Article
Immunology
Jong Youl Kim, Jiwon Kim, Meiying Huang, Renee Kosonen, Jong Eun Lee
Summary: Microglia plays a significant role in the migration of monocyte-derived macrophages in neuroinflammatory conditions caused by microglial activation. The released chemokines by microglia can interact with CCR4 and CCR5 receptors on monocyte-derived macrophages, inducing their migration. CCR4 and CCR5 may be explored as new therapeutic targets for neuroinflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Stephanie Solier, Michele Mondini, Lydia Meziani, Arnaud Jacquel, Catherine Lacout, Tom Vanden Berghe, Yvon Jule, Jean-Claude Martinou, Gerard Pierron, Julie Riviere, Marc Deloger, Corinne Dupuy, Anny Slama-Schwok, Nathalie Droin, Peter Vandenabeele, Patrick Auberger, Eric Deutsch, Jamel El-Benna, Pham My-Chan Dang, Eric Solary
Summary: Circulating monocytes are recruited to damaged tissues to generate macrophages that modulate disease progression. Activation of caspase-3 and caspase-7, located near mitochondria, is involved in the generation of monocyte-derived macrophages stimulated by Colony-stimulating factor-1 (CSF-1). A non-conventional pathway that involves caspases and activates NOX2 is responsible for CSF1-driven monocyte differentiation, and targeting this pathway may have therapeutic implications for modulating macrophage polarization in damaged tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Giuseppe Rizzo, Julius Gropper, Marie Piollet, Ehsan Vafadarnejad, Anna Rizakou, Sourish Reddy Bandi, Panagiota Arampatzi, Tobias Krammer, Nina DiFabion, Oliver Dietrich, Anahi Paula Arias-Loza, Marco Prinz, Matthias Mack, Kai Schlepckow, Christian Haass, Jean Sebastien Silvestre, Alma Zernecke, Antoine Emmanuel Saliba, Clement Cochain
Summary: The study utilized single-cell immune profiling to map the transition of monocyte/macrophage populations in the infarcted heart, revealing the origin and dynamic changes of cardiac macrophages. In summary, the research provides valuable insights into how these cells can be potentially modulated to enhance post-ischaemic heart repair.
CARDIOVASCULAR RESEARCH
(2023)
Article
Immunology
Arturo Gonzalez de la Aleja, Cristina Herrero, Monica Torres-Torresano, Juan Vladimir de la Rosa, Barbara Alonso, Enrique Capa-Sardon, Ittai B. Muller, Gerrit Jansen, Amaya Puig-Kroeger, Miguel A. Vega, Antonio Castrillo, Angel L. Corbi
Summary: LXR activation limits the anti-inflammatory polarization of human macrophages and promotes the acquisition of an inflammatory profile, which is associated with the expression of specific genes and the release of activin A.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Denho Ravi, Erato Ntinopoulou, Nessim Guetta, Manuela Weier, Verena Vogel, Barbara Spellerberg, Parham Sendi, Sandrine Gremlich, Thierry Roger, Eric Giannoni
Summary: This study compares the response of newborn and adult macrophages to GBS. The findings show that newborn macrophages exhibit higher levels of cytokine release in response to GBS, and may play a significant role in the progression of GBS infection in newborns.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Jennillee Wallace, Hemil Gonzalez, Reshma Rajan, Srinivas D. Narasipura, Amber K. Virdi, Arnold Z. Olali, Ankur Naqib, Zarema Arbieva, Mark Maienschein-Cline, Lena Al-Harthi
Summary: Combination antiretroviral therapy (cART) has significantly improved the treatment of HIV/AIDS, but it may also affect cell dysregulation and increase susceptibility to comorbidities in persons living with HIV (PLWH).
