Review
Pharmacology & Pharmacy
Xirui Guo, Xuerong Yang, Qi Li, Xiaoyan Shen, Huiyun Zhong, Yong Yang
Summary: Systemic lupus erythematosus (SLE) is a chronic diffuse connective tissue illness characterized by multisystem and multiorgan involvement. Intake of probiotics alters the composition of the gut microbiome, contributing to prevent the progression of SLE and alleviate symptoms in animal models. Probiotics supplementation may serve as a potentially novel approach in the treatment of SLE.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Paul Curtiss, Amanda M. Walker, Benjamin F. Chong
Summary: This study reviewed patient cohorts and populations to investigate the progression of cutaneous lupus to systemic lupus. The study found variations in the progression rates between adult and pediatric groups, which were attributed to differences in patient populations, study design, diagnostic criteria, and follow-up time. Risk factors associated with the development of systemic lupus included positive anti-nuclear antibodies, hematologic abnormalities, and a higher number of lupus classification criteria at baseline.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Patrick Klueber, Steffen K. Meurer, Jessica Lambertz, Roman Schwarz, Silke Zechel-Gran, Till Braunschweig, Sabine Hurka, Eugen Domann, Ralf Weiskirchen
Summary: Lipocalin 2 plays important roles in innate immune responses, iron sequestration, and gut microbiota composition. In this study, we found significant differences in microbiota composition between wild type and Lcn2 null mice, with the null mice showing lower fecal DNA quantity and specific taxonomic changes, particularly with an increase in certain bacteria like Escherichia and Staphylococcus. Additionally, knockout mice exhibited higher immune cell infiltration and abundance of segmented filamentous bacteria in the ileum.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Rheumatology
Yu Lei, Qianmei Liu, Qilin Li, Cheng Zhao, Ming Zhao, Qianjin Lu
Summary: This article summarizes the research on the relationship between microbiota dysbiosis and systemic lupus erythematosus (SLE), and provides new strategies for exploring the mechanisms and treating patients with SLE.
CURRENT RHEUMATOLOGY REPORTS
(2023)
Review
Immunology
Longhuan Ma, Laurence Morel
Summary: Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease with an unknown etiology. Increased gut permeability and dysbiosis of gut microbiota are associated with SLE progression. Impaired intestinal barrier allows translocation of bacteria and bacterial components into systemic organs, leading to immune cell activation and autoantibody generation. Restoring microbial balance eliminates gut leakage.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Qian Chen, Jie Wang, Mengmeng Xiang, Yilun Wang, Zhixiong Zhang, Jun Liang, Jinhua Xu
Summary: This review summarizes the potential links between ferroptosis and systemic lupus erythematosus (SLE), elucidates the role of ferroptosis in SLE pathogenesis, and proposes a new therapeutic strategy for SLE.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Warren A. James, Elizabeth Ogunrinde, Zhuang Wan, Diane L. Kamen, Jim Oates, Gary S. Gilkeson, Wei Jiang
Summary: This study analyzed the blood and stool samples from patients with systemic lupus erythematosus (SLE) and healthy controls (HCs) to investigate the microbial community composition. It was found that the plasma microbiome had distinct community and greater heterogeneity compared to the gut microbiome. The decreased plasma alpha diversity in patients with SLE suggests an altered plasma microbiome, which may play a role in the immune perturbations and pathogenesis of SLE.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Rheumatology
Patrick Coit, Xiavan Roopnarinesingh, Lourdes Ortiz-Fernandez, Kathleen McKinnon-Maksimowicz, Emily E. Lewis, Joan T. Merrill, W. Joseph McCune, Jonathan D. Wren, Amr H. Sawalha
Summary: This study analyzed the genome-wide DNA methylation of lupus patients and found that in addition to the hypomethylation of interferon-regulated genes, the miR-17-92 cluster also showed hypomethylation in patients with lupus, which is associated with T cell activation. The expression of miR-19b1 and miR-18a was significantly correlated with lupus disease activity.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
May Yee Choi, Ann Elaine Clarke, Murray Urowitz, John Hanly, Yvan St-Pierre, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Sasha Bernatsky, Daniel J. Wallace, David Isenberg, Anisur Rahman, Joan T. Merrill, Paul R. Fortin, Dafna D. Gladman, Ian N. Bruce, Michelle Petri, Ellen M. Ginzler, Mary Anne Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Jonsen, Graciela S. Alarcon, Ronald F. van Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, Sam Lim, Murat Inanc, Ken Kalunian, Soren Jacobsen, Christine Peschken, Diane L. Kamen, Anca Askanase, Jill P. Buyon, Karen H. Costenbader, Marvin J. Fritzler
