Review
Immunology
Joshua M. Moreau, Maria Velegraki, Chelsea Bolyard, Michael D. Rosenblum, Zihai Li
Summary: TGF-beta 1 plays a crucial role in the development and function of T-reg, although its pleiotropic and context-dependent activity makes it complicated.
SCIENCE IMMUNOLOGY
(2022)
Article
Immunology
Jialing Liu, Xingqiang Lai, Yingying Bao, Wenfeng Xie, Zhishan Li, Jieying Chen, Gang Li, Tao Wang, Weijun Huang, Yuanchen Ma, Jiahao Shi, Erming Zhao, Andy Peng Xiang, Qiuli Liu, Xiaoyong Chen
Summary: Intraperitoneally delivered mesenchymal stem cells (MSCs) secrete THBS1 to boost IL-10(+)Bregs and control the progression and recurrence of inflammatory bowel disease (IBD).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Wojciech Dawicki, Hui Huang, Yanna Ma, Jennifer Town, Xiaobei Zhang, Chris D. Rudulier, John R. Gordon
Summary: CD40 signaling in DC10 plays a crucial role in promoting IL-10 expression and robust induction of tolerance, including activation of induced Treg.
Article
Cell Biology
Jikai Cui, Heng Xu, Jizhang Yu, Yuan Li, Zhang Chen, Yanqiang Zou, Xi Zhang, Yifan Du, Jiahong Xia, Jie Wu
Summary: Regulatory T cells differentiation is inhibited by IL-4 through epigenetic modulations. HDAC9 is involved in histone deacetylation process, affecting Foxp3 gene transcription, while sodium butyrate can abolish the inhibitory effects of IL-4.
CELL DEATH & DISEASE
(2021)
Article
Genetics & Heredity
Min-Yu Tu, Kuei-Yang Han, Ying-Wei Lan, Ku-Yi Chang, Cheng-Wei Lai, Theresa Staniczek, Chung-Yu Lai, Kowit-Yu Chong, Chuan-Mu Chen
Summary: Research suggests that the specific SNP combination of TGF-beta 1 (-509) and IL-10 (+1927) may act as a predictive factor for postmenopausal osteoporosis in Taiwanese women. Females with TGF-beta 1 SNP (-509 C/C) and IL-10 SNP (+1927 C/C) genotypes showed benefit for femoral neck T-scores, while those with TGF-beta 1 SNP (-509 T/T) and IL-10 SNP (+1927 A/A) genotypes had a significant decrease in total hip BMD T-scores. The combination of SNPs in the TGF-beta 1 and IL-10 genes may play a role in the development of osteoporosis.
Article
Multidisciplinary Sciences
Akimichi Inaba, Zewen Kelvin Tuong, Tian X. X. Zhao, Andrew P. P. Stewart, Rebeccah Mathews, Lucy Truman, Rouchelle Sriranjan, Jane Kennet, Kourosh Saeb-Parsy, Linda Wicker, Frank Waldron-Lynch, Joseph Cheriyan, John A. A. Todd, Ziad Mallat, Menna R. R. Clatworthy
Summary: Activation of B cells expressing CD25 can be enhanced by low-dose recombinant IL-2, leading to increased secretion of IL-10. Administration of low dose IL-2 to patients results in an increase in IL-10-producing B cells. Single-cell RNA sequencing reveals enrichment of regulatory B cell gene signature in plasma cell populations from IL-2-treated patients, with significant down-regulation of the transcriptional repressor BACH2. BACH2 suppression leads to increased B cell IL-10, suggesting its role in promoting an immunoregulatory phenotype in B cells through IL-2 modulation.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Daniel F. Cruz, Nilay Mitash, Fangping Mu, Carlos M. Farinha, Agnieszka Swiatecka-Urban
Summary: This study reveals the regulatory network of LMTK2 and its intersection with the TGF-beta 1 signaling pathway, demonstrating the important role of LMTK2 in cellular functions and disease pathways.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Nahal Emami Fard, Maria Xiao, Roma Sehmi
Summary: Growing evidence suggests the critical role of ILC2 in allergic inflammatory conditions, and this review provides a comprehensive overview of a newly discovered regulatory subtype of ILC2. These ILC2 subsets, capable of producing the anti-inflammatory cytokine IL-10, hold potential significance for immune regulation and management of T2 inflammatory conditions.