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Immunology
Carmen W. E. Embregts, Annelieke S. Wentzel, Alexander T. den Dekker, Wilfred F. J. van IJcken, Ralph Stadhouders, Corine H. GeurtsvanKessel
Summary: Macrophages play a crucial role in the immune response to rabies virus (RABV). This study revealed that RABV induces activation and polarization of macrophages, leading to an antiviral response. The RABV-stimulated macrophages express multiple signature genes of M1, M2a, and M2c phenotypes, and activate pathways related to interferon and antiviral response.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Caroline B. K. Mathiesen, Asha M. Rudjord-Levann, Monika Gad, Jesper Larsen, Finn Sellebjerg, Anders Elm Pedersen
Summary: Cladribine has shown to reduce the inflammatory potential and phagocytic activity of M1 macrophages without affecting the differentiation or phenotype of these cells in relevant therapeutic concentrations in vitro. This could have a beneficial clinical impact in the treatment of MS by reducing plaque development while leaving M1 macrophages intact for protection against infections.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Physiology
Peter K. Moore, Kelsey C. Anderson, Shannon A. McManus, Ting -Hui Tu, Emily M. King, Kara J. Mould, Elizabeth F. Redente, Peter M. Henson, William J. Janssen, Alexandra L. McCubbrey
Summary: This study characterized the subtypes and transcriptomic profiles of interstitial macrophages (IMs) in the lung during homeostasis and acute lung inflammation induced by lipopolysaccharide (LPS). The results show that IMs can be divided into distinct subsets based on the expression of folate receptor I3 (FRI3), and during inflammation, there are recruited monocyte-derived IMs with unique gene expression profiles. These findings suggest that IMs have different functions during inflammation.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Immunology
Kaitryn E. Ronning, Sarah J. Karlen, Marie E. Burns
Summary: The study found that monocytic cells infiltrating the retina during photoreceptor loss differentiate into monocyte-derived macrophages that can remain in the retina long-term. These cells exhibit gene expression similar to microglia, but differ in morphology and function from resident microglia.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Multidisciplinary Sciences
Joey A. Charbonneau, Lara Maister, Manos Tsakiris, Eliza Bliss-Moreau
Summary: The ability to perceive internal bodily signals plays a critical role in biological and psychological functions. Rhesus monkeys have a human-like capacity to integrate interoceptive signals from the heart with exteroceptive audiovisual information.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Microbiology
Jose J. Rivera Rivas, Charles J. Czuprynski
Summary: Histophilus somni is a Gram-negative coccobacillus that causes diffuse vasculitis and intravascular thrombosis in cattle. Our study demonstrates that exposure to H. somni cells causes monocyte-derived macrophages to release microparticles with pro-coagulant activity, potentially amplifying thrombus formation.
VETERINARY MICROBIOLOGY
(2022)
Article
Respiratory System
R. Singh, K. B. R. Belchamber, P. S. Fenwick, K. Chana, G. Donaldson, J. A. Wedzicha, P. J. Barnes, L. E. Donnelly
Summary: The study found that impaired COPD macrophage phagocytosis of Haemophilus influenzae, but not Streptococcus pneumoniae, is associated with exacerbation frequency, resulting in the formation of pro-inflammatory macrophages in these frequent exacerbators. Targeting drugs to improve macrophage phagocytosis in these patients may be beneficial in disease management.
RESPIRATORY RESEARCH
(2021)
Article
Genetics & Heredity
Eun Gyung Park, Yun Ju Lee, Jae-Won Huh, Sang-Je Park, Hiroo Imai, Woo Ryung Kim, Du Hyeong Lee, Jung-min Kim, Hae Jin Shin, Heui-Soo Kim
Summary: Transposable elements (TEs) are mobile DNA entities that can move within the host genome. While they are typically silenced via mutations in the genome over evolutionary time, they still play an important role in the host genome by acting as regulatory elements and serving as a source of miRNAs. This study identified MDTEs in the Macaca mulatta genome and examined their expression and potential functional implications.
Article
Immunology
Steven P. Cass, Olivia Mekhael, Danya Thayaparan, Joshua J. C. McGrath, Spencer D. Revill, Matthew F. Fantauzzi, Peiyao Wang, Amir Reihani, Aaron Hayat, Christopher S. Stevenson, Anna Dvorkin-Gheva, Fernando M. Botelho, Martin R. Stampfli, Kjetil Ask
Summary: Cigarette smoke exposure altered the composition of pulmonary macrophages by expanding CD11b(+) subpopulations. These compositional changes were associated with attenuated fibrogenesis, as well as predominant M1 polarization and decreased fibrotic activity.
FRONTIERS IN IMMUNOLOGY
(2021)