Summary: In a longitudinal analysis of a large international incident SLE cohort, three ANA assays demonstrated high positivity rates and commutability. However, over a 5-year follow-up, there was a modest variation in ANA assay performance.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Biochemistry & Molecular Biology
Madhu Ramaswamy, Raj Tummala, Katie Streicher, Andre Nogueira da Costa, Philip Z. Brohawn
Summary: Systemic lupus erythematosus (SLE) presents a challenging treatment landscape due to its multifaceted etiology and complex immunopathogenesis. While targeting the B-cell pathway has limitations, recent approval of anifrolumab, a type I interferon-blocking antibody, highlights the therapeutic potential of targeting the dysregulated interferon pathway in SLE patients. Further research into the pleiotropic biology of interferons and their intersection with SLE disease pathology will be crucial for the development of effective targeted therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Rheumatology
May Yee Choi, Irene Chen, Ann Elaine Clarke, Marvin J. Fritzler, Katherine A. Buhler, Murray Urowitz, John Hanly, Yvan St-Pierre, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Sasha Bernatsky, Daniel J. Wallace, David Alan Isenberg, Anisur Rahman, Joan T. Merrill, Paul R. Fortin, Dafna D. Gladman, Ian N. Bruce, Michelle Petri, Ellen M. Ginzler, Mary Anne Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Jonsen, Graciela S. Alarcon, Ronald F. van Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, Sam Lim, Murat Inanc, Kenneth Kalunian, Soren Jacobsen, Christine Peschken, Diane L. Kamen, Anca Askanase, Jill P. Buyon, David Sontag, Karen H. Costenbader
Summary: A novel longitudinal clustering technique was used to analyze comprehensive autoantibody data from a large, well-characterised, multinational inception SLE cohort, in order to determine predictive profiles of clinical outcomes.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Immunology
Julia Lichtnekert, Hans-Joachim Anders, Maciej Lech
Summary: Lupus nephritis is a severe manifestation of systemic lupus erythematosus, and its treatment still faces many challenges. The progression of chronic kidney disease poses risks to patients, while the development of biomarkers provides hope for personalized treatment.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Jorge A. Soto, Felipe Melo-Gonzalez, Claudia A. Riedel, Susan M. Bueno, Alexis M. Kalergis
Summary: CLE is an autoimmune disorder characterized by autoantibody secretion and immune cell recruitment, similar to SLE. It can be divided into different types with varying severity of skin lesions. Type I IFN plays a significant role in the development of CLE. Research aims to develop effective treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Jae Il Shin, Keum Hwa Lee, Seoyeon Park, Jae Won Yang, Hyung Ju Kim, Kwanhyuk Song, Seungyeon Lee, Hyeyoung Na, Yong Jun Jang, Ju Yun Nam, Soojin Kim, Chaehyun Lee, Chanhee Hong, Chohwan Kim, Minhyuk Kim, Uichang Choi, Jaeho Seo, Hyunsoo Jin, BoMi Yi, Se Jin Jeong, Yeon Ook Sheok, Haedong Kim, Sangmin Lee, Sangwon Lee, Young Soo Jeong, Se Jin Park, Ji Hong Kim, Andreas Kronbichler
Summary: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with various manifestations, including pleuropulmonary involvement. The precise mechanism of pleuropulmonary involvement in SLE is not well-understood, but type 1 interferons, immune complexes, and neutrophils likely play important roles. There are multiple types of pleuropulmonary involvement, and various diagnostic tools and immunosuppressive therapies are used. However, specific therapies for pleuropulmonary involvement in SLE remain limited.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Oncology
Yijing Zhan, Qianmei Liu, Bo Zhang, Xin Huang, Qianjin Lu
Summary: Systemic lupus erythematosus (SLE) is a complex autoimmune disease involving genetic predisposition, epigenetic dysregulation, immune system overactivation, and environmental factors. Although the association between microbiota and metabolic or gastrointestinal diseases has been established, their role in autoimmunity, particularly in SLE, remains largely unknown. This review summarizes the latest research on the role and mechanisms of microbiota in SLE and the advancements in diagnostic and therapeutic strategies based on microbiota for SLE.
