Article
Biology
Lucie A. Bergeron, Soren Besenbacher, Jaco Bakker, Jiao Zheng, Panyi Li, George Pacheco, Mikkel-Holger S. Sinding, Maria Kamilari, M. Thomas P. Gilbert, Mikkel H. Schierup, Guojie Zhang
Summary: The study revealed that the rate of de novo mutations in rhesus macaques is positively correlated with paternal age, with the paternal lineage contributing most of the mutations. Approximately 3.5% of de novo mutations were shared between siblings, likely arising from early developmental stages. The estimated yearly mutation rate in rhesus macaques also provided insights into primate evolution when compared to traditional molecular clock methods.
Article
Cell Biology
Yoshifumi Mori, Seiji Takashima, Mito Kanatsu-Shinohara, Zheng Yi, Takashi Shinohara
Summary: The study found that Cdc42 is essential for the development of the germline niche, as its deficiency results in a significant reduction in the number of spermatogonial stem cells in the testes, affecting GDNF expression and Sertoli cell development.
Article
Immunology
David Zemmour, Louis-Marie Charbonnier, Juliette Leon, Emmanuelle Six, Sevgi Keles, Marianne Delville, Mehdi Benamar, Safa Baris, Julien Zuber, Karin Chen, Benedicte Neven, Maria I. Garcia-Lloret, Frank M. Ruemmele, Carlo Brugnara, Nadine Cerf-Bensussan, Frederic Rieux-Laucat, Marina Cavazzana, Isabelle Andre, Talal A. Chatila, Diane Mathis, Christophe Benoist
Summary: FOXP3 deficiency leads to the alteration of regulatory T cells in both mice and patients with IPEX syndrome, resulting in fatal autoimmunity. The study found a two-step pathogenesis model where core FOXP3-dependent genes are downregulated, destabilizing T-reg cells and promoting systemic inflammation, ultimately disrupting immune homeostasis. Treatment with interleukin-2 improved survival by targeting the T-reg-like compartment.
Article
Chemistry, Medicinal
C. K. Sruthi, Meher K. Prakash
Summary: Predictions of mutational effects are improving in accuracy through advanced AI algorithms trained on experimental data. This study aimed to gain insights into the contributions of different mutation attributes to the effects, and to develop universal rules for mapping descriptors to mutational effects. The research extracted relationships between physicochemical descriptors and mutational effects, and identified universal trends in the contributions of certain factors to the effects.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2021)
Article
Oncology
Tao Wang, Yang Yang, Huayi Feng, Bo Cui, Zheng Lv, Wenlei Zhao, Xiangyi Zhang, Xin Ma
Summary: Birt-Hogg-Dube syndrome is an autosomal dominant condition characterized by skin fibrofolliculomas, lung cysts, pneumothorax, and renal cancer. Research suggests a link between FLCN mutations and TFEB/TFE3, mTOR, and cilia.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Danuta Gasior-Perczak, Artur Kowalik, Krzysztof Gruszczynski, Agnieszka Walczyk, Monika Siolek, Iwona Palyga, Slawomir Trepka, Estera Mikina, Tomasz Trybek, Janusz Kopczynski, Agnieszka Suligowska, Rafal Slusarczyk, Agnieszka Gonet, Jaroslaw Jaskulski, Pawel Orlowski, Magdalena Chrapek, Stanislaw Gozdz, Aldona Kowalska
Summary: The study aimed to assess whether CHEK2 mutations predict a worse clinical course in papillary thyroid cancer patients. Truncating CHEK2 mutations were significantly associated with vascular invasion and intermediate/high initial recurrence risk, while missense mutations were not. However, neither type of mutation affected primary treatment response or disease outcome.
Article
Urology & Nephrology
Yong Yang, Guoying Zhang, Chen Hu, Wei Luo, Haiyang Jiang, Shaoyou Liu, Hong Yang
Summary: This study comprehensively characterizes the germline mutational status for genitourinary cancers and finds that pathogenic and likely pathogenic germline mutations increase the risk and indicate poor prognosis of these cancers.