Article
Immunology
Patricia Ramos-Ramirez, Carina Malmhall, Omar Tliba, Madeleine Radinger, Apostolos Bossios
Summary: Adiponectin/AdipoR1 axis promotes IL-10 release by Tregs, mainly in Helios(-) Tregs, and the effect was amplified by T2 inflammation in Helios(+) Tregs. This suggests a potential role of adiponectin in regulating Treg function in human inflammatory conditions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Daniel Maranatha, Helmia Hasan, Arief Bakhtiar, Anita Widyoningroem, Aryati
Summary: This study evaluated the association of TNF-alpha, TGF-beta 1, amphiregulin, IL-2, and EGFR with pulmonary fibrosis after COVID-19 pneumonia. The results suggest that TNF-alpha and TGF-beta 1 potentially participate in the process of pulmonary fibrosis in COVID-19.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Article
Rheumatology
Junji Xu, Ousheng Liu, Dandan Wang, Fu Wang, Dunfang Zhang, Wenwen Jin, Alexander Cain, Andrew Bynum, Na Liu, Yichen Han, WanJun Chen
Summary: In this study, researchers developed an immunotherapy for SS-like symptoms in NOD/LtJ mice by depleting CD4+ T cells and administering specific peptides. The treatment successfully generated antigen-specific Treg cells that suppressed inflammation and maintained salivary gland function. This finding suggests a potential therapy for SS treatment in humans.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yulai Fang, Qin Zhang, Changjun Lv, Yilei Guo, Yue He, Pengxiang Guo, Zhifeng Wei, Yufeng Xia, Yue Dai
Summary: This study reveals the crucial role of mitochondrial dynamics in the differentiation of regulatory T cells, showing that mitochondrial fusion drives metabolic reprogramming and facilitates the generation of Treg cells.
Article
Immunology
Takashi MaruYama, Shuhei Kobayashi, Hiroko Nakatsukasa, Yuki Moritoki, Daiki Taguchi, Yoichi Sunagawa, Tatsuya Morimoto, Atsuko Asao, Wenwen Jin, Yuji Owada, Naoto Ishii, Yoshiharu Iwabuchi, Akihiko Yoshimura, WanJun Chen, Hiroyuki Shibata
Summary: Regulatory T cells (Tregs) orchestrate antitumor immune responses, with TGF-beta promoting Treg generation through NF-kappa B/p300 and SMAD signaling pathways. GO-Y030 inhibits Treg generation and stability by blocking these pathways, resulting in potent anticancer effects in vivo tumor models.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Mei Tang, Fuya Jia, Fang Nan, Fengqiong Zuo, Zhu Yuan, Dunfang Zhang
Summary: This review summarizes the functions of cytokines in the generation of Treg cells and concludes that four members of the gamma c family cytokines, transforming growth factor beta, and three members of the TNF superfamily cytokines play vital roles in regulating tTreg cell generation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Krzysztof Piersiala, Eric Hjalmarsson, Pedro Farrajota Neves da Silva, Vilma Lagebro, Aeneas Kolev, Magnus Starkhammar, Alexandra Elliot, Linda Marklund, Eva Munck-Wikland, Gregori Margolin, Susanna Kumlien Georen, Lars-Olaf Cardell
Summary: It has been established that T cells play a significant role in anti-tumor immune response, while the contribution of B cells has been insufficiently studied. In this research, the proportions and characteristics of B cells in tumor draining lymph nodes (TDLNs) and non-TDLNs from oral squamous cell carcinoma patients were analyzed. The results showed that TDLNs had a higher proportion of B cells, especially immunosuppressive regulatory B cells, compared to non-TDLNs. The presence of regulatory B cells in TDLNs may hinder the effectiveness of novel cancer immunotherapies in head and neck cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Immunology
M. -C. Gaudreau, B. M. Johnson, R. Gudi, M. M. Al-Gadban, C. Vasu
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2015)
Article
Immunology
B. M. Johnson, M. -C. Gaudreau, M. M. Al-Gadban, R. Gudi, C. Vasu
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Radhika Gudi, Courtney J. Haycraft, P. Darwin Bell, Zihai Li, Chenthamarakshan Vasu
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Medicine, Research & Experimental