FRONTIERS OF MEDICINE
(2022)
Article
Immunology
M. -C. Gaudreau, B. M. Johnson, R. Gudi, M. M. Al-Gadban, C. Vasu
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Radhika Gudi, Courtney J. Haycraft, P. Darwin Bell, Zihai Li, Chenthamarakshan Vasu
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Medicine, Research & Experimental
Yongliang Zhang, Bill X. Wu, Alessandra Metelli, Jessica E. Thaxton, Feng Hong, Saleh Rachidi, Ephraim Ansa-Addo, Shaoli Sun, Chenthamarakshan Vasu, Yi Yang, Bei Liu, Zihai Li
JOURNAL OF CLINICAL INVESTIGATION
(2015)
Article
Endocrinology & Metabolism
Subha Karumuthil-Melethil, M. Hanief Sofi, Radhika Gudi, Benjamin M. Johnson, Nicolas Perez, Chenthamarakshan Vasu
Article
Multidisciplinary Sciences
Marie-Claude Gaudreau, Damien Grapton, Anne Helness, Charles Vadnais, Jennifer Fraszczak, Peiman Shooshtarizadeh, Brian Wilhelm, Francois Robert, Florian Heyd, Tarik Moroy
SCIENTIFIC REPORTS
(2016)
Article
Immunology
Radhika Gudi, Nicolas Perez, Benjamin M. Johnson, M. Hanief Sofi, Robert Brown, Songhua Quan, Subha Karumuthil-Melethil, Chenthamarakshan Vasu
Article
Endocrinology & Metabolism
M. Hanief Sofi, Benjamin M. Johnson, Radhika R. Gudi, Amy Jolly, Marie-Claude Gaudreau, Chenthamarakshan Vasu
Article
Nutrition & Dietetics
Radhika Gudi, Jada Suber, Robert Brown, Benjamin M. Johnson, Chenthamarakshan Vasu
JOURNAL OF NUTRITION
(2020)
Article
Multidisciplinary Sciences
Wei Sun, Radhika R. Gudi, Benjamin M. Johnson, Chenthamarakshan Vasu
SCIENTIFIC REPORTS
(2020)
Article
Immunology
Marie-Claude Gaudreau, Radhika R. Gudi, Gongbo Li, Benjamin M. Johnson, Chenthamarakshan Vasu
Summary: This study demonstrates the potential of using MSCs to produce and deliver Gastrin in vivo for protecting insulin-producing beta-cells and ameliorating the disease progression in Type 1 diabetes, showing promising results in delaying hyperglycemia in NOD mice and restoring euglycemia in early-hyperglycemic mice.
Article
Immunology
Radhika Gudi, Soumyabrata Roy, Wei Sun, Chenthamarakshan Vasu
Summary: This study investigates the faecal IgA abundance and nAg reactivity in different lupus-prone mouse models and its correlation with eventual serum autoantibody levels. The results show that the faecal IgA abundance and nAg reactivity vary among different models and are age-dependent. Importantly, faecal IgA in these mice exhibit significant levels of nAg reactivity from a juvenile age. Furthermore, the pre-seropositive stage nAg reactivity of faecal IgA correlates well with eventual serum autoantibody levels. Gender differences in serum autoantibody levels are preceded by similar differences in faecal IgA abundance and nAg reactivity. These findings suggest that faecal IgA features, particularly nAg reactivity, could serve as a biomarker for early prediction of eventual systemic autoimmunity in lupus-prone subjects.
Article
Immunology
Radhika R. Gudi, Benjamin M. Johnson, Marie-Claude Gaudreau, Wei Sun, Lauren Ball, Chenthamarakshan Vasu
Summary: The incidence of systemic lupus erythematosus (SLE) is higher in women than men, and the mechanisms underlying this gender bias are not well understood. Using lupus-prone mice, researchers have found that the intestinal immune system and gut microbiota play a role in the development of SLE, and depletion of gut microbiota provides better disease protection in females. Female lupus-prone mice with higher gut permeability at a young age were found to have higher expression levels of pro-inflammatory factors, faecal IgA abundance, and eventual systemic autoantibody levels and proteinuria onset. Disease protection achieved by depleting gut microbiota in female mice was associated with reduced gut inflammatory protein levels, intestinal permeability, and circulating microbial DNA levels. However, transplantation of gut microbiota from juvenile males and females did not affect gut inflammatory features or permeability. These findings suggest that early-onset intestinal inflammation, systemic autoantibody production, and disease progression in female lupus-prone mice are linked to higher gut permeability.