Article
Cell Biology
Takeshi Kimura, Michaela Bosakova, Yosuke Nonaka, Eva Hruba, Kie Yasuda, Satoshi Futakawa, Takuo Kubota, Bohumil Fafilek, Tomas Gregor, Sara P. Abraham, Regina Gomolkova, Silvie Belaskova, Martin Pesl, Fabiana Csukasi, Ivan Duran, Masatoshi Fujiwara, Michaela Kavkova, Tomas Zikmund, Josef Kaiser, Marcela Buchtova, Deborah Krakow, Yoshikazu Nakamura, Keiichi Ozono, Pavel Krejci
Summary: The study demonstrates that RBM-007 can effectively inhibit FGFR3 signaling, repair detrimental effects on cartilage and skeletal development, providing a potential therapeutic approach for achondroplasia and other FGFR3-related skeletal dysplasias.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Milirani Das, Guruswami Gurusubramanian, Vikas Kumar Roy
Summary: The expression of the apelin system in the adult testis of rat and mice has been shown. It has been emphasized that regulation of testicular activity in early stages is important for sustaining normal testicular activity in adulthood. The expression of apelin receptor (APJ) in the adult testis has been shown, but the developmental expression of APJ and its role have not been explored. The present study examined the testicular expression of APJ during postnatal stages and found that it is developmentally regulated with a positive correlation with circulating apelin, testosterone, and androstenedione. Inhibition of APJ resulted in suppressed testicular proliferation, increased apoptosis, and increased estrogen secretion. AR expression was also down-regulated by APJ inhibition. These findings suggest that apelin signaling during early developmental stages is required for stimulating germ cell proliferation and inhibiting apoptosis. The exact mechanism of apelin-mediated regulation of testicular activity during early postnatal stages needs further investigation. The results indicate the importance of apelin-mediated signaling in regulating germ cell proliferation, apoptosis, and AR expression during early postnatal stage.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Cell Biology
Xi He, Sarah E. Smith, Shiyuan Chen, Hua Li, Di Wu, Paloma Meneses-Giles, Yongfu Wang, Mark Hembree, Kexi Yi, Xia Zhao, Fengli Guo, Jay R. Unruh, Lucinda E. Maddera, Zulin Yu, Allison Scott, Anoja Perera, Yan Wang, Chongbei Zhao, KyeongMin Bae, Andrew Box, Jeffrey S. Haug, Fang Tao, Deqing Hu, Darrick M. Hansen, Pengxu Qian, Subhrajit Saha, Dan Dixon, Shrikant Anant, Da Zhang, Edward H. Lin, Weijing Sun, Leanne M. Wiedemann, Linheng Li
Summary: The study reveals a bidirectional crosstalk between treatment-resistant tumor-initiating stem cells (TrTSC) and the tumor microenvironment (TME), leading to a contexture that promotes tumor growth and immunosuppression.
Article
Microbiology
Jingjing Wang, Mengsi Zhang, Xiaochun Cui, Xiang Gao, Weifeng Sun, Xinna Ge, Yongning Zhang, Xin Guo, Jun Han, Lei Zhou, Hanchun Yang
Summary: This study provides direct scientific evidence for the reversion to virulence of PRRS MLV and offers valuable clues for exploring its molecular mechanism.