Yongliang Zhang, Bill X. Wu, Alessandra Metelli, Jessica E. Thaxton, Feng Hong, Saleh Rachidi, Ephraim Ansa-Addo, Shaoli Sun, Chenthamarakshan Vasu, Yi Yang, Bei Liu, Zihai Li
JOURNAL OF CLINICAL INVESTIGATION
(2015)
Article
Immunology
Palash Bhattacharya, Jilao Fan, Christine Haddad, Abdul Essani, Anupama Gopisetty, Hatem A. Elshabrawy, Chenthamarakshan Vasu, Bellur S. Prabhakar
CLINICAL IMMUNOLOGY
(2014)
Article
Endocrinology & Metabolism
Subha Karumuthil-Melethil, M. Hanief Sofi, Radhika Gudi, Benjamin M. Johnson, Nicolas Perez, Chenthamarakshan Vasu
Article
Immunology
Anupama Gopisetty, Palash Bhattacharya, Christine Haddad, Joseph C. Bruno, Chenthamarakshan Vasu, Lucio Miele, Bellur S. Prabhakar
JOURNAL OF IMMUNOLOGY
(2013)
Article
Immunology
Subha Karumuthil-Melethil, Radhika Gudi, Benjamin M. Johnson, Nicolas Perez, Chenthamarakshan Vasu
JOURNAL OF IMMUNOLOGY
(2014)
Article
Immunology
Radhika Gudi, Nicolas Perez, Benjamin M. Johnson, M. Hanief Sofi, Robert Brown, Songhua Quan, Subha Karumuthil-Melethil, Chenthamarakshan Vasu
Article
Endocrinology & Metabolism
M. Hanief Sofi, Benjamin M. Johnson, Radhika R. Gudi, Amy Jolly, Marie-Claude Gaudreau, Chenthamarakshan Vasu
Article
Nutrition & Dietetics
Radhika Gudi, Jada Suber, Robert Brown, Benjamin M. Johnson, Chenthamarakshan Vasu
JOURNAL OF NUTRITION
(2020)
Article
Multidisciplinary Sciences
Wei Sun, Radhika R. Gudi, Benjamin M. Johnson, Chenthamarakshan Vasu
SCIENTIFIC REPORTS
(2020)
Article
Immunology
Marie-Claude Gaudreau, Radhika R. Gudi, Gongbo Li, Benjamin M. Johnson, Chenthamarakshan Vasu
Summary: This study demonstrates the potential of using MSCs to produce and deliver Gastrin in vivo for protecting insulin-producing beta-cells and ameliorating the disease progression in Type 1 diabetes, showing promising results in delaying hyperglycemia in NOD mice and restoring euglycemia in early-hyperglycemic mice.
Article
Immunology
Radhika Gudi, Soumyabrata Roy, Wei Sun, Chenthamarakshan Vasu
Summary: This study investigates the faecal IgA abundance and nAg reactivity in different lupus-prone mouse models and its correlation with eventual serum autoantibody levels. The results show that the faecal IgA abundance and nAg reactivity vary among different models and are age-dependent. Importantly, faecal IgA in these mice exhibit significant levels of nAg reactivity from a juvenile age. Furthermore, the pre-seropositive stage nAg reactivity of faecal IgA correlates well with eventual serum autoantibody levels. Gender differences in serum autoantibody levels are preceded by similar differences in faecal IgA abundance and nAg reactivity. These findings suggest that faecal IgA features, particularly nAg reactivity, could serve as a biomarker for early prediction of eventual systemic autoimmunity in lupus-prone subjects.
Article
Immunology
Radhika R. Gudi, Benjamin M. Johnson, Marie-Claude Gaudreau, Wei Sun, Lauren Ball, Chenthamarakshan Vasu
Summary: The incidence of systemic lupus erythematosus (SLE) is higher in women than men, and the mechanisms underlying this gender bias are not well understood. Using lupus-prone mice, researchers have found that the intestinal immune system and gut microbiota play a role in the development of SLE, and depletion of gut microbiota provides better disease protection in females. Female lupus-prone mice with higher gut permeability at a young age were found to have higher expression levels of pro-inflammatory factors, faecal IgA abundance, and eventual systemic autoantibody levels and proteinuria onset. Disease protection achieved by depleting gut microbiota in female mice was associated with reduced gut inflammatory protein levels, intestinal permeability, and circulating microbial DNA levels. However, transplantation of gut microbiota from juvenile males and females did not affect gut inflammatory features or permeability. These findings suggest that early-onset intestinal inflammation, systemic autoantibody production, and disease progression in female lupus-prone mice are linked to higher gut permeability.