings in a mouse model. These findings provide insights into the mechanisms and potential therapeutic targets for individuals with IRAEs.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Ilaria Grazia Zizzari, Alessandra Di Filippo, Andrea Botticelli, Lidia Strigari, Angelina Pernazza, Emma Rullo, Maria Gemma Pignataro, Alessio Ugolini, Fabio Scirocchi, Francesca Romana Di Pietro, Ernesto Rossi, Alain Gelibter, Giovanni Schinzari, Giulia D'Amati, Aurelia Rughetti, Paolo Marchetti, Marianna Nuti, Chiara Napoletano
Summary: CD137(+) T cells recognize and react to tumors, and high levels of CD137(+) T cells are associated with better clinical status and longer survival, while immunosuppressive sCD137 is associated with poor survival. CD137(+) T cells can serve as a biomarker for successful immunotherapy.
CLINICAL CANCER RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Xiao-Tang Yin, Nicholas K. Baugnon, Rohini Krishnan, Chloe A. Potter, Sudha Yarlagadda, Tammie L. Keadle, Patrick M. Stuart
Summary: Costimulatory interactions are crucial for developing immune responses to infections, but the role of CD137 costimulation in herpetic stromal keratitis (HSK) is not well understood. This study explored the impact of CD137 on HSK using B6- CD137L-/- mice and antagonistic/agonistic antibodies to CD137. The findings demonstrate that CD137 costimulation reduces corneal disease and plays an important role in the CD8+ T cell response in the trigeminal ganglia.
JOURNAL OF GENERAL VIROLOGY
(2022)
Review
Immunology
Brigette C. Duckworth, Raymond Z. Qin, Joanna R. Groom
Summary: Lymph nodes play a critical role in immune response and immunosurveillance. Intranodal migration is essential for T cell activation and differentiation. The spatial regulation of T cell fates and the potential for promoting T-SCM differentiation are areas of focus for future research.
IMMUNOLOGICAL REVIEWS
(2022)
Article
Immunology
Jian Tang, Xian Jia, Jian Li, Junchen Dong, Jiayu Wang, Wanyun Li, Yuzhen Zhu, Yanyan Hu, Bowen Hou, Chunjie Lin, Yu Cong, Tong Ren, Changsheng Yan, Hongying Yang, Qian Lai, Haiping Zheng, Yuzhou Bao, Namrata Gautam, Hong-Rui Wang, Bing Xu, Xiao Lei Chen, Qing Li, Nicholas R. J. Gascoigne, Guo Fu
Summary: CD8(+) T cells are crucial in antiviral immune responses and Themis plays a critical role in their differentiation and function, regulating viral infection.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Federica Agliano, Timofey A. Karginov, Antoine Menoret, Anthony Provatas, Anthony T. Vella
Summary: NAM has been found to affect T cell responses by impairing the transition of naive T cells into effector T cells, as well as impacting effector T cells themselves. NAM enhances the glycolysis of effector T cells while reducing the production of IFN gamma. These findings suggest that NAM has the potential to be a powerful treatment for diseases associated with T cell hyperactivation.
Article
Cell Biology
Saeed Daneshmandi, Teresa Cassel, Penghui Lin, Richard M. Higashi, Gerburg M. Wulf, Vassiliki A. Boussiotis, Teresa W-M Fan, Pankaj Seth
Summary: Genetic ablation or pharmacologic inhibition of the PPP enzyme 6PGD enhances the generation of potent CD8(+) T effector cells, which show strong anti-tumor functions through metabolic reprogramming and balancing ROS production.
Article
Immunology
Vanessa Neitzke-Montinelli, Carolina Caloba, Guilherme Melo, Bianca B. Frade, Enzo Caramez, Luciano Mazzoccoli, Andre N. A. Goncalves, Helder I. Nakaya, Renata M. Pereira, Miriam B. F. Werneck, Joao P. B. Viola
Summary: This study established a novel in vitro CD8 T cell activation and culture regimen to generate differentiated cells consistent with central memory-like cells. In vitro memory cells provided long-term immunological protection and showed potential for immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Mahmoud Abdelbary, Samuel J. Hobbs, James S. Gibbs, Jonathan W. Yewdell, Jeffrey C. Nolz
Summary: This study investigates how the strength of T cell receptor signaling changes the chemotactic properties of effector CD8(+) T cells to promote tissue-residency. The researchers found that TCR signaling enhances CXCR6-mediated migration and suppresses migration toward sphingosine-1-phosphate, indicating the programming of a 'chemotactic switch' following secondary antigen encounter within non-lymphoid tissues. Blimp1 is identified as the critical target of TCR re-stimulation necessary for establishing this chemotactic switch and efficient T-RM differentiation.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Andrea M. Amitrano, Brandon J. Berry, Kihong Lim, Kyun-Do Kim, Richard E. Waugh, Andrew P. Wojtovich, Minsoo Kim
Summary: Cancer immunotherapy is more effective against hematological malignancies than solid tumors due to metabolic challenges in the tumor microenvironment. Mitochondria play a key role in CD8(+) T cell activation and effector function. Enhanced mitochondrial function is associated with improved T cell migration and effector function, highlighting the importance of mitochondrial metabolism in T cell responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Shweta Mahajan, Aria Alexander, Zachary Koenig, Nicholas Saba, Nina Prasanphanich, David A. Hildeman, Claire A. Chougnet, Emily Defranco, Sandra Andorf, Tamara Tilburgs
Summary: Decidual CD8(+) T cells play a critical role in providing immunity to infection and immune tolerance for fetal and placental antigens. These cells include shared blood T cells and unique decidual T cells, and the specificity of decidual CD8(+) T cells is closely related to their function and tissue residency.
Article
Immunology
Anna Schoellhorn, Ana Maia, Felix Kimmerle, Jan Born, Hans-Georg Rammensee, Stoyan Dimitrov, Cecile Gouttefangeas
Summary: Common flow cytometry-based methods for functional assessment of antigen-specific T cells have limitations such as complex experimental settings and high unspecific background. A simple method for detecting activated ss(2)-integrins in combination with established cell surface activation induced markers was developed, allowing improved assessment of low-frequency T cell responses. The extracellular staining of these markers highly correlated with intracellular cytokine production in CD4(+) and CD8(+) T cells. This method is useful for epitope discovery projects and simultaneous monitoring of low-frequency antigen-specific T cell responses.
FRONTIERS IN IMMUNOLOGY
(2023)