MICROBIOLOGY SPECTRUM
(2022)
Article
Dermatology
He-chen Huang, Yan Chen, Jie Hu, Xiu-tian Guo, Shao-rong Zhou, Qi-qi Yang, Yu-qing Du, Yu Jin, Guo-bin Liu, Yun-hua Peng
Summary: This meta-analysis examined the effect of quercetin and its derivatives on wound healing in animal experiments. The results showed that quercetin promoted faster wound closure in animals compared to the control group. The study also found that quercetin inhibited inflammatory response, accelerated angiogenesis, fibroblast proliferation, and collagen deposition. These findings suggest that quercetin and its derivatives can promote the recovery of cutaneous wounds in animals.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Immunology
Xun-Jia Ye, Rong Xu, Si-Ying Liu, Bo Hu, Zi-Jian Shi, Fu-Li Shi, Bo Zeng, Li-Hui Xu, Yuan-Ting Huang, Ming-Ye Chen, Qing-Bing Zha, Xian-Hui He, Dong-Yun Ouyang
Summary: The study discovered that taraxasterol (TAS), an active ingredient in dandelion, can inhibit the activation and proliferation of T lymphocytes by suppressing IL-2 expression and its signaling pathway, thereby ameliorating Con A-induced acute hepatitis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Chizuru Ito, Tsukasa Makino, Tohru Mutoh, Masahide Kikkawa, Kiyotaka Toshimori
Summary: Normal sperm flagellar shape and movement are crucial for fertilization. The proteins ODF4, AK1, and AK2 play important roles in the morphology and function of sperm flagella. Deletion of ODF4 leads to abnormal flagellar shape and movement, resulting in male infertility. This study demonstrates the relationship between ODF4, AK1, and AK2 in regulating flagellar structure and function.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Zhou Zhang, Ping Li, Ping Sun
Summary: The expression and mutation of SAMHD1 have a significant impact on the prognosis of colon cancer. Low expression of SAMHD1 is associated with increased patient mortality. The dNTPase function of SAMHD1 may inhibit colon cancer cell proliferation and enhance apoptosis. Additionally, first-line chemotherapy with 5-FU has a time-dependent effect.
Article
Pharmacology & Pharmacy
Ren-Rong Tian, Ming-Xu Zhang, Lin-Tao Zhang, Peng Zhang, Jian-Ping Ma, Mingyue Liu, Martin Devenport, Pan Zheng, Xiao-Liang Zhang, Xiao-Dong Lian, Mei Ye, Hong-Yi Zheng, Wei Pang, Gao-Hong Zhang, Li-Guo Zhang, Yang Liu, Yong-Tang Zheng
ANTIVIRAL RESEARCH
(2018)
Article
Cell Biology
Xuexiang Du, Mingyue Liu, Juanjuan Su, Peng Zhang, Fei Tang, Peiying Ye, Martin Devenport, Xu Wang, Yan Zhang, Yang Liu, Pan Zheng
Article
Biochemistry & Molecular Biology
Weijie Yin, Yan Song, Xing Chang
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Oncology
Ran Tao, Najiba Murad, Zhenhua Xu, Peng Zhang, Konstantin Okonechnikov, Marcel Kool, Samuel Rivero-Hinojosa, Christopher Lazarski, Pan Zheng, Yang Liu, Charles G. Eberhart, Brian R. Rood, Roger Packer, Yanxin Pei
Article
Cell Biology
Tuan Qi, Mengmeng Sun, Chao Zhang, Pengda Chen, Changchun Xiao, Xing Chang
Article
Cardiac & Cardiovascular Systems
Jia Li, Kaiying Wang, Yuchen Zhang, Tuan Qi, Juanjuan Yuan, Lei Zhang, Han Qiu, Jinxi Wang, Huang-Tian Yang, Yi Dai, Yan Song, Xing Chang
Summary: The study analyzed a novel murine model of DMD and examined the feasibility of using a cytidine base editor for exon skipping in vivo. The results showed that AAV9-eTAM treatment in the mouse model restored dystrophin and improved cardiac and skeletal muscle functions significantly.
Letter
Cardiac & Cardiovascular Systems
Jia Li, Xing Chang
Article
Cell Biology
Lei-Lei Chen, Carmen Morcelle, Zhou-Li Cheng, Xiufei Chen, Yanping Xu, Yajing Gao, Jun-Bin Song, Zhijun Li, Matthew Smith, Miao Shi, Yezhang Zhu, Neng Zhou, Meng Cheng, Chenxi He, Kwei-Yan Liu, Guoping Lu, Lei Zhang, Cheng Zhang, Jinye Zhang, Yiping Sun, Tuan Qi, Yingying Lyu, Zhi-Zhong Ren, Xian-Ming Tan, Fei Lan, Ying Liu, Hui Yang, Caiwen Duan, Xing Chang, Yufeng Zhou, Li Shen, Albert Baldwin, Kun-Liang Guan, Yue Xiong, Dan Ye, Jiayong Yin, Maoxiang Qian
Summary: This study reveals that ITA acts as an immune modulatory metabolite by inhibiting TET enzymes to suppress inflammatory responses. ITA binds to the catalytic site of TET2, inhibiting its regulation of lipopolysaccharide-induced genes and reducing acute pulmonary edema and organ injury caused by lipopolysaccharide stimulation.
NATURE CELL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Lizhen Zhu, Geng Li, Zhixin Liang, Tuan Qi, Kui Deng, Jiancheng Yu, Yue Peng, Jusheng Zheng, Yan Song, Xing Chang
Summary: Iron deficiencies are the most common nonenteric syndromes observed in patients with inflammatory bowel disease. This study reveals that the homeostasis of regulatory T cells in the intestine depends on high cellular iron levels, which are facilitated by the short-chain fatty acid pentanoate produced by intestinal microbiota. The findings demonstrate the association between nutrient uptake, specifically iron, and immune tolerance in the intestine.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Han Qiu, Geng Li, Juanjuan Yuan, Dian Yang, Yunqing Ma, Feng Wang, Yi Dai, Xing Chang
Summary: This study demonstrates that base editors can efficiently induce exon skipping by disrupting exonic splicing enhancers, providing a new treatment strategy for DMD and other RNA mis-splicing diseases and expanding the repertoire of potential targets.
Article
Medicine, Research & Experimental
Christopher M. Bailey, Yan Liu, Mingyue Liu, Xuexiang Du, Martin Devenport, Pan Zheng, Yang Liu, Yin Wang
Summary: This study found that targeting HIF-1α inhibition can increase the expression of PD-L1 on tumor cells and tumor-infiltrating myeloid cells, activating immune cells and leading to tumor rejection. The HIF-1α inhibitor Echinomycin not only enhances the immunotherapeutic effects of anti-CTLA-4 therapy, but also protects against immune-related adverse events by increasing PD-L1 levels in normal tissues.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Cell Biology
Boyi Zhang, Qilai Long, Shanshan Wu, Qixia Xu, Shuling Song, Liu Han, Min Qian, Xiaohui Ren, Hanxin Liu, Jing Jiang, Jianming Guo, Xiaoling Zhang, Xing Chang, Qiang Fu, Eric W-F Lam, Judith Campisi, James L. Kirkland, Yu Sun
Summary: Cellular senescence is regulated by histone H3-specific demethylase KDM4, which is associated with changes in H3K9/H3K36 methylation and poorer survival in prostate cancer patients. Targeting KDM4 reduces senescence-associated secretory phenotype (SASP) in stromal cells, promoting cancer cell apoptosis and prolonging survival in experimental animals. This study suggests KDM4 as a key modulator in manipulating cellular senescence and limiting its contribution to age-related pathologies, including cancer.
Letter
Cell Biology
Han Gao, Haiyan Cai, Jia Liu, Xiaoxiao Wang, Pan Zheng, Martin Devenport, Ting Xu, Fei Dou, Yang Liu, Aiwu Zhou
Article
Biochemical Research Methods
Yunqing Ma, Juanjuan Yuan, Xing Chang
Letter
Immunology
Ning Li, Pan Zheng, Yang Liu
CELLULAR & MOLECULAR IMMUNOLOGY
(